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Gene: Lamb2 (laminin subunit beta 2) Rattus norvegicus
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Symbol: Lamb2
Name: laminin subunit beta 2
Description: Predicted to have extracellular matrix structural constituent and integrin binding activity. Predicted to be involved in several processes, including animal organ development; neurogenesis; and substrate adhesion-dependent cell spreading. Predicted to localize to laminin-3 complex; neuromuscular junction; and synaptic cleft. Used to study proteinuria. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; small cell lung carcinoma pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: laminin chain B3; Laminin chain beta 2; laminin subunit beta-2; laminin, beta 2; laminin-11 subunit beta; laminin-14 subunit beta; laminin-15 subunit beta; laminin-3 subunit beta; laminin-4 subunit beta; laminin-7 subunit beta; laminin-9 subunit beta; MGC93588; S-LAM beta; S-laminin subunit beta; SLAM
Orthologs:
Homo sapiens (human) : LAMB2 (laminin subunit beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Lamb2 (laminin, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lamb2 (laminin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMB2 (laminin subunit beta 2)
Canis lupus familiaris (dog) : LAMB2 (laminin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lamb2 (laminin subunit beta 2)
Sus scrofa (pig) : LAMB2 (laminin subunit beta 2)
Chlorocebus sabaeus (African green monkey) : LAMB2 (laminin subunit beta 2)
Heterocephalus glaber (naked mole-rat) : Lamb2 (laminin subunit beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,268,335 - 117,280,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,268,337 - 117,280,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,613,044 - 116,625,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,474,916 - 108,487,056 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lamb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2988
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.