Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of EGFL7 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Egfl7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EGFL7 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EGFL7 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EGFL7 mRNA | CTD | PMID:32109520 and PMID:33387578 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of EGFL7 mRNA | CTD | PMID:19162173 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Egfl7 (Mus musculus) | 6480464 | bisphenol S affects the methylation of EGFL7 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Fenretinide results in increased expression of EGFL7 mRNA | CTD | PMID:28973697 | 4-phenylbutyric acid | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | 4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form | CTD | PMID:19116145 | 4-phenylbutyric acid | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form | CTD | PMID:19116145 | 5-aza-2'-deoxycytidine | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Decitabine results in increased expression of EGFL7 mRNA and Decitabine results in increased expression of EGFL7 mRNA alternative form | CTD | PMID:19116145 and PMID:32006662 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [Decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form more ... | CTD | PMID:19116145 and PMID:32006662 | acrylamide | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of EGFL7 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of EGFL7 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EGFL7 mRNA | CTD | PMID:33354967 | aflatoxin B1 | decreases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EGFL7 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EGFL7 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EGFL7 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EGFL7 mRNA | CTD | PMID:33212167 | Aroclor 1254 | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of EGFL7 mRNA | CTD | PMID:23650126 | benzo[a]pyrene | multiple interactions | ISO | Egfl7 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to EGFL7 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | affects methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EGFL7 5' UTR and Benzo(a)pyrene affects the methylation of EGFL7 intron | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EGFL7 promoter | CTD | PMID:27901495 | benzo[b]fluoranthene | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of EGFL7 mRNA | CTD | PMID:26377693 | benzo[e]pyrene | increases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of EGFL7 intron | CTD | PMID:30157460 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EGFL7 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EGFL7 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of EGFL7 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EGFL7 mRNA | CTD | PMID:33296240 and PMID:34947998 | bisphenol A | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of EGFL7 mRNA | CTD | PMID:29275510 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of EGFL7 promoter | CTD | PMID:22457795 | caffeine | increases phosphorylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of EGFL7 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of EGFL7 mRNA | CTD | PMID:37019170 | crocidolite asbestos | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of EGFL7 mRNA | CTD | PMID:32006662 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of EGFL7 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of EGFL7 mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | entinostat results in increased expression of EGFL7 mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | Egfl7 (Mus musculus) | 6480464 | Ethanol affects the expression of EGFL7 mRNA | CTD | PMID:30319688 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of EGFL7 mRNA | CTD | PMID:31881178 | folic acid | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of EGFL7 mRNA | CTD | PMID:21867686 | fulvestrant | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EGFL7 gene | CTD | PMID:31601247 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of EGFL7 mRNA | CTD | PMID:22061828 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of EGFL7 mRNA | CTD | PMID:33387578 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of EGFL7 mRNA | CTD | PMID:24136188 | hydrogen cyanide | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Hydrogen Cyanide results in decreased expression of EGFL7 mRNA | CTD | PMID:33914522 | lead(0) | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Lead results in decreased expression of EGFL7 mRNA | CTD | PMID:19921347 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA | CTD | PMID:16415329 | manganese(II) chloride | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | manganese chloride results in increased expression of EGFL7 mRNA | CTD | PMID:17467022 | mercury dibromide | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of EGFL7 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA | CTD | PMID:27188386 | methamphetamine | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA | CTD | PMID:19564919 | methamphetamine | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of EGFL7 mRNA | CTD | PMID:26307267 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of EGFL7 mRNA | CTD | PMID:19564919 | methapyrilene | increases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of EGFL7 intron | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of EGFL7 mRNA | CTD | PMID:28001369 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:12756304 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | ISO | Egfl7 (Mus musculus) | 6480464 | [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of EGFL7 mRNA | CTD | PMID:25566086 | N-methyl-4-phenylpyridinium | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of EGFL7 mRNA | CTD | PMID:24810058 | N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA | CTD | PMID:16415329 | nickel atom | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Nickel results in decreased expression of EGFL7 mRNA | CTD | PMID:25583101 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EGFL7 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Egfl7 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of EGFL7 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of EGFL7 mRNA | CTD | PMID:34911549 | p-chloromercuribenzoic acid | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of EGFL7 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of EGFL7 mRNA | CTD | PMID:33387578 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of EGFL7 mRNA | CTD | PMID:19162173 | phenylmercury acetate | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of EGFL7 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA | CTD | PMID:27188386 | potassium cyanide | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Potassium Cyanide results in decreased expression of EGFL7 mRNA | CTD | PMID:33914522 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of EGFL7 mRNA | CTD | PMID:19162173 | ranitidine | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA | CTD | PMID:16415329 | resveratrol | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of EGFL7 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | EGFL7 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | SCH 23390 | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA | CTD | PMID:19564919 | tetraphene | increases expression | ISO | Egfl7 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of EGFL7 mRNA | CTD | PMID:26377693 | thimerosal | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | Thimerosal results in decreased expression of EGFL7 mRNA | CTD | PMID:24675092 | thimerosal | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of EGFL7 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of EGFL7 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EGFL7 mRNA | CTD | PMID:25729387 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of EGFL7 mRNA | CTD | PMID:33387578 | trimellitic anhydride | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of EGFL7 mRNA | CTD | PMID:19042947 | tris(2-butoxyethyl) phosphate | affects expression | ISO | EGFL7 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of EGFL7 mRNA | CTD | PMID:29024780 | trovafloxacin | decreases expression | ISO | Egfl7 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of EGFL7 mRNA | CTD | PMID:35537566 | valproic acid | increases methylation | ISO | EGFL7 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of EGFL7 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EGFL7 mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EGFL7 mRNA | CTD | PMID:25979313 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of EGFL7 mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of EGFL7 mRNA | CTD | PMID:22570695 | zinc sulfate | decreases expression | ISO | EGFL7 (Homo sapiens) | 6480464 | Zinc Sulfate results in decreased expression of EGFL7 mRNA | CTD | PMID:12756304 | |