(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735779 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DIO2 mRNA CTD PMID:22079256 (E,E)-hydramethylnon decreases activity ISO RGD:735779 6480464 hydramethylnon results in decreased activity of DIO2 protein CTD PMID:30561685 (S)-amphetamine increases expression ISO RGD:68620 6480464 Dextroamphetamine results in increased expression of DIO2 mRNA CTD PMID:19194377 1,2,4-trimethylbenzene increases expression EXP 6480464 pseudocumene results in increased expression of DIO2 protein CTD PMID:17337753 17alpha-ethynylestradiol increases expression ISO RGD:68620 6480464 Ethinyl Estradiol results in increased expression of DIO2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of DIO2 mRNA CTD PMID:17351261 17alpha-ethynylestradiol multiple interactions ISO RGD:68620 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DIO2 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:735779 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA more ... CTD PMID:17404688 more ... 17beta-estradiol multiple interactions EXP 6480464 Estradiol promotes the reaction [4 more ... CTD PMID:30099086 17beta-estradiol increases expression ISO RGD:735779 6480464 Estradiol results in increased expression of DIO2 mRNA CTD PMID:21795739 17beta-estradiol increases expression ISO RGD:68620 6480464 Estradiol results in increased expression of DIO2 mRNA CTD PMID:19484750 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:24878560 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:735779 6480464 2 more ... CTD PMID:26004626 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:68620 6480464 2 more ... CTD PMID:27420076 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:68620 6480464 2 more ... CTD PMID:27420076 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:735779 6480464 2 more ... CTD PMID:26004626 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68620 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DIO2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DIO2 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68620 6480464 Tetrachlorodibenzodioxin results in increased expression of DIO2 mRNA CTD PMID:17942748 2,4-dibromophenyl 2,4,5-tribromophenyl ether multiple interactions ISO RGD:735779 6480464 2 more ... CTD PMID:26004626 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression ISO RGD:735779 6480464 2 more ... CTD PMID:26004626 , PMID:26705709 2,4-dinitrophenol multiple interactions ISO RGD:68620 6480464 [2, 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA CTD PMID:24872412 2-Ethylhexyl acrylate decreases activity ISO RGD:735779 6480464 2-ethylhexyl acrylate results in decreased activity of DIO2 protein CTD PMID:30561685 2-hydroxypropanoic acid decreases expression ISO RGD:735779 6480464 Lactic Acid results in decreased expression of DIO2 mRNA CTD PMID:30851411 3,3',5'-triiodo-L-thyronine multiple interactions ISO RGD:735779 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine more ... CTD PMID:26004626 3,3',5'-triiodo-L-thyronine decreases activity ISO RGD:735779 6480464 Triiodothyronine, Reverse results in decreased activity of DIO2 protein CTD PMID:26004626 3,3',5'-triiodothyronine multiple interactions ISO RGD:735779 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine more ... CTD PMID:26004626 3,3',5'-triiodothyronine decreases activity ISO RGD:735779 6480464 Triiodothyronine, Reverse results in decreased activity of DIO2 protein CTD PMID:26004626 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:735779 6480464 2 more ... CTD PMID:17327447 more ... 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of DIO2 mRNA CTD PMID:25646720 3,3',5-triiodo-L-thyronine increases chemical synthesis EXP 6480464 DIO2 protein results in increased chemical synthesis of Triiodothyronine CTD PMID:17615150 3,7-dihydropurine-6-thione increases expression EXP 6480464 Mercaptopurine results in increased expression of DIO2 mRNA CTD PMID:23358152 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:735779 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA CTD PMID:28628672 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:68620 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA more ... CTD PMID:29288687 , PMID:32417366 4,4'-sulfonyldiphenol increases expression ISO RGD:68620 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of DIO2 mRNA CTD PMID:30951980 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone decreases activity ISO RGD:735779 6480464 Kathon 930 results in decreased activity of DIO2 protein CTD