Vnn1 (vanin 1) - Rat Genome Database

Name: Vnn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Vnn1 (vanin 1) Rattus norvegicus

Analyze

Symbol:

Vnn1

Name:

vanin 1

RGD ID:

1310075

Description:

Predicted to enable pantetheine hydrolase activity. Predicted to be involved in several processes, including coenzyme A catabolic process; positive regulation of T cell differentiation in thymus; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in plasma membrane and side of membrane. Orthologous to human VNN1 (vanin 1); PARTICIPATES IN pantothenic acid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC114385; pantetheinase; Tiff66

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	VNN1 (vanin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Vnn1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Vnn1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	VNN1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	VNN1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Vnn1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	VNN1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Vnn1 (vanin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	VNN2 (vanin 2)	HGNC	OrthoDB
Homo sapiens (human):	SLC36A2 (solute carrier family 36 member 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	VNN1 (vanin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Vnn1 (vanin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Btnd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32750	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32751	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	vanin-like	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	vnn1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)

Allele / Splice:

Vnn1^em2Mcwi Vnn1^em1Mcwi

Genetic Models:

SS-Vnn1^em1Mcwi SS-Vnn1^em2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	23,356,324 - 23,366,629 (-)	NCBI		GRCr8
mRatBN7.2	1	21,537,084 - 21,547,395 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	21,537,094 - 21,547,395 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	21,316,351 - 21,326,676 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	27,316,396 - 27,326,721 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	21,513,723 - 21,524,007 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	22,614,832 - 22,625,134 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	22,614,783 - 22,625,204 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	24,089,365 - 24,099,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	22,087,290 - 22,097,592 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	22,090,508 - 22,100,537 (-)	NCBI
Celera	1	20,280,201 - 20,290,503 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atopic dermatitis (ISO)

celiac disease (ISO)

Dyslipidemias (ISO)

inflammatory bowel disease (ISO)

pancreatic ductal adenocarcinoma (ISO)

psoriasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aldehydo-D-glucosamine (ISO)

allyl alcohol (ISO)

alpha-Zearalanol (EXP)

amiodarone (EXP,ISO)

amphotericin B (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bosentan (ISO)

buspirone (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloroform (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

ciglitazone (ISO)

cisplatin (ISO)

Citreoviridin (ISO)

clofibrate (EXP,ISO)

Clofop (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

corn oil (EXP)

cyanocob(III)alamin (ISO)

cyclosporin A (ISO)

cysteamine (ISO)

dapagliflozin (EXP)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dibenzofurans (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dimethylarsinic acid (ISO)

diquat (ISO)

diuron (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

ethylene glycol (EXP,ISO)

fenofibrate (EXP,ISO)

finasteride (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

fructose (EXP)

gemfibrozil (EXP)

gentamycin (EXP)

glafenine (EXP)

glutathione (ISO)

glycine betaine (ISO)

GW 4064 (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

L-ethionine (EXP)

L-methionine (ISO)

leflunomide (EXP,ISO)

metformin (EXP)

methapyrilene (EXP)

methotrexate (ISO)

methylarsonic acid (ISO)

Muraglitazar (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP,ISO)

nefazodone (EXP)

nimesulide (EXP)

nitrofen (EXP)

ochratoxin A (EXP)

oleic acid (ISO)

omeprazole (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

permethrin (ISO)

phenformin (EXP)

phenobarbital (ISO)

phenol (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

pravastatin (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

spirotetramat (ISO)

streptozocin (EXP)

Tesaglitazar (EXP)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (EXP,ISO)

valdecoxib (EXP)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute inflammatory response (ISO)

biological_process (ND)

cell-cell adhesion (ISO)

chronic inflammatory response (ISO)

coenzyme A catabolic process (ISO)

inflammatory response (ISO)

innate immune response (ISO)

pantothenate metabolic process (IBA,ISO)

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (ISO)

positive regulation of T cell differentiation in thymus (ISO)

Cellular Component

extracellular space (ISO)

plasma membrane (IEA)

side of membrane (IEA)

Molecular Function

pantetheine hydrolase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pantothenic acid metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.	Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.

