Mef2d (myocyte enhancer factor 2D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mef2d (myocyte enhancer factor 2D) Rattus norvegicus
Analyze
Symbol: Mef2d
Name: myocyte enhancer factor 2D
RGD ID: 621489
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Orthologous to human MEF2D (myocyte enhancer factor 2D); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93400; myocyte-specific enhancer factor 2D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,904,332 - 175,933,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,903,959 - 175,930,760 (+)EnsemblGRCr8
mRatBN7.22173,606,054 - 173,635,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,606,490 - 173,634,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,751,841 - 180,777,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,774,196 - 178,799,948 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,373,781 - 173,399,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,511,775 - 187,541,285 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,512,164 - 187,538,026 (+)Ensemblrn6Rnor6.0
Rnor_5.02206,915,181 - 206,944,302 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,221,078 - 180,246,917 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,553,069 - 167,578,692 (+)NCBICelera
RGSC_v3.12180,171,183 - 180,197,019 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
oleanolic acid  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Hata Y and Sudhof TC, J Biol Chem 1995 Jun 2;270(22):13022-8.
4. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Leupin O, etal., J Bone Miner Res. 2007 Dec;22(12):1957-67.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Yang CC, etal., Nucleic Acids Res 1998 Oct 15;26(20):4771-7.
11. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis. Zhao X, etal., Mol Cell Biochem. 2015 Feb;400(1-2):1-7. doi: 10.1007/s11010-014-2228-7. Epub 2014 Dec 4.
Additional References at PubMed
PMID:7760790   PMID:8900141   PMID:9738004   PMID:9858528   PMID:10458488   PMID:12061776   PMID:12130539   PMID:15014501   PMID:15024082   PMID:15480995   PMID:15491989   PMID:15610731  
PMID:15735306   PMID:15737621   PMID:16024167   PMID:16112871   PMID:16484497   PMID:16870618   PMID:17158926   PMID:17336904   PMID:17945419   PMID:18093911   PMID:19683055   PMID:19801631  
PMID:20363751   PMID:20399744   PMID:20590529   PMID:20816781   PMID:20833138   PMID:21057871   PMID:22147266   PMID:22215669   PMID:22357862   PMID:25931508   PMID:26294766   PMID:28473466  
PMID:28807675   PMID:29118903   PMID:30523159   PMID:34232128  


Genomics

Comparative Map Data
Mef2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,904,332 - 175,933,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,903,959 - 175,930,760 (+)EnsemblGRCr8
mRatBN7.22173,606,054 - 173,635,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,606,490 - 173,634,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,751,841 - 180,777,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,774,196 - 178,799,948 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,373,781 - 173,399,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,511,775 - 187,541,285 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,512,164 - 187,538,026 (+)Ensemblrn6Rnor6.0
Rnor_5.02206,915,181 - 206,944,302 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,221,078 - 180,246,917 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,553,069 - 167,578,692 (+)NCBICelera
RGSC_v3.12180,171,183 - 180,197,019 (+)NCBI
Cytogenetic Map2q34NCBI
MEF2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,463,727 - 156,500,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,463,727 - 156,500,779 (-)Ensemblhg38GRCh38
GRCh371156,433,519 - 156,470,567 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,700,143 - 154,737,153 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341153,246,591 - 153,283,602NCBI
Celera1129,506,529 - 129,543,551 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,793,584 - 127,830,590 (-)NCBIHuRef
CHM1_11157,829,813 - 157,866,945 (-)NCBICHM1_1
T2T-CHM13v2.01155,602,298 - 155,639,356 (-)NCBIT2T-CHM13v2.0
Mef2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,049,248 - 88,079,398 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,049,679 - 88,079,393 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38388,141,941 - 88,172,091 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,142,372 - 88,172,086 (+)Ensemblmm10GRCm38
MGSCv37387,946,317 - 87,973,089 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36388,228,354 - 88,254,650 (+)NCBIMGSCv36mm8
Celera388,181,996 - 88,208,762 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
