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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triptorelin
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Accession:CHEBI:63633 term browser browse the term
Definition:An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide
 related_synonym: (6-D-Tryptophan)luteinizing hormone-releasing hormone;   (D-Trp6)-GnRH;   Formula=C64H82N18O13;   InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1;   InChIKey=VXKHXGOKWPXYNA-PGBVPBMZSA-N;   Luteinizing hormone-releasing factor (pig), 6-D-tryptophan;   SMILES=CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O;   pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;   triptorelina;   triptoreline;   triptorelinum
 xref: CAS:57773-63-4;   Drug_Central:2968;   KEGG:D06247
 xref_mesh: MESH:D017329
 xref: PMID:21040957;   PMID:21600174;   PMID:21693037;   PMID:21771987;   PMID:22231041;   Patent:EP1354952;   Patent:US2002111603;   Reaxys:9317315;   Wikipedia:Triptorelin


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triptorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnrhr gonadotropin releasing hormone receptor multiple interactions
affects expression
ISO [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Progesterone promotes the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] CTD PMID:17185802 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases expression
EXP Triptorelin Pamoate results in decreased expression of LHB protein
Triptorelin Pamoate results in increased expression of LHB protein
CTD PMID:3158510, PMID:20463352 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]]; testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein] CTD PMID:20463352 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A protein CTD PMID:20463352 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde6d phosphodiesterase 6D decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE6D mRNA CTD PMID:20463352 NCBI chr 9:93,562,099...93,607,061
Ensembl chr 9:93,562,095...93,607,087
JBrowse link
G Pde9a phosphodiesterase 9A decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE9A mRNA CTD PMID:20463352 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression
multiple interactions
EXP Triptorelin Pamoate results in decreased expression of PRKG1 mRNA; Triptorelin Pamoate results in decreased expression of PRKG1 protein
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]; testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]
CTD PMID:20463352 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prl prolactin multiple interactions ISO
EXP
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]
Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]
CTD PMID:2954994, PMID:3158510 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antineoplastic agent 17001
              triptorelin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                peptide 9396
                                                  oligopeptide 1199
                                                    triptorelin 8
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