Dnmt3b (DNA methyltransferase 3 beta) - Rat Genome Database

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Gene: Dnmt3b (DNA methyltransferase 3 beta) Rattus norvegicus
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
RGD ID: 1303274
Description: Enables DNA binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to hyperoxia; and response to alkaloid. Predicted to be located in chromosome, centromeric region and nucleoplasm. Predicted to be part of catalytic complex and heterochromatin. Predicted to be active in nucleus. Biomarker of anxiety disorder; congenital heart disease; fetal alcohol spectrum disorder; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase 3B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Dnmt3b-ps1   Dnmt3b-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83162,590,777 - 162,629,313 (+)NCBIGRCr8
mRatBN7.23142,130,588 - 142,169,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,032,579 - 146,071,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,616,397 - 154,655,021 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,356,679 - 152,395,302 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,131,541 - 149,170,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,510,828 - 155,591,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,030,737 - 144,069,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,936,358 - 143,974,887 (+)NCBI
Celera3140,873,202 - 140,910,431 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
anxiety disorder  (IEP)
autism spectrum disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (IEP)
Craniofacial Abnormalities  (ISO)
Dysmenorrhea  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Mammary Neoplasms  (IEP)
facioscapulohumeral muscular dystrophy 4  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP)
gastric body carcinoma  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
immunodeficiency-centromeric instability-facial anomalies syndrome  (ISO)
immunodeficiency-centromeric instability-facial anomalies syndrome 1  (ISO,ISS)
Kabuki Syndrome 1  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Multiple Primary Neoplasms  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Oral Lichen Planus  (ISO)
oral squamous cell carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
skin melanoma  (ISO)
spermatogenic failure 3  (ISO)
Stomach Neoplasms  (ISO)
thymoma  (ISO)
type 1 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-hydroxy-2'-deoxyguanosine  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
diphenylcyclopropenone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gibberellin A3  (EXP)
glycine betaine  (ISO)
glyphosate  (EXP)
guggulsterone  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
LY294002  (ISO)
malathion  (EXP)
menadione  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pelargonidin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
procyanidin B2  (ISO)
pterostilbene  (ISO)
pyrethrins  (EXP)
quartz  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tangeretin  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers. Azad AK, etal., Cancer. 2012 Mar 15;118(6):1554-65. doi: 10.1002/cncr.26446. Epub 2011 Aug 25.
2. Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells. Bai S, etal., J Biol Chem. 2006 May 12;281(19):13604-11. Epub 2006 Mar 14.
3. DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Bai S, etal., Mol Cell Biol. 2005 Jan;25(2):751-66.
4. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
5. The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma. Chen MF, etal., Cancer. 2012 Aug 15;118(16):4074-89. doi: 10.1002/cncr.26736. Epub 2011 Dec 27.
6. Significance of DNMT3b in oral cancer. Chen WC, etal., PLoS One. 2014 Mar 13;9(3):e89956. doi: 10.1371/journal.pone.0089956. eCollection 2014.
7. Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis. Coppede F, etal., PLoS One. 2013 Nov 19;8(11):e80846. doi: 10.1371/journal.pone.0080846. eCollection 2013.
8. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Cowin PA, etal., Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
9. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
10. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. de Vogel S, etal., Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96. doi: 10.1158/1055-9965.EPI-09-0289. Epub 2009 Oct 20.
11. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
12. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Elsner VR, etal., Exp Gerontol. 2013 Feb;48(2):136-9. doi: 10.1016/j.exger.2012.11.011. Epub 2012 Nov 30.
13. Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study. Fan H, etal., J Exp Clin Cancer Res. 2008 Jul 28;27:24. doi: 10.1186/1756-9966-27-24.
14. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
15. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
16. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Fonseca-Silva T, etal., Pathobiology. 2012;79(1):18-23. doi: 10.1159/000330171. Epub 2012 Jan 12.
17. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Guo X, etal., Mol Biol Rep. 2010 Jan;37(1):219-25. doi: 10.1007/s11033-009-9626-z. Epub 2009 Jul 22.
20. High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. Hayette S, etal., PLoS One. 2012;7(12):e51527. doi: 10.1371/journal.pone.0051527. Epub 2012 Dec 10.
