Adam17 (ADAM metallopeptidase domain 17) - Rat Genome Database

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Gene: Adam17 (ADAM metallopeptidase domain 17) Rattus norvegicus
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Symbol: Adam17
Name: ADAM metallopeptidase domain 17
RGD ID: 620404
Description: Predicted to have PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Localizes to several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Predicted to colocalize with cell-cell junction; focal adhesion; and ruffle membrane. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM 17; disintegrin and metalloproteinase domain-containing protein 17; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2640,872,936 - 40,920,700 (-)NCBI
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nonylphenol  (ISO)
7alpha-hydroxycholesterol  (EXP)
aceclofenac  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP)
calcium dichloride  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
melittin  (ISO)
methyl methanesulfonate  (ISO)
Methylthiouracil  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP)
nicotinic acid  (EXP)
oxycodone  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (IEA,ISO)
B cell differentiation  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IEA,ISO)
cell motility  (ISO)
cellular response to high density lipoprotein particle stimulus  (IEA,ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
germinal center formation  (ISO)
integrin-mediated signaling pathway  (IEA)
membrane protein ectodomain proteolysis  (IBA,IEA,IMP,ISO,ISS,TAS)
negative regulation of apoptotic process  (IDA)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of neuron projection development  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
Notch receptor processing  (IEA,ISO,ISS)
Notch signaling pathway  (IBA)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular component movement  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA,ISO)
positive regulation of epidermal growth factor-activated receptor activity  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell chemotaxis  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
production of molecular mediator involved in inflammatory response  (ISO)
protein processing  (IEA,ISO)
proteolysis  (ISO,ISS,TAS)
receptor transactivation  (IEA,IMP,ISO)
regulation of axon regeneration  (ISO)
regulation of mast cell apoptotic process  (ISO)
regulation of neuron migration  (ISO)
response to antineoplastic agent  (IEP)
response to drug  (ISO)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
spermatogenesis  (IEP)
spleen development  (ISO)
T cell differentiation in thymus  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
wound healing, spreading of epidermal cells  (IEA,ISO)