PMID:30561685 4-hydroxynon-2-enal decreases expression ISO RGD:68620 6480464 4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide increases expression ISO RGD:68620 6480464 Fenretinide results in increased expression of DIO2 mRNA CTD PMID:28973697 4-nonylphenol multiple interactions ISO RGD:735779 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 4-tert-Octylphenol multiple interactions ISO RGD:735779 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 5-azacytidine decreases expression ISO RGD:735779 6480464 Azacitidine results in decreased expression of DIO2 mRNA CTD PMID:20823114 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of DIO2 mRNA CTD PMID:25825206 6alpha-methylprednisolone increases expression ISO RGD:735779 6480464 Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 8-Br-cAMP multiple interactions ISO RGD:735779 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of and results in increased activity of DIO2 protein CTD PMID:11425850 8-Br-cAMP increases activity EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein CTD PMID:18420745 8-Br-cAMP multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]] more ... CTD PMID:18420745 9-cis-retinoic acid decreases expression ISO RGD:735779 6480464 Alitretinoin results in decreased expression of DIO2 mRNA CTD PMID:36805303 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of DIO2 mRNA CTD PMID:18430446 aflatoxin B1 decreases expression ISO RGD:735779 6480464 Aflatoxin B1 results in decreased expression of DIO2 mRNA CTD PMID:22100608 aflatoxin B1 decreases methylation ISO RGD:735779 6480464 Aflatoxin B1 results in decreased methylation of DIO2 gene CTD PMID:27153756 all-trans-retinoic acid decreases expression ISO RGD:735779 6480464 Tretinoin results in decreased expression of DIO2 mRNA CTD PMID:36805303 alpha-hexylcinnamaldehyde decreases activity ISO RGD:735779 6480464 hexyl cinnamic aldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 alpha-linolenic acid decreases activity ISO RGD:735779 6480464 alpha-Linolenic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 Archazolid B decreases expression ISO RGD:735779 6480464 archazolid B results in decreased expression of DIO2 mRNA CTD PMID:25218289 arsane multiple interactions ISO RGD:735779 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of DIO2 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO RGD:735779 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of DIO2 mRNA CTD PMID:32525701 atrazine increases expression ISO RGD:735779 6480464 Atrazine results in increased expression of DIO2 mRNA CTD PMID:18461179 Aurothioglucose multiple interactions ISO RGD:735779 6480464 [Aurothioglucose results in decreased activity of DIO2 protein] which affects the metabolism of Thyroxine CTD PMID:25962824 benzalkonium chloride decreases activity ISO RGD:735779 6480464 Benzalkonium Compounds results in decreased activity of DIO2 protein CTD PMID:30561685 benzo[a]pyrene decreases expression ISO RGD:735779 6480464 Benzo(a)pyrene results in decreased expression of DIO2 mRNA CTD PMID:22178795 benzo[a]pyrene increases methylation ISO RGD:735779 6480464 Benzo(a)pyrene results in increased methylation of DIO2 exon, Benzo(a)pyrene results in increased methylation of DIO2 promoter CTD PMID:27901495 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:735779 6480464 7 more ... CTD PMID:20018196 , PMID:20382639 benzo[a]pyrene diol epoxide I increases expression ISO RGD:735779 6480464 7 more ... CTD PMID:19150397 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DIO2 mRNA CTD PMID:18164116 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735779 6480464 Diethylhexyl Phthalate results in decreased expression of DIO2 mRNA, Diethylhexyl Phthalate results in decreased expression of DIO2 protein CTD PMID:32201330 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:68620 6480464 Diethylhexyl Phthalate results in decreased expression of DIO2 mRNA, Diethylhexyl Phthalate results in decreased expression of DIO2 protein CTD PMID:35354077 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of DIO2 mRNA CTD PMID:22504913 bisphenol A increases methylation ISO RGD:735779 6480464 bisphenol A results in increased methylation of DIO2 gene CTD PMID:31601247 bisphenol A multiple interactions EXP 6480464 Estradiol promotes the reaction [bisphenol A results in decreased expression of DIO2 mRNA] CTD PMID:30099086 bisphenol A decreases expression ISO RGD:735779 6480464 bisphenol A results in decreased expression of DIO2 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:68620 6480464 bisphenol