Rictor (RPTOR independent companion of MTOR, complex 2) - Rat Genome Database

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Gene: Rictor (RPTOR independent companion of MTOR, complex 2) Rattus norvegicus
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Symbol: Rictor
Name: RPTOR independent companion of MTOR, complex 2
RGD ID: 1307224
Description: Predicted to enable several functions, including ATP binding activity; protein serine/threonine kinase activator activity; and zinc ion binding activity. Involved in positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of phosphorylation. Predicted to be part of TORC2 complex and serine/threonine protein kinase complex. Predicted to be active in endoplasmic reticulum; lysosome; and plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2); PARTICIPATES IN mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fyb; FYN binding protein; LOC310131; rapamycin-insensitive companion of mTOR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Rictorem4Mcwi  
Genetic Models: SS-Rictorem4Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,539,279 - 57,631,291 (+)NCBIGRCr8
mRatBN7.2255,811,877 - 55,903,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,811,322 - 55,901,426 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0256,013,898 - 56,105,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,052,643 - 56,101,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,754,848 - 75,846,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,982,784 - 56,071,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,911,016 - 55,999,761 (+)NCBI
Celera251,432,223 - 51,524,001 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1,4-phenylenediamine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
emetine  (ISO)
entinostat  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
metformin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer. Bian Y, etal., Biochem Biophys Res Commun. 2015 Aug 21;464(2):534-40. doi: 10.1016/j.bbrc.2015.07.001. Epub 2015 Jul 6.
2. RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors. Cheng H, etal., Cancer Discov. 2015 Dec;5(12):1262-70. doi: 10.1158/2159-8290.CD-14-0971. Epub 2015 Sep 14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma. Hou G, etal., Biomed Pharmacother. 2018 Oct;106:1348-1356. doi: 10.1016/j.biopha.2018.07.075. Epub 2018 Jul 23.
5. Molecular characterization of gallbladder cancer using somatic mutation profiling. Javle M, etal., Hum Pathol. 2014 Apr;45(4):701-8. doi: 10.1016/j.humpath.2013.11.001. Epub 2013 Nov 12.
6. RICTOR expression in esophageal squamous cell carcinoma and its clinical significance. Jiang WJ, etal., Med Oncol. 2017 Mar;34(3):32. doi: 10.1007/s12032-017-0894-5. Epub 2017 Jan 28.
7. Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma. Kaibori M, etal., Dig Dis Sci. 2015 Apr;60(4):919-28. doi: 10.1007/s10620-014-3417-7. Epub 2014 Nov 5.
8. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
9. Correlation between immunohistochemistry and RICTOR fluorescence in situ hybridization amplification in small cell lung carcinoma. Krencz I, etal., Hum Pathol. 2019 Nov;93:74-80. doi: 10.1016/j.humpath.2019.08.018. Epub 2019 Aug 24.
10. mTOR signaling in growth control and disease. Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
11. Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Li W, etal., Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.
12. RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. Lu Z, etal., Acta Pharm Sin B. 2020 Jun;10(6):1004-1019. doi: 10.1016/j.apsb.2020.01.010. Epub 2020 Jan 26.
13. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
14. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
15. MiR-424/503-mediated Rictor upregulation promotes tumor progression. Oneyama C, etal., PLoS One. 2013 Nov 11;8(11):e80300. doi: 10.1371/journal.pone.0080300. eCollection 2013.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo. Roulin D, etal., Mol Cancer. 2010 Mar 12;9:57. doi: 10.1186/1476-4598-9-57.
23. RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR. Sakre N, etal., Oncotarget. 2017 Jan 24;8(4):5992-6002. doi: 10.18632/oncotarget.13362.
24. Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis. Schmidt KM, etal., Neoplasia. 2018 Dec;20(12):1198-1208. doi: 10.1016/j.neo.2018.10.001. Epub 2018 Nov 4.
25. mTOR activity and its prognostic significance in human colorectal carcinoma depending on C1 and C2 complex-related protein expression. Sticz T, etal., J Clin Pathol. 2017 May;70(5):410-416. doi: 10.1136/jclinpath-2016-203913. Epub 2016 Oct 11.
26. Overexpression of Rictor protein and Rictor-H. pylori interaction has impact on tumor progression and prognosis in patients with gastric cancer. Wang F, etal., Folia Histochem Cytobiol. 2020;58(2):96-107. doi: 10.5603/FHC.a2020.0015. Epub 2020 Jun 26.
27. [Expression of Rictor and mTOR in colorectal cancer and their clinical significance]. Wang LF, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2016 Mar;36(3):396-400.
28. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, etal., Mol Cancer Res. 2020 Mar;18(3):414-423. doi: 10.1158/1541-7786.MCR-19-0525. Epub 2020 Jan 13.
29. Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway. Xu Z, etal., Exp Mol Med. 2018 Jan 5;50(1):e417. doi: 10.1038/emm.2017.158.