Cellular Component

References

References - curated
1. Bax DV, etal., J Biol Chem. 2004 May 21;279(21):22377-86. Epub 2004 Feb 16.
2. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
3. Cardellini M, etal., Diabetes. 2009 Jul 6.
4. Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8.
5. Colon AL, etal., Cytokine 2001 Dec 21;16(6):220-6.
6. Elliott KJ, etal., J Mol Cell Cardiol. 2013 Sep;62:1-7. doi: 10.1016/j.yjmcc.2013.05.005. Epub 2013 May 17.
7. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Gelling RW, etal., Endocrinology. 2008 Dec;149(12):6053-64. doi: 10.1210/en.2008-0775. Epub 2008 Aug 7.
10. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
11. GOA data from the GO Consortium
12. Hartl D, etal., Mol Psychiatry. 2018 Jul 9. pii: 10.1038/s41380-018-0091-8. doi: 10.1038/s41380-018-0091-8.
13. Hurtado O, etal., J Cereb Blood Flow Metab 2002 May;22(5):576-85.
14. Jones BA, etal., Arthritis Rheum. 2013 Nov;65(11):2814-25. doi: 10.1002/art.38095.
15. Liechti FD, etal., Infect Immun. 2014 Apr;82(4):1710-8. doi: 10.1128/IAI.00073-14. Epub 2014 Feb 3.
16. Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795.
17. MGD data from the GO Consortium
18. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
19. Monroy A, etal., Diabetologia. 2009 Jul 25.
20. Mulder GM, etal., Nephrol Dial Transplant. 2012 May;27(5):2114-22. doi: 10.1093/ndt/gfr583. Epub 2011 Oct 19.
21. Myhre GM, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1213-9. Epub 2004 Jul 29.
22. Nadadur RD, etal., J Appl Physiol (1985). 2012 Jul;113(1):149-58. doi: 10.1152/japplphysiol.01349.2011. Epub 2012 May 24.
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Okamura Y, etal., Neurosci Res. 2011 Sep;71(1):63-70. doi: 10.1016/j.neures.2011.05.012. Epub 2011 May 27.
25. OMIM Disease Annotation Pipeline
26. Peschon JJ, etal., Science 1998 Nov 13;282(5392):1281-4.
27. Pipeline to import KEGG annotations from KEGG into RGD
28. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9.
30. Prakasam HS, etal., Mol Biol Cell. 2014 Nov 15;25(23):3798-812. doi: 10.1091/mbc.E14-03-0818. Epub 2014 Sep 17.
31. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
32. RGD automated data pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. Rybnikova E, etal., Neurosci Res. 2012 Apr;72(4):364-73. doi: 10.1016/j.neures.2011.12.010. Epub 2012 Jan 2.
36. Urriola-Muñoz P, etal., Biol Res. 2014 Jul 4;47:31. doi: 10.1186/0717-6287-47-31.
37. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
38. Wang L, etal., Neurochem Res. 2014 Jul;39(7):1338-45. doi: 10.1007/s11064-014-1317-z. Epub 2014 May 3.
39. Zeng SY, etal., Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026. Epub 2013 Jul 11.
Additional References at PubMed
PMID:9034190   PMID:9034191   PMID:9574564   PMID:9920899   PMID:12207026   PMID:12535668   PMID:12743035   PMID:12777399   PMID:12849708   PMID:14625290   PMID:14761956   PMID:14960606  
PMID:15337756   PMID:15691827   PMID:15739225   PMID:16034137   PMID:16179345   PMID:16399672   PMID:16737974   PMID:17010968   PMID:17245433   PMID:17371977   PMID:17655843   PMID:17786981  
PMID:17884817   PMID:18276953   PMID:18322947   PMID:18373975   PMID:18383040   PMID:18423996   PMID:18483258   PMID:18625725   PMID:18676862   PMID:18713734   PMID:18772236   PMID:19581512  
PMID:19717015   PMID:19796498   PMID:19946888   PMID:20087163   PMID:20359533   PMID:20501791   PMID:20610799   PMID:21170088   PMID:21357274   PMID:21411748   PMID:22413019   PMID:23389627  
PMID:23834487   PMID:24006456   PMID:24226769   PMID:24227843   PMID:24813629   PMID:24871629   PMID:24990881   PMID:25049354   PMID:25468996   PMID:26175156   PMID:26598506   PMID:26651291  
PMID:26944439   PMID:30046277   PMID:30551445   PMID:30953402  


Genomics

Comparative Map Data
Adam17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2640,872,936 - 40,920,700 (-)NCBI
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
ADAM17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl29,488,486 - 9,556,732 (-)EnsemblGRCh38hg38GRCh38
GRCh3829,488,486 - 9,555,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3729,628,615 - 9,695,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,546,843 - 9,613,368 (-)NCBINCBI36hg18NCBI36
Build 3429,580,010 - 9,646,496NCBI
Celera29,541,264 - 9,607,791 (-)NCBI
Cytogenetic Map2p25.1NCBI
HuRef29,474,897 - 9,541,735 (-)NCBIHuRef
CHM1_129,558,004 - 9,625,229 (-)NCBICHM1_1
Adam17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,373,510 - 21,423,633 (-)NCBIGRCm39mm39
GRCm39 Ensembl1221,373,510 - 21,423,633 (-)Ensembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBImm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
Adam17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,180,252 - 5,218,216 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,180,241 - 5,218,298 (-)NCBIChiLan1.0ChiLan1.0
ADAM17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A9,641,194 - 9,708,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBIMhudiblu_PPA_v0panPan3
ADAM17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,589,874 - 6,638,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,589,878 - 6,638,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,517,667 - 6,566,403 (-)NCBI
ROS_Cfam_1.0176,687,702 - 6,737,271 (-)NCBI
UMICH_Zoey_3.1176,580,977 - 6,629,669 (-)NCBI
UNSW_CanFamBas_1.0176,583,178 - 6,631,850 (-)NCBI
UU_Cfam_GSD_1.0176,597,002 - 6,645,753 (-)NCBI
Adam17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,109,736 - 51,148,960 (-)NCBI
SpeTri2.0NW_0049365325,864,851 - 5,904,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,795,426 - 126,853,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,795,513 - 126,853,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,176,533 - 135,222,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM17
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,092,093 - 98,157,657 (+)NCBI
ChlSab1.1 Ensembl1498,092,044 - 98,157,217 (+)Ensembl
Vero_WHO_p1.0NW_02366604514,163,022 - 14,230,392 (-)NCBI
Adam17
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624969212,089 - 254,532 (+)NCBI

