Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619991
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Vegfa
Name:	vascular endothelial growth factor A

Acc ID:	CHEBI:4784
Term:	enalapril
Definition:	A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID:	MESH:D004656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Vegfa	increases expression	EXP		6480464	CTD	Enalapril results in increased expression of VEGFA protein	PMID:21263376
Vegfa	multiple interactions	EXP		6480464	CTD	Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]	PMID:12110003
Vegfa	multiple interactions	ISO	VEGFA (Homo sapiens)	6480464	CTD	Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]	PMID:16202860 PMID:17299153

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