Gli2 (GLI family zinc finger 2) - Rat Genome Database

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Gene: Gli2 (GLI family zinc finger 2) Rattus norvegicus
Analyze
Symbol: Gli2
Name: GLI family zinc finger 2
RGD ID: 1309270
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and zinc ion binding activity. Involved in positive regulation of collagen biosynthetic process; prostate gland development; and response to mechanical stimulus. Predicted to be located in several cellular components, including axoneme; ciliary tip; and nuclear lumen. Predicted to be active in nucleus. Biomarker of esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GLI-Kruppel family member GLI2; LOC304729; zinc finger protein GLI2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21329,946,882 - 30,163,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1329,946,809 - 30,163,574 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1332,529,564 - 32,585,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01333,817,400 - 33,873,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,093,715 - 31,149,850 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01334,829,021 - 35,049,172 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1334,829,139 - 35,048,444 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01339,955,094 - 40,170,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41331,551,089 - 31,607,264 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11331,555,563 - 31,574,381 (-)NCBI
Celera1329,844,054 - 29,900,050 (-)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
captopril  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crotonaldehyde  (ISO)
curcumin  (EXP)
Cyclopamine  (EXP)
cyproconazole  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diethyl malate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
gallic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (ISO)
goralatide  (EXP,ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sonidegib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vismodegib  (ISO)
vitamin E  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure development  (ISO)
anatomical structure formation involved in morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
axon guidance  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to virus  (ISO)
cerebellar cortex morphogenesis  (ISO)
chondrocyte differentiation  (ISO)
cochlea morphogenesis  (ISO)
developmental growth  (ISO)
dorsal/ventral neural tube patterning  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic digestive tract development  (ISO)
embryonic digit morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
floor plate formation  (ISO)
gene expression  (ISO)
hair follicle morphogenesis  (ISO)
head development  (ISO)
heart development  (ISO)
hindbrain development  (ISO)
hindgut morphogenesis  (ISO)
in utero embryonic development  (ISO)
kidney development  (ISO)
lung development  (ISO)
mammary gland development  (ISO)
mammary gland duct morphogenesis  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube development  (ISO)
neuron development  (ISO)
neuron differentiation  (ISO)
notochord regression  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast development  (ISO)
osteoblast differentiation  (ISO)
pattern specification process  (ISO)
pituitary gland development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prostate gland development  (IEP)
prostatic bud formation  (ISO)
proximal/distal pattern formation  (ISO)
regulation of smoothened signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to mechanical stimulus  (IEP)
skeletal system development  (ISO)
smoothened signaling pathway  (IBA,ISO)
smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (ISO)
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  (ISO)
smoothened signaling pathway involved in ventral spinal cord interneuron specification  (ISO)
spinal cord dorsal/ventral patterning  (ISO)
spinal cord motor neuron differentiation  (ISO)
spinal cord ventral commissure morphogenesis  (ISO)
stem cell proliferation  (ISO)
tube development  (ISO)
ventral midline development  (ISO)
ventral spinal cord development  (ISO)

