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Gene: Dio2 (iodothyronine deiodinase 2) Rattus norvegicus
Symbol: Dio2
Name: iodothyronine deiodinase 2
RGD ID: 68418
Description: Exhibits thyroxine 5'-deiodinase activity. Involved in response to cold; response to lipopolysaccharide; and thyroid hormone generation. Predicted to localize to extracellular region and integral component of membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; deiodinase iodothyronine type 2; deiodinase iodothyronine type II; deiodinase, iodothyronine, type 2; deiodinase, iodothyronine, type II; DIOII; Porf1; preoptic regulatory factor 1; type 2 DI; type II iodothyronine deiodinase; type-II 5'-deiodinase
Homo sapiens (human) : DIO2 (iodothyronine deiodinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Dio2 (deiodinase, iodothyronine, type II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
Chlorocebus sabaeus (African green monkey) : DIO2 (iodothyronine deiodinase 2)
Heterocephalus glaber (naked mole-rat) : Dio2 (iodothyronine deiodinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
Cytogenetic Map6q31NCBI
RH 3.4 Map6755.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dio2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68418
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.