Acaa1b (acetyl-Coenzyme A acyltransferase 1B) - Rat Genome Database

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Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B) Rattus norvegicus
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Symbol: Acaa1b
Name: acetyl-Coenzyme A acyltransferase 1B
RGD ID: 1562373
Description: Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; clofibrate; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; LOC501072; peroxisomal 3-ketoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-CoA thiolase B; RGD1562373; similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B); similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,750,771 - 127,759,589 (-)NCBIGRCr8
mRatBN7.28118,872,996 - 118,881,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,474,990 - 124,483,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,673,946 - 122,682,730 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,506,637 - 120,515,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,836,235 - 127,845,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,032,830 - 127,052,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,110,413 - 124,118,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8118,033,536 - 118,055,577 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP,ISO)
cocaine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diquat  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP)
troglitazone  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Ghys K, etal., Biochem J. 2002 Jul 1;365(Pt 1):41-50.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1680677   PMID:2307679   PMID:3036803   PMID:12477932   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Acaa1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,750,771 - 127,759,589 (-)NCBIGRCr8
mRatBN7.28118,872,996 - 118,881,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,474,990 - 124,483,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,673,946 - 122,682,730 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,506,637 - 120,515,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,836,235 - 127,845,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,032,830 - 127,052,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,110,413 - 124,118,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8118,033,536 - 118,055,577 (-)NCBICelera
Cytogenetic Map8q32NCBI
Acaa1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,977,111 - 118,986,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,977,091 - 118,986,161 (-)EnsemblGRCm39 Ensembl
GRCm389119,148,043 - 119,157,093 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,148,023 - 119,157,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,057,161 - 119,066,211 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369118,996,741 - 119,005,791 (-)NCBIMGSCv36mm8
Celera9119,615,929 - 119,624,979 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI

Variants

.
Variants in Acaa1b
46 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
BI276716  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map81310.9UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000097414   ⟹   ENSRNOP00000094349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105624   ⟹   ENSRNOP00000091673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106186   ⟹   ENSRNOP00000086036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
RefSeq Acc Id: NM_001040019   ⟹   NP_001035108
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,750,771 - 127,759,569 (-)NCBI
mRatBN7.28118,873,025 - 118,881,825 (-)NCBI
Rnor_5.08127,032,830 - 127,052,532 (-)NCBI
RGSC_v3.48124,110,413 - 124,118,950 (-)RGD
Celera8118,033,536 - 118,055,577 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081996   ⟹   XP_038937924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,750,960 - 127,759,589 (-)NCBI
mRatBN7.28118,872,996 - 118,881,852 (-)NCBI
RefSeq Acc Id: NP_001035108   ⟸   NM_001040019
- Peptide Label: precursor
- UniProtKB: P07871 (UniProtKB/Swiss-Prot),   Q4G049 (UniProtKB/Swiss-Prot),   A6I3V2 (UniProtKB/TrEMBL),   A0A8I6AEX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937924   ⟸   XM_039081996
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000094349   ⟸   ENSRNOT00000097414
Ensembl Acc Id: ENSRNOP00000091673   ⟸   ENSRNOT00000105624
Ensembl Acc Id: ENSRNOP00000086036   ⟸   ENSRNOT00000106186
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07871-F1-model_v2 AlphaFold P07871 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562373 AgrOrtholog
BioCyc Gene G2FUF-28804 BioCyc
Ensembl Genes ENSRNOG00000067803 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006757 UniProtKB/Swiss-Prot
  ENSRNOG00060018265 UniProtKB/Swiss-Prot
  ENSRNOG00065004545 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000097414.1 UniProtKB/TrEMBL
  ENSRNOT00000105624.1 UniProtKB/TrEMBL
  ENSRNOT00000106186.1 UniProtKB/Swiss-Prot
  ENSRNOT00055011064 UniProtKB/Swiss-Prot
  ENSRNOT00060031504 UniProtKB/Swiss-Prot
  ENSRNOT00065006691 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370360 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like_sf_Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:501072 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112779 IMAGE-MGC_LOAD
NCBI Gene 501072 ENTREZGENE
PANTHER 3-KETOACYL-COA THIOLASE B, PEROXISOMAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-KETOACYL-COA THIOLASE, PEROXISOMAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acaa1b PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000067803 RatGTEx
  ENSRNOG00055006757 RatGTEx
  ENSRNOG00060018265 RatGTEx
  ENSRNOG00065004545 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AEX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALE7_RAT UniProtKB/TrEMBL
  A6I3V2 ENTREZGENE, UniProtKB/TrEMBL
  P07871 ENTREZGENE
  Q4G049 ENTREZGENE
  THIKB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4G049 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-03 Acaa1b  acetyl-Coenzyme A acyltransferase 1B  RGD1562373  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562373  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)   RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)    similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)  LOC501072  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501072  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)      Symbol and Name status set to provisional 70820 PROVISIONAL