A results in increased expression of DIO2 mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO RGD:735779 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA CTD PMID:28628672 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DIO2 mRNA CTD PMID:25181051 more ... Bisphenol A diglycidyl ether decreases activity ISO RGD:735779 6480464 2, 2-bis(4-glycidyloxyphenyl)propane results in decreased activity of DIO2 protein CTD PMID:30561685 Bisphenol B decreases expression EXP 6480464 bisphenol B results in decreased expression of DIO2 mRNA CTD PMID:28167136 bisphenol F multiple interactions ISO RGD:735779 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA CTD PMID:28628672 bisphenol F increases expression ISO RGD:68620 6480464 bisphenol F results in increased expression of DIO2 mRNA CTD PMID:30951980 boron nitride decreases expression ISO RGD:735779 6480464 boron nitride results in decreased expression of DIO2 mRNA CTD PMID:30644070 bucladesine multiple interactions ISO RGD:735779 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA CTD PMID:20823114 butein decreases activity ISO RGD:735779 6480464 butein results in decreased activity of DIO2 protein CTD PMID:17327447 calcitriol increases activity ISO RGD:68620 6480464 Calcitriol results in increased activity of DIO2 protein CTD PMID:15471965 cannabidiol decreases expression ISO RGD:735779 6480464 Cannabidiol results in decreased expression of DIO2 mRNA CTD PMID:33244087 captafol decreases activity ISO RGD:735779 6480464 captafol results in decreased activity of DIO2 protein CTD PMID:30561685 carbon nanotube decreases expression ISO RGD:735779 6480464 Nanotubes, Carbon results in decreased expression of DIO2 mRNA CTD PMID:24389112 carbon nanotube increases expression ISO RGD:68620 6480464 Nanotubes more ... CTD PMID:25554681 chlordecone decreases activity ISO RGD:735779 6480464 Chlordecone results in decreased activity of DIO2 protein CTD PMID:30561685 chlorothalonil decreases activity ISO RGD:735779 6480464 tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 cholesterol increases degradation ISO RGD:735779 6480464 Cholesterol results in increased degradation of DIO2 protein CTD PMID:30545937 ciglitazone increases activity ISO RGD:735779 6480464 ciglitazone results in increased activity of DIO2 protein CTD PMID:19036883 ciglitazone multiple interactions ISO RGD:735779 6480464 PPARG protein promotes the reaction [ciglitazone results in increased activity of DIO2 protein] CTD PMID:19036883 cisplatin multiple interactions ISO RGD:735779 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of DIO2 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:735779 6480464 Cisplatin results in decreased expression of DIO2 mRNA CTD PMID:27392435 cobalt dichloride increases activity EXP 6480464 cobaltous chloride results in increased activity of DIO2 protein CTD PMID:17615150 colforsin daropate hydrochloride increases activity ISO RGD:68620 6480464 Colforsin results in increased activity of DIO2 protein CTD PMID:19036883 colforsin daropate hydrochloride multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein] more ... CTD PMID:18420745 colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of DIO2 mRNA CTD PMID:18420745 copper atom decreases expression EXP 6480464 Copper results in decreased expression of DIO2 mRNA CTD PMID:30556269 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of DIO2 mRNA CTD PMID:30556269 cycloheximide multiple interactions ISO RGD:735779 6480464 [Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2 more ... CTD PMID:11425850 , PMID:26004626 cycloheximide decreases activity ISO RGD:735779 6480464 Cycloheximide results in decreased activity of DIO2 protein CTD PMID:11425850 cyclosporin A increases expression ISO RGD:68620 6480464 Cyclosporine results in increased expression of DIO2 mRNA CTD PMID:19770486 DDE multiple interactions EXP 6480464 [2 more ... CTD PMID:24878560 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of DIO2 mRNA CTD PMID:30844666 decabromodiphenyl ether decreases expression ISO RGD:68620 6480464 decabromobiphenyl ether results in decreased expression of DIO2 mRNA CTD PMID:31161897 decabromodiphenyl ether increases expression ISO RGD:735779 6480464 decabromobiphenyl ether results in increased expression of DIO2 mRNA CTD PMID:34166751 decabromodiphenyl ether decreases expression ISO RGD:735779 6480464 decabromobiphenyl ether results in decreased expression of DIO2 protein CTD PMID:34166751 desferrioxamine B increases activity EXP 6480464 Deferoxamine results in increased activity of DIO2 