21. The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer. Hernandez-Sotelo D, etal., Mol Biol Rep. 2013 Jul;40(7):4275-80. doi: 10.1007/s11033-013-2511-9. Epub 2013 May 16.
22. DNA methyltransferase 3B (DNMT3B -579G>T) promotor polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt. Khorshied MM and El-Ghamrawy MK, Gene. 2012 Dec 10;511(1):34-7. doi: 10.1016/j.gene.2012.09.024. Epub 2012 Sep 18.
23. Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL). Kn H, etal., Cancer Biol Ther. 2004 Oct;3(10):989-94. Epub 2004 Oct 2.
24. DNMT3B polymorphisms and risk of primary lung cancer. Lee SJ, etal., Carcinogenesis. 2005 Feb;26(2):403-9. Epub 2004 Nov 4.
25. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, etal., Genomics 2004 Jul;84(1):193-204.
26. Abnormal DNA methylation in CD4+ T cells from people with latent autoimmune diabetes in adults. Li Y, etal., Diabetes Res Clin Pract. 2011 Nov;94(2):242-8. doi: 10.1016/j.diabres.2011.07.027. Epub 2011 Aug 23.
27. [The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia]. Li Y, etal., Zhonghua Nei Ke Za Zhi. 2005 Aug;44(8):588-91.
28. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
29. Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study. Liu Z, etal., Cancer Lett. 2008 Sep 8;268(1):158-65. doi: 10.1016/j.canlet.2008.03.034. Epub 2008 May 1.
30. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
31. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
32. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Meunier L, etal., Endocrinology. 2012 Apr;153(4):1936-47. doi: 10.1210/en.2011-1109. Epub 2012 Feb 14.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
35. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
36. The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis. Nam EJ, etal., Rheumatol Int. 2010 Aug;30(10):1299-303. doi: 10.1007/s00296-009-1141-y. Epub 2009 Sep 24.
37. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Nguyen T, etal., Epigenetics. 2011 Mar;6(3):388-94. Epub 2011 Mar 1.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Park HJ, etal., Cancer Lett. 2006 Feb 28;233(2):271-8.
40. Correlations among PPARgamma, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer. Pazienza V, etal., PPAR Res. 2012;2012:461784. doi: 10.1155/2012/461784. Epub 2012 Aug 8.
41. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Cocaine represses protein phosphatase-1Cbeta through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Pol Bodetto S, etal., Neuropharmacology. 2013 Oct;73:31-40. doi: 10.1016/j.neuropharm.2013.05.005. Epub 2013 May 18.
44. Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue. Qin W, etal., Nutr Cancer. 2014;66(2):270-7. doi: 10.1080/01635581.2014.868910. Epub 2014 Jan 21.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Sharma D, etal., Mol Endocrinol. 2013 Jul;27(7):1142-52. doi: 10.1210/me.2013-1079. Epub 2013 May 13.
49. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. Su PH, etal., Oncogene. 2013 Jan 3;32(1):15-26. doi: 10.1038/onc.2012.29. Epub 2012 Feb 13.
50. Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma. Su X, etal., Oncol Rep. 2010 Mar;23(3):819-26.
51. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Tao J, etal., J Clin Immunol. 2008 Sep;28(5):432-9. doi: 10.1007/s10875-008-9223-2. Epub 2008 Aug 6.
52. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Tryndyak VP, etal., Carcinogenesis. 2006 Aug;27(8):1713-20. Epub 2006 Apr 22.
53. Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior. Wang X, etal., Mol Neurobiol. 2013 Dec;48(3):544-55. doi: 10.1007/s12035-013-8444-4. Epub 2013 Mar 26.
54. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Wu Y, etal., Fertil Steril. 2007 Jan;87(1):24-32. Epub 2006 Nov 1.
55. DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia. Xiong L, etal., FEBS J. 2012 Dec;279(23):4318-26. doi: 10.1111/febs.12021. Epub 2012 Nov 7.
56. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Xiong Y, etal., Gynecol Oncol. 2005 Mar;96(3):601-9.
57. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Xu GL, etal., Nature. 1999 Nov 11;402(6758):187-91.
58. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Zhang C, etal., Neurosci Lett. 2009 Oct 25;462(3):308-11. doi: 10.1016/j.neulet.2009.06.085. Epub 2009 Jul 2.
