Acaa1b (acetyl-Coenzyme A acyltransferase 1B)

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Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B) Rattus norvegicus

Analyze

Symbol:

Acaa1b

Name:

acetyl-Coenzyme A acyltransferase 1B

RGD ID:

1562373

Description:

Predicted to have acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Localizes to peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; clofibrate; doxorubicin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; LOC501072; LOW QUALITY PROTEIN: 3-ketoacyl-CoA thiolase B, peroxisomal; peroxisomal 3-ketoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-CoA thiolase B; RGD1562373; similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B); similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)

RGD Orthologs

Mouse

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Acaa1b (acetyl-Coenzyme A acyltransferase 1B)	RGD	RGD
Other homologs ²
Homo sapiens (human):	ACAA1 (acetyl-CoA acyltransferase 1)	HGNC	HomoloGene, Panther
Alliance orthologs ³
Homo sapiens (human):	ACAA1 (acetyl-CoA acyltransferase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Acaa1a (acetyl-Coenzyme A acyltransferase 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Acaa1b (acetyl-Coenzyme A acyltransferase 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	acaa1 (acetyl-CoA acyltransferase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	POT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI
Rnor_6.0	8	127,836,235 - 127,845,296 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	118,033,536 - 118,055,577 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congestive heart failure (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

aspartame (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

captan (ISO)

carbon nanotube (ISO)

clofibrate (EXP,ISO)

cocaine (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

doxorubicin (EXP)

folic acid (ISO)

folpet (ISO)

lipopolysaccharide (ISO)

microcystin-LR (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phlorizin (ISO)

pirinixic acid (ISO)

pravastatin (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

pyrazinecarboxamide (EXP)

quercetin (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sulfasalazine (ISO)

tacrolimus hydrate (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

Triptolide (EXP)

troglitazone (ISO)

vinclozolin (EXP)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IBA)

phenylacetate catabolic process (IBA)

Cellular Component

peroxisome (IBA,IDA)

Molecular Function

acetyl-CoA C-acetyltransferase activity (IEA)

acetyl-CoA C-acyltransferase activity (IBA)

acetyl-CoA C-myristoyltransferase activity (IEA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

fatty acid metabolic pathway (IEA)

unsaturated fatty acid biosynthetic pathway (IEA)

valine, leucine and isoleucine degradation pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Ghys K, etal., Biochem J. 2002 Jul 1;365(Pt 1):41-50.
3.	Pipeline to import KEGG annotations from KEGG into RGD
4.	RGD automated data pipeline
5.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1680677	PMID:2307679	PMID:3036803	PMID:12477932	PMID:15489334	PMID:18614015

Genomics

Comparative Map Data

Acaa1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI
Rnor_6.0	8	127,836,235 - 127,845,296 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	118,033,536 - 118,055,577 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Acaa1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	118,977,111 - 118,986,161 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	118,977,091 - 118,986,161 (-)	Ensembl
GRCm38	9	119,148,043 - 119,157,093 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	119,148,023 - 119,157,093 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	119,057,161 - 119,066,211 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	118,996,741 - 119,005,791 (-)	NCBI			mm8
Celera	9	119,615,929 - 119,624,979 (-)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI

Position Markers

BI276716

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	8	1310.9	UniSTS
Cytogenetic Map	8	q32	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	50529480	128036471	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	65717449	128033050	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	83894304	128894304	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	89058229	132243842	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102051964	133307652	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	104682575	133307652	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	104682575	133307652	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	107769005	129956433	Rat

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001040019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D90063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_001040019 ⟹ NP_001035108

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	118,873,025 - 118,881,825 (-)	NCBI
Rnor_5.0	8	127,032,830 - 127,052,532 (-)	NCBI
RGSC_v3.4	8	124,110,413 - 124,118,950 (-)	RGD
Celera	8	118,033,536 - 118,055,577 (-)	RGD