Additional References at PubMed

PMID:8934567	PMID:11491533	PMID:12477932	PMID:14966568	PMID:15282320	PMID:21544065	PMID:22399813	PMID:23376485	PMID:24106341	PMID:25478849	PMID:26932716	PMID:27014792
PMID:30332759	PMID:31514290	PMID:34768879	PMID:35352799

Genomics

Comparative Map Data

Vnn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	23,356,324 - 23,366,629 (-)	NCBI		GRCr8
mRatBN7.2	1	21,537,084 - 21,547,395 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	21,537,094 - 21,547,395 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	21,316,351 - 21,326,676 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	27,316,396 - 27,326,721 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	21,513,723 - 21,524,007 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	22,614,832 - 22,625,134 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	22,614,783 - 22,625,204 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	24,089,365 - 24,099,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	22,087,290 - 22,097,592 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	22,090,508 - 22,100,537 (-)	NCBI
Celera	1	20,280,201 - 20,290,503 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

VNN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,680,849 - 132,714,055 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,680,849 - 132,714,055 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	133,001,988 - 133,035,194 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	133,044,422 - 133,076,881 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	133,044,422 - 133,076,881	NCBI
Celera	6	133,748,822 - 133,782,014 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,576,916 - 130,610,106 (-)	NCBI		HuRef
CHM1_1	6	133,265,672 - 133,298,869 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,875,818 - 133,909,022 (-)	NCBI		T2T-CHM13v2.0

Vnn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	23,770,586 - 23,781,242 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	23,770,586 - 23,781,241 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	23,894,688 - 23,905,344 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	23,894,688 - 23,905,343 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	23,614,494 - 23,625,149 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	23,573,041 - 23,594,755 (+)	NCBI		MGSCv36	mm8
Celera	10	24,828,202 - 24,838,840 (+)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	11.33	NCBI

Vnn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	13,238,603 - 13,259,577 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	13,238,307 - 13,266,800 (-)	NCBI	ChiLan1.0	ChiLan1.0

VNN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	152,665,525 - 152,697,484 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	150,572,617 - 150,604,502 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	130,459,268 - 130,491,167 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	134,566,110 - 134,598,784 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	134,566,117 - 134,598,784 (-)	Ensembl	panpan1.1		panPan2

VNN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	25,678,039 - 25,704,579 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	25,678,042 - 25,696,807 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	26,742,992 - 26,770,993 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	25,767,887 - 25,802,756 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	25,767,890 - 25,796,358 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	25,690,559 - 25,711,049 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	25,596,017 - 25,624,588 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	25,852,617 - 25,901,434 (-)	NCBI		UU_Cfam_GSD_1.0

Vnn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	120,920,545 - 120,951,976 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	701,892 - 729,526 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936560	701,857 - 729,516 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VNN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	31,000,255 - 31,024,505 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	31,003,338 - 31,023,731 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	34,520,052 - 34,544,689 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Vnn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	6,867,953 - 6,892,186 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624753	6,869,269 - 6,892,217 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Vnn1
75 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	402
Count of miRNA genes:	231
Interacting mature miRNAs:	266
Transcripts:	ENSRNOT00000021694
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354647	Despr8	Despair related QTL 8		0.0000341	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	1	24744506	Rat
2298546	Neuinf4	Neuroinflammation QTL 4	5.1		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	1	1	28736750	Rat
2313053	Bss51	Bone structure and strength QTL 51	3.8	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	1	32356093	Rat
2313070	Bss52	Bone structure and strength QTL 52	4.4	0.0001	body length (VT:0001256)	body length (CMO:0000013)	1	1	32356093	Rat
2313090	Bmd69	Bone mineral density QTL 69	4.4	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	1	32356093	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat
1578650	Bmd6	Bone mineral density QTL 6	12.2		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	1	509108	43284926	Rat
1578651	Bmd7	Bone mineral density QTL 7	14.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	1	509108	43284926	Rat
1578669	Bss9	Bone structure and strength QTL 9	6.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	1	509108	43284926	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
1600360	Mcs16	Mammary carcinoma susceptibility QTL 16	2.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	2244390	43433040	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	4393289	49393289	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	5925877	24697545	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	9856001	54856001	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	10992065	55992065	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11481312	75088344	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2317755	Glom22	Glomerulus QTL 22	3.8		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	11481482	32355910	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	11835181	56835181	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	15431621	49361612	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	0.00000072	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	15431621	49361612	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	16206210	49268520	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	19333571	56983283	Rat
1558642	Prcr2	Prostate cancer resistance QTL 2	4.3		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	1	20763158	44095856	Rat
724520	Bp145	Blood pressure QTL 145	2.1	0.0024	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	20784828	65784828	Rat

