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Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B) Rattus norvegicus

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Symbol:

Acaa1b

Name:

acetyl-Coenzyme A acyltransferase 1B

RGD ID:

1562373

Description:

Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid derivative biosynthetic process and monocarboxylic acid metabolic process. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; clofibrate; Cuprizon.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; LOC501072; peroxisomal 3-ketoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-CoA thiolase B; RGD1562373; similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B); similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Acaa1b (acetyl-Coenzyme A acyltransferase 1B)	RGD	RGD
Other homologs ²
Homo sapiens (human):	ACAA1 (acetyl-CoA acyltransferase 1)	HGNC	Ensembl, HomoloGene, OrthoDB, Panther, PhylomeDB
Alliance orthologs ³
Homo sapiens (human):	ACAA1 (acetyl-CoA acyltransferase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Acaa1b (acetyl-Coenzyme A acyltransferase 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acaa1 (acetyl-CoA acyltransferase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acaa1 (acetyl-CoA acyltransferase 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	POT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	POT1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acaa1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	127,750,771 - 127,759,589 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	127,750,743 - 127,759,569 (-)	Ensembl				GRCr8
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	118,872,997 - 118,881,825 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	124,474,990 - 124,483,776 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	122,673,946 - 122,682,730 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	120,506,637 - 120,515,424 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	127,836,235 - 127,845,296 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	118,033,536 - 118,055,577 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congestive heart failure (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

aspartame (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

captan (ISO)

carbon nanotube (ISO)

clofibrate (EXP,ISO)

cocaine (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

diquat (ISO)

doxorubicin (EXP)

epoxiconazole (ISO)

ethanol (ISO)

etomoxir (EXP)

folic acid (ISO)

folpet (ISO)

fructose (ISO)

inulin (ISO)

lipopolysaccharide (ISO)

Mesaconitine (EXP)

microcystin-LR (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phlorizin (ISO)

pirinixic acid (ISO)

pravastatin (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

pyrazinecarboxamide (EXP)

quercetin (ISO)

rotenone (EXP)

senecionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfasalazine (ISO)

tacrolimus hydrate (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Torularhodin (ISO)

trichloroethene (EXP,ISO)

Triptolide (EXP)

troglitazone (ISO)

vinclozolin (EXP)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alpha-linolenic acid metabolic process (ISO)

fatty acid beta-oxidation (IBA)

fatty acid beta-oxidation using acyl-CoA oxidase (IEA,ISO)

fatty acid derivative biosynthetic process (ISO)

fatty acid metabolic process (IEA)

lipid metabolic process (IEA)

long-chain fatty acid biosynthetic process (ISO)

phenylacetate catabolic process (IBA)

unsaturated fatty acid biosynthetic process (ISO)

Cellular Component

cytoplasm (IEA)

peroxisomal matrix (ISO)

peroxisome (IBA,IDA,IEA)

Molecular Function

acetyl-CoA C-acetyltransferase activity (IEA)

acetyl-CoA C-acyltransferase activity (IBA,IEA,ISO)

acetyl-CoA C-myristoyltransferase activity (IEA)

acyltransferase activity (IEA)

acyltransferase activity, transferring groups other than amino-acyl groups (IEA)

protein binding (IPI)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

fatty acid metabolic pathway (IEA)

unsaturated fatty acid biosynthetic pathway (IEA)

valine, leucine and isoleucine degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.	Ghys K, etal., Biochem J. 2002 Jul 1;365(Pt 1):41-50.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1680677	PMID:2307679	PMID:3036803	PMID:12477932	PMID:15489334	PMID:18614015

Genomics

Comparative Map Data

Acaa1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	127,750,771 - 127,759,589 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	127,750,743 - 127,759,569 (-)	Ensembl				GRCr8
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	118,872,997 - 118,881,825 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	124,474,990 - 124,483,776 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	122,673,946 - 122,682,730 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	120,506,637 - 120,515,424 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	127,836,235 - 127,845,296 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	118,033,536 - 118,055,577 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Acaa1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	118,977,111 - 118,986,149 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	118,977,091 - 118,986,161 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	119,148,043 - 119,157,093 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	119,148,023 - 119,157,093 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	119,057,161 - 119,066,211 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	118,996,741 - 119,005,791 (-)	NCBI		MGSCv36	mm8
Celera	9	119,615,929 - 119,624,979 (-)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	71.33	NCBI

