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Gene: Ren (renin) Rattus norvegicus
Symbol: Ren
Name: renin
RGD ID: 3554
Description: Exhibits endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including peptide metabolic process; response to lipopolysaccharide; and response to purine-containing compound. Localizes to cytoplasm and extracellular space. Used to study hypertension. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy; hypertension; and portal hypertension. Orthologous to human REN (renin); PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin 1; renin 1 structural
Homo sapiens (human) : REN (renin)  HGNC  Alliance
Mus musculus (house mouse) : Ren1 (renin 1 structural)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ren (renin)
Pan paniscus (bonobo/pygmy chimpanzee) : REN (renin)
Canis lupus familiaris (dog) : REN (renin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ren (renin)
Sus scrofa (pig) : REN (renin)
Chlorocebus sabaeus (African green monkey) : REN (renin)
Heterocephalus glaber (naked mole-rat) : Ren (renin)
more info ...
Allele / Splice: Renem1Mcwi  
Genetic Models: SS-Renem1Mcwi
Is Marker For: Strains:   SS.BN-(D13Rat20-D13Rat127)/Mcwi   SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi  
QTLs:   Bp24   Bp5  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
Cytogenetic Map13q13NCBI
RH 3.4 Map13170.9RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ren
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3554
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.