59. [Association of DNA methyltransferase 3B gene polymorphism with early-onset schizophrenia]. Zhang C, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Dec;27(6):697-9. doi: 10.3760/cma.j.issn.1003-9406.2010.06.022.
60. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhang Q, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Feb;31(2):92-5.
61. Association between DNA methyltransferases 3B gene polymorphisms and the susceptibility to acute myeloid leukemia in Chinese Han population. Zheng Q, etal., PLoS One. 2013 Sep 17;8(9):e74626. doi: 10.1371/journal.pone.0074626. eCollection 2013.
Additional References at PubMed
PMID:9662389   PMID:10555141   PMID:11919202   PMID:11934864   PMID:14519686   PMID:15456878   PMID:16543361   PMID:17303076   PMID:17938196   PMID:18056424   PMID:18413740   PMID:18567530  
PMID:18814855   PMID:19796622   PMID:20548288   PMID:21378119   PMID:22133874   PMID:23754746   PMID:25190601   PMID:25416223   PMID:27856912   PMID:33099744   PMID:33298433   PMID:34428744  
PMID:36173508   PMID:36430472  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83162,590,777 - 162,629,313 (+)NCBIGRCr8
mRatBN7.23142,130,588 - 142,169,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,032,579 - 146,071,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,616,397 - 154,655,021 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,356,679 - 152,395,302 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,131,541 - 149,170,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,510,828 - 155,591,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,030,737 - 144,069,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,936,358 - 143,974,887 (+)NCBI
Celera3140,873,202 - 140,910,431 (+)NCBICelera
Cytogenetic Map3q41NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382032,762,385 - 32,809,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,762,385 - 32,809,359 (+)EnsemblGRCh38hg38GRCh38
GRCh372031,350,191 - 31,397,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,813,852 - 30,860,823 (+)NCBINCBI36Build 36hg18NCBI36
Celera2028,104,119 - 28,151,087 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,137,312 - 28,184,284 (+)NCBIHuRef
CHM1_12031,253,633 - 31,300,607 (+)NCBICHM1_1
T2T-CHM13v2.02034,489,113 - 34,536,082 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392153,491,332 - 153,529,650 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,491,370 - 153,529,650 (+)EnsemblGRCm39 Ensembl
GRCm382153,649,411 - 153,687,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,649,450 - 153,687,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,475,190 - 153,513,466 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,340,895 - 153,379,168 (+)NCBIMGSCv36mm8
Celera2159,495,468 - 159,534,017 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.79NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542228,380,591 - 28,421,301 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,380,595 - 28,427,012 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22138,453,003 - 38,499,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,446,101 - 38,493,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,049,993 - 29,096,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,169,081 - 30,215,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,186,069 - 30,215,487 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12422,096,386 - 22,123,378 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,096,349 - 22,122,900 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,724,710 - 21,769,260 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,765,878 - 22,810,458 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,782,662 - 22,810,452 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,042,034 - 22,086,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,150,746 - 22,195,021 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,581,755 - 22,626,058 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640171,116,001 - 171,139,372 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648519,547,836 - 19,570,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1736,345,816 - 36,386,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11736,345,715 - 36,386,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,282,731 - 41,322,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1237,128,635 - 37,176,033 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,146,538 - 37,174,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605089,724,034 - 89,772,846 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248426,450,852 - 6,475,785 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248426,450,972 - 6,505,929 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dnmt3b
