Dio2 (iodothyronine deiodinase 2) - Rat Genome Database

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Gene: Dio2 (iodothyronine deiodinase 2) Rattus norvegicus
Analyze
Symbol: Dio2
Name: iodothyronine deiodinase 2
RGD ID: 68418
Description: Enables thyroxine 5'-deiodinase activity. Involved in response to lipopolysaccharide and thyroid hormone generation. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5DII; deiodinase iodothyronine type 2; deiodinase iodothyronine type II; deiodinase, iodothyronine, type 2; deiodinase, iodothyronine, type II; DIOII; Porf1; preoptic regulatory factor 1; type 2 DI; type II iodothyronine deiodinase; type-II 5'-deiodinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Thshl1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86115,396,308 - 115,410,594 (-)NCBIGRCr8
mRatBN7.26109,665,523 - 109,679,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6109,665,523 - 109,679,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6109,817,319 - 109,831,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06110,116,102 - 110,130,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06109,485,837 - 109,500,136 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
RH 3.4 Map6755.1RGD
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E,E)-hydramethylnon  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrophenol  (ISO)
2-Ethylhexyl acrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Aurothioglucose  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
boron nitride  (ISO)
bucladesine  (ISO)
butein  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captafol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dibenziodolium  (EXP)
Didecyldimethylammonium  (ISO)
diethyl hydrogen phosphate  (EXP)
diethylstilbestrol  (EXP)
Dimethyl succinate  (EXP)
dinocap  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
Ethylenethiourea  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluazinam  (ISO)
formaldehyde  (ISO)
Geniposide  (ISO)
genistein  (EXP)
glyphosate  (EXP,ISO)
GW 7647  (ISO)
harmine  (ISO)
hexachlorobenzene  (EXP)
hydramethylnon  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP,ISO)
iodomethane  (EXP)
Iopanoic acid  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
Licarin A  (ISO)
Licochalcone B  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methyltrioctylammonium chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nickel sulfate  (ISO)
octhilinone  (ISO)
p-tert-Amylphenol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thyroxine  (EXP,ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tricetin  (ISO)
triflumizole  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
xanthohumol  (ISO)
zoledronic acid  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Cettour-Rose P, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E980-7.
2. Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. Croteau W, etal., J Clin Invest 1996 Jul 15;98(2):405-17.
3. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. de Jesus LA, etal., J Clin Invest. 2001 Nov;108(9):1379-85. doi: 10.1172/JCI13803.
4. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Fekete C, etal., Brain Res. 2005 Sep 14;1056(1):97-9.
5. Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. Fiorito M, etal., Obesity (Silver Spring). 2007 Dec;15(12):2889-95.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Induction of type 2 deiodinase activity by cyclic guanosine 3',5'-monophosphate in cultured rat glial cells. Gondou A, etal., Thyroid 1998 Jul;8(7):615-22.
9. Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects. Grarup N, etal., J Clin Endocrinol Metab. 2007 Jan;92(1):363-6. Epub 2006 Oct 31.
10. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Gumieniak O, etal., Hypertension. 2007 Mar;49(3):461-6. Epub 2007 Jan 15.
11. Daily variations in type II iodothyronine deiodinase activity in the rat brain as controlled by the biological clock. Kalsbeek A, etal., Endocrinology. 2005 Mar;146(3):1418-27. Epub 2004 Nov 18.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes. Martinez-deMena R, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1119-27.
14. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Mentuccia D, etal., Diabetes. 2002 Mar;51(3):880-3.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins. Montero-Pedrazuela A, etal., Endocrinology 2003 Mar;144(3):1045-52.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Wassen FW, etal., Endocrinology 2002 Jul;143(7):2812-5.
Additional References at PubMed
PMID:2293025   PMID:10330996   PMID:10403186   PMID:10583730   PMID:11731615   PMID:12586753   PMID:12959985   PMID:15691884   PMID:15746256   PMID:16098513   PMID:17615150   PMID:17628004  
PMID:18197581   PMID:18218695   PMID:18539729   PMID:18566113   PMID:19651899   PMID:20501675   PMID:20719854   PMID:21397282   PMID:21704117   PMID:22479358   PMID:22719053   PMID:22815055  
PMID:22956722   PMID:23142811   PMID:23296253   PMID:24362948   PMID:24601886   PMID:24635351   PMID:25294216   PMID:25555216   PMID:26861177   PMID:26994513   PMID:28763438  


