Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Gli2 (GLI-Kruppel family member GLI2) Mus musculus
Analyze
Symbol: Gli2
Name: GLI-Kruppel family member GLI2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of nervous system development. Localizes to several cellular components, including the axoneme; ciliary tip; and nuclear speck. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Orthologous to human GLI2 (GLI family zinc finger 2); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW546128; Tax helper protein; zinc finger protein GLI2
Orthologs:
Homo sapiens (human) : GLI2 (GLI family zinc finger 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gli2 (GLI family zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli2 (GLI family zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI2 (GLI family zinc finger 2)
Canis lupus familiaris (dog) : GLI2 (GLI family zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli2 (GLI family zinc finger 2)
Sus scrofa (pig) : GLI2 (GLI family zinc finger 2)
Chlorocebus sabaeus (African green monkey) : GLI2 (GLI family zinc finger 2)
Heterocephalus glaber (naked mole-rat) : Gli2 (GLI family zinc finger 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1118,834,132 - 119,053,619 (-)Ensembl
GRCm381118,834,061 - 119,054,405 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371120,730,638 - 120,950,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv361120,661,607 - 120,881,165 (-)NCBImm8
Celera1121,494,112 - 121,713,823 (-)NCBICelera
Cytogenetic Map1 E2.3NCBI
cM Map152.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gli2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319523
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.