Sequence:

show sequence

CTAATCGGTGGGACGCACCTCCGCGATGCATCGGCTGCAGGTAGTGCTGGGCCACCTGGCCGGC
CGGTCCGAGTCGAGCTCCGCGCTGCAAGCCGCGCCCTGCTCTGCGGGCTTCCCGCAGGCCTCGG
CCTCCGACGTGGTGGTGGTGCACGGACAGCGCACCCCCATCGGCCGCGCCGGCCGCGGCGGCTT
CAAGGACACCACCCCCGACGAGCTTCTGTCGGCCGTGTTGACCGCGGTTCTCCAGGATGTGAAG
CCAAAGCCTGAGTGTCTGGGAGACATCTCCGTGGGCAATGTGCTTCAGCCCGGGGCCGGAGCCG
CAATGGCACGCATCGCCCAGTTCCTGAGTGGCATCCCAGAGACCGTGCCTCTGTCAGCAGTCAA
CAGACAGTGTTCATCGGGACTGCAGGCAGTGGCCAACATTGCTGGTGGCATCAGAAATGGGTCT
TACGACATTGGCATGGCCTGTGGGGTGGAGTCCATGACCCTGTCTGAGAGAGGCAACCCTGGGA
ATATTTCCTCCCGTCTTCTGGAGAACGAGAAGGCCAGAGACTGCCTGATTCCTATGGGGATAAC
CTCGGAGAATGTGGCTGAGCGGTTTGGCATCTCACGGCAGAAGCAGGATGCCTTCGCGCTGGCC
TCTCAGCAGAAGGCAGCAAGCGCCCAGAGCAAAGGCTGCTTCCGTGCTGAGATCGTGCCTGTGA
CAACCACTGTCCTCGATGACAAGGGTGACAGGAAAACCATCACCGTGTCTCAGGATGAGGGTGT
CCGCCCCAGCACCACCATGGAGGGCCTGGCCAAGCTGAAGCCTGCCTTCAAGGATGGAGGCTCT
ACCACGGCTGGAAACTCCAGTCAGGTGAGTGATGGAGCAGCCGCCGTCCTGCTGGCCCGGAGGT
CCAAGGCTGAAGAACTGGGCCTCCCCATCCTTGGCGTCCTGAGGTCCTATGCAGTGGTCGGGGT
CCCTCCTGACATCATGGGCATCGGACCTGCCTATGCCATCCCTGCGGCCTTGCAGAAAGCAGGG
CTGACTGTGAATGACATAGACATCTTTGAGATCAATGAGGCCTTTGCAAGTCAGGCCCTCTACT
GTGTGGAGAAGCTGGGAATTCCTGCAGAAAAGGTGAACCCCCTGGGGGGTGCAATAGCCCTGGG
CCACCCCCTGGGCTGCACCGGAGCAAGGCAGGTGGTCACGCTGCTCAATGAGCTGAAGCGCCGA
GGCAGACGGGCTTATGGCGTGGTGTCCATGTGCATCGGGACTGGGATGGGAGCCGCTGCTGTCT
TTGAATACCCTGGGAACTGAGGCCCTGACTGCAGGCACTACCCAGAGAGTCCTATAGTAGTGTC
TGGAGAGGGATGGTACAGAAGCCATCTTCGTGGGACACTCAGCAGTGGAGGGATTTGTCACAGC
ACTTTAATTTAGAAAATGTAATCGCAATACGGGCACAAGGGCATCCAATCCACTCCTCTCAGTT
GAACCAAAGACAGCGCACGTCACACGTGACCACAGGACAACATGTTTCTGAGGGACAGTGGCCT
CATGAATAGTGGGCATGAGGGGCATAGTAAATGTATGTTATCTC

hide sequence

RefSeq Acc Id:

XM_017596152 ⟹ XP_017451641

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	127,836,235 - 127,845,296 (-)	NCBI