Mef2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,569,399 - 2,602,579 (-)Ensembl
ChiLan1.0NW_0049555452,569,399 - 2,602,580 (-)NCBIChiLan1.0ChiLan1.0
MEF2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,343,978 - 93,381,688 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,075,869 - 93,113,583 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,806,705 - 131,844,420 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,637,823 - 135,664,623 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,637,801 - 135,653,866 (-)EnsemblpanPan2panpan1.1
MEF2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,455,771 - 41,473,807 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,458,514 - 41,470,197 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha740,929,884 - 40,960,479 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0741,306,586 - 41,337,187 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,306,639 - 41,336,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,088,046 - 41,118,654 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,141,343 - 41,171,916 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,425,048 - 41,455,649 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mef2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,629,915 - 26,652,822 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,660,016 - 5,675,166 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,660,306 - 5,685,333 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,581,598 - 93,616,983 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1493,581,563 - 93,616,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,218,116 - 102,236,160 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEF2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,358,647 - 7,394,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,358,653 - 7,396,972 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660386,659,027 - 6,694,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mef2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,687,572 - 1,714,238 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248851,685,423 - 1,714,462 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mef2d
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000051394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
D1S262E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,625,227 - 173,625,339 (+)MAPPERmRatBN7.2
Rnor_6.02187,530,893 - 187,531,004NCBIRnor6.0
Rnor_5.02206,933,910 - 206,934,021UniSTSRnor5.0
RGSC_v3.42180,239,783 - 180,239,894UniSTSRGSC3.4
Celera2167,571,558 - 167,571,669UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ005425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051394   ⟹   ENSRNOP00000041061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,903,959 - 175,930,202 (+)Ensembl
mRatBN7.2 Ensembl2173,606,490 - 173,632,361 (+)Ensembl
Rnor_6.0 Ensembl2187,512,164 - 187,538,026 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099885   ⟹   ENSRNOP00000095486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,903,959 - 175,930,760 (+)Ensembl
mRatBN7.2 Ensembl2173,606,490 - 173,632,361 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117239   ⟹   ENSRNOP00000092351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,904,377 - 175,930,760 (+)Ensembl
mRatBN7.2 Ensembl2173,606,490 - 173,634,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117311   ⟹   ENSRNOP00000079168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,903,959 - 175,930,760 (+)Ensembl
mRatBN7.2 Ensembl2173,606,490 - 173,634,457 (+)Ensembl
RefSeq Acc Id: NM_030860   ⟹   NP_110487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,332 - 175,930,198 (+)NCBI
mRatBN7.22173,606,490 - 173,632,362 (+)NCBI
Rnor_6.02187,512,164 - 187,538,027 (+)NCBI
Rnor_5.02206,915,181 - 206,944,302 (+)NCBI
RGSC_v3.42180,221,078 - 180,246,917 (+)RGD
Celera2167,553,069 - 167,578,692 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232771   ⟹   XP_006232833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,905,127 - 175,933,451 (+)NCBI
mRatBN7.22173,607,114 - 173,635,620 (+)NCBI
Rnor_6.02187,512,497 - 187,541,285 (+)NCBI
Rnor_5.02206,915,181 - 206,944,302 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591127   ⟹   XP_017446616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
mRatBN7.22173,606,069 - 173,635,620 (+)NCBI
Rnor_6.02187,511,776 - 187,541,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591130   ⟹   XP_017446619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,905,186 - 175,933,451 (+)NCBI
mRatBN7.22173,607,451 - 173,635,620 (+)NCBI
Rnor_6.02187,513,104 - 187,541,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103204   ⟹   XP_038959132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