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:116
Interacting mature miRNAs:155
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,158,376 - 142,158,451 (+)MAPPERmRatBN7.2
mRatBN7.23142,195,729 - 142,195,804 (+)MAPPERmRatBN7.2
Rnor_6.03149,198,110 - 149,198,184NCBIRnor6.0
Rnor_6.03149,159,316 - 149,159,390NCBIRnor6.0
Rnor_5.03155,576,334 - 155,576,408UniSTSRnor5.0
Rnor_5.03155,538,611 - 155,538,685UniSTSRnor5.0
RGSC_v3.43144,058,520 - 144,058,594UniSTSRGSC3.4
RGSC_v3.43144,097,377 - 144,097,451UniSTSRGSC3.4
Celera3140,937,252 - 140,937,326UniSTS
Celera3140,899,686 - 140,899,760UniSTS
Cytogenetic Map3q41UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,153,093 - 142,154,418 (+)MAPPERmRatBN7.2
Rnor_6.03149,154,033 - 149,155,357NCBIRnor6.0
Rnor_5.03155,533,328 - 155,534,652UniSTSRnor5.0
RGSC_v3.43144,053,237 - 144,054,561UniSTSRGSC3.4
Celera3140,894,403 - 140,895,727UniSTS
Cytogenetic Map3q41UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,165,241 - 142,165,985 (+)MAPPERmRatBN7.2
mRatBN7.23142,205,382 - 142,206,153 (+)MAPPERmRatBN7.2
Rnor_6.03149,207,898 - 149,208,668NCBIRnor6.0
Rnor_6.03149,166,179 - 149,166,922NCBIRnor6.0
Rnor_5.03155,586,122 - 155,586,892UniSTSRnor5.0
Rnor_5.03155,545,474 - 155,546,217UniSTSRnor5.0
RGSC_v3.43144,065,383 - 144,066,126UniSTSRGSC3.4
RGSC_v3.43144,107,027 - 144,107,797UniSTSRGSC3.4
Celera3140,946,902 - 140,947,672UniSTS
Celera3140,906,549 - 140,907,292UniSTS
Cytogenetic Map3q41UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,159,601 - 142,159,993 (+)MAPPERmRatBN7.2
Rnor_6.03149,160,541 - 149,160,932NCBIRnor6.0
Rnor_5.03155,539,836 - 155,540,227UniSTSRnor5.0
RGSC_v3.43144,059,745 - 144,060,136UniSTSRGSC3.4
Celera3140,900,911 - 140,901,302UniSTS
Cytogenetic Map3q41UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 10 12 6 6 6 8 12 18
Low 3 32 45 35 13 35 4 5 66 22 23 11 4
Below cutoff 1 4 6 1 4


RefSeq Acc Id: ENSRNOT00000015482   ⟹   ENSRNOP00000015482
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)Ensembl
Rnor_6.0 Ensembl3149,144,795 - 149,168,760 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090321   ⟹   ENSRNOP00000070758
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,130,592 - 142,168,823 (+)Ensembl
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097170   ⟹   ENSRNOP00000096797
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)Ensembl
RefSeq Acc Id: NM_001396349   ⟹   NP_001383278
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr83162,590,777 - 162,629,313 (+)NCBI
mRatBN7.23142,130,588 - 142,169,128 (+)NCBI
RefSeq Acc Id: ENSRNOP00000070758   ⟸   ENSRNOT00000090321
RefSeq Acc Id: ENSRNOP00000015482   ⟸   ENSRNOT00000015482
RefSeq Acc Id: ENSRNOP00000096797   ⟸   ENSRNOT00000097170
RefSeq Acc Id: NP_001383278   ⟸   NM_001396349
- UniProtKB: A0A8I6AVL3 (UniProtKB/TrEMBL),   A6KHW2 (UniProtKB/TrEMBL),   F1LQ40 (UniProtKB/TrEMBL),   Q1LZ51 (UniProtKB/TrEMBL)
Protein Domains
PHD-type   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1LZ51-F1-model_v2 AlphaFold Q1LZ51 1-859 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303274 AgrOrtholog
BioCyc Gene G2FUF-47210 BioCyc
Ensembl Genes ENSRNOG00000010625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015482.7 UniProtKB/TrEMBL
  ENSRNOT00000090321.2 UniProtKB/TrEMBL
  ENSRNOT00000097170.1 UniProtKB/TrEMBL
  PWWP, helical domain UniProtKB/TrEMBL
InterPro ADD UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:444985 UniProtKB/TrEMBL
  ADDz_Dnmt3b UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
PhenoGen Dnmt3b PhenoGen
RatGTEx ENSRNOG00000010625 RatGTEx
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
UniProt Secondary F1LQ40 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Dnmt3b  DNA methyltransferase 3 beta  Dnmt3b  DNA (cytosine-5-)-methyltransferase 3 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Dnmt3b  DNA (cytosine-5-)-methyltransferase 3 beta  Dnmt3b  DNA methyltransferase 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Dnmt3b  DNA methyltransferase 3B      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Dnmt3b  DNA methyltransferase 3B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mouse homolog is expressed in oocytes 1304004