protein CTD PMID:17615150 dexamethasone multiple interactions ISO RGD:735779 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA CTD PMID:28628672 dexamethasone multiple interactions ISO RGD:68620 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA more ... CTD PMID:29288687 , PMID:32417366 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein] CTD PMID:17615150 Didecyldimethylammonium decreases activity ISO RGD:735779 6480464 didecyldimethylammonium results in decreased activity of DIO2 protein CTD PMID:30561685 diethyl hydrogen phosphate increases expression EXP 6480464 diethyl phosphate results in increased expression of DIO2 mRNA CTD PMID:31835022 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of DIO2 mRNA CTD PMID:22504913 Dimethyl succinate increases activity EXP 6480464 dimethyl succinate results in increased activity of DIO2 protein CTD PMID:17615150 dinocap decreases activity ISO RGD:735779 6480464 dinocap results in decreased activity of DIO2 protein CTD PMID:30561685 dioxygen multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein], Oxygen deficiency results in decreased degradation of and results in increased activity of DIO2 protein CTD PMID:17615150 dioxygen multiple interactions ISO RGD:68620 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DIO2 mRNA CTD PMID:30529165 disodium selenite multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]], Sodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]] CTD PMID:18420745 dorsomorphin multiple interactions ISO RGD:735779 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:735779 6480464 Doxorubicin results in increased expression of DIO2 mRNA CTD PMID:29803840 elemental selenium multiple interactions ISO RGD:735779 6480464 Selenium results in increased expression of and results in increased activity of DIO2 protein CTD PMID:11425850 elemental selenium increases activity ISO RGD:68620 6480464 Selenium results in increased activity of DIO2 protein CTD PMID:15471965 ethanol increases expression ISO RGD:68620 6480464 Ethanol results in increased expression of DIO2 mRNA CTD PMID:30319688 ethanol affects expression ISO RGD:68620 6480464 Ethanol affects the expression of DIO2 mRNA CTD PMID:30319688 fipronil decreases activity ISO RGD:735779 6480464 fipronil results in decreased activity of DIO2 protein CTD PMID:30561685 fisetin increases activity ISO RGD:735779 6480464 fisetin results in increased activity of DIO2 protein CTD PMID:17327447 fluazinam decreases activity ISO RGD:735779 6480464 fluazinam results in decreased activity of DIO2 protein CTD PMID:30561685 formaldehyde increases expression ISO RGD:735779 6480464 Formaldehyde results in increased expression of DIO2 mRNA CTD PMID:28937961 Geniposide decreases expression ISO RGD:68620 6480464 geniposide results in decreased expression of DIO2 mRNA CTD PMID:34718029 genistein increases expression EXP 6480464 Genistein results in increased expression of DIO2 mRNA CTD PMID:22504913 glyphosate affects expression EXP 6480464 glyphosate affects the expression of DIO2 mRNA CTD PMID:27916585 GW 7647 increases activity ISO RGD:735779 6480464 GW 7647 results in increased activity of DIO2 protein CTD PMID:19036883 GW 7647 multiple interactions ISO RGD:735779 6480464 PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein] CTD PMID:19036883 harmine increases expression ISO RGD:68620 6480464 Harmine results in increased expression of DIO2 protein CTD PMID:27805061 hexachlorobenzene decreases expression EXP 6480464 Hexachlorobenzene results in decreased expression of DIO2 mRNA CTD PMID:29277037 hydramethylnon decreases activity ISO RGD:735779 6480464 hydramethylnon results in decreased activity of DIO2 protein CTD PMID:30561685 hydrogen peroxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]] more ... CTD PMID:18420745 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of DIO2 mRNA CTD PMID:16184411 indometacin multiple interactions ISO RGD:735779 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA CTD PMID:28628672 indometacin multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DIO2 mRNA] CTD PMID:16184411 iodomethane decreases activity EXP 6480464 methyl iodide results in decreased activity of DIO2 protein CTD PMID:19519149 Iopanoic acid decreases activity ISO RGD:735779 6480464 Iopanoic Acid results in decreased activity of DIO2 protein CTD PMID:35179606 isoprenaline increases expression ISO RGD:68620 6480464 Isoproterenol results in increased expression of DIO2 mRNA CTD PMID:20003209 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of DIO2 mRNA CTD