Tec (tec protein tyrosine kinase) - Rat Genome Database
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Gene: Tec (tec protein tyrosine kinase) Rattus norvegicus
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Symbol: Tec
Name: tec protein tyrosine kinase
RGD ID: 620973
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity. Involved in tissue regeneration. Predicted to localize to cell-cell junction; cytoskeleton; and plasma membrane. Orthologous to human TEC (tec protein tyrosine kinase); PARTICIPATES IN erythropoietin signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cytoplasmic tyrosine kinase; cytoplasmic tyrosine kinase, Dscr28C related; cytoplasmic tyrosine kinase, Dscr28C related (Drosophila); tyrosine-protein kinase Tec
Orthologs:
Homo sapiens (human) : TEC (tec protein tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Tec (tec protein tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tec (tec protein tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TEC (tec protein tyrosine kinase)
Canis lupus familiaris (dog) : TEC (tec protein tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tec (tec protein tyrosine kinase)
Sus scrofa (pig) : TEC (tec protein tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : TEC (tec protein tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Tec (tec protein tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01437,918,884 - 38,027,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1437,918,652 - 38,027,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,729,168 - 37,838,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,756,486 - 37,865,180 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11437,838,323 - 37,868,527 (+)NCBI
Celera1434,607,791 - 34,715,833 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9299487   PMID:9652744   PMID:10518561   PMID:12477932   PMID:21094130   PMID:23793062  


Genomics

Comparative Map Data
Tec
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01437,918,884 - 38,027,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1437,918,652 - 38,027,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,729,168 - 37,838,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,756,486 - 37,865,180 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11437,838,323 - 37,868,527 (+)NCBI
Celera1434,607,791 - 34,715,833 (+)NCBICelera
Cytogenetic Map14p11NCBI
TEC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl448,135,783 - 48,269,838 (-)EnsemblGRCh38hg38GRCh38
GRCh38448,135,783 - 48,269,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37448,137,800 - 48,271,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,832,557 - 47,966,571 (-)NCBINCBI36hg18NCBI36
Build 34447,978,728 - 48,112,742NCBI
Celera448,586,515 - 48,720,532 (-)NCBI
Cytogenetic Map4p12-p11NCBI
HuRef447,457,565 - 47,591,606 (-)NCBIHuRef
CHM1_1448,136,907 - 48,270,950 (-)NCBICHM1_1
Tec
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,913,061 - 73,025,997 (-)NCBI
GRCm38572,755,718 - 72,868,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,755,716 - 72,868,483 (-)EnsemblGRCm38mm10GRCm38
MGSCv37573,146,962 - 73,259,687 (-)NCBIGRCm37mm9NCBIm37
MGSCv36573,034,873 - 73,147,618 (-)NCBImm8
Celera570,005,814 - 70,119,901 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
Tec
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955443340,940 - 476,702 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443339,678 - 474,029 (+)NCBIChiLan1.0ChiLan1.0
TEC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1484,618,088 - 84,750,319 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl484,618,088 - 84,750,319 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0473,885,588 - 74,018,061 (+)NCBI
TEC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1343,978,573 - 44,062,795 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11343,978,964 - 44,111,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tec
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648214,248,277 - 14,341,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl838,051,056 - 38,182,182 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1838,051,053 - 38,182,259 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2840,100,495 - 40,275,177 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TEC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl272,024,719 - 2,117,763 (+)Ensembl
ChlSab1.1271,982,549 - 2,118,533 (+)NCBI
Tec
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
D14Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01438,008,403 - 38,008,555NCBIRnor6.0
Rnor_5.01437,818,685 - 37,818,837UniSTSRnor5.0
RGSC_v3.41437,845,655 - 37,845,808RGDRGSC3.4
RGSC_v3.41437,845,656 - 37,845,808UniSTSRGSC3.4
RGSC_v3.11437,848,980 - 37,849,133RGD
Celera1434,696,308 - 34,696,463UniSTS
Cytogenetic Map14p11UniSTS
RH144023  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01437,976,338 - 37,976,601NCBIRnor6.0
Rnor_5.01437,786,425 - 37,786,688UniSTSRnor5.0
RGSC_v3.41437,813,591 - 37,813,854UniSTSRGSC3.4
