Iapp (islet amyloid polypeptide) - Rat Genome Database

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Gene: Iapp (islet amyloid polypeptide) Rattus norvegicus
Analyze
Symbol: Iapp
Name: islet amyloid polypeptide
RGD ID: 2854
Description: Predicted to enable identical protein binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; and eating behavior. Predicted to be located in inclusion body and neuronal cell body. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 3,3',5,5'-tetrabromobisphenol A; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amylin; DAP; diabetes-associated peptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,237,013 - 175,244,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,237,115 - 175,242,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,532,318 - 181,537,233 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,316,585 - 177,321,500 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04175,937,142 - 175,942,057 (+)NCBIRnor_WKY
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
RH 3.4 Map41043.4RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Clark A, etal., Lancet. 1987 Aug 1;2(8553):231-4.
2. Amyloid ß (Aß) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. Fu W, etal., J Biol Chem. 2012 May 25;287(22):18820-30. doi: 10.1074/jbc.M111.331181. Epub 2012 Apr 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes. Hayden MR, etal., Exp Biol Med (Maywood). 2008 Sep;233(9):1109-23. Epub 2008 Jul 18.
6. Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia. Heptulla RA, etal., J Clin Endocrinol Metab. 2009 May;94(5):1608-11. Epub 2009 Feb 3.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Nishi M, etal., Proc Natl Acad Sci U S A 1989 Aug;86(15):5738-42.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Amylin receptor blockade stimulates food intake in rats. Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R568-74. Epub 2004 May 6.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man. van Mansfeld AD, etal., Biochim Biophys Acta 1990 Oct 23;1087(2):235-40.
16. Direct detection of transient alpha-helical states in islet amyloid polypeptide. Williamson JA and Miranker AD, Protein Sci. 2007 Jan;16(1):110-7. Epub 2006 Nov 22.
17. Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide. Woerle HJ, etal., Diabetes Care. 2008 Dec;31(12):2325-31.
18. Amyloid oligomers in diabetic and nondiabetic human pancreas. Zhao HL, etal., Transl Res. 2009 Jan;153(1):24-32. Epub 2008 Nov 19.
Additional References at PubMed
PMID:2357234   PMID:2654937   PMID:2666169   PMID:2679555   PMID:9838101   PMID:11782784   PMID:12589759   PMID:12717720   PMID:12958059   PMID:14532296   PMID:14615061   PMID:14970190  
PMID:15572200   PMID:15710403   PMID:15802374   PMID:16142909   PMID:16553787   PMID:16890462   PMID:17428511   PMID:17481674   PMID:17640888   PMID:17693256   PMID:17703089   PMID:18346817  
PMID:18408164   PMID:18458326   PMID:18486611   PMID:18669592   PMID:18989932   PMID:19146426   PMID:19456151   PMID:19554505   PMID:19811608   PMID:19948124   PMID:20028124   PMID:20141758  
PMID:20416330   PMID:20668029   PMID:21130765   PMID:21138812   PMID:21266296   PMID:21606325   PMID:21865171   PMID:21965599   PMID:21984830   PMID:22014233   PMID:22106265   PMID:22334700  
PMID:22522254   PMID:22944668   PMID:23219578   PMID:23493863   PMID:24042052   PMID:24561193   PMID:25002582   PMID:25649462   PMID:25706385   PMID:26221949   PMID:26676252   PMID:26840340  
PMID:27566545   PMID:28665109   PMID:28912603   PMID:29523142   PMID:30803034   PMID:32436936   PMID:32587390   PMID:34264642  


Genomics

Comparative Map Data
Iapp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,237,013 - 175,244,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,237,115 - 175,242,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,532,318 - 181,537,233 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,316,585 - 177,321,500 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04175,937,142 - 175,942,057 (+)NCBIRnor_WKY
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
