Gene: Ercc6 (ERCC excision repair 6, chromatin remodeling factor) Rattus norvegicus
Analyze
Symbol:
Ercc6
Name:
ERCC excision repair 6, chromatin remodeling factor
Description:
Predicted to have several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including DNA repair; growth; and positive regulation of macromolecule metabolic process. Predicted to localize to the nuclear lumen and site of DNA damage. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Cockayne syndrome; UV-sensitive syndrome; age related macular degeneration 5; lung cancer; and premature ovarian failure. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; amphetamine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DNA excision repair protein ERCC-6; excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; LOC306274
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB
Mus musculus (house mouse):
Ercc6 (excision repair cross-complementing rodent repair deficiency, complementation group 6) HGNC
NCBI, OMA, HomoloGene, Inparanoid, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ercc6 (ERCC excision repair 6, chromatin remodeling factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ercc6 (ERCC excision repair 6, chromatin remodeling factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RAD54L (RAD54 like) HGNC
Panther
Homo sapiens (human):
RAD54B (RAD54 homolog B) HGNC
Panther
Homo sapiens (human):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) HGNC
Panther
Homo sapiens (human):
ERCC6L2 (ERCC excision repair 6 like 2) HGNC
Panther
Alliance orthologs 3
Homo sapiens (human):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor)
Alliance
DIOPT (HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Mus musculus (house mouse):
Ercc6 (excision repair cross-complementing rodent repair deficiency, complementation group 6)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
ercc6 (excision repair cross-complementation group 6)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
RAD26
Alliance
DIOPT (Ensembl Compara, InParanoid, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 8,734,028 - 8,804,610 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 8,734,035 - 8,804,610 (+) Ensembl Rnor_5.0 16 10,699,983 - 10,770,565 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 8,024,881 - 8,091,587 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 8,024,868 - 8,088,560 (+) NCBI Celera 16 7,365,531 - 7,432,176 (-) NCBI Celera Cytogenetic Map 16 p16 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
age related macular degeneration 5 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 5 ClinVar PMID:10767341 more ... age related macular degeneration 5 ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:613761 ClinVar PMID:16754848 , PMID:17854076 Cerebrooculofacioskeletal Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal Syndrome ClinVar Cerebrooculofacioskeletal Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal Syndrome ClinVar PMID:18414213 more ... Cerebrooculofacioskeletal Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal Syndrome ClinVar PMID:18414213 Cerebrooculofacioskeletal Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal Syndrome ClinVar PMID:25741868 Cerebrooculofacioskeletal Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal Syndrome ClinVar PMID:18414213 , PMID:25741868 Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: CEREBROOCULOFACIOSKELETAL SYNDROME 1 ClinVar PMID:10767341 more ... Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: CEREBROOCULOFACIOSKELETAL SYNDROME 1 ClinVar PMID:10767341 more ... Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: CEREBROOCULOFACIOSKELETAL SYNDROME 1 ClinVar PMID:18414213 more ... Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: CEREBROOCULOFACIOSKELETAL SYNDROME 1 ClinVar PMID:25741868 Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:214150 ClinVar PMID:18628313 , PMID:27004399 Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:214150 ClinVar PMID:10739753 Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:214150 ClinVar PMID:18628313 Cockayne syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 , PMID:25741868 Cockayne syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:133540 ClinVar PMID:25741868 Cockayne syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:133540 ClinVar PMID:18414213 Cockayne syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by OMIM:133540 ClinVar Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome B ClinVar PMID:10767341 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome B ClinVar PMID:10767341 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome B ClinVar PMID:26749132 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:20122405 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 , PMID:19894250 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne Syndrome, Type II ClinVar PMID:18628313 , PMID:27004399 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:10767341 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:10196384 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:9443879 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18446857 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 , PMID:25741868 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome B ClinVar PMID:15486090 more ... Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:10196384 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome B ClinVar PMID:25741868 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 Cockayne Syndrome B ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Cockayne syndrome, type B ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: De Sanctis-Cacchione syndrome ClinVar PMID:10767341 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:11809892 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:10767341 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:26218421 , PMID:27186691 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:19894250 , PMID:27004399 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:20122405 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:9443879 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:25356239 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 , PMID:19894250 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:25463447 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:26620705 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18628313 , PMID:27004399 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:19894250 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:25741868 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:18414213 , PMID:25741868 De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:10196384 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar PMID:10767341 more ... De Sanctis-Cacchione Syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: DE SANCTIS-CACCHIONE SYNDROME ClinVar genetic disease ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10767341 more ... genetic disease ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10767341 more ... genetic disease ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10767341 more ... genetic disease ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10767341 more ... lung cancer ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Lung cancer, somatic ClinVar PMID:10767341 more ... lung cancer ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Lung cancer, susceptibility to ClinVar PMID:16754848 , PMID:17854076 macular degeneration ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:18414213 macular degeneration ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:18414213 more ... macular degeneration ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:18414213 , PMID:25741868 macular degeneration ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:25741868 macular degeneration ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar melanoma ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Malignant melanoma ClinVar Premature Ovarian Failure 11 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Premature ovarian failure 11 ClinVar PMID:26218421 Premature Ovarian Failure 11 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Premature ovarian failure 11 ClinVar PMID:10767341 more ... Premature Ovarian Failure 11 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Premature ovarian failure 11 ClinVar PMID:26218421 , PMID:27186691 schizophrenia ISO RGD:1323005 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311 UV-sensitive syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: UV-sensitive syndrome ClinVar PMID:10767341 more ... UV-sensitive syndrome ISO RGD:1323005 8554872 ClinVar Annotator: match by term: UV-sensitive syndrome ClinVar PMID:15486090 more ... UV-Sensitive Syndrome 1 ISO RGD:1323005 8554872 ClinVar Annotator: match by term: UV-SENSITIVE SYNDROME 1 ClinVar PMID:10767341 more ...
Imported Annotations - CTD