Celera1434,664,807 - 34,665,070UniSTS
Cytogenetic Map14p11UniSTS
RH141346  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01438,027,527 - 38,027,706NCBIRnor6.0
Rnor_5.01437,837,826 - 37,838,005UniSTSRnor5.0
RGSC_v3.41437,864,780 - 37,864,959UniSTSRGSC3.4
Celera1434,715,433 - 34,715,612UniSTS
Cytogenetic Map14p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14975643572854397Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin141053997755539977Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)141053997755539977Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)141072926861873323Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141915991938289187Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141916189343957503Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141919154143957628Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)142018938665189386Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)142026622343957628Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)142145756566457565Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143303991261783215Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143316331673391571Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:56
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000003125
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 17 19 17 6 10
Low 1 43 31 24 24 8 10 74 35 35 1 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003125   ⟹   ENSRNOP00000003125
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1437,919,233 - 38,027,925 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088441   ⟹   ENSRNOP00000075313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1437,918,652 - 38,027,920 (+)Ensembl
RefSeq Acc Id: NM_053432   ⟹   NP_445884
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,919,233 - 38,027,927 (+)NCBI
Rnor_5.01437,729,168 - 37,838,252 (+)NCBI
RGSC_v3.41437,756,486 - 37,865,180 (+)RGD
Celera1434,607,791 - 34,715,833 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250910   ⟹   XP_006250972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,942,035 - 38,027,953 (+)NCBI
Rnor_5.01437,729,168 - 37,838,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250911   ⟹   XP_006250973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,918,884 - 38,027,953 (+)NCBI
Rnor_5.01437,729,168 - 37,838,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599398   ⟹   XP_017454887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,942,331 - 38,027,953 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445884   ⟸   NM_053432
- UniProtKB: B2RYC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250973   ⟸   XM_006250911
- Peptide Label: isoform X1
- UniProtKB: B2RYC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250972   ⟸   XM_006250910
- Peptide Label: isoform X1
- UniProtKB: B2RYC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454887   ⟸   XM_017599398
- Peptide Label: isoform X1
- UniProtKB: B2RYC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003125   ⟸   ENSRNOT00000003125
RefSeq Acc Id: ENSRNOP00000075313   ⟸   ENSRNOT00000088441
Protein Domains
PH   Protein kinase   SH2   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699300
Promoter ID:EPDNEW_R9821
Type:multiple initiation site
Name:Tec_2
Description:tec protein tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9822  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,918,621 - 37,918,681EPDNEW
RGD ID:13699297
Promoter ID:EPDNEW_R9822
Type:multiple initiation site
Name:Tec_1
Description:tec protein tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9821  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01437,919,237 - 37,919,297EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620973 AgrOrtholog
Ensembl Genes ENSRNOG00000002278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003125 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075313 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003125 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000088441 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934247 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tec_SH3 UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report rno:84492 UniProtKB/TrEMBL
MGC_CLONE MGC:188447 IMAGE-MGC_LOAD
NCBI Gene 84492 ENTREZGENE
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Tec PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniGene Rn.11797 ENTREZGENE
UniProt A0A0G2KA94_RAT UniProtKB/TrEMBL
  B2RYC7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tec  tec protein tyrosine kinase  Tec  cytoplasmic tyrosine kinase, Dscr28C related (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Tec  cytoplasmic tyrosine kinase, Dscr28C related (Drosophila)  Tec  tec protein tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Tec  tec protein tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in liver 631955
gene_regulation induced in regeneration liver; induced by EGF 631955
 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.