Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klk8
Name: kallikrein related-peptidase 8
Acc ID: CHEBI:6426
Term: leupeptin
Definition: A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death.
Chemical ID: MESH:C032854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klk8decreases activityISOKLK8 (Homo sapiens)6480464CTDleupeptin results in decreased activity of KLK8 proteinPMID:16800733
Go Back to source page   Continue to Ontology report