Cellular Component
axoneme  (ISO)
ciliary tip  (ISO)
cilium  (ISO)
cytoplasm  (ISO)
membrane  (ISO)
motile cilium  (ISO)
nuclear speck  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Sonic hedgehog (SHH) and glioblastoma-2 (Gli-2) expressions are associated with poor jaundice-free survival in biliary atresia. Jung HY, etal., J Pediatr Surg. 2015 Mar;50(3):371-6. doi: 10.1016/j.jpedsurg.2014.08.025. Epub 2014 Dec 20.
5. Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. Kim PC, etal., J Pediatr Surg. 2001 Feb;36(2):381-4. doi: 10.1053/jpsu.2001.20722.
6. Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion. Li T, etal., Int J Clin Exp Pathol. 2015 Nov 1;8(11):14574-9. eCollection 2015.
7. Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate. Liu ZH, etal., Environ Toxicol. 2016 Mar;31(3):261-8. doi: 10.1002/tox.22040. Epub 2014 Sep 12.
8. Sonic Hedgehog Signaling Affected by Promoter Hypermethylation Induces Aberrant Gli2 Expression in Spina Bifida. Lu XL, etal., Mol Neurobiol. 2016 Oct;53(8):5413-24. doi: 10.1007/s12035-015-9447-0. Epub 2015 Oct 7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
11. Anorectal malformations caused by defects in sonic hedgehog signaling. Mo R, etal., Am J Pathol. 2001 Aug;159(2):765-74.
12. Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo. Morrow D, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C488-96. Epub 2006 Aug 30.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Pu Y, etal., Dev Biol 2004 Sep 15;273(2):257-75.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Defective sonic hedgehog signaling in esophageal atresia with tracheoesophageal fistula. Spilde TL, etal., Surgery. 2003 Aug;134(2):345-50.
22. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. Zhang J, etal., J Int Med Res. 2009 Nov-Dec;37(6):1842-50.
Additional References at PubMed
PMID:8378770   PMID:8575294   PMID:9006072   PMID:9247260   PMID:9557682   PMID:9636069   PMID:9655799   PMID:9655803   PMID:9731531   PMID:10409510   PMID:10693670   PMID:10725236  
PMID:11238441   PMID:11748151   PMID:11783999   PMID:12165851   PMID:14602680   PMID:15175043   PMID:15215207   PMID:15496441   PMID:15614767   PMID:15994174   PMID:16054035   PMID:16254602  
PMID:16267219   PMID:16316410   PMID:16342201   PMID:16364285   PMID:16396903   PMID:16553965   PMID:16571625   PMID:16571630   PMID:16611981   PMID:16707121   PMID:16880529   PMID:16950124  
PMID:17035233   PMID:17328886   PMID:17395647   PMID:18590716   PMID:19056373   PMID:19103752   PMID:19124651   PMID:19286674   PMID:19654211   PMID:19684112   PMID:20159594   PMID:21029651  
PMID:21209331   PMID:21552265   PMID:21653639   PMID:22689656   PMID:22771375   PMID:22841643   PMID:23333501   PMID:25644602   PMID:25808752   PMID:26565916   PMID:28778798   PMID:29487109  
PMID:34999183  


Genomics

Comparative Map Data
Gli2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21329,946,882 - 30,163,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1329,946,809 - 30,163,574 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1332,529,564 - 32,585,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01333,817,400 - 33,873,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,093,715 - 31,149,850 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01334,829,021 - 35,049,172 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1334,829,139 - 35,048,444 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01339,955,094 - 40,170,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41331,551,089 - 31,607,264 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11331,555,563 - 31,574,381 (-)NCBI
Celera1329,844,054 - 29,900,050 (-)NCBICelera
Cytogenetic Map13q11NCBI
GLI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382120,735,868 - 120,992,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2120,735,623 - 120,992,653 (+)EnsemblGRCh38hg38GRCh38
GRCh372121,493,444 - 121,750,229 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362121,266,327 - 121,466,321 (+)NCBINCBI36Build 36hg18NCBI36
Celera2114,879,848 - 115,075,199 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2113,876,969 - 114,072,693 (+)NCBIHuRef
CHM1_12121,559,011 - 121,754,271 (+)NCBICHM1_1
T2T-CHM13v2.02121,171,586 - 121,428,571 (+)NCBIT2T-CHM13v2.0
Gli2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391118,761,791 - 118,987,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1118,761,862 - 118,981,349 (-)EnsemblGRCm39 Ensembl
GRCm381118,834,061 - 119,054,405 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1118,834,132 - 119,053,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv371120,730,638 - 120,950,196 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361120,661,607 - 120,881,165 (-)NCBIMGSCv36mm8
Celera1121,494,112 - 121,713,823 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.17NCBI
Gli2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554598,892,869 - 9,118,499 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554598,892,917 - 9,124,672 (-)NCBIChiLan1.0ChiLan1.0
GLI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B22,750,199 - 23,007,333 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B7,665,403 - 7,922,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B121,242,932 - 121,499,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B121,303,831 - 121,497,442 (+)Ensemblpanpan1.1panPan2
GLI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11929,128,401 - 29,383,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1929,130,227 - 29,383,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1929,385,203 - 29,640,495 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01930,500,404 - 30,754,986 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1930,501,230 - 30,755,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11929,191,227 - 29,444,875 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01929,361,839 - 29,547,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01930,542,746 - 30,798,466 (-)NCBIUU_Cfam_GSD_1.0
Gli2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530391,769,648 - 92,002,404 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646949,617,095 - 49,673,213 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646949,616,552 - 49,788,760 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1530,313,817 - 30,579,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11530,312,528 - 30,580,272 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21535,267,097 - 35,303,278 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1109,302,890 - 9,561,287 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl109,304,645 - 9,369,115 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606113,127,973 - 13,388,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gli2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473224,159,312 - 24,328,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473224,159,407 - 24,381,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gli2
1232 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:771
Count of miRNA genes:313
Interacting mature miRNAs:402
Transcripts:ENSRNOT00000009963
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat

Markers in Region
D13M1Mit189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21330,094,422 - 30,094,583 (+)MAPPERmRatBN7.2
Rnor_6.01334,979,897 - 34,980,057NCBIRnor6.0
Rnor_5.01340,103,087 - 40,103,247UniSTSRnor5.0
RGSC_v3.41331,699,189 - 31,699,349UniSTSRGSC3.4
Celera1329,993,046 - 29,993,206UniSTS
Cytogenetic Map13q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 28 12 29
Low 3 43 28 15 16 15 6 9 44 14 11 11 6
Below cutoff 27 24 3 24 2 2 2 9 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009963   ⟹   ENSRNOP00000009963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1329,946,809 - 30,163,574 (-)Ensembl
Rnor_6.0 Ensembl1334,829,139 - 35,048,444 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104979   ⟹   ENSRNOP00000093230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1329,947,623 - 30,163,340 (-)Ensembl
RefSeq Acc Id: NM_001107169   ⟹   NP_001100639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21329,946,882 - 30,163,589 (-)NCBI
Rnor_6.01334,829,021 - 34,885,485 (-)NCBI
Rnor_5.01339,955,094 - 40,170,750 (-)NCBI
RGSC_v3.41331,551,089 - 31,607,264 (-)RGD
Celera1329,844,054 - 29,900,050 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090669   ⟹   XP_038946597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21329,948,464 - 30,111,037 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100639 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946597 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009963
  ENSRNOP00000009963.7
  ENSRNOP00000093230.1
Reference Protein Sequences
RefSeq Acc Id: NP_001100639   ⟸   NM_001107169
- UniProtKB: F1M2B7 (UniProtKB/TrEMBL),   A6K7W2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009963   ⟸   ENSRNOT00000009963
RefSeq Acc Id: XP_038946597   ⟸   XM_039090669
- Peptide Label: isoform X2
- UniProtKB: A6K7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093230   ⟸   ENSRNOT00000104979
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M2B7-F1-model_v2 AlphaFold F1M2B7 1-1544 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698761
Promoter ID:EPDNEW_R9286
Type:multiple initiation site
Name:Gli2_1
Description:GLI family zinc finger 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01335,048,525 - 35,048,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309270 AgrOrtholog
BioCyc Gene G2FUF-18525 BioCyc
Ensembl Genes ENSRNOG00000007261 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009963 ENTREZGENE
  ENSRNOT00000009963.7 UniProtKB/TrEMBL
  ENSRNOT00000104979.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro GLI-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 304729 ENTREZGENE
PANTHER PTHR45718 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN GLI2 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Gli2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007261 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6AWR3_RAT UniProtKB/TrEMBL
  A6K7W2 ENTREZGENE, UniProtKB/TrEMBL
  F1M2B7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Gli2  GLI family zinc finger 2  Gli2  GLI-Kruppel family member GLI2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gli2  GLI-Kruppel family member GLI2   Gli2_predicted  GLI-Kruppel family member GLI2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gli2_predicted  GLI-Kruppel family member GLI2 (predicted)      Symbol and Name status set to approved 70820 APPROVED