age related macular degeneration 5 ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD Arthrogryposis ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628313 cataract ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628313 Cockayne syndrome ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9443879 more ... Craniofacial Abnormalities ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628313 De Sanctis-Cacchione Syndrome ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10767341 Growth Disorders ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628313 Hearing Loss ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25440059 Lung Neoplasms ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17854076 macular degeneration ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16754848 microcephaly ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10739753 , PMID:18628313 microphthalmia ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10739753 Premature Aging ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25440059 Psychomotor Disorders ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628313 UV-sensitive syndrome ISO RGD:1323005 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26972010 Imported Annotations - MGI
lung cancer ISS RGD:1323005 13592920 OMIM:211980 more ... MouseDO Imported Annotations - OMIM
age related macular degeneration 5 susceptibility ISO RGD:1323005 7240710 OMIM Cerebrooculofacioskeletal Syndrome 1 ISO RGD:1323005 7240710 OMIM Cockayne Syndrome B ISO RGD:1323005 7240710 OMIM De Sanctis-Cacchione Syndrome ISO RGD:1323005 7240710 OMIM Lung Neoplasms ISO RGD:1323005 7240710 OMIM Premature Ovarian Failure 11 ISO RGD:1323005 7240710 OMIM UV-Sensitive Syndrome 1 ISO RGD:1323005 7240710 OMIM
17beta-estradiol increases expression ISO RGD:1323005 6480464 Estradiol results in increased expression of ERCC6 mRNA CTD PMID:22082530 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1323005 6480464 Tetrachlorodibenzodioxin results in increased expression of ERCC6 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ERCC6 mRNA CTD PMID:21215274 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ERCC6 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased abundance of Lactic Acid CTD PMID:25440059 2-hydroxypropanoic acid decreases expression ISO RGD:1323005 6480464 Lactic Acid results in decreased expression of ERCC6 mRNA CTD PMID:30851411 3-aminobenzamide multiple interactions ISO RGD:1323005 6480464 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides] CTD PMID:25440059 3-aminobenzamide affects response to substance ISO RGD:1323005 6480464 ERCC6 gene mutant form affects the susceptibility to 3-aminobenzamide CTD PMID:25440059 3-hydroxybutyric acid multiple interactions ISO RGD:1622854 6480464 Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid] CTD PMID:25440059 3-hydroxybutyric acid multiple interactions ISO RGD:1323005 6480464 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A] more ... CTD PMID:25440059 3-hydroxybutyric acid decreases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid CTD PMID:25440059 3-methylcholanthrene multiple interactions ISO RGD:1323005 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to ERCC6 promoter] CTD PMID:20348232 5-aza-2'-deoxycytidine increases expression ISO RGD:1323005 6480464 Decitabine results in increased expression of ERCC6 mRNA CTD PMID:22082530 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1323005 6480464 6-chloro-2 more ... CTD PMID:25440059 acetyl-CoA decreases abundance ISO RGD:1323005 6480464 ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A CTD PMID:25440059 acetyl-CoA multiple interactions ISO RGD:1323005 6480464 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A] more ... CTD PMID:25440059 adenosine 5'-monophosphate increases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate CTD PMID:25440059 aflatoxin B1 increases methylation ISO RGD:1323005 6480464 Aflatoxin B1 results in increased methylation of ERCC6 gene, Aflatoxin B1 results in increased methylation of ERCC6 intron CTD PMID:27153756 , PMID:30157460 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of ERCC6 mRNA CTD PMID:30779732 antirheumatic drug increases expression ISO RGD:1323005 6480464 Antirheumatic Agents results in increased expression of ERCC6 mRNA CTD PMID:24449571 arsane affects expression ISO RGD:1323005 6480464 Arsenic affects the expression of ERCC6 CTD PMID:21235219 arsenic atom affects expression ISO RGD:1323005 6480464 Arsenic affects the expression of ERCC6 CTD PMID:21235219 arsenous acid affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to Arsenic Trioxide CTD PMID:22280988 ascaridole affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to ascaridole CTD PMID:22280988 ATP decreases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate CTD PMID:25440059 ATP multiple interactions ISO RGD:1622854 6480464 nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate] CTD PMID:25440059 benzo[a]pyrene increases expression ISO RGD:1323005 6480464 Benzo(a)pyrene results in increased expression of ERCC6 mRNA CTD PMID:20064835 , PMID:28461126 benzo[a]pyrene affects methylation ISO RGD:1323005 6480464 