Lamb2 (laminin subunit beta 2) - Rat Genome Database

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Gene: Lamb2 (laminin subunit beta 2) Rattus norvegicus
Analyze
Symbol: Lamb2
Name: laminin subunit beta 2
RGD ID: 2988
Description: Predicted to enable integrin binding activity. Predicted to be a structural constituent of synapse-associated extracellular matrix. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Predicted to be located in basement membrane and synapse. Predicted to be part of laminin-3 complex. Predicted to be active in neuromuscular junction and synaptic cleft. Used to study proteinuria. Human ortholog(s) of this gene implicated in Pierson syndrome; nephrotic syndrome type 5; and primary open angle glaucoma. Orthologous to human LAMB2 (laminin subunit beta 2); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; small cell lung carcinoma pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: laminin chain B3; Laminin chain beta 2; laminin subunit beta-2; laminin, beta 2; laminin-11 subunit beta; laminin-14 subunit beta; laminin-15 subunit beta; laminin-3 subunit beta; laminin-4 subunit beta; laminin-7 subunit beta; laminin-9 subunit beta; MGC93588; S-LAM beta; S-laminin subunit beta; SLAM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,056,899 - 118,069,090 (+)NCBIGRCr8
mRatBN7.28109,178,367 - 109,190,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,178,409 - 109,190,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,796,758 - 114,808,880 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,996,090 - 113,008,212 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,838,730 - 110,850,852 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,268,335 - 117,280,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,268,337 - 117,280,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,613,044 - 116,625,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,474,916 - 108,487,056 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Brodifacoum  (EXP)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chrysin  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dimethyl sulfoxide  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
griseofulvin  (ISO)
hydrogen peroxide  (ISO)
kaempferol  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
quercetin  (ISO)
rotenone  (EXP)
rutin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion. Chen YM, etal., J Am Soc Nephrol. 2011 May;22(5):849-58. doi: 10.1681/ASN.2010060632. Epub 2011 Apr 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. Hunter DD, etal., Nature 1989 Mar 16;338(6212):229-34.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Reductions in laminin beta2 mRNA translation are responsible for impaired IGFBP-5-mediated mesangial cell migration in the presence of high glucose. Schaeffer V, etal., Am J Physiol Renal Physiol. 2010 Feb;298(2):F314-22. doi: 10.1152/ajprenal.00483.2009. Epub 2009 Oct 28.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Identification of Missense Extracellular Matrix Gene Variants in a Large Glaucoma Pedigree and Investigation of the N700S Thrombospondin-1 Variant in Normal and Glaucomatous Trabecular Meshwork Cells. Wirtz MK, etal., Curr Eye Res. 2022 Jan;47(1):79-90. doi: 10.1080/02713683.2021.1945109. Epub 2021 Jul 6.
15. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Zenker M, etal., Hum Mol Genet. 2004 Nov 1;13(21):2625-32. Epub 2004 Sep 14.
Additional References at PubMed
PMID:2099832   PMID:7670489   PMID:7885444   PMID:8034675   PMID:9396756   PMID:9641682   PMID:10964500   PMID:12477932   PMID:14557481   PMID:15577901   PMID:16041630   PMID:16886065  
PMID:17189701   PMID:17418794   PMID:19199708   PMID:19295126   PMID:19907020   PMID:20551380   PMID:20566382   PMID:22513850   PMID:23533145   PMID:24006456   PMID:27068509   PMID:27425256  
PMID:27559042  