PMID:15345674 isoprenaline increases activity EXP 6480464 Isoproterenol results in increased activity of DIO2 protein CTD PMID:15345674 kaempferol increases activity ISO RGD:735779 6480464 kaempferol results in increased activity of DIO2 protein CTD PMID:17327447 kaempferol increases expression ISO RGD:735779 6480464 kaempferol results in increased expression of DIO2 mRNA CTD PMID:17327447 kaempferol multiple interactions ISO RGD:735779 6480464 kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine] CTD PMID:17327447 lactacystin multiple interactions ISO RGD:735779 6480464 lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein] more ... CTD PMID:11425850 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of DIO2 mRNA CTD PMID:22641619 Licarin A multiple interactions ISO RGD:68620 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA CTD PMID:29288687 Licochalcone B decreases expression ISO RGD:735779 6480464 licochalcone B results in decreased expression of DIO2 mRNA CTD PMID:33647349 linoleic acid decreases activity ISO RGD:735779 6480464 Linoleic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 lipopolysaccharide increases activity ISO RGD:735779 6480464 Lipopolysaccharides results in increased activity of DIO2 protein CTD PMID:16728495 lipopolysaccharide multiple interactions ISO RGD:735779 6480464 [S-(1 more ... CTD PMID:16728495 , PMID:35811015 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of DIO2 mRNA CTD PMID:21068073 lipopolysaccharide increases activity EXP 6480464 Lipopolysaccharides results in increased activity of DIO2 protein CTD PMID:21068073 lipopolysaccharide multiple interactions EXP 6480464 Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein] more ... CTD PMID:21068073 lipopolysaccharide increases expression ISO RGD:735779 6480464 Lipopolysaccharides results in increased expression of DIO2 mRNA CTD PMID:16728495 , PMID:35811015 lithocholic acid multiple interactions ISO RGD:68620 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein] CTD PMID:19036883 lithocholic acid increases activity ISO RGD:68620 6480464 Lithocholic Acid results in increased activity of DIO2 protein CTD PMID:19036883 lithocholic acid increases expression ISO RGD:68620 6480464 Lithocholic Acid results in increased expression of DIO2 mRNA CTD PMID:19036883 masoprocol decreases activity ISO RGD:735779 6480464 Masoprocol results in decreased activity of DIO2 protein CTD PMID:30561685 medroxyprogesterone acetate decreases expression ISO RGD:735779 6480464 Medroxyprogesterone Acetate results in decreased expression of DIO2 mRNA CTD PMID:20843944 medroxyprogesterone acetate multiple interactions ISO RGD:735779 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA CTD PMID:20823114 mercaptopurine increases expression EXP 6480464 Mercaptopurine results in increased expression of DIO2 mRNA CTD PMID:23358152 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of DIO2 mRNA CTD PMID:19149911 methyltrioctylammonium chloride decreases activity ISO RGD:735779 6480464 trioctylmethylammonium results in decreased activity of DIO2 protein CTD PMID:30561685 microcystin-LR increases expression ISO RGD:68620 6480464 cyanoginosin LR results in increased expression of DIO2 protein CTD PMID:25497113 mifepristone increases expression ISO RGD:735779 6480464 Mifepristone results in increased expression of DIO2 mRNA CTD PMID:17584828 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]] more ... CTD PMID:21068073 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:735779 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of DIO2 mRNA CTD PMID:36695872 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:68620 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein] CTD PMID:19036883 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]] CTD PMID:18420745 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:735779 6480464 [Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2 more ... CTD PMID:11425850 , PMID:26004626 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO RGD:735779 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DIO2 protein CTD PMID:26004626 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases activity EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of DIO2 protein CTD PMID:17615150 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DIO2 mRNA CTD PMID:18164116 naphthalenes increases expression EXP 6480464 Naphthalenes results in increased expression of DIO2 protein CTD PMID:17337753 nickel sulfate increases expression ISO RGD:735779 6480464 nickel sulfate