Markers in Region

Vnn1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	21,543,810 - 21,543,926 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	22,621,550 - 22,621,665	NCBI	Rnor6.0
Rnor_5.0	1	24,096,083 - 24,096,198	UniSTS	Rnor5.0
RGSC_v3.4	1	22,094,008 - 22,094,123	UniSTS	RGSC3.4
Celera	1	20,286,919 - 20,287,034	UniSTS
Cytogenetic Map	1	p12	UniSTS

RH131037

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	21,537,626 - 21,537,844 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	22,615,368 - 22,615,585	NCBI	Rnor6.0
Rnor_5.0	1	24,089,901 - 24,090,118	UniSTS	Rnor5.0
RGSC_v3.4	1	22,087,826 - 22,088,043	UniSTS	RGSC3.4
Celera	1	20,280,737 - 20,280,954	UniSTS
RH 3.4 Map	1	217.1	UniSTS
Cytogenetic Map	1	p12	UniSTS

Genetic Models

This gene Vnn1 is modified in the following models/strains:

SS-Vnn1^em1Mcwi SS-Vnn1^em2Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		41	22	14	11	14				23	29	11
Low	3	2	35	27	8	27	7	9	23	12	12		7
Below cutoff							1	2	51				1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000021694 ⟹ ENSRNOP00000021694

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	21,537,094 - 21,547,395 (-)	Ensembl
Rnor_6.0 Ensembl	1	22,614,783 - 22,625,204 (-)	Ensembl

RefSeq Acc Id:

NM_001025623 ⟹ NP_001020794

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	23,356,327 - 23,366,629 (-)	NCBI
mRatBN7.2	1	21,537,091 - 21,547,395 (-)	NCBI
Rnor_6.0	1	22,614,832 - 22,625,134 (-)	NCBI
Rnor_5.0	1	24,089,365 - 24,099,667 (-)	NCBI
RGSC_v3.4	1	22,087,290 - 22,097,592 (-)	RGD
Celera	1	20,280,201 - 20,290,503 (-)	RGD

Sequence:

show sequence

TTAAAATTAACCTTTTAAATTTATTTTGAAGACACCAAGGTCTGGGCACCACGTGATTCGTGCT
TTTTTTTTTTTTTACCATAAAAGTAGGAAGCTACGTTTTGGTTTTCCGCAGTCTTTGGACTTCA
GCATGAGCCTGTCTCGGTGGCTGGCGTGGGCTGCAGCGTTTTCCGTCTTCTGTGTCTTAAAAGT
CAGCTCTCTGGACACTTTCCTCGCAGCTGTTTACGAGCATGCTGTGATCCTGCCTAAAGTCACC
CTGTTACCTGTGTCTCACAGTGAGGCACTGGCATTAATGAACCAGAATCTGGACCTTCTGGAAG
GAGCGATCTTATCAGCAGCTAAGCAGGGTGCGCACATTATTGTGACTCCAGAAGATGGTATATA
CGGTGTGCAGTTCACCAGGGATACCATCTACCCATACCTGGAGGATATCCCAGACCCTCAAGTA
AACTGGATACCCTGTGATAATCCGGAAAGATTTGGCTCTACCCCGGTGCAGGAGAGACTCAGCT
GCTTGGCCAAGAACAACTCAATCTATGTCGTGGCGAACATGGGAGACAAGAAGCCATGCAACAC
CAGCGACTCTCACTGTCCACCTGACGGCCGATTCCAATACAACACTGATGTGGTGTTTGATTCC
CGGGGTAAATTGGTTGCCAGATACCATAAGCAAAACCTTTTCATGGGAGAAGAGCAATTCAATG
CCCCCCCGGAGCCTGAGGTCGTGACTTTTGACACCCCCTTTGGAAAGTTTGGCATCTTCACCTG
TTTCGATATTCTCTTCCATGATCCTGCTGTCACCCTAGTGACAGAGTTCCAGGTGGACACCATA
CTGTTCCCAACTGCCTGGATGGACGTGCTTCCTCATTTGGCAGCCATTGAATTCCACTCAGCTT
GGGCTATAGGCATGGGAGTCAATTTCCTAGCAGCTAATCTACATATTCCCTTGAGGAGAATGAC
AGGAAGTGGTATCTATGCACCCGATTCTCCACGGGCCTTTCATTATGACAGGAAGACACAGGAA
GGAAAGCTCCTCCTTGCACAGCTGGACTCTCACCCGAGTCACTCCCCAGTGAACTGGACTTCCT
ATGCCAGCAGTGTAGAAGCACCCCCAACTGAAAAGGAGGAATTTCGGAGTTTTGTTTTCTTTGA
TGAGTTTACCTTTGTGGAGCTCAAAGGGATCACAGGAAATTACACTGTTTGCCAGAACGACCTC
TGCTGTCATCTAAGCTACCAGATGTCTGAGAAGCGAGCTGATGAAGTTTATGCTCTTGGGGCTT
TTGACGGGTTGCACACCGTGGAAGGGCAGTATCACCTGCAGATTTGCATTCTGCTAAAGTGTAA
AACTACCAATTTACGCACCTGTGGTAGTTCAGTGGACACAGCTTCTACCAGGTTTGAAATGTTC
TCCCTCAGTGGCACTTTTGGAACGCGGTATGTCTTCCCTGAGGTGTTGCTGAGTGAAGTCAAGC
TTGCTCCTGGGGAGTTTCAGGTGTTGAGTGACGGGCGCCTGGTTAGCCTGAAGCCAACGTCTGG
ACCTGTGTTAACAGTCGGTCTCTTTGGGAGGTTGTATGAGAAGGACTGGGCATCAAATGCTTCC
TCAGACCTCATAGCACACTCACTGATAATAATGCTGATCCTAGCTCCTATTATACATTACTTGT
GTTAATAGAATTTCTACATTTTCTGTTTTATTTAGAACATTTAAAATTGGTAGGTGCAGAAAAA
AAAGTATCTGTTTGCCAACAGTGGACTCTGGGGTAAACAAATAAAGTGCCTCCTCTTTAGAGGA
GCATGCGTCCCAGATACACTTCAGGAAAATTAATAAAACTTTGAGCATTGGTCTATCTTAGAAC
TGAGATGTTGGGCCAAATGAAGGTCACATATATTTGATTCAGTTAAAAGGCACTTCAAAATATC
ATAATATATATTTATAAGACATTTGAATCTATTATACATCTTACTCGGTTATGGTTAAAATTTT
CAGTAAGTTTGTTCATTTGGGCTATTAAGTATATTATCTCAATAAATACATTTCCATTCTCTTA
AGAGGCAAATCCTGTAGCTTTAGTTCTTCAGTTCAAGTCCCAGTTCCCACAACCTCAGAACGTG
ACTGTCTTGGTGTCTTGGGAAATAAATACCTAAGTGACATCCTTAGCATGGGCTTTAATCTGAT
ATGACTGCTATCCTCAGAAGAAATCAGGACAAAGGTGAGAATCAAGTGAAGACCATGTGAACAC
AGAGAAAGATGGCCGTCTACAACAAGGAAAGGGGCCTCAGGAGAAAGCAACCTGCTAACATGTT
GAACTTCCAGGCCCCCAGAATATTGAGGCAATAAATTTCTCTTTTAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039103008 ⟹ XP_038958936

