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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triptorelin
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Accession:CHEBI:63633 term browser browse the term
Definition:An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide
 related_synonym: (6-D-Tryptophan)luteinizing hormone-releasing hormone;   (D-Trp6)-GnRH;   Formula=C64H82N18O13;   InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1;   InChIKey=VXKHXGOKWPXYNA-PGBVPBMZSA-N;   Luteinizing hormone-releasing factor (pig), 6-D-tryptophan;   SMILES=CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O;   pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;   triptorelina;   triptoreline;   triptorelinum
 xref: CAS:57773-63-4;   Drug_Central:2968;   KEGG:D06247
 xref_mesh: MESH:D017329
 xref: PMID:21040957;   PMID:21600174;   PMID:21693037;   PMID:21771987;   PMID:22231041;   Patent:EP1354952;   Patent:US2002111603;   Reaxys:9317315;   Wikipedia:Triptorelin



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triptorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnrhr gonadotropin releasing hormone receptor multiple interactions
affects expression
ISO [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Progesterone promotes the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] CTD PMID:17185802 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases expression
EXP Triptorelin Pamoate results in decreased expression of LHB protein
Triptorelin Pamoate results in increased expression of LHB protein
CTD PMID:3158510 PMID:20463352 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]]; testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein] CTD PMID:20463352 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A protein CTD PMID:20463352 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pde6d phosphodiesterase 6D decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE6D mRNA CTD PMID:20463352 NCBI chr 9:87,192,991...87,237,926
Ensembl chr 9:87,192,983...87,237,969
JBrowse link
G Pde9a phosphodiesterase 9A decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE9A mRNA CTD PMID:20463352 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression
multiple interactions
EXP Triptorelin Pamoate results in decreased expression of PRKG1 mRNA; Triptorelin Pamoate results in decreased expression of PRKG1 protein
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]; testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]
CTD PMID:20463352 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Prl prolactin multiple interactions ISO
EXP
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]
Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]
CTD PMID:2954994 PMID:3158510 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

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  CHEBI ontology 20089
    role 20042
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          drug 19655
            antineoplastic agent 17669
              triptorelin 8
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                peptide 9504
                                                  oligopeptide 1290
                                                    triptorelin 8
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