results in increased expression of DIO2 mRNA CTD PMID:22714537 octhilinone decreases activity ISO RGD:735779 6480464 2-n-octyl-4-isothiazolin-3-one results in decreased activity of DIO2 protein CTD PMID:30561685 p-tert-Amylphenol multiple interactions ISO RGD:735779 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 paraquat increases expression ISO RGD:68620 6480464 Paraquat results in increased expression of DIO2 mRNA CTD PMID:21463325 phenethyl isothiocyanate decreases expression ISO RGD:735779 6480464 phenethyl isothiocyanate results in decreased expression of DIO2 mRNA CTD PMID:26678675 phenylephrine increases activity EXP 6480464 Phenylephrine results in increased activity of DIO2 protein CTD PMID:15345674 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of DIO2 mRNA CTD PMID:15345674 phenylmercury acetate multiple interactions ISO RGD:735779 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA CTD PMID:27188386 phthalaldehyde decreases activity ISO RGD:735779 6480464 o-Phthalaldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 pioglitazone increases expression ISO RGD:68620 6480464 pioglitazone results in increased expression of DIO2 mRNA CTD PMID:19036883 pioglitazone increases activity ISO RGD:68620 6480464 pioglitazone results in increased activity of DIO2 protein CTD PMID:19036883 pioglitazone multiple interactions ISO RGD:735779 6480464 PPARG protein promotes the reaction [pioglitazone results in increased activity of DIO2 protein] CTD PMID:19036883 pioglitazone increases activity ISO RGD:735779 6480464 pioglitazone results in increased activity of DIO2 protein CTD PMID:19036883 pirinixic acid decreases expression ISO RGD:68620 6480464 pirinixic acid results in decreased expression of DIO2 mRNA CTD PMID:16985257 potassium chromate decreases expression ISO RGD:735779 6480464 potassium chromate(VI) results in decreased expression of DIO2 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:735779 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DIO2 mRNA CTD PMID:22079256 prednisolone increases expression ISO RGD:735779 6480464 Prednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 progesterone multiple interactions ISO RGD:735779 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of DIO2 mRNA, [Progesterone co-treated with Estradiol] results in decreased expression of DIO2 mRNA CTD PMID:17404688 , PMID:20660070 progesterone decreases expression ISO RGD:735779 6480464 Progesterone results in decreased expression of DIO2 mRNA CTD PMID:17404688 purine-6-thiol increases expression EXP 6480464 Mercaptopurine results in increased expression of DIO2 mRNA CTD PMID:23358152 quercetin increases activity ISO RGD:735779 6480464 Quercetin results in increased activity of DIO2 protein CTD PMID:17327447 quinoxyfen decreases activity ISO RGD:735779 6480464 quinoxyfen results in decreased activity of DIO2 protein CTD PMID:30561685 rac-lactic acid decreases expression ISO RGD:735779 6480464 Lactic Acid results in decreased expression of DIO2 mRNA CTD PMID:30851411 Rebamipide multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DIO2 mRNA] CTD PMID:16184411 resveratrol decreases activity ISO RGD:735779 6480464 resveratrol results in decreased activity of DIO2 protein CTD PMID:17327447 S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO RGD:735779 6480464 S-(1, 2-dichlorovinyl)cysteine results in increased expression of DIO2 mRNA CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO RGD:735779 6480464 [S-(1 more ... CTD PMID:35811015 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein] CTD PMID:18420745 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA] CTD PMID:18420745 SB 431542 multiple interactions ISO RGD:735779 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA CTD PMID:27188386 scopolamine increases expression EXP 6480464 Scopolamine results in increased expression of DIO2 mRNA CTD PMID:12818353 selenium atom increases activity ISO RGD:68620 6480464 Selenium results in increased activity of DIO2 protein CTD PMID:15471965 selenium atom multiple interactions ISO RGD:735779 6480464 Selenium results in increased expression of and results in increased activity of DIO2 protein CTD PMID:11425850 serpentine asbestos increases expression ISO RGD:735779 6480464 Asbestos, Serpentine results in increased expression of DIO2 mRNA CTD PMID:29523930 silicon dioxide decreases expression ISO RGD:735779 6480464 Silicon Dioxide analog results in decreased expression of DIO2 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:68620 6480464 Silicon Dioxide results in