Benzo(a)pyrene affects the methylation of ERCC6 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate increases response to substance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased susceptibility to Diethylhexyl Phthalate CTD PMID:15340056 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ERCC6 mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ERCC6 gene CTD PMID:28505145 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of ERCC6 promoter CTD PMID:22457795 carbazoles affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to Carbazoles CTD PMID:22280988 choline multiple interactions ISO RGD:1622854 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC6 gene CTD PMID:20938992 cisplatin multiple interactions ISO RGD:1323005 6480464 ERCC6 protein inhibits the reaction [Cisplatin results in increased activity of ATR protein] more ... CTD PMID:21324906 cisplatin decreases expression ISO RGD:1622854 6480464 Cisplatin results in decreased expression of ERCC6 mRNA CTD PMID:24865317 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of ERCC6 mRNA CTD PMID:26739623 cisplatin decreases response to substance ISO RGD:1622854 6480464 ERCC6 protein results in decreased susceptibility to Cisplatin CTD PMID:21324906 cisplatin increases response to substance ISO RGD:1323005 6480464 ERCC6 protein mutant form results in increased susceptibility to Cisplatin CTD PMID:21324906 citric acid decreases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in decreased abundance of Citric Acid CTD PMID:25440059 copper(II) sulfate decreases expression ISO RGD:1323005 6480464 Copper Sulfate results in decreased expression of ERCC6 mRNA CTD PMID:19549813 cypermethrin increases expression ISO RGD:1622854 6480464 cypermethrin results in increased expression of ERCC6 mRNA CTD PMID:21142847 diarsenic trioxide affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to Arsenic Trioxide CTD PMID:22280988 doxorubicin decreases expression ISO RGD:1323005 6480464 Doxorubicin results in decreased expression of ERCC6 mRNA CTD PMID:29803840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of ERCC6 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1622854 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC6 gene CTD PMID:20938992 formaldehyde decreases expression ISO RGD:1323005 6480464 Formaldehyde results in decreased expression of ERCC6 mRNA CTD PMID:20655997 genistein increases expression EXP 6480464 Genistein results in increased expression of ERCC6 protein CTD PMID:24552547 glycidol increases expression EXP 6480464 glycidol results in increased expression of ERCC6 mRNA CTD PMID:24915197 hydrogen peroxide affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to Hydrogen Peroxide CTD PMID:25136123 hydrogen peroxide multiple interactions ISO RGD:1323005 6480464 [ERCC6 protein affects the susceptibility to Hydrogen Peroxide] which affects the expression of H2AX protein CTD PMID:25136123 Illudin S increases response to substance ISO RGD:1323005 6480464 ERCC6 mutant form results in increased susceptibility to illudin S CTD PMID:28076683 irofulven increases response to substance ISO RGD:1323005 6480464 ERCC6 mutant form results in increased susceptibility to irofulven CTD PMID:28076683 L-methionine multiple interactions ISO RGD:1622854 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC6 gene CTD PMID:20938992 lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of ERCC6 mRNA CTD PMID:26739623 lutein decreases expression ISO RGD:1622854 6480464 Lutein results in decreased expression of ERCC6 mRNA CTD PMID:24865317 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of ERCC6 mRNA CTD PMID:28659758 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1323005 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 N-ribosylnicotinamide multiple interactions ISO RGD:1622854 6480464 nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate], nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of NAD] CTD PMID:25440059 NAD zwitterion multiple interactions ISO RGD:1622854 6480464 nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of NAD] CTD PMID:25440059 NAD zwitterion decreases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in decreased abundance of NAD CTD PMID:25440059 NAD zwitterion increases ADP-ribosylation ISO RGD:1323005 6480464 NAD results in increased ADP-ribosylation of ERCC6 protein CTD PMID:25440059 NAD zwitterion increases metabolic processing ISO RGD:1323005 6480464 ERCC6 gene mutant form results in increased metabolism of NAD CTD PMID:25440059 NAD zwitterion multiple interactions ISO RGD:1323005 6480464 ERCC6 gene mutant form promotes the reaction [N-(oxo-5 more ... CTD PMID:25440059 NAD(+) multiple interactions ISO RGD:1323005 6480464 ERCC6 gene