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Gene: Gli2 (GLI-Kruppel family member GLI2) Mus musculus
Symbol: Gli2
Name: GLI-Kruppel family member GLI2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of nervous system development. Localizes to several cellular components, including the axoneme; ciliary tip; and nuclear speck. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Orthologous to human GLI2 (GLI family zinc finger 2); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW546128; Tax helper protein; zinc finger protein GLI2
Homo sapiens (human) : GLI2 (GLI family zinc finger 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gli2 (GLI family zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli2 (GLI family zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI2 (GLI family zinc finger 2)
Canis lupus familiaris (dog) : GLI2 (GLI family zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli2 (GLI family zinc finger 2)
Sus scrofa (pig) : GLI2 (GLI family zinc finger 2)
Chlorocebus sabaeus (African green monkey) : GLI2 (GLI family zinc finger 2)
Heterocephalus glaber (naked mole-rat) : Gli2 (GLI family zinc finger 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1118,834,132 - 119,053,619 (-)Ensembl
GRCm381118,834,061 - 119,054,405 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371120,730,638 - 120,950,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv361120,661,607 - 120,881,165 (-)NCBImm8
Celera1121,494,112 - 121,713,823 (-)NCBICelera
Cytogenetic Map1 E2.3NCBI
cM Map152.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gli2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319523
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.