30. mTORC1 and mTORC2 differentially promote natural killer cell development. Yang C, etal., Elife. 2018 May 29;7. pii: 35619. doi: 10.7554/eLife.35619.
31. mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis. Zhang F, etal., Cancer Res. 2010 Nov 15;70(22):9360-70. doi: 10.1158/0008-5472.CAN-10-0207. Epub 2010 Oct 26.
32. The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer. Zheng G, etal., Oncotarget. 2015 Mar 30;6(9):6931-43. doi: 10.18632/oncotarget.3165.
Additional References at PubMed
PMID:15268862   PMID:15467718   PMID:15718470   PMID:16962653   PMID:16962829   PMID:21045808   PMID:21177249   PMID:23092880   PMID:23288930   PMID:24036451   PMID:24270265   PMID:24740015  
PMID:25897075   PMID:25970154   PMID:28035937   PMID:30637733   PMID:32232913  


Genomics

Comparative Map Data
Rictor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,539,279 - 57,631,291 (+)NCBIGRCr8
mRatBN7.2255,811,877 - 55,903,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,811,322 - 55,901,426 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0256,013,898 - 56,105,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,052,643 - 56,101,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,754,848 - 75,846,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,982,784 - 56,071,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,911,016 - 55,999,761 (+)NCBI
Celera251,432,223 - 51,524,001 (+)NCBICelera
Cytogenetic Map2q16NCBI
RICTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38538,937,920 - 39,074,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl538,937,920 - 39,074,402 (-)EnsemblGRCh38hg38GRCh38
GRCh37538,938,022 - 39,074,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36538,973,779 - 39,110,260 (-)NCBINCBI36Build 36hg18NCBI36
Celera538,824,519 - 38,961,093 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef538,889,559 - 39,026,140 (-)NCBIHuRef
CHM1_1538,939,974 - 39,076,492 (-)NCBICHM1_1
T2T-CHM13v2.0539,187,325 - 39,323,906 (-)NCBIT2T-CHM13v2.0
Rictor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,737,827 - 6,829,882 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,737,860 - 6,829,882 (+)EnsemblGRCm39 Ensembl
GRCm38156,708,349 - 6,800,401 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,708,379 - 6,800,401 (+)EnsemblGRCm38mm10GRCm38
MGSCv37156,658,381 - 6,750,401 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,655,598 - 6,747,602 (+)NCBIMGSCv36mm8
Celera156,556,757 - 6,648,820 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.25NCBI
Rictor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542623,468,112 - 23,582,587 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542623,468,112 - 23,582,587 (-)NCBIChiLan1.0ChiLan1.0
RICTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2471,261,938 - 71,398,082 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,415,572 - 69,551,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0571,299,215 - 71,435,290 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1576,390,408 - 76,474,207 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,389,130 - 76,469,830 (+)Ensemblpanpan1.1panPan2
RICTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1469,903,393 - 70,013,168 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl469,936,379 - 70,010,566 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha469,572,398 - 69,689,560 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0470,411,989 - 70,529,395 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,412,019 - 70,529,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1470,160,959 - 70,278,302 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0470,273,578 - 70,390,878 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0470,812,437 - 70,929,811 (+)NCBIUU_Cfam_GSD_1.0
Rictor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213228,057,440 - 228,173,553 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365183,198,337 - 3,310,000 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365183,198,312 - 3,314,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RICTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1624,109,939 - 24,311,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11624,109,934 - 24,250,019 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21625,357,044 - 25,498,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RICTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1437,758,531 - 37,885,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl437,762,901 - 37,873,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607128,126,791 - 28,254,601 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rictor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475915,837,064 - 15,968,894 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475915,837,027 - 15,973,248 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rictor
160 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:113
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000029565, ENSRNOT00000075595