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat

Markers in Region

BI276716

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	8	1310.9	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
8	5	48	23	110	33	5	47	69	22	31	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001040019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D90063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000097414 ⟹ ENSRNOP00000094349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	127,750,743 - 127,759,569 (-)	Ensembl
mRatBN7.2 Ensembl	8	118,872,997 - 118,881,825 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105624 ⟹ ENSRNOP00000091673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	127,750,743 - 127,759,569 (-)	Ensembl
mRatBN7.2 Ensembl	8	118,872,997 - 118,881,825 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106186 ⟹ ENSRNOP00000086036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	127,750,743 - 127,759,569 (-)	Ensembl
mRatBN7.2 Ensembl	8	118,872,997 - 118,881,825 (-)	Ensembl

RefSeq Acc Id:

NM_001040019 ⟹ NP_001035108

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	127,750,771 - 127,759,569 (-)	NCBI
mRatBN7.2	8	118,873,025 - 118,881,825 (-)	NCBI
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	RGD
Celera	8	118,033,536 - 118,055,577 (-)	RGD

Sequence:

show sequence

CTAATCGGTGGGACGCACCTCCGCGATGCATCGGCTGCAGGTAGTGCTGGGCCACCTGGCCGGC
CGGTCCGAGTCGAGCTCCGCGCTGCAAGCCGCGCCCTGCTCTGCGGGCTTCCCGCAGGCCTCGG
CCTCCGACGTGGTGGTGGTGCACGGACAGCGCACCCCCATCGGCCGCGCCGGCCGCGGCGGCTT
CAAGGACACCACCCCCGACGAGCTTCTGTCGGCCGTGTTGACCGCGGTTCTCCAGGATGTGAAG
CCAAAGCCTGAGTGTCTGGGAGACATCTCCGTGGGCAATGTGCTTCAGCCCGGGGCCGGAGCCG
CAATGGCACGCATCGCCCAGTTCCTGAGTGGCATCCCAGAGACCGTGCCTCTGTCAGCAGTCAA
CAGACAGTGTTCATCGGGACTGCAGGCAGTGGCCAACATTGCTGGTGGCATCAGAAATGGGTCT
TACGACATTGGCATGGCCTGTGGGGTGGAGTCCATGACCCTGTCTGAGAGAGGCAACCCTGGGA
ATATTTCCTCCCGTCTTCTGGAGAACGAGAAGGCCAGAGACTGCCTGATTCCTATGGGGATAAC
CTCGGAGAATGTGGCTGAGCGGTTTGGCATCTCACGGCAGAAGCAGGATGCCTTCGCGCTGGCC
TCTCAGCAGAAGGCAGCAAGCGCCCAGAGCAAAGGCTGCTTCCGTGCTGAGATCGTGCCTGTGA
CAACCACTGTCCTCGATGACAAGGGTGACAGGAAAACCATCACCGTGTCTCAGGATGAGGGTGT
CCGCCCCAGCACCACCATGGAGGGCCTGGCCAAGCTGAAGCCTGCCTTCAAGGATGGAGGCTCT
ACCACGGCTGGAAACTCCAGTCAGGTGAGTGATGGAGCAGCCGCCGTCCTGCTGGCCCGGAGGT
CCAAGGCTGAAGAACTGGGCCTCCCCATCCTTGGCGTCCTGAGGTCCTATGCAGTGGTCGGGGT
CCCTCCTGACATCATGGGCATCGGACCTGCCTATGCCATCCCTGCGGCCTTGCAGAAAGCAGGG
CTGACTGTGAATGACATAGACATCTTTGAGATCAATGAGGCCTTTGCAAGTCAGGCCCTCTACT
GTGTGGAGAAGCTGGGAATTCCTGCAGAAAAGGTGAACCCCCTGGGGGGTGCAATAGCCCTGGG
CCACCCCCTGGGCTGCACCGGAGCAAGGCAGGTGGTCACGCTGCTCAATGAGCTGAAGCGCCGA
GGCAGACGGGCTTATGGCGTGGTGTCCATGTGCATCGGGACTGGGATGGGAGCCGCTGCTGTCT
TTGAATACCCTGGGAACTGAGGCCCTGACTGCAGGCACTACCCAGAGAGTCCTATAGTAGTGTC
TGGAGAGGGATGGTACAGAAGCCATCTTCGTGGGACACTCAGCAGTGGAGGGATTTGTCACAGC
ACTTTAATTTAGAAAATGTAATCGCAATACGGGCACAAGGGCATCCAATCCACTCCTCTCAGTT
GAACCAAAGACAGCGCACGTCACACGTGACCACAGGACAACATGTTTCTGAGGGACAGTGGCCT
CATGAATAGTGGGCATGAGGGGCATAGTAAATGTATGTTATCTC

hide sequence

RefSeq Acc Id:

