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Gene: Dio2 (iodothyronine deiodinase 2) Rattus norvegicus
Symbol: Dio2
Name: iodothyronine deiodinase 2
Description: Exhibits thyroxine 5'-deiodinase activity. Involved in response to cold; response to lipopolysaccharide; and thyroid hormone generation. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; deiodinase iodothyronine type 2; deiodinase iodothyronine type II; deiodinase, iodothyronine, type 2; deiodinase, iodothyronine, type II; DIOII; Porf1; preoptic regulatory factor 1; type 2 DI; type II iodothyronine deiodinase; type-II 5'-deiodinase
Homo sapiens (human) : DIO2 (iodothyronine deiodinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Dio2 (deiodinase, iodothyronine, type II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
Cytogenetic Map6q31NCBI
RH 3.4 Map6755.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dio2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68418
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.