increased expression of DIO2 mRNA CTD PMID:29203145 sodium arsenate multiple interactions ISO RGD:735779 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of DIO2 mRNA CTD PMID:32525701 sodium arsenate affects expression ISO RGD:68620 6480464 sodium arsenate affects the expression of DIO2 mRNA CTD PMID:28813693 sodium arsenite increases expression ISO RGD:68620 6480464 sodium arsenite results in increased expression of DIO2 mRNA CTD PMID:28813693 sodium arsenite decreases expression ISO RGD:68620 6480464 sodium arsenite results in decreased expression of DIO2 mRNA CTD PMID:36209798 sodium arsenite decreases expression ISO RGD:735779 6480464 sodium arsenite results in decreased expression of DIO2 mRNA CTD PMID:34032870 Soman increases expression EXP 6480464 Soman results in increased expression of DIO2 mRNA CTD PMID:19281266 sotorasib multiple interactions ISO RGD:735779 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DIO2 mRNA CTD PMID:36139627 sulfasalazine multiple interactions ISO RGD:735779 6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein], Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]] CTD PMID:16728495 sulfasalazine multiple interactions EXP 6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein], Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA] CTD PMID:21068073 sulforaphane decreases expression ISO RGD:735779 6480464 sulforaphane results in decreased expression of DIO2 mRNA CTD PMID:31838189 tamoxifen increases expression ISO RGD:68620 6480464 Tamoxifen results in increased expression of DIO2 mRNA CTD PMID:25123088 temozolomide increases expression ISO RGD:735779 6480464 Temozolomide results in increased expression of DIO2 mRNA CTD PMID:31758290 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of DIO2 mRNA CTD PMID:12832660 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of DIO2 mRNA CTD PMID:31150632 tetraphene decreases expression ISO RGD:68620 6480464 benz(a)anthracene results in decreased expression of DIO2 mRNA CTD PMID:26377693 thyroxine multiple interactions ISO RGD:735779 6480464 2 more ... CTD PMID:11425850 more ... thyroxine multiple interactions ISO RGD:68620 6480464 2 more ... CTD PMID:27420076 thyroxine decreases expression ISO RGD:68620 6480464 Thyroxine results in decreased expression of DIO2 mRNA CTD PMID:27420076 thyroxine decreases activity EXP 6480464 Thyroxine results in decreased activity of DIO2 protein CTD PMID:17615150 thyroxine increases metabolic processing ISO RGD:735779 6480464 DIO2 protein results in increased metabolism of Thyroxine CTD PMID:11108274 more ... thyroxine affects metabolic processing ISO RGD:735779 6480464 DIO2 protein mutant form affects the metabolism of Thyroxine CTD PMID:11108274 titanium dioxide decreases expression ISO RGD:68620 6480464 titanium dioxide results in decreased expression of DIO2 mRNA CTD PMID:23557971 trametinib multiple interactions ISO RGD:735779 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DIO2 mRNA CTD PMID:36139627 triflumizole decreases activity ISO RGD:735779 6480464 triflumizol results in decreased activity of DIO2 protein CTD PMID:30561685 troglitazone increases activity ISO RGD:735779 6480464 troglitazone results in increased activity of DIO2 protein CTD PMID:19036883 troglitazone decreases expression ISO RGD:68620 6480464 troglitazone results in decreased expression of DIO2 mRNA CTD PMID:28973697 troglitazone multiple interactions ISO RGD:735779 6480464 PPARG protein promotes the reaction [troglitazone results in increased activity of DIO2 protein] CTD PMID:19036883 undecane increases expression EXP 6480464 undecane results in increased expression of DIO2 protein CTD PMID:17337753 valproic acid decreases methylation ISO RGD:735779 6480464 Valproic Acid results in decreased methylation of DIO2 gene CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of DIO2 mRNA CTD PMID:29427782 vitamin E increases expression ISO RGD:735779 6480464 Vitamin E results in increased expression of DIO2 mRNA CTD PMID:19244175 xanthohumol decreases activity ISO RGD:735779 6480464 xanthohumol results in decreased activity of DIO2 protein CTD PMID:30561685 xanthohumol multiple interactions ISO RGD:735779 6480464 [xanthohumol results in decreased activity of DIO2 protein] which affects the metabolism of Thyroxine CTD PMID:25962824 zoledronic acid decreases expression ISO RGD:735779 6480464 zoledronic acid results in decreased expression of DIO2 mRNA CTD PMID:24714768 zoxamide decreases activity ISO RGD:735779 6480464 zoxamide results in decreased activity of DIO2 protein CTD PMID:30561685
