Iapp (islet amyloid polypeptide) - Rat Genome Database
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Gene: Iapp (islet amyloid polypeptide) Rattus norvegicus
Analyze
Symbol: Iapp
Name: islet amyloid polypeptide
RGD ID: 2854
Description: Predicted to have identical protein binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; and eating behavior. Predicted to localize to extracellular space; inclusion body; and neuronal cell body. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 3,3',5,5'-tetrabromobisphenol A; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: amylin; DAP; diabetes-associated peptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,237,013 - 175,244,373 (+)NCBI
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
RH 3.4 Map41043.4RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2357234   PMID:2654937   PMID:2666169   PMID:2679555   PMID:9838101   PMID:11782784   PMID:12589759   PMID:12717720   PMID:12958059   PMID:14532296   PMID:14615061   PMID:14970190  
PMID:15572200   PMID:15710403   PMID:15802374   PMID:16142909   PMID:16553787   PMID:16890462   PMID:17428511   PMID:17481674   PMID:17640888   PMID:17693256   PMID:17703089   PMID:18346817  
PMID:18408164   PMID:18458326   PMID:18486611   PMID:18669592   PMID:18989932   PMID:19146426   PMID:19456151   PMID:19554505   PMID:19811608   PMID:19948124   PMID:20028124   PMID:20141758  
PMID:20416330   PMID:20668029   PMID:21130765   PMID:21138812   PMID:21266296   PMID:21606325   PMID:21865171   PMID:21965599   PMID:21984830   PMID:22014233   PMID:22106265   PMID:22334700  
PMID:22522254   PMID:22944668   PMID:23219578   PMID:23493863   PMID:24042052   PMID:24561193   PMID:25002582   PMID:25649462   PMID:25706385   PMID:26221949   PMID:26676252   PMID:26840340  
PMID:27566545   PMID:28665109   PMID:28912603   PMID:29523142   PMID:30803034   PMID:32587390  


Genomics

Comparative Map Data
Iapp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,237,013 - 175,244,373 (+)NCBI
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
RH 3.4 Map41043.4RGD
Cytogenetic Map4q44NCBI
IAPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1221,354,959 - 21,379,980 (+)EnsemblGRCh38hg38GRCh38
GRCh381221,354,959 - 21,379,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371221,507,893 - 21,532,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,417,085 - 21,423,683 (+)NCBINCBI36hg18NCBI36
Build 341221,417,084 - 21,423,683NCBI
Celera1226,681,196 - 26,688,308 (+)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1221,299,907 - 21,307,017 (+)NCBIHuRef
CHM1_11221,491,270 - 21,498,381 (+)NCBICHM1_1
Iapp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,244,151 - 142,249,546 (+)NCBIGRCm39mm39
GRCm39 Ensembl6142,244,149 - 142,249,687 (+)Ensembl
GRCm386142,298,425 - 142,303,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,298,423 - 142,303,961 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,246,945 - 142,252,340 (+)NCBIGRCm37mm9NCBIm37
MGSCv366142,255,650 - 142,261,039 (+)NCBImm8
Celera6145,357,925 - 145,363,320 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map673.81NCBI
Iapp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,835,037 - 16,840,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,834,940 - 16,841,071 (-)NCBIChiLan1.0ChiLan1.0
IAPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,520,986 - 67,528,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,520,986 - 67,528,103 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01264,918,000 - 64,925,191 (-)NCBIMhudiblu_PPA_v0panPan3
IAPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,295,481 - 26,299,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,295,481 - 26,299,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,156,535 - 20,161,021 (+)NCBI
ROS_Cfam_1.02726,621,265 - 26,625,751 (-)NCBI
UMICH_Zoey_3.12726,484,470 - 26,488,955 (-)NCBI
UNSW_CanFamBas_1.02726,462,824 - 26,467,310 (-)NCBI
UU_Cfam_GSD_1.02719,861,411 - 19,865,898 (+)NCBI
LOC101954740
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440494587,540,811 - 87,546,687 (-)NCBI
SpeTri2.0NW_0049365485,463,829 - 5,469,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IAPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103218731
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBI
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)Ensembl
Iapp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBI

Position Markers
D4Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,509,765 - 176,509,907NCBIRnor6.0
Rnor_5.04240,723,308 - 240,723,450UniSTSRnor5.0
RGSC_v3.44179,854,700 - 179,854,843RGDRGSC3.4
RGSC_v3.44179,854,701 - 179,854,843UniSTSRGSC3.4
RGSC_v3.14180,099,824 - 180,099,967RGD
Celera4163,769,128 - 163,769,270UniSTS
RH 3.4 Map41030.7UniSTS
RH 3.4 Map41030.7RGD
RH 2.0 Map41058.1RGD
Cytogenetic Map4q44UniSTS
D4Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,509,714 - 176,510,013NCBIRnor6.0
Rnor_5.04240,723,257 - 240,723,556UniSTSRnor5.0
RGSC_v3.44179,854,650 - 179,854,949UniSTSRGSC3.4
Celera4163,769,077 - 163,769,376UniSTS
Cytogenetic Map4q44UniSTS
D4Mgh29  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,509,753 - 176,509,897NCBIRnor6.0
Rnor_5.04240,723,296 - 240,723,440UniSTSRnor5.0
RGSC_v3.44179,854,688 - 179,854,833RGDRGSC3.4
RGSC_v3.44179,854,689 - 179,854,833UniSTSRGSC3.4
RGSC_v3.14180,099,812 - 180,099,957RGD
Celera4163,769,116 - 163,769,260UniSTS
FHH x ACI Map4112.37UniSTS
FHH x ACI Map4112.37RGD
Cytogenetic Map4q44UniSTS
D4Got138  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,509,733 - 176,510,025NCBIRnor6.0
Rnor_5.04240,723,276 - 240,723,568UniSTSRnor5.0
RGSC_v3.44179,854,668 - 179,854,961RGDRGSC3.4
RGSC_v3.44179,854,669 - 179,854,961UniSTSRGSC3.4
RGSC_v3.14180,099,793 - 180,100,085RGD
Celera4163,769,096 - 163,769,388UniSTS
RH 3.4 Map41044.9RGD
RH 3.4 Map41044.9UniSTS
RH 2.0 Map4898.1RGD
Cytogenetic Map4q44UniSTS
Iapp  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,515,839 - 176,516,058NCBIRnor6.0
Rnor_5.04240,729,382 - 240,729,601UniSTSRnor5.0
RGSC_v3.44179,860,775 - 179,860,994UniSTSRGSC3.4
Celera4163,775,202 - 163,775,421UniSTS
Cytogenetic Map4q44UniSTS
RH94796  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,510,411 - 176,510,709NCBIRnor6.0
Rnor_5.04240,723,954 - 240,724,252UniSTSRnor5.0
RGSC_v3.44179,855,347 - 179,855,645UniSTSRGSC3.4
Celera4163,769,774 - 163,770,072UniSTS
Cytogenetic Map4q44UniSTS
RH142197  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04176,510,778 - 176,510,975NCBIRnor6.0
Rnor_5.04240,724,321 - 240,724,518UniSTSRnor5.0
RGSC_v3.44179,855,714 - 179,855,911UniSTSRGSC3.4
Celera4163,770,141 - 163,770,338UniSTS
RH 3.4 Map41043.4UniSTS
Cytogenetic Map4q44UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4131834282176834282Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4136351734180689124Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4136908430182878540Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4145373934176509907Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4137171018182171018Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157423126184226339Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)4134917642179917642Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4131864442176864442Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155386197184226339Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4145547014184226339Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4145547014184226339Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4156855449184226339Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4146497452184226339Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:156
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000016614
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1
Low 3 9 5 9 5 1 16 14 10
Below cutoff 3 12 8 8 8 1 1 9 5 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016614   ⟹   ENSRNOP00000016614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)Ensembl
RefSeq Acc Id: NM_012586   ⟹   NP_036718
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,237,490 - 175,242,405 (+)NCBI
Rnor_6.04176,511,020 - 176,515,935 (+)NCBI
Rnor_5.04240,723,950 - 240,731,446 (+)NCBI
RGSC_v3.44179,855,956 - 179,860,871 (+)RGD
Celera4163,770,383 - 163,775,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237614   ⟹   XP_006237676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,237,013 - 175,244,373 (+)NCBI
Rnor_6.04176,509,863 - 176,517,903 (+)NCBI
Rnor_5.04240,723,950 - 240,731,446 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036718   ⟸   NM_012586
- Peptide Label: precursor
- UniProtKB: P12969 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006237676   ⟸   XM_006237614
- Peptide Label: isoform X1
- UniProtKB: P12969 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016614   ⟸   ENSRNOT00000016614

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693484
Promoter ID:EPDNEW_R4008
Type:single initiation site
Name:Iapp_1
Description:islet amyloid polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,510,637 - 176,510,697EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2854 AgrOrtholog
Ensembl Genes ENSRNOG00000012417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016614 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016614 UniProtKB/Swiss-Prot
InterPro Calcitonin-like UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot
  Calcitonin_CS UniProtKB/Swiss-Prot
  Calcitonin_peptide-like UniProtKB/Swiss-Prot
  Pro-islet_amyloid_polypep UniProtKB/Swiss-Prot
KEGG Report rno:24476 UniProtKB/Swiss-Prot
NCBI Gene 24476 ENTREZGENE
PANTHER PTHR10505 UniProtKB/Swiss-Prot
  PTHR10505:SF4 UniProtKB/Swiss-Prot
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot
PharmGKB IAPP RGD
PhenoGen Iapp PhenoGen
PRINTS ISLETAMYLOID UniProtKB/Swiss-Prot
PROSITE CALCITONIN UniProtKB/Swiss-Prot
SMART CALCITONIN UniProtKB/Swiss-Prot
UniProt IAPP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Iapp  Islet amyloid polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation gene contains a TATA-box, a CCAAT-sequence and a GT-element 729418