RH 3.4 Map41043.4RGD
Cytogenetic Map4q44NCBI
IAPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,354,959 - 21,379,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1221,354,959 - 21,379,980 (+)EnsemblGRCh38hg38GRCh38
GRCh371221,507,893 - 21,532,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,417,085 - 21,423,683 (+)NCBINCBI36Build 36hg18NCBI36
Build 341221,417,084 - 21,423,683NCBI
Celera1226,681,196 - 26,688,308 (+)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,299,907 - 21,307,017 (+)NCBIHuRef
CHM1_11221,491,270 - 21,498,381 (+)NCBICHM1_1
T2T-CHM13v2.01221,233,632 - 21,258,654 (+)NCBIT2T-CHM13v2.0
Iapp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,244,151 - 142,249,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,244,149 - 142,249,687 (+)EnsemblGRCm39 Ensembl
GRCm386142,298,425 - 142,303,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,298,423 - 142,303,961 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,246,945 - 142,252,340 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,255,650 - 142,261,039 (+)NCBIMGSCv36mm8
Celera6145,357,925 - 145,363,320 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map673.81NCBI
Iapp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,835,037 - 16,840,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,834,940 - 16,841,071 (-)NCBIChiLan1.0ChiLan1.0
IAPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,520,986 - 67,528,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,520,986 - 67,528,103 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01264,918,000 - 64,925,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IAPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,295,481 - 26,299,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,295,481 - 26,299,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,156,535 - 20,161,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,621,265 - 26,625,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,621,265 - 26,625,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,484,470 - 26,488,955 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,462,824 - 26,467,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,861,411 - 19,865,898 (+)NCBIUU_Cfam_GSD_1.0
Iapp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,540,811 - 87,546,687 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365485,463,829 - 5,469,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IAPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IAPP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,897,267 - 13,904,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iapp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,584,225 - 17,593,693 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D4Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,236,234 - 175,236,377 (+)MAPPERmRatBN7.2
Rnor_6.04176,509,765 - 176,509,907NCBIRnor6.0
Rnor_5.04240,723,308 - 240,723,450UniSTSRnor5.0
RGSC_v3.44179,854,700 - 179,854,843RGDRGSC3.4
RGSC_v3.44179,854,701 - 179,854,843UniSTSRGSC3.4
RGSC_v3.14180,099,824 - 180,099,967RGD
Celera4163,769,128 - 163,769,270UniSTS
RH 3.4 Map41030.7UniSTS
RH 3.4 Map41030.7RGD
RH 2.0 Map41058.1RGD
Cytogenetic Map4q44UniSTS
D4Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,236,183 - 175,236,483 (+)MAPPERmRatBN7.2
Rnor_6.04176,509,714 - 176,510,013NCBIRnor6.0
Rnor_5.04240,723,257 - 240,723,556UniSTSRnor5.0
RGSC_v3.44179,854,650 - 179,854,949UniSTSRGSC3.4
Celera4163,769,077 - 163,769,376UniSTS
Cytogenetic Map4q44UniSTS
D4Mgh29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,236,222 - 175,236,367 (+)MAPPERmRatBN7.2
Rnor_6.04176,509,753 - 176,509,897NCBIRnor6.0
Rnor_5.04240,723,296 - 240,723,440UniSTSRnor5.0
RGSC_v3.44179,854,688 - 179,854,833RGDRGSC3.4
RGSC_v3.44179,854,689 - 179,854,833UniSTSRGSC3.4
RGSC_v3.14180,099,812 - 180,099,957RGD
Celera4163,769,116 - 163,769,260UniSTS
FHH x ACI Map4112.37UniSTS
FHH x ACI Map4112.37RGD
Cytogenetic Map4q44UniSTS
D4Got138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,236,202 - 175,236,495 (+)MAPPERmRatBN7.2