mRatBN7.22173,606,054 - 173,635,620 (+)NCBI
RefSeq Acc Id: XM_039103206   ⟹   XP_038959134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
mRatBN7.22173,606,054 - 173,635,620 (+)NCBI
RefSeq Acc Id: XM_039103208   ⟹   XP_038959136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
mRatBN7.22173,606,054 - 173,635,620 (+)NCBI
RefSeq Acc Id: XM_063282616   ⟹   XP_063138686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,905,127 - 175,933,451 (+)NCBI
RefSeq Acc Id: XM_063282617   ⟹   XP_063138687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
RefSeq Acc Id: XM_063282618   ⟹   XP_063138688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,905,127 - 175,933,451 (+)NCBI
RefSeq Acc Id: XR_005500377
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,904,516 - 175,933,451 (+)NCBI
mRatBN7.22173,606,054 - 173,635,620 (+)NCBI
RefSeq Acc Id: NP_110487   ⟸   NM_030860
- UniProtKB: Q66HL8 (UniProtKB/Swiss-Prot),   O89038 (UniProtKB/Swiss-Prot),   A6J655 (UniProtKB/TrEMBL),   A0A8I5ZM68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232833   ⟸   XM_006232771
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSU7 (UniProtKB/TrEMBL),   A0A8I6AGD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446616   ⟸   XM_017591127
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSU7 (UniProtKB/TrEMBL),   A0A8I6AGD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446619   ⟸   XM_017591130
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSU7 (UniProtKB/TrEMBL),   A0A8I6AGD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041061   ⟸   ENSRNOT00000051394
RefSeq Acc Id: XP_038959136   ⟸   XM_039103208
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038959132   ⟸   XM_039103204
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLN1 (UniProtKB/TrEMBL),   A0A8I6AGD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959134   ⟸   XM_039103206
- Peptide Label: isoform X5
- UniProtKB: Q66HL8 (UniProtKB/Swiss-Prot),   O89038 (UniProtKB/Swiss-Prot),   A0A8I5ZM68 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079168   ⟸   ENSRNOT00000117311
Ensembl Acc Id: ENSRNOP00000092351   ⟸   ENSRNOT00000117239
Ensembl Acc Id: ENSRNOP00000095486   ⟸   ENSRNOT00000099885
RefSeq Acc Id: XP_063138687   ⟸   XM_063282617
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138688   ⟸   XM_063282618
- Peptide Label: isoform X4
- UniProtKB: Q66HL8 (UniProtKB/Swiss-Prot),   O89038 (UniProtKB/Swiss-Prot),   A6J655 (UniProtKB/TrEMBL),   A0A8I5ZM68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138686   ⟸   XM_063282616
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLN1 (UniProtKB/TrEMBL),   A0A8I6AGD9 (UniProtKB/TrEMBL)
Protein Domains
MADS-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89038-F1-model_v2 AlphaFold O89038 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691429
Promoter ID:EPDNEW_R1953
Type:initiation region
Name:Mef2d_1
Description:myocyte enhancer factor 2D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,512,170 - 187,512,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621489 AgrOrtholog
BioCyc Gene G2FUF-52515 BioCyc
Ensembl Genes ENSRNOG00000031778 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051394 ENTREZGENE
  ENSRNOT00000099885 ENTREZGENE
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134848 IMAGE-MGC_LOAD
InterPro HJURP_C UniProtKB/Swiss-Prot
  MADS_MEF2-like UniProtKB/Swiss-Prot
  TF_MADSbox UniProtKB/Swiss-Prot
  TF_MADSbox_sf UniProtKB/Swiss-Prot
KEGG Report rno:81518 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93400 IMAGE-MGC_LOAD
NCBI Gene 81518 ENTREZGENE
PANTHER MADS BOX PROTEIN UniProtKB/Swiss-Prot
  MYOCYTE-SPECIFIC ENHANCER FACTOR 2D UniProtKB/Swiss-Prot
Pfam HJURP_C UniProtKB/Swiss-Prot
  SRF-TF UniProtKB/Swiss-Prot
PhenoGen Mef2d PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot
  MADS_BOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031778 RatGTEx
SMART MADS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot
UniProt A0A0G2JSU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLN1 ENTREZGENE, UniProtKB/TrEMBL
  A6J655 ENTREZGENE, UniProtKB/TrEMBL
  MEF2D_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL8 ENTREZGENE
UniProt Secondary Q66HL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mef2d  myocyte enhancer factor 2D      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mef2d  myocyte enhancer factor 2D      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with mitogen-activated protein kinase (MAP kinase), ERK5/BMK1 633239
gene_product member of the superfamily of transcription factors containing MADS domain 633239