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Gene: Cntf (ciliary neurotrophic factor) Rattus norvegicus
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Symbol: Cntf
Name: ciliary neurotrophic factor
Description: Exhibits ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Localizes to several cellular components, including the cytoplasm; neuronal cell body; and nucleus. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Huntington's disease; glaucoma; multiple sclerosis; obesity; and psychotic disorder. Orthologous to human CNTF (ciliary neurotrophic factor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ciliary neurotropic factor
Orthologs:
Homo sapiens (human) : CNTF (ciliary neurotrophic factor)  HGNC  Alliance
Mus musculus (house mouse) : Cntf (ciliary neurotrophic factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cntf (ciliary neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : CNTF (ciliary neurotrophic factor)
Canis lupus familiaris (dog) : CNTF (ciliary neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cntf (ciliary neurotrophic factor)
Sus scrofa (pig) : CNTF (ciliary neurotrophic factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01229,599,009 - 229,601,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01236,752,366 - 236,754,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,842,668 - 215,844,691 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11216,001,097 - 216,003,121 (-)NCBI
Celera1207,298,120 - 207,300,143 (-)NCBICelera
Cytogenetic Map1q43NCBI
RH 3.4 Map11492.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cntf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2370
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.