GLI2 (GLI family zinc finger 2) - Rat Genome Database
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Pathways
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Gene: GLI2 (GLI family zinc finger 2) Canis lupus familiaris
Analyze
Symbol: GLI2
Name: GLI family zinc finger 2
RGD ID: 12398827
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anatomical structure development (ortholog); anatomical structure formation involved in morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Animal Disease Models (ortholog); Anorectal Malformations (ortholog); FOUND IN axoneme (ortholog); ciliary tip (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: zinc finger protein GLI2; zinc finger protein GLI2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1929,130,227 - 29,383,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11929,128,401 - 29,383,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure development  (ISO)
anatomical structure formation involved in morphogenesis  (ISO)
anterior/posterior pattern specification  (IEA,ISO)
axon guidance  (IEA,ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
cell differentiation  (ISO)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to virus  (ISO)
cerebellar cortex morphogenesis  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
cochlea morphogenesis  (IEA,ISO)
developmental growth  (IEA,ISO)
dorsal/ventral neural tube patterning  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic digestive tract development  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
epidermal cell differentiation  (ISO)
floor plate formation  (IEA,ISO)
hair follicle morphogenesis  (IEA)
head development  (ISO)
heart development  (IEA,ISO)
hindbrain development  (ISO)
hindgut morphogenesis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
kidney development  (IEA,ISO)
lung development  (IEA,ISO)
mammary gland development  (ISO)
mammary gland duct morphogenesis  (IEA,ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural tube development  (ISO)
neuron development  (ISO)
notochord regression  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast development  (IEA,ISO)
osteoblast differentiation  (ISO)
pattern specification process  (ISO)
pituitary gland development  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (IEA)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland development  (ISO)
prostatic bud formation  (IEA,ISO)
proximal/distal pattern formation  (IEA,ISO)
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to mechanical stimulus  (ISO)
skeletal system development  (ISO)
smoothened signaling pathway  (IBA,ISO)
smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (IEA,ISO)
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation  (IEA,ISO)
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  (IEA,ISO)
smoothened signaling pathway involved in ventral spinal cord interneuron specification  (IEA,ISO)
spinal cord dorsal/ventral patterning  (ISO)
spinal cord motor neuron differentiation  (ISO)
spinal cord ventral commissure morphogenesis  (IEA,ISO)
tube development  (ISO)
ventral midline development  (ISO)
ventral spinal cord development  (ISO)

Cellular Component
axoneme  (IEA,ISO)
ciliary tip  (IEA,ISO)
cilium  (ISO)
cytoplasm  (ISO)
membrane  (IEA,ISO)
motile cilium  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleolus  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GLI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1929,130,227 - 29,383,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11929,128,401 - 29,383,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
GLI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2120,735,623 - 120,992,653 (+)EnsemblGRCh38hg38GRCh38
GRCh382120,735,868 - 120,992,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372121,493,441 - 121,750,229 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372121,493,444 - 121,750,229 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362121,266,327 - 121,466,321 (+)NCBINCBI36hg18NCBI36
Celera2114,879,848 - 115,075,199 (+)NCBI
Cytogenetic Map2q14.2NCBI
HuRef2113,876,969 - 114,072,693 (+)NCBIHuRef
CHM1_12121,559,011 - 121,754,271 (+)NCBICHM1_1
Gli2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391118,761,791 - 118,987,578 (-)NCBIGRCm39mm39
GRCm381118,834,061 - 119,054,405 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1118,834,132 - 119,053,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv371120,730,638 - 120,950,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv361120,661,607 - 120,881,165 (-)NCBImm8
Celera1121,494,112 - 121,713,823 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.17NCBI
Gli2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21329,946,809 - 30,163,901 (-)NCBI
Rnor_6.0 Ensembl1334,829,139 - 35,048,444 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01334,829,021 - 35,049,172 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01339,955,094 - 40,170,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41331,551,089 - 31,607,264 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11331,555,563 - 31,574,381 (-)NCBI
Celera1329,844,054 - 29,900,050 (-)NCBICelera
Cytogenetic Map13q11NCBI
Gli2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554598,892,869 - 9,118,499 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554598,892,917 - 9,124,672 (-)NCBIChiLan1.0ChiLan1.0
GLI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B121,242,932 - 121,499,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B121,303,831 - 121,497,442 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B7,665,403 - 7,922,840 (+)NCBIMhudiblu_PPA_v0panPan3
Gli2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493646949,616,552 - 49,788,760 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1530,313,817 - 30,579,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11530,312,528 - 30,580,272 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21535,267,097 - 35,303,278 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLI2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1109,302,890 - 9,561,287 (-)NCBI
ChlSab1.1 Ensembl109,304,645 - 9,369,115 (-)Ensembl
Gli2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473224,159,407 - 24,381,495 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 16 6 6 12 10 5
Below cutoff 5 6 6 6 6 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014121472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000007784   ⟹   ENSCAFP00000007216
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1929,130,227 - 29,383,658 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080332   ⟹   ENSCAFP00000059486
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1929,134,875 - 29,383,658 (-)Ensembl
RefSeq Acc Id: XM_014121472   ⟹   XP_013976947
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11929,128,401 - 29,383,324 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013976947   ⟸   XM_014121472
- Sequence:
RefSeq Acc Id: ENSCAFP00000059486   ⟸   ENSCAFT00000080332
RefSeq Acc Id: ENSCAFP00000007216   ⟸   ENSCAFT00000007784
Protein Domains
C2H2-type

Promoters
RGD ID:13686718
Promoter ID:EPDNEW_C4786
Type:multiple initiation site
Name:GLI2_1
Description:GLI family zinc finger 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11929,383,631 - 29,383,691EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000007216 UniProtKB/TrEMBL
  ENSCAFP00000059486 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007784 UniProtKB/TrEMBL
  ENSCAFT00000080332 UniProtKB/TrEMBL
InterPro GLI-like UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene GLI2 ENTREZGENE
PANTHER PTHR45718 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A5F4D173_CANLF UniProtKB/TrEMBL
  F1PB81_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41257 ENTREZGENE