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Got394  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8257,537,110 - 57,537,389 (+)Marker Load Pipeline
mRatBN7.2255,809,708 - 55,809,987 (+)MAPPERmRatBN7.2
Rnor_6.0256,011,622 - 56,011,900NCBIRnor6.0
Rnor_5.0275,752,947 - 75,753,225UniSTSRnor5.0
RGSC_v3.4255,980,922 - 55,981,200UniSTSRGSC3.4
Celera251,430,024 - 51,430,302UniSTS
Cytogenetic Map2q16UniSTS
D2Got385  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8257,537,114 - 57,537,388 (+)Marker Load Pipeline
mRatBN7.2255,809,712 - 55,809,986 (+)MAPPERmRatBN7.2
Rnor_6.0256,011,626 - 56,011,899NCBIRnor6.0
Rnor_5.0275,752,951 - 75,753,224UniSTSRnor5.0
RGSC_v3.4255,980,926 - 55,981,199UniSTSRGSC3.4
Celera251,430,028 - 51,430,301UniSTS
Cytogenetic Map2q16UniSTS
D2Got376  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8257,537,114 - 57,537,309 (+)Marker Load Pipeline
mRatBN7.2255,809,712 - 55,809,907 (+)MAPPERmRatBN7.2
Rnor_6.0256,011,626 - 56,011,820NCBIRnor6.0
Rnor_5.0275,752,951 - 75,753,145UniSTSRnor5.0
RGSC_v3.4255,980,926 - 55,981,120UniSTSRGSC3.4
Celera251,430,028 - 51,430,222UniSTS
Cytogenetic Map2q16UniSTS


Genetic Models
This gene Rictor is modified in the following models/strains:
SS-Rictorem4Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000029565   ⟹   ENSRNOP00000030782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,811,322 - 55,901,426 (+)Ensembl
Rnor_6.0 Ensembl256,052,643 - 56,101,803 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109110   ⟹   ENSRNOP00000079615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,811,928 - 55,901,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112769   ⟹   ENSRNOP00000079071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,857,970 - 55,901,426 (+)Ensembl
RefSeq Acc Id: XM_008760807   ⟹   XP_008759029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,539,279 - 57,631,291 (+)NCBI
mRatBN7.2255,811,877 - 55,903,893 (+)NCBI
Rnor_6.0256,013,898 - 56,105,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103527   ⟹   XP_038959455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,539,279 - 57,631,291 (+)NCBI
mRatBN7.2255,811,877 - 55,903,893 (+)NCBI
RefSeq Acc Id: XM_039103528   ⟹   XP_038959456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,539,279 - 57,619,252 (+)NCBI
mRatBN7.2255,811,877 - 55,891,854 (+)NCBI
RefSeq Acc Id: XM_063282846   ⟹   XP_063138916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,539,279 - 57,631,291 (+)NCBI
RefSeq Acc Id: XP_008759029   ⟸   XM_008760807
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000030782   ⟸   ENSRNOT00000029565
RefSeq Acc Id: XP_038959455   ⟸   XM_039103527
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNG4 (UniProtKB/TrEMBL),   F1M4J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959456   ⟸   XM_039103528
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000079615   ⟸   ENSRNOT00000109110
Ensembl Acc Id: ENSRNOP00000079071   ⟸   ENSRNOT00000112769
RefSeq Acc Id: XP_063138916   ⟸   XM_063282846
- Peptide Label: isoform X2
- UniProtKB: F1M4J0 (UniProtKB/TrEMBL)
Protein Domains
Rapamycin-insensitive companion of mTOR   Rapamycin-insensitive companion of mTOR middle   Rapamycin-insensitive companion of mTOR N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4J0-F1-model_v2 AlphaFold F1M4J0 1-1697 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307224 AgrOrtholog
BioCyc Gene G2FUF-54150 BioCyc
Ensembl Genes ENSRNOG00000011341 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029565 ENTREZGENE
  ENSRNOT00000029565.7 UniProtKB/TrEMBL
  ENSRNOT00000109110 ENTREZGENE
  ENSRNOT00000109110.1 UniProtKB/TrEMBL
  ENSRNOT00000112769.1 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Pianissimo_fam UniProtKB/TrEMBL
  Pianissimo_N UniProtKB/TrEMBL
  Rictor_IV UniProtKB/TrEMBL
  RICTOR_M UniProtKB/TrEMBL
  RICTOR_phospho UniProtKB/TrEMBL
  RICTOR_V UniProtKB/TrEMBL
KEGG Report rno:310131 UniProtKB/TrEMBL
NCBI Gene 310131 ENTREZGENE
PANTHER PTHR13298 UniProtKB/TrEMBL
  RAPAMYCIN-INSENSITIVE COMPANION OF MTOR UniProtKB/TrEMBL
Pfam RasGEF_N_2 UniProtKB/TrEMBL
  RICTOR_M UniProtKB/TrEMBL
  RICTOR_N UniProtKB/TrEMBL
  RICTOR_phospho UniProtKB/TrEMBL
  RICTOR_V UniProtKB/TrEMBL
PhenoGen Rictor PhenoGen
RatGTEx ENSRNOG00000011341 RatGTEx
SMART RasGEF_N_2 UniProtKB/TrEMBL
  RICTOR_M UniProtKB/TrEMBL
  RICTOR_N UniProtKB/TrEMBL
  RICTOR_phospho UniProtKB/TrEMBL
  RICTOR_V UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5ZNG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQ26_RAT UniProtKB/TrEMBL
  F1M4J0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-07-20 Rictor  RPTOR independent companion of MTOR, complex 2  Rictor  rapamycin-insensitive companion of mTOR  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Rictor  rapamycin-insensitive companion of mTOR  Fyb_predicted  FYN binding protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Fyb_predicted  FYN binding protein (predicted)      Symbol and Name status set to approved 70820 APPROVED