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Gene: Dnmt3b (DNA methyltransferase 3 beta) Rattus norvegicus
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
RGD ID: 1303274
Description: Exhibits DNA binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to hyperoxia; and response to alkaloid. Localizes to cytoplasm and nucleus. Biomarker of anxiety disorder; congenital heart disease; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine.
Type: protein-coding
Also known as: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase 3B
Homo sapiens (human) : DNMT3B (DNA methyltransferase 3 beta)  HGNC  Alliance
Mus musculus (house mouse) : Dnmt3b (DNA methyltransferase 3B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3b (DNA methyltransferase 3 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3B (DNA methyltransferase 3 beta)
Canis lupus familiaris (dog) : DNMT3B (DNA methyltransferase 3 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3b (DNA methyltransferase 3 beta)
Sus scrofa (pig) : DNMT3B (DNA methyltransferase 3 beta)
Chlorocebus sabaeus (African green monkey) : DNMT3B (DNA methyltransferase 3 beta)
Heterocephalus glaber (naked mole-rat) : Dnmt3b (DNA methyltransferase 3 beta)
more info ...
Related Pseudogenes: Dnmt3b-ps1   Dnmt3b-ps2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03149,131,541 - 149,170,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,510,828 - 155,591,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,030,737 - 144,069,265 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,936,358 - 143,974,887 (+)NCBI
Celera3140,873,202 - 140,910,431 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dnmt3b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1303274
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.