Genomics

Comparative Map Data
Dio2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86115,396,308 - 115,410,594 (-)NCBIGRCr8
mRatBN7.26109,665,523 - 109,679,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6109,665,523 - 109,679,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6109,817,319 - 109,831,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06110,116,102 - 110,130,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06109,485,837 - 109,500,136 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
RH 3.4 Map6755.1RGD
Cytogenetic Map6q31NCBI
DIO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1480,197,526 - 80,387,757 (-)EnsemblGRCh38hg38GRCh38
GRCh371480,663,869 - 80,697,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBICelera
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
T2T-CHM13v2.01474,407,785 - 74,441,322 (-)NCBIT2T-CHM13v2.0
Dio2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391290,691,326 - 90,705,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1290,691,326 - 90,705,812 (-)EnsemblGRCm39 Ensembl
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBIMGSCv36mm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1244.05NCBI
Dio2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554383,950,983 - 3,960,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554383,946,830 - 3,961,049 (-)NCBIChiLan1.0ChiLan1.0
DIO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21581,289,683 - 81,308,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11480,506,186 - 80,527,254 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01460,756,781 - 60,775,255 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11479,956,305 - 79,970,938 (-)NCBIpanpan1.1PanPan1.1panPan2
DIO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1852,686,211 - 52,695,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl852,686,211 - 52,695,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha852,244,364 - 52,253,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0852,915,654 - 52,924,683 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl852,910,578 - 53,101,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1852,604,180 - 52,613,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0852,606,880 - 52,615,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0852,999,420 - 53,008,436 (-)NCBIUU_Cfam_GSD_1.0
Dio2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864023,285,838 - 23,299,412 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364888,769,555 - 8,783,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7103,096,433 - 103,323,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17103,096,414 - 103,110,749 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27109,299,323 - 109,308,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12457,521,806 - 57,536,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605345,260,845 - 45,447,678 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dio2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473421,787,705 - 21,802,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dio2
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:42
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000005162
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
D6Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26109,679,474 - 109,679,654 (+)MAPPERmRatBN7.2
Rnor_6.06114,489,109 - 114,489,288NCBIRnor6.0
Rnor_5.06123,752,501 - 123,752,680UniSTSRnor5.0
RGSC_v3.46114,317,229 - 114,317,408UniSTSRGSC3.4
Celera6107,452,821 - 107,453,000UniSTS
Cytogenetic Map6q31UniSTS
RH142433  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26109,679,399 - 109,679,614 (+)MAPPERmRatBN7.2
Rnor_6.06114,489,034 - 114,489,248NCBIRnor6.0
Rnor_5.06123,752,426 - 123,752,640UniSTSRnor5.0
RGSC_v3.46114,317,154 - 114,317,368UniSTSRGSC3.4
Celera6107,452,746 - 107,452,960UniSTS
RH 3.4 Map6755.1UniSTS
Cytogenetic Map6q31UniSTS
BE101746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26109,669,134 - 109,669,303 (+)MAPPERmRatBN7.2
Rnor_6.06114,478,769 - 114,478,937NCBIRnor6.0
Rnor_5.06123,742,161 - 123,742,329UniSTSRnor5.0
RGSC_v3.46114,306,889 - 114,307,057UniSTSRGSC3.4
Celera6107,442,463 - 107,442,631UniSTS
RH 3.4 Map6755.1UniSTS
Cytogenetic Map6q31UniSTS
RH138032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26109,670,484 - 109,670,625 (+)MAPPERmRatBN7.2
Rnor_6.06114,480,119 - 114,480,259NCBIRnor6.0
Rnor_5.06123,743,511 - 123,743,651UniSTSRnor5.0
RGSC_v3.46114,308,239 - 114,308,379UniSTSRGSC3.4
Celera6107,443,813 - 107,443,953UniSTS
RH 3.4 Map6757.5UniSTS
Cytogenetic Map6q31UniSTS
Dio2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26109,670,700 - 109,671,022 (+)MAPPERmRatBN7.2
Rnor_6.06114,480,335 - 114,480,656NCBIRnor6.0
Rnor_5.06123,743,727 - 123,744,048UniSTSRnor5.0
Celera6107,444,029 - 107,444,350UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 48 109 44 42 12 23 12 6 158 90 89 41 56 30