mutant form promotes the reaction [N-(oxo-5 more ... CTD PMID:25440059 NAD(+) decreases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in decreased abundance of NAD CTD PMID:25440059 NAD(+) increases ADP-ribosylation ISO RGD:1323005 6480464 NAD results in increased ADP-ribosylation of ERCC6 protein CTD PMID:25440059 NAD(+) increases metabolic processing ISO RGD:1323005 6480464 ERCC6 gene mutant form results in increased metabolism of NAD CTD PMID:25440059 NAD(+) multiple interactions ISO RGD:1622854 6480464 nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of NAD] CTD PMID:25440059 nicotinamide multiple interactions ISO RGD:1323005 6480464 ERCC6 gene mutant form promotes the reaction [N-(oxo-5 more ... CTD PMID:25440059 nicotinamide increases abundance ISO RGD:1323005 6480464 ERCC6 gene mutant form results in increased abundance of Niacinamide CTD PMID:25440059 NMN zwitterion decreases abundance ISO RGD:1323005 6480464 ERCC6 gene mutant form results in decreased abundance of Nicotinamide Mononucleotide CTD PMID:25440059 NU 1025 multiple interactions ISO RGD:1323005 6480464 NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides] CTD PMID:25440059 NU 1025 affects response to substance ISO RGD:1323005 6480464 ERCC6 gene mutant form affects the susceptibility to NU 1025 CTD PMID:25440059 oxaliplatin affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to oxaliplatin CTD PMID:16773204 ozone multiple interactions ISO RGD:1622854 6480464 ERCC6 gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein], ERCC6 gene mutant form promotes the reaction [Ozone results in increased expression of TNF protein] CTD PMID:17095637 paraquat increases response to substance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased susceptibility to Paraquat CTD PMID:12509265 , PMID:15340056 permethrin multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of ERCC6 mRNA CTD PMID:28659758 potassium bromate multiple interactions ISO RGD:1323005 6480464 veliparib promotes the reaction [ERCC6 protein affects the susceptibility to potassium bromate] CTD PMID:25136123 potassium bromate affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to potassium bromate CTD PMID:25136123 potassium dichromate decreases expression ISO RGD:1622854 6480464 Potassium Dichromate results in decreased expression of ERCC6 mRNA CTD PMID:23608068 Pyridostigmine bromide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of ERCC6 mRNA CTD PMID:28659758 rac-lactic acid increases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased abundance of Lactic Acid CTD PMID:25440059 rac-lactic acid decreases expression ISO RGD:1323005 6480464 Lactic Acid results in decreased expression of ERCC6 mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:1622854 6480464 resveratrol inhibits the reaction [ERCC6 gene mutant form results in decreased expression of BCL2 protein] more ... CTD PMID:25440059 rotenone affects response to substance ISO RGD:1323005 6480464 ERCC6 protein affects the susceptibility to Rotenone CTD PMID:25136123 silver atom increases expression ISO RGD:1622854 6480464 Silver results in increased expression of ERCC6 mRNA CTD PMID:19429238 silver(0) increases expression ISO RGD:1622854 6480464 Silver results in increased expression of ERCC6 mRNA CTD PMID:19429238 sodium arsenite decreases expression ISO RGD:1622854 6480464 sodium arsenite results in decreased expression of ERCC6 mRNA CTD PMID:17558810 succinic acid increases abundance ISO RGD:1622854 6480464 ERCC6 gene mutant form results in increased abundance of Succinic Acid CTD PMID:25440059 superoxide decreases abundance ISO RGD:1323005 6480464 ERCC6 protein results in decreased abundance of Superoxides CTD PMID:25440059 superoxide multiple interactions ISO RGD:1323005 6480464 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides] more ... CTD PMID:25440059 superoxide increases abundance ISO RGD:1323005 6480464 ERCC6 gene mutant form results in increased abundance of Superoxides CTD PMID:25440059 urethane increases expression ISO RGD:1323005 6480464 Urethane results in increased expression of ERCC6 mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:1323005 6480464 Valproic Acid results in decreased methylation of ERCC6 gene CTD PMID:29154799 veliparib multiple interactions ISO RGD:1323005 6480464 veliparib promotes the reaction [ERCC6 protein affects the susceptibility to potassium bromate] CTD PMID:25136123