Rnor_6.04176,509,733 - 176,510,025NCBIRnor6.0
Rnor_5.04240,723,276 - 240,723,568UniSTSRnor5.0
RGSC_v3.44179,854,668 - 179,854,961RGDRGSC3.4
RGSC_v3.44179,854,669 - 179,854,961UniSTSRGSC3.4
RGSC_v3.14180,099,793 - 180,100,085RGD
Celera4163,769,096 - 163,769,388UniSTS
RH 3.4 Map41044.9UniSTS
RH 3.4 Map41044.9RGD
RH 2.0 Map4898.1RGD
Cytogenetic Map4q44UniSTS
Iapp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,242,308 - 175,242,528 (+)MAPPERmRatBN7.2
Rnor_6.04176,515,839 - 176,516,058NCBIRnor6.0
Rnor_5.04240,729,382 - 240,729,601UniSTSRnor5.0
RGSC_v3.44179,860,775 - 179,860,994UniSTSRGSC3.4
Celera4163,775,202 - 163,775,421UniSTS
Cytogenetic Map4q44UniSTS
RH94796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,236,880 - 175,237,179 (+)MAPPERmRatBN7.2
Rnor_6.04176,510,411 - 176,510,709NCBIRnor6.0
Rnor_5.04240,723,954 - 240,724,252UniSTSRnor5.0
RGSC_v3.44179,855,347 - 179,855,645UniSTSRGSC3.4
Celera4163,769,774 - 163,770,072UniSTS
Cytogenetic Map4q44UniSTS
RH142197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,237,247 - 175,237,445 (+)MAPPERmRatBN7.2
Rnor_6.04176,510,778 - 176,510,975NCBIRnor6.0
Rnor_5.04240,724,321 - 240,724,518UniSTSRnor5.0
RGSC_v3.44179,855,714 - 179,855,911UniSTSRGSC3.4
Celera4163,770,141 - 163,770,338UniSTS
RH 3.4 Map41043.4UniSTS
Cytogenetic Map4q44UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:156
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000016614
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1
Low 3 9 5 9 5 1 16 14 10
Below cutoff 3 12 8 8 8 1 1 9 5 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016614   ⟹   ENSRNOP00000016614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,237,115 - 175,242,920 (+)Ensembl
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)Ensembl
RefSeq Acc Id: NM_012586   ⟹   NP_036718
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,237,490 - 175,242,405 (+)NCBI
Rnor_6.04176,511,020 - 176,515,935 (+)NCBI
Rnor_5.04240,723,950 - 240,731,446 (+)NCBI
RGSC_v3.44179,855,956 - 179,860,871 (+)RGD
Celera4163,770,383 - 163,775,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237614   ⟹   XP_006237676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,237,013 - 175,244,373 (+)NCBI
Rnor_6.04176,509,863 - 176,517,903 (+)NCBI
Rnor_5.04240,723,950 - 240,731,446 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036718   ⟸   NM_012586
- Peptide Label: precursor
- UniProtKB: P12969 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006237676   ⟸   XM_006237614
- Peptide Label: isoform X1
- UniProtKB: P12969 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016614   ⟸   ENSRNOT00000016614

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12969-F1-model_v2 AlphaFold P12969 1-93 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693484
Promoter ID:EPDNEW_R4008
Type:single initiation site
Name:Iapp_1
Description:islet amyloid polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,510,637 - 176,510,697EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2854 AgrOrtholog
BioCyc Gene G2FUF-42499 BioCyc
Ensembl Genes ENSRNOG00000012417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016614 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016614 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Calcitonin-like UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot
  Calcitonin_CS UniProtKB/Swiss-Prot
  Calcitonin_peptide-like UniProtKB/Swiss-Prot
  Pro-islet_amyloid_polypep UniProtKB/Swiss-Prot
KEGG Report rno:24476 UniProtKB/Swiss-Prot
NCBI Gene 24476 ENTREZGENE
PANTHER PTHR10505 UniProtKB/Swiss-Prot
  PTHR10505:SF4 UniProtKB/Swiss-Prot
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot
PharmGKB IAPP RGD
PhenoGen Iapp PhenoGen
PRINTS ISLETAMYLOID UniProtKB/Swiss-Prot
PROSITE CALCITONIN UniProtKB/Swiss-Prot
SMART CALCITONIN UniProtKB/Swiss-Prot
UniProt IAPP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Iapp  Islet amyloid polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation gene contains a TATA-box, a CCAAT-sequence and a GT-element 729418