Sequence


Ensembl Acc Id: ENSRNOT00000005162   ⟹   ENSRNOP00000005162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099607   ⟹   ENSRNOP00000093973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6109,665,523 - 109,679,809 (-)Ensembl
RefSeq Acc Id: NM_031720   ⟹   NP_113908
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86115,396,308 - 115,410,594 (-)NCBI
mRatBN7.26109,665,523 - 109,679,809 (-)NCBI
Rnor_6.06114,475,156 - 114,489,443 (-)NCBI
Rnor_5.06123,743,030 - 123,752,835 (-)NCBI
RGSC_v3.46114,307,758 - 114,317,563 (-)RGD
Celera6107,438,850 - 107,453,155 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113908 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093973.1
  ENSRNOP00055037615
  ENSRNOP00060028203
GenBank Protein P70551 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113908   ⟸   NM_031720
- UniProtKB: P70551 (UniProtKB/Swiss-Prot),   O70179 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005162   ⟸   ENSRNOT00000005162
Ensembl Acc Id: ENSRNOP00000093973   ⟸   ENSRNOT00000099607

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18889-F1-model_v2 AlphaFold P18889 1-37 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68418 AgrOrtholog
BioCyc Gene G2FUF-36667 BioCyc
BioCyc Pathway PWY-6260 [thyroid hormone metabolism I (via deiodination)] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
BioCyc Pathway Image PWY-6260 BioCyc
  PWY-6261 BioCyc
Ensembl Genes ENSRNOG00000003891 Ensembl
  ENSRNOG00000062383 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055026584 UniProtKB/Swiss-Prot
  ENSRNOG00060019869 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000099607.1 UniProtKB/Swiss-Prot
  ENSRNOT00055045883 UniProtKB/Swiss-Prot
  ENSRNOT00060034371 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:65162 UniProtKB/Swiss-Prot
NCBI Gene 65162 ENTREZGENE
PANTHER PTHR11781 UniProtKB/Swiss-Prot
  TYPE II IODOTHYRONINE DEIODINASE UniProtKB/Swiss-Prot
Pfam T4_deiodinase UniProtKB/Swiss-Prot
PhenoGen Dio2 PhenoGen
PIRSF IOD UniProtKB/Swiss-Prot
PROSITE T4_DEIODINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003891 RatGTEx
  ENSRNOG00000062383 RatGTEx
  ENSRNOG00055026584 RatGTEx
  ENSRNOG00060019869 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
TIGR TC234443
UniProt IOD2_RAT UniProtKB/Swiss-Prot
  O70179 ENTREZGENE
  P70551 ENTREZGENE
  PORF1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70179 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-30 Dio2  iodothyronine deiodinase 2  Dio2  deiodinase, iodothyronine, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-02 Dio2  deiodinase, iodothyronine, type II  Porf1  preoptic regulatory factor 1  Data merged from RGD:68951 737654 APPROVED
2003-04-09 Dio2  deiodinase, iodothyronine, type II  Dio2  deiodinase, iodothyronine, type 2  Name updated 629478 APPROVED
2003-04-09 Dio2  deiodinase, iodothyronine, type II    deiodinase, iodothyronine, type 2  Name updated 629478 APPROVED
2002-06-10 Dio2  deiodinase, iodothyronine, type 2      Name updated 70584 APPROVED
2002-06-10 Porf1  preoptic regulatory factor-1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brown adipose tissue 631305
gene_regulation mRNA induced during the first 2 postnatal weeks of age in neuroendocrine brain regions; mRNA increases from P15 through P60 in male rats, and decreases during the same period in female rats 724650
gene_regulation mRNA expression is induced by leptin in brown adipose tissue 631305
gene_regulation induced in response to cold-exposure induced norepinephrine release 628323