Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IMPACT mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of IMPACT mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IMPACT mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Impact (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of IMPACT mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IMPACT mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of IMPACT mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IMPACT mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IMPACT promoter] | CTD | PMID:17942748 and PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Impact (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of IMPACT mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IMPACT mRNA | CTD | PMID:20106945 and PMID:21632981 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Impact (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of IMPACT mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | Impact (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA | CTD | PMID:19191707 | 4-hydroxynon-2-enal | increases expression | ISO | Impact (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA | CTD | PMID:19191707 | 4-hydroxyphenyl retinamide | increases expression | ISO | Impact (Mus musculus) | 6480464 | Fenretinide results in increased expression of IMPACT mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of IMPACT mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of IMPACT mRNA | CTD | PMID:30047161 | aflatoxin B1 | increases expression | ISO | Impact (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of IMPACT mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of IMPACT mRNA | CTD | PMID:33167477 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of IMPACT mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of IMPACT mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Impact (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of IMPACT mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | IMPACT (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to IMPACT mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases expression | ISO | Impact (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of IMPACT mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | increases methylation | ISO | IMPACT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of IMPACT promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | affects expression | ISO | Impact (Mus musculus) | 6480464 | Diethylhexyl Phthalate affects the expression of IMPACT mRNA | CTD | PMID:21636974 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of IMPACT mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Impact (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of IMPACT mRNA | CTD | PMID:19850644 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of IMPACT mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of IMPACT mRNA | CTD | PMID:34947998 | Brodifacoum | increases expression | EXP | | 6480464 | bromfenacoum results in increased expression of IMPACT protein | CTD | PMID:28903499 | cadmium atom | increases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Cadmium results in increased expression of IMPACT mRNA | CTD | PMID:24376830 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of IMPACT mRNA | CTD | PMID:19010381 | cadmium dichloride | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | MT3 affects the reaction [Cadmium Chloride affects the expression of IMPACT mRNA] | CTD | PMID:20371981 | carbon nanotube | decreases expression | ISO | Impact (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of IMPACT mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | IMPACT (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to IMPACT gene] | CTD | PMID:28238834 | chloroethene | decreases expression | ISO | Impact (Mus musculus) | 6480464 | Vinyl Chloride results in decreased expression of IMPACT mRNA | CTD | PMID:18579281 | ciprofibrate | increases expression | ISO | Impact (Mus musculus) | 6480464 | ciprofibrate results in increased expression of IMPACT mRNA | CTD | PMID:12771043 | cisplatin | increases phosphorylation | ISO | Impact (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of IMPACT protein | CTD | PMID:22006019 | clobetasol | increases expression | ISO | Impact (Mus musculus) | 6480464 | Clobetasol results in increased expression of IMPACT mRNA | CTD | PMID:27462272 | clofibrate | increases expression | ISO | Impact (Mus musculus) | 6480464 | Clofibrate results in increased expression of IMPACT mRNA | CTD | PMID:17585979 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of IMPACT mRNA | CTD | PMID:24386269 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of IMPACT mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of IMPACT mRNA | CTD | PMID:30556269 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of IMPACT mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of IMPACT mRNA | CTD | PMID:27989131 | cyproconazole | increases expression | ISO | Impact (Mus musculus) | 6480464 | cyproconazole results in increased expression of IMPACT mRNA | CTD | PMID:22334560 | dibutyl phthalate | increases expression | ISO | Impact (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of IMPACT mRNA | CTD | PMID:21266533 | epoxiconazole | increases expression | ISO | Impact (Mus musculus) | 6480464 | epoxiconazole results in increased expression of IMPACT mRNA | CTD | PMID:22334560 | ethanol | affects splicing | ISO | Impact (Mus musculus) | 6480464 | Ethanol affects the splicing of IMPACT mRNA | CTD | PMID:30319688 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of IMPACT mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | Impact (Mus musculus) | 6480464 | Folic Acid results in decreased expression of IMPACT mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IMPACT mRNA | CTD | PMID:22206623 | fulvestrant | increases methylation | ISO | IMPACT (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of IMPACT gene | CTD | PMID:31601247 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of IMPACT mRNA | CTD | PMID:33387578 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of IMPACT mRNA | CTD | PMID:24136188 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of IMPACT mRNA | CTD | PMID:30047161 | methylmercury chloride | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of IMPACT mRNA | CTD | PMID:28001369 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | increases expression | ISO | Impact (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IMPACT mRNA | CTD | PMID:25566086 | N-nitrosodiethylamine | increases expression | ISO | Impact (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of IMPACT mRNA | CTD | PMID:12771043 | ozone | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of IMPACT mRNA | CTD | PMID:34911549 | paracetamol | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of IMPACT mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of IMPACT mRNA | CTD | PMID:33387578 | paracetamol | affects expression | ISO | Impact (Mus musculus) | 6480464 | Acetaminophen affects the expression of IMPACT mRNA | CTD | PMID:17562736 | pentachlorophenol | increases expression | ISO | Impact (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of IMPACT mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of IMPACT mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of IMPACT mRNA | CTD | PMID:36331819 | phenobarbital | increases expression | ISO | Impact (Mus musculus) | 6480464 | Phenobarbital results in increased expression of IMPACT mRNA | CTD | PMID:19482888 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of IMPACT mRNA | CTD | PMID:30047161 | phenobarbital | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IMPACT mRNA] | CTD | PMID:19482888 | pirinixic acid | multiple interactions | ISO | Impact (Mus musculus) | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of IMPACT mRNA] | CTD | PMID:17950772 | pirinixic acid | increases expression | ISO | Impact (Mus musculus) | 6480464 | pirinixic acid results in increased expression of IMPACT mRNA | CTD | PMID:17950772 more ... | propiconazole | increases expression | ISO | Impact (Mus musculus) | 6480464 | propiconazole results in increased expression of IMPACT mRNA | CTD | PMID:21278054 and PMID:22334560 | resveratrol | multiple interactions | ISO | IMPACT (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of IMPACT mRNA | CTD | PMID:23557933 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of IMPACT mRNA | CTD | PMID:19281266 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of IMPACT mRNA | CTD | PMID:30047161 | sunitinib | decreases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of IMPACT mRNA | CTD | PMID:31533062 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IMPACT mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Impact (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of IMPACT mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of IMPACT mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of IMPACT mRNA | CTD | PMID:34492290 | troglitazone | decreases expression | ISO | Impact (Mus musculus) | 6480464 | troglitazone results in decreased expression of IMPACT mRNA | CTD | PMID:28973697 | troglitazone | increases expression | ISO | Impact (Mus musculus) | 6480464 | troglitazone results in increased expression of IMPACT mRNA | CTD | PMID:28973697 | urethane | decreases expression | ISO | Impact (Mus musculus) | 6480464 | Urethane results in decreased expression of IMPACT mRNA | CTD | PMID:16289808 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of IMPACT mRNA | CTD | PMID:24136188 | valproic acid | increases expression | ISO | IMPACT (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of IMPACT mRNA | CTD | PMID:23179753 and PMID:27188386 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of IMPACT mRNA | CTD | PMID:19015723 | |