Genomics

Comparative Map Data
Lamb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,056,899 - 118,069,090 (+)NCBIGRCr8
mRatBN7.28109,178,367 - 109,190,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,178,409 - 109,190,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,796,758 - 114,808,880 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,996,090 - 113,008,212 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,838,730 - 110,850,852 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,268,335 - 117,280,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,268,337 - 117,280,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,613,044 - 116,625,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,474,916 - 108,487,056 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
LAMB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,121,114 - 49,133,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,121,114 - 49,133,118 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,158,547 - 49,170,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,133,551 - 49,145,603 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,133,551 - 49,145,603NCBI
Celera349,115,499 - 49,127,552 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,217,083 - 49,229,135 (-)NCBIHuRef
CHM1_1349,111,294 - 49,123,346 (-)NCBICHM1_1
T2T-CHM13v2.0349,149,186 - 49,161,187 (-)NCBIT2T-CHM13v2.0
Lamb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,357,080 - 108,367,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,356,935 - 108,367,729 (+)EnsemblGRCm39 Ensembl
GRCm389108,479,847 - 108,490,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,479,736 - 108,490,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,382,193 - 108,392,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,338,049 - 108,348,632 (+)NCBIMGSCv36mm8
Celera9108,089,281 - 108,099,994 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.4NCBI
Lamb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,115,087 - 1,127,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,115,412 - 1,127,264 (-)NCBIChiLan1.0ChiLan1.0
LAMB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,099,617 - 49,111,578 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,104,385 - 49,116,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,045,419 - 49,057,340 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,125,348 - 50,137,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,125,460 - 50,137,074 (-)Ensemblpanpan1.1panPan2
LAMB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,036,967 - 40,062,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,050,157 - 40,062,523 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,949,768 - 39,980,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,388,459 - 40,419,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,387,822 - 40,419,510 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,759,167 - 39,786,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,158,837 - 40,189,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,439,108 - 40,470,170 (+)NCBIUU_Cfam_GSD_1.0
Lamb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,065,681 - 64,080,848 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529826,142 - 841,337 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529826,178 - 841,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,738,286 - 31,750,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,738,282 - 31,750,623 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,969,986 - 34,981,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,523,763 - 10,535,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,523,717 - 10,536,207 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,545,957 - 156,558,194 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,145,643 - 3,159,101 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,145,643 - 3,158,781 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lamb2
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000072098
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
GDB:580683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,179,290 - 109,180,909 (+)MAPPERmRatBN7.2
Rnor_6.08117,269,256 - 117,270,874NCBIRnor6.0
Rnor_5.08116,613,959 - 116,615,577UniSTSRnor5.0
Celera8108,475,798 - 108,477,416UniSTS
GDB:580686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,180,603 - 109,181,590 (+)MAPPERmRatBN7.2
Rnor_6.08117,270,569 - 117,271,555NCBIRnor6.0
Rnor_5.08116,615,272 - 116,616,258UniSTSRnor5.0
Celera8108,477,111 - 108,478,097UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 16 6 12 6 8 11 66 35 35 11 8
Low 41 35 7 35 8 6
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000072098   ⟹   ENSRNOP00000065052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,178,409 - 109,190,549 (+)Ensembl
Rnor_6.0 Ensembl8117,268,337 - 117,280,517 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083578   ⟹   ENSRNOP00000072697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,178,410 - 109,190,549 (+)Ensembl
Rnor_6.0 Ensembl8117,268,375 - 117,280,510 (+)Ensembl
RefSeq Acc Id: NM_012974   ⟹   NP_037106
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,056,947 - 118,069,087 (+)NCBI
mRatBN7.28109,178,409 - 109,190,549 (+)NCBI
Rnor_6.08117,268,374 - 117,280,514 (+)NCBI
Rnor_5.08116,613,044 - 116,625,220 (+)NCBI
Celera8108,474,916 - 108,487,056 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006243709   ⟹   XP_006243771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,056,899 - 118,069,090 (+)NCBI
mRatBN7.28109,178,367 - 109,190,552 (+)NCBI
Rnor_6.08117,268,335 - 117,280,517 (+)NCBI
Rnor_5.08116,613,044 - 116,625,220 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080881   ⟹   XP_038936809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,056,905 - 118,069,090 (+)NCBI
mRatBN7.28109,178,367 - 109,190,552 (+)NCBI
RefSeq Acc Id: XM_039080882   ⟹   XP_038936810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,057,132 - 118,069,090 (+)NCBI
mRatBN7.28109,178,582 - 109,190,552 (+)NCBI
RefSeq Acc Id: NP_037106   ⟸   NM_012974
- Peptide Label: precursor
- UniProtKB: P15800 (UniProtKB/Swiss-Prot),   Q5M7W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243771   ⟸   XM_006243709
- Peptide Label: isoform X1
- UniProtKB: M0R6K0 (UniProtKB/TrEMBL),   A6I359 (UniProtKB/TrEMBL),   Q5M7W9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072697   ⟸   ENSRNOT00000083578
Ensembl Acc Id: ENSRNOP00000065052   ⟸   ENSRNOT00000072098
RefSeq Acc Id: XP_038936809   ⟸   XM_039080881
- Peptide Label: isoform X2
- UniProtKB: Q5M7W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936810   ⟸   XM_039080882
- Peptide Label: isoform X3
- UniProtKB: Q5M7W9 (UniProtKB/TrEMBL)
Protein Domains
Laminin EGF-like   Laminin IV type B   Laminin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15800-F1-model_v2 AlphaFold P15800 1-1801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696303
Promoter ID:EPDNEW_R6827
Type:multiple initiation site
Name:Lamb2_1
Description:laminin subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,268,362 - 117,268,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2988 AgrOrtholog
BioCyc Gene G2FUF-29139 BioCyc
Ensembl Genes ENSRNOG00000047768 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072098.3 UniProtKB/TrEMBL
  ENSRNOT00000083578.2 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107264 IMAGE-MGC_LOAD
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_IV_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25473 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93588 IMAGE-MGC_LOAD
NCBI Gene 25473 ENTREZGENE
PANTHER LAMININ SUBUNIT GAMMA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_IV_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lamb2 PhenoGen
PRINTS EGFLAMININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_LAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_IVB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047768 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217452
UniProt A6I359 ENTREZGENE, UniProtKB/TrEMBL
  LAMB2_RAT UniProtKB/Swiss-Prot
  M0R6K0 ENTREZGENE, UniProtKB/TrEMBL
  P15800 ENTREZGENE
  Q5M7W9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Lamb2  laminin subunit beta 2  Lamb2  laminin, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lamb2  Laminin chain beta 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization found in the synaptic cleft of the neuromuscular junction 728961