Biological Process activation of JNKK activity ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3654809 , PMID:16319174) RGD MGI:MGI:3654809 , PMID:16319174 activation of JNKK activity IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 activation of JUN kinase activity ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3654809 , PMID:16319174) RGD MGI:MGI:3654809 , PMID:16319174 activation of JUN kinase activity IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 ATP-dependent chromatin remodeling IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 ATP-dependent chromatin remodeling ISO RGD:1323005 1624291 (PMID:29203878) RGD PMID:29203878 base-excision repair ISO RGD:1323005 1624291 (PMID:9973627) RGD PMID:9973627 base-excision repair IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 biological_process ND 1598407 12/2016: no relevant rat data RGD cellular response to DNA damage stimulus ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:2137100 more ... RGD MGI:MGI:2137100 more ... DNA damage checkpoint IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA damage checkpoint ISO RGD:1323005 1624291 (PMID:25820262) RGD PMID:25820262 DNA duplex unwinding IEA GO:0003678 1600115 GO_REF:0000108 GOC GO_REF:0000108 DNA repair ISO RGD:1622854 1624291 MGI:MGI:1097693 more ... RGD MGI:MGI:1861042 more ... DNA repair ISO RGD:1323005 1624291 (PMID:26218421) RGD PMID:26218421 double-strand break repair via classical nonhomologous end joining IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 double-strand break repair via classical nonhomologous end joining ISO RGD:1323005 1624291 (PMID:29545921) RGD PMID:29545921 intrinsic apoptotic signaling pathway in response to DNA damage ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:1913261 , PMID:11005836) RGD MGI:MGI:1913261 , PMID:11005836 intrinsic apoptotic signaling pathway in response to DNA damage IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 multicellular organism growth ISO RGD:1622854 1624291 MGI:MGI:95412 more ... RGD MGI:MGI:5314556 , PMID:22323595 multicellular organism growth IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of double-strand break repair via nonhomologous end joining IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of double-strand break repair via nonhomologous end joining ISO RGD:1323005 1624291 (PMID:25820262) RGD PMID:25820262 neurogenesis ISO RGD:1323005 1624291 (PMID:24874740) RGD PMID:24874740 neuron differentiation ISO RGD:1323005 1624291 (PMID:24874740) RGD PMID:24874740 neuron projection development IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection development ISO RGD:1323005 1624291 (PMID:24874740) RGD PMID:24874740 photoreceptor cell maintenance ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3699047 , PMID:17145777) RGD MGI:MGI:3699047 , PMID:17145777 photoreceptor cell maintenance IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of defense response to virus by host ISO RGD:1323005 1624291 (PMID:22483866) RGD PMID:22483866 positive regulation of DNA repair ISO RGD:1323005 1624291 UniProtKB:P0DP91 , UniProtKB:Q03468 (PMID:22483866) RGD PMID:22483866 positive regulation of DNA-templated transcription, elongation ISO RGD:1323005 1624291 (PMID:9326587) RGD PMID:9326587 positive regulation of DNA-templated transcription, elongation IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of double-strand break repair via homologous recombination IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of double-strand break repair via homologous recombination ISO RGD:1323005 1624291 (PMID:25820262) RGD PMID:25820262 positive regulation of gene expression ISO RGD:1323005 1624291 (PMID:22483866) RGD PMID:22483866 positive regulation of peptidyl-serine phosphorylation of STAT protein ISO RGD:1323005 1624291 (PMID:22483866) RGD PMID:22483866 positive regulation of protein tyrosine kinase activity IEA GO:0030296 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of transcription initiation from RNA polymerase II promoter IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription initiation from RNA polymerase II promoter ISO RGD:1622854 1624291 MGI:MGI:1932102 more ... RGD MGI:MGI:5314556 , PMID:22323595 pyrimidine dimer repair ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:87553 , PMID:9150142) RGD MGI:MGI:87553 , PMID:9150142 pyrimidine dimer repair IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of DNA-templated transcription, elongation ISO RGD:1323005 1624291 (PMID:9326587) RGD PMID:9326587 response to gamma radiation ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3054497 , PMID:15340056) RGD MGI:MGI:3054497 , PMID:15340056 response to gamma radiation IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to oxidative stress ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:2448221 , PMID:12509265) RGD MGI:MGI:2448221 , PMID:12509265 response to oxidative stress ISO RGD:1323005 1624291 UniProtKB:P00519 (PMID:16107709), (PMID:17626041) RGD PMID:16107709 , PMID:17626041 response to superoxide ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3054497 , PMID:15340056) RGD MGI:MGI:3054497 , PMID:15340056 response to superoxide IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to toxic substance ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:2137100 , PMID:11408355) RGD MGI:MGI:2137100 , PMID:11408355 response to toxic substance IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to UV ISO RGD:1323005 1624291 (PMID:16916636) RGD PMID:16916636 response to UV ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3054497 more ... RGD MGI:MGI:3054497 more ... response to UV-B IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to UV-B ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:1859141 more ... RGD MGI:MGI:1859141 more ... response to X-ray IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to X-ray ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:3613277 more ... RGD MGI:MGI:3613277 more ... single strand break repair IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 single strand break repair ISO RGD:1323005 1624291 (PMID:29545921) RGD PMID:29545921 transcription elongation from RNA polymerase I promoter ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:5496981 , PMID:23562818) RGD MGI:MGI:5496981 , PMID:23562818 transcription elongation from RNA polymerase I promoter IEA UniProtKB:F8VPZ5 , ensembl:ENSMUSP000000662561600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription-coupled nucleotide-excision repair ISO RGD:1622854 1624291 MGI:MGI:1932102 (MGI:MGI:2448221 more ... RGD MGI:MGI:2448221 more ... transcription-coupled nucleotide-excision repair ISO RGD:1323005 1624291 (PMID:10564257), (PMID:16916636), (PMID:26620705) RGD PMID:10564257 more ... transcription-coupled nucleotide-excision repair IBA MGI:MGI:1100494 more ... 13792537 PMID:21873635 GO_Central Cellular Component cellular_component ND 1598407 12/2016: no relevant rat data RGD nuclear body ISO RGD:1323005 1624291 RGD GO_REF:0000052 nucleolus IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus ISO RGD:1323005 1624291 (PMID:16107709), (PMID:17626041) RGD PMID:16107709 , PMID:17626041 nucleoplasm ISO RGD:1323005 1624291 (PMID:16107709) RGD GO_REF:0000052, PMID:16107709 nucleus IBA PANTHER:PTN001326493 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:1323005 1624291 (PMID:12560492), (PMID:17626041) RGD PMID:12560492 , PMID:17626041 site of DNA damage IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 site of DNA damage ISO RGD:1323005 1624291 (PMID:28292928) RGD PMID:28292928 transcription elongation factor complex ISO RGD:1323005 1624291 (PMID:9326587) RGD PMID:9326587 transcription elongation factor complex IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ATP binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 ATP binding IEA InterPro:IPR000330 1600115 GO_REF:0000002 InterPro GO_REF:0000002 ATP binding ISO RGD:1323005 1624291 (PMID:12560492), (PMID:16107709) RGD PMID:12560492 , PMID:16107709 chromatin binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding ISO RGD:1323005 1624291 (PMID:16916636), (PMID:25820262), (PMID:26620705) RGD PMID:16916636 more ... DNA binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA binding ISO RGD:1323005 1624291 (PMID:12560492), (PMID:16107709), (PMID:8999876) RGD PMID:12560492 more ... DNA helicase activity NOT ISO RGD:1323005 1624291 (PMID:8999876) RGD PMID:8999876 DNA-dependent ATPase activity ISO RGD:1323005 1624291 (PMID:12560492), (PMID:16107709), (PMID:25820262), (PMID:8999876) RGD PMID:12560492 more ... DNA-dependent ATPase activity IBA PANTHER:PTN001326493 more ... 13792537 PMID:21873635 GO_Central molecular_function ND 1598407 12/2016: no relevant rat data RGD protein binding ISO RGD:1323005 1624291 UniProtKB:O00232 more ... RGD PMID:10944529 more ... protein C-terminus binding ISO RGD:1323005 1624291 UniProtKB:P28715 (PMID:16246722) RGD PMID:16246722 protein C-terminus binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein N-terminus binding ISO RGD:1323005 1624291 UniProtKB:Q13216-1 (PMID:7664335) RGD PMID:7664335 protein N-terminus binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein tyrosine kinase activator activity IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein tyrosine kinase activator activity ISO RGD:1323005 1624291 (PMID:17626041) RGD PMID:17626041 protein-containing complex binding ISO RGD:1323005 1624291 (PMID:16916636) RGD PMID:16916636 protein-containing complex binding IEA UniProtKB:Q03468 , ensembl:ENSP000003480891600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase binding ISO RGD:1323005 1624291 (PMID:26218421) RGD PMID:26218421 sequence-specific DNA binding ISO RGD:1323005 1624291 (PMID:22483866) RGD PMID:22483866
Gene-Chemical Interaction Annotations