XM_039081996 ⟹ XP_038937924

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	127,750,960 - 127,759,589 (-)	NCBI
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001035108	(Get FASTA)	NCBI Sequence Viewer
	XP_038937924	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41497	(Get FASTA)	NCBI Sequence Viewer
	AAH98757	(Get FASTA)	NCBI Sequence Viewer
	BAA14107	(Get FASTA)	NCBI Sequence Viewer
	EDL76923	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000086036
	ENSRNOP00000086036.1
GenBank Protein	P07871	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001035108 ⟸ NM_001040019
- Peptide Label:	precursor
- UniProtKB:	P07871 (UniProtKB/Swiss-Prot), Q4G049 (UniProtKB/Swiss-Prot), A6I3V2 (UniProtKB/TrEMBL), A0A8I6AEX9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGQRTPIGRAGRGGFKDTTPDEL LSAVLTAVLQDVKPKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQ AVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERF GISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEG LAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIG PAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGA RQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN hide sequence

RefSeq Acc Id:	XP_038937924 ⟸ XM_039081996
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000094349 ⟸ ENSRNOT00000097414

Ensembl Acc Id:

ENSRNOP00000091673 ⟸ ENSRNOT00000105624

Ensembl Acc Id:

ENSRNOP00000086036 ⟸ ENSRNOT00000106186

Protein Domains

Thiolase C-terminal Thiolase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P07871-F1-model_v2	AlphaFold	P07871	1-424	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562373	AgrOrtholog
BioCyc Gene	G2FUF-28804	BioCyc
Ensembl Genes	ENSRNOG00000067803	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000106186	ENTREZGENE
	ENSRNOT00000106186.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.47.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7370360	IMAGE-MGC_LOAD
InterPro	Thiolase	UniProtKB/Swiss-Prot
	Thiolase-like	UniProtKB/Swiss-Prot
	Thiolase-like_sf_Thiolase	UniProtKB/Swiss-Prot
	Thiolase_acyl_enz_int_AS	UniProtKB/Swiss-Prot
	Thiolase_AS	UniProtKB/Swiss-Prot
	Thiolase_C	UniProtKB/Swiss-Prot
	Thiolase_CS	UniProtKB/Swiss-Prot
	Thiolase_N	UniProtKB/Swiss-Prot
KEGG Report	rno:501072	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112779	IMAGE-MGC_LOAD
NCBI Gene	501072	ENTREZGENE
PANTHER	3-KETOACYL-COA THIOLASE B, PEROXISOMAL	UniProtKB/Swiss-Prot
	3-KETOACYL-COA THIOLASE, PEROXISOMAL	UniProtKB/Swiss-Prot
Pfam	Thiolase_C	UniProtKB/Swiss-Prot
	Thiolase_N	UniProtKB/Swiss-Prot
PhenoGen	Acaa1b	PhenoGen
PIRSF	Ac-CoA_Ac_transf	UniProtKB/Swiss-Prot
PROSITE	THIOLASE_1	UniProtKB/Swiss-Prot
	THIOLASE_2	UniProtKB/Swiss-Prot
	THIOLASE_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000067803	RatGTEx
Superfamily-SCOP	SSF53901	UniProtKB/Swiss-Prot
UniProt	A0A8I6AEX9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ALE7_RAT	UniProtKB/TrEMBL
	A6I3V2	ENTREZGENE, UniProtKB/TrEMBL
	P07871	ENTREZGENE
	Q4G049	ENTREZGENE
	THIKB_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q4G049	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-12-03	Acaa1b	acetyl-Coenzyme A acyltransferase 1B	RGD1562373	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1562373	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-10	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)		similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)	Name updated	1299863	APPROVED
2006-03-07	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)	LOC501072	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501072	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)			Symbol and Name status set to provisional	70820	PROVISIONAL

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)