Position Markers
RH128637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,872,490 - 40,872,671 (+)MAPPER
Rnor_6.0643,400,074 - 43,400,254NCBIRnor6.0
Rnor_5.0660,267,783 - 60,267,963UniSTSRnor5.0
RGSC_v3.4641,881,981 - 41,882,161UniSTSRGSC3.4
Celera640,159,553 - 40,159,733UniSTS
RH 3.4 Map6226.2UniSTS
Cytogenetic Map6q16UniSTS
RH70698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,874,062 - 40,874,213 (+)MAPPER
Rnor_6.0643,401,646 - 43,401,796NCBIRnor6.0
Rnor_5.0660,269,355 - 60,269,505UniSTSRnor5.0
RGSC_v3.4641,883,553 - 41,883,703UniSTSRGSC3.4
Celera640,161,125 - 40,161,275UniSTS
Cytogenetic Map6q16UniSTS
RH141932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,872,997 - 40,873,209 (+)MAPPER
Rnor_6.0643,400,581 - 43,400,792NCBIRnor6.0
Rnor_5.0660,268,290 - 60,268,501UniSTSRnor5.0
RGSC_v3.4641,882,488 - 41,882,699UniSTSRGSC3.4
Celera640,160,060 - 40,160,271UniSTS
RH 3.4 Map6227.5UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63425776653855198Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63626028860606186Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63819641260606431Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:395
Count of miRNA genes:223
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000010648
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 48 32 19 32 6 6 74 35 39 11 6
Low 9 9 9 2 5 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081110   ⟹   ENSRNOP00000073012
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)Ensembl
RefSeq Acc Id: NM_020306   ⟹   NP_064702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2640,872,942 - 40,920,700 (-)NCBI
Rnor_6.0643,400,525 - 43,448,280 (-)NCBI
Rnor_5.0660,268,228 - 60,315,989 (-)NCBI
RGSC_v3.4641,882,432 - 41,930,755 (-)RGD
Celera640,160,004 - 40,207,760 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112795   ⟹   XP_038968723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2640,872,936 - 40,893,345 (-)NCBI
Protein Sequences
Protein RefSeqs NP_064702 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968723 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA10072 (Get FASTA)   NCBI Sequence Viewer  
  EDM03171 (Get FASTA)   NCBI Sequence Viewer  
  EDM03172 (Get FASTA)   NCBI Sequence Viewer  
  Q9Z1K9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_064702   ⟸   NM_020306
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000073012   ⟸   ENSRNOT00000081110
RefSeq Acc Id: XP_038968723   ⟸   XM_039112795
- Peptide Label: isoform X1
Protein Domains
Disintegrin   Peptidase M12B

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694517
Promoter ID:EPDNEW_R5040
Type:initiation region
Name:Adam17_1
Description:ADAM metallopeptidase domain 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,448,175 - 43,448,235EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620404 AgrOrtholog
Ensembl Genes ENSRNOG00000060694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073012 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081110 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:57027 UniProtKB/Swiss-Prot
NCBI Gene 57027 ENTREZGENE
Pfam ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam17 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADA17_RAT UniProtKB/Swiss-Prot
  G3V711_RAT UniProtKB/TrEMBL
  Q9Z1K9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam17  ADAM metallopeptidase domain 17  Adam17  a disintegrin and metallopeptidase domain 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Adam17  a disintegrin and metallopeptidase domain 17  Adam17  a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Adam17  a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)    a disintegrin and metalloproteinase domain 17  Name updated 1299863 APPROVED
2002-08-07 Adam17  a disintegrin and metalloproteinase domain 17      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression increased expression induced by oxygen-glucose deprivation induces release of TNF-alpha, which inhibits apoptosis via activation of NFkappaB 632021
gene_process release of TNF-alpha promotes apoptosis inhibition 632021
gene_regulation upregulated in response to oxygen glucose deprivation 632021