Sequence:

show sequence

ATTTTGTAGCCCAGACTGGCCTTGAACTTGCGCAGAAACCACTTGCACCATCACAGGTGCAGAC
GGATGAGCTTAAGGAGTGGTTTTGAAGTTTATTTGACCAGCATTGAGAAGCTGCGAGGTGGTGG
TGGGATGGATGGTGGGACTTTCCTTCTGATTGGCTGTAGAATGGGTAGGCGGGACTTATGAAAA
ATGCAAGGCTCCCATTGGCTCTGCCCTGTGCCAGCCGGTGTCTTTTATTCTCTGGGGTCAGCAC
CCAGAGCCCAGGCTAATCGGTGGGACGCACCTCCGCGATGCATCGGCTGCAGGTAGTGCTGGGC
CACCTGGCCGGCCGGTCCGAGTCGAGCTCCGCGCTGCAAGCCGCGCCCTGCTCTGCGGGCTTCC
CGCAGGCCTCGGCCTCCGACGTGGTGGTGGTGCACGGACGGCGCACCCCCATCGGCCGCGCCGG
CCGCGGCGGCTTCAAGGACACCACCCCCGACGAGCTTCTGTCGGCCGTGTTGACCGCGGTTCTC
CAGGATGTGAAGCTAAAGCCTGAGTGTCTGGGAGACATCTCCGTGGGCAATGTGCTTCAGCCCG
GGGCCGGAGCCGCAATGGCACGCATCGCCCAGTTCCTGAGTGGCATCCCAGAGACCGTGCCTCT
GTCAGCAGTCAACAGACAGTGTTCATCGGGACTGCAGGCAGTGGCCAACATTGCTGGTGGCATC
AGAAATGGGTCTTACGACATTGGCATGGCCTGTGGGGTGGAGTCCATGACCCTGTCTGAGAGAG
GCAACCCTGGGAATATTTCCTCCCGTCTTCTGGAGAACGAGAAGGCCAGAGACTGCCTGATTCC
TATGGGGATAACCTCGGAGAATGTGGCTGAGCGGTTTGGCATCTCACGGCAGAAGCAGGATGCC
TTCGCGCTGGCCTCTCAGCAGAAGGGCAGCAAGCGCCCAGAGCCAAAGGCCTGCTTCCGTGCTG
AGATCGGTGCCTGTGCAACCACTGCTTTCGATGACAAGGGTGACAGGAAAACCATCACCGTGTC
TCAGGATGAGGGTGTCCGCCCCAGCAGCACCATGGAGGGCCTGGCCAAGCTGAAAGCTGCCTCT
CAGGATGGAGGGCTCTTACCACGTCCTGGGAGCAGTGGGCCGGATTAGGGCCGATCTAGTCAGG
TGAGTGATGGAGCGCCGCGTCTGCTGNNGCGCCGGAGGTCCAAGGCTGAAGAACTGGGCCTCCC
CATCCTTGGCGTCCTGAGGTCTATGCAGTGGTCGGGGTCCTCCTGACATCATGGCATCGGACCT
GCCTATGCCATCCCTGCGGCTTGCAGAACAGGTGAGGGCTGAACTGTGAATGACATAGACATCT
TTGAGATCATGAGGCCTTTGCAAGTCAGCGCCCTCTACTGTGTGGAGAAGCTGGGATTCCTGCG
AAAAGAGTGGAACCCTGGGGGGTTGCAATGCCTGGGCCACCCCCTGGGCTGCCCTGGAGCAAGG
CAGGTGGTCCGCTGCTCAATGGAGCTGAAGCGCCGAGGCCGGAGGCTTATGGACGTGGTGTCCA
TGTGCATCGGGACTGGGATGGGAGCCGCTGCTGTCTTTGAATACCCTGGGAACTGAGGCCCTGA
CTGCAGGCACTACCCAGAGAGTCCTATAGTAGTGTCTGGAGAGGAGGATGGTACAGAAGCCATC
TTCGTGGGACATTCAGCAGTGGAGGGTTTTGTCACAGCACTTTATTTAGAAAATGTAATCGCAA
TGGGCACAAGGGCATCCAATCCACTCTCTCAGTTGAACCCAAGACAGTGCACGTCACACGTGAC
CACAGGACAACATGTTTCTGAGGGACAGTGGCCTCATGAATAGTGGGCATAG

hide sequence

RefSeq Acc Id:

XM_039081996 ⟹ XP_038937924

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	118,872,996 - 118,881,852 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001035108	(Get FASTA)	NCBI Sequence Viewer
	XP_038937924	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41497	(Get FASTA)	NCBI Sequence Viewer
	AAH98757	(Get FASTA)	NCBI Sequence Viewer
	BAA14107	(Get FASTA)	NCBI Sequence Viewer
	EDL76923	(Get FASTA)	NCBI Sequence Viewer
	P07871	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001035108 ⟸ NM_001040019

- Peptide Label:

precursor

- Sequence:

show sequence

MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGQRTPIGRAGRGGFKDTTPDEL
LSAVLTAVLQDVKPKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQ
AVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERF
GISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEG
LAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIG
PAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGA
RQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN

hide sequence

RefSeq Acc Id:

XP_017451641 ⟸ XM_017596152

- Peptide Label:

isoform X1

- Sequence:

show sequence

MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGRRTPIGRAGRGGFKDTTPDEL
LSAVLTAVLQDVKLKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQ
AVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERF
GISRQKQDAFALASQQKGSKRPEPKACFRAEIGACATTAFDDKGDRKTITVSQDEGVRPSSTME
GLAKLKAASQDGGLLPRPGSSGPDXGRSSQVSDGAPRLLXRRRSKAEELGLPILGVLRSMQWSG
SSXHHGIGPAYAIPAACRTGEGXTVNDIDIFEIMRPLQVSALYCVEKLGFLRKEWNPGGLQCLG
HPLGCPGARQVVRCSMELKRRGRRLMDVVSMCIGTGMGAAAVFEYPGN

hide sequence

RefSeq Acc Id:	XP_038937924 ⟸ XM_039081996
- Peptide Label:	isoform X1

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562373	AgrOrtholog
Gene3D-CATH	3.40.47.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7370360	IMAGE-MGC_LOAD
InterPro	Thiolase	UniProtKB/Swiss-Prot
	Thiolase-like	UniProtKB/Swiss-Prot
	Thiolase_acyl_enz_int_AS	UniProtKB/Swiss-Prot
	Thiolase_AS	UniProtKB/Swiss-Prot
	Thiolase_C	UniProtKB/Swiss-Prot
	Thiolase_CS	UniProtKB/Swiss-Prot
	Thiolase_N	UniProtKB/Swiss-Prot
KEGG Report	rno:501072	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112779	IMAGE-MGC_LOAD
NCBI Gene	501072	ENTREZGENE
Pfam	Thiolase_C	UniProtKB/Swiss-Prot
	Thiolase_N	UniProtKB/Swiss-Prot
PhenoGen	Acaa1b	PhenoGen
PIRSF	Ac-CoA_Ac_transf	UniProtKB/Swiss-Prot
PROSITE	THIOLASE_1	UniProtKB/Swiss-Prot
	THIOLASE_2	UniProtKB/Swiss-Prot
	THIOLASE_3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53901	UniProtKB/Swiss-Prot
TIGRFAMs	AcCoA-C-Actrans	UniProtKB/Swiss-Prot
UniProt	P07871	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q4G049	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-12-03	Acaa1b	acetyl-Coenzyme A acyltransferase 1B	RGD1562373	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1562373	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B)	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-10	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (predicted)		similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)	Name updated	1299863	APPROVED
2006-03-07	RGD1562373_predicted	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B) (predicted)	LOC501072	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501072	similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl-CoA thiolase B)			Symbol and Name status set to provisional	70820	PROVISIONAL

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)