Acaa1b (acetyl-Coenzyme A acyltransferase 1B) - Rat Genome Database

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Pathways
Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B) Rattus norvegicus
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Symbol: Acaa1b
Name: acetyl-Coenzyme A acyltransferase 1B
RGD ID: 1562373
Description: Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid derivative biosynthetic process and monocarboxylic acid metabolic process. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; clofibrate; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; LOC501072; peroxisomal 3-ketoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-CoA thiolase B; RGD1562373; similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B); similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,750,771 - 127,759,589 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,750,743 - 127,759,569 (-)EnsemblGRCr8
mRatBN7.28118,872,996 - 118,881,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,474,990 - 124,483,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,673,946 - 122,682,730 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,506,637 - 120,515,424 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,836,235 - 127,845,296 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,032,830 - 127,052,532 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,110,413 - 124,118,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,033,536 - 118,055,577 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
aspartame  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP,ISO)
cocaine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diquat  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
etomoxir  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP)
troglitazone  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Ghys K, etal., Biochem J. 2002 Jul 1;365(Pt 1):41-50.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1680677   PMID:2307679   PMID:3036803   PMID:12477932   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Acaa1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,750,771 - 127,759,589 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,750,743 - 127,759,569 (-)EnsemblGRCr8
mRatBN7.28118,872,996 - 118,881,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,474,990 - 124,483,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,673,946 - 122,682,730 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,506,637 - 120,515,424 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,836,235 - 127,845,296 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,032,830 - 127,052,532 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,110,413 - 124,118,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,033,536 - 118,055,577 (-)NCBICelera
Cytogenetic Map8q32NCBI
Acaa1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,977,111 - 118,986,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,977,091 - 118,986,161 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,148,043 - 119,157,093 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,148,023 - 119,157,093 (-)Ensemblmm10GRCm38
MGSCv379119,057,161 - 119,066,211 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369118,996,741 - 119,005,791 (-)NCBIMGSCv36mm8
Celera9119,615,929 - 119,624,979 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
BI276716  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map81310.9UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
8 5 48 23 110 33 5 47 69 22 31 31

Sequence


Ensembl Acc Id: ENSRNOT00000097414   ⟹   ENSRNOP00000094349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,750,743 - 127,759,569 (-)Ensembl
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105624   ⟹   ENSRNOP00000091673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,750,743 - 127,759,569 (-)Ensembl
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106186   ⟹   ENSRNOP00000086036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,750,743 - 127,759,569 (-)Ensembl
mRatBN7.2 Ensembl8118,872,997 - 118,881,825 (-)Ensembl
RefSeq Acc Id: NM_001040019   ⟹   NP_001035108
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,750,771 - 127,759,569 (-)NCBI
mRatBN7.28118,873,025 - 118,881,825 (-)NCBI
Rnor_5.08127,032,830 - 127,052,532 (-)NCBI
RGSC_v3.48124,110,413 - 124,118,950 (-)RGD
Celera8118,033,536 - 118,055,577 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081996   ⟹   XP_038937924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,750,960 - 127,759,589 (-)NCBI
mRatBN7.28118,872,996 - 118,881,852 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001035108 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937924 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41497 (Get FASTA)   NCBI Sequence Viewer  
  AAH98757 (Get FASTA)   NCBI Sequence Viewer  
  BAA14107 (Get FASTA)   NCBI Sequence Viewer  
  EDL76923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086036
  ENSRNOP00000086036.1
GenBank Protein P07871 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001035108   ⟸   NM_001040019
- Peptide Label: precursor
- UniProtKB: P07871 (UniProtKB/Swiss-Prot),   Q4G049 (UniProtKB/Swiss-Prot),   A6I3V2 (UniProtKB/TrEMBL),   A0A8I6AEX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937924   ⟸   XM_039081996
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000094349   ⟸   ENSRNOT00000097414
Ensembl Acc Id: ENSRNOP00000091673   ⟸   ENSRNOT00000105624
Ensembl Acc Id: ENSRNOP00000086036   ⟸   ENSRNOT00000106186
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07871-F1-model_v2 AlphaFold P07871 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562373 AgrOrtholog
BioCyc Gene G2FUF-28804 BioCyc
Ensembl Genes ENSRNOG00000067803 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106186 ENTREZGENE
  ENSRNOT00000106186.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370360 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase-like_sf_Thiolase UniProtKB/Swiss-Prot
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:501072 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112779 IMAGE-MGC_LOAD
NCBI Gene 501072 ENTREZGENE
PANTHER 3-KETOACYL-COA THIOLASE B, PEROXISOMAL UniProtKB/Swiss-Prot
  3-KETOACYL-COA THIOLASE, PEROXISOMAL UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PhenoGen Acaa1b PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot
  THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000067803 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A8I6AEX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALE7_RAT UniProtKB/TrEMBL
  A6I3V2 ENTREZGENE, UniProtKB/TrEMBL
  P07871 ENTREZGENE
  Q4G049 ENTREZGENE
  THIKB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4G049 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-03 Acaa1b  acetyl-Coenzyme A acyltransferase 1B  RGD1562373  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562373  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)   RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)    similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562373_predicted  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)  LOC501072  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501072  similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)      Symbol and Name status set to provisional 70820 PROVISIONAL