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	23,356,324 - 23,364,217 (-)	NCBI
mRatBN7.2	1	21,537,084 - 21,544,983 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020794	(Get FASTA)	NCBI Sequence Viewer
	XP_038958936	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98934	(Get FASTA)	NCBI Sequence Viewer
	EDL87746	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021694
	ENSRNOP00000021694.4

RefSeq Acc Id:	NP_001020794 ⟸ NM_001025623
- Peptide Label:	precursor
- UniProtKB:	Q4KLZ0 (UniProtKB/TrEMBL), F7FPD6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLSRWLAWAAAFSVFCVLKVSSLDTFLAAVYEHAVILPKVTLLPVSHSEALALMNQNLDLLEG AILSAAKQGAHIIVTPEDGIYGVQFTRDTIYPYLEDIPDPQVNWIPCDNPERFGSTPVQERLSC LAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSRGKLVARYHKQNLFMGEEQFNA PPEPEVVTFDTPFGKFGIFTCFDILFHDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAW AIGMGVNFLAANLHIPLRRMTGSGIYAPDSPRAFHYDRKTQEGKLLLAQLDSHPSHSPVNWTSY ASSVEAPPTEKEEFRSFVFFDEFTFVELKGITGNYTVCQNDLCCHLSYQMSEKRADEVYALGAF DGLHTVEGQYHLQICILLKCKTTNLRTCGSSVDTASTRFEMFSLSGTFGTRYVFPEVLLSEVKL APGEFQVLSDGRLVSLKPTSGPVLTVGLFGRLYEKDWASNASSDLIAHSLIIMLILAPIIHYLC hide sequence

RefSeq Acc Id:

ENSRNOP00000021694 ⟸ ENSRNOT00000021694

RefSeq Acc Id:	XP_038958936 ⟸ XM_039103008
- Peptide Label:	isoform X1

Protein Domains

CN hydrolase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KLZ0-F1-model_v2	AlphaFold	Q4KLZ0	1-512	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689531

Promoter ID:

EPDNEW_R55

Type:

multiple initiation site

Name:

Vnn1_1

Description:

vanin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	22,625,023 - 22,625,083	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310075	AgrOrtholog
BioCyc Gene	G2FUF-62078	BioCyc
Ensembl Genes	ENSRNOG00000016219	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021694	ENTREZGENE
	ENSRNOT00000021694.7	UniProtKB/TrEMBL
Gene3D-CATH	3.60.110.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7441890	IMAGE-MGC_LOAD
InterPro	Biotinidase/VNN	UniProtKB/TrEMBL
	Biotinidase_euk	UniProtKB/TrEMBL
	C-N_Hydrolase_sf	UniProtKB/TrEMBL
	Ntlse/CNhydtse	UniProtKB/TrEMBL
	Vanin_C	UniProtKB/TrEMBL
KEGG Report	rno:29142	UniProtKB/TrEMBL
MGC_CLONE	MGC:114385	IMAGE-MGC_LOAD
NCBI Gene	29142	ENTREZGENE
PANTHER	PANTETHEINASE	UniProtKB/TrEMBL
	PTHR10609	UniProtKB/TrEMBL
Pfam	CN_hydrolase	UniProtKB/TrEMBL
	Vanin_C	UniProtKB/TrEMBL
PhenoGen	Vnn1	PhenoGen
PIRSF	Biotinidase	UniProtKB/TrEMBL
PROSITE	CN_HYDROLASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016219	RatGTEx
Superfamily-SCOP	Ntlse/CNhydtse	UniProtKB/TrEMBL
UniProt	F7FPD6	ENTREZGENE, UniProtKB/TrEMBL
	Q4KLZ0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Vnn1	vanin 1	Vnn1_predicted	vanin 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Vnn1_predicted	vanin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)