Gene: Adam17 (ADAM metallopeptidase domain 17) Rattus norvegicus
Symbol: Adam17
Name: ADAM metallopeptidase domain 17
Description: ENCODES a protein that exhibits metalloendopeptidase activity; metallopeptidase activity; integrin binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis; negative regulation of apoptotic process; B cell differentiation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis; thoracic aortic aneurysm; Blister (ortholog); FOUND IN cell surface; plasma membrane; actin cytoskeleton (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM 17; disintegrin and metalloproteinase domain-containing protein 17; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Homo sapiens (human) : ADAM17 (ADAM metallopeptidase domain 17)  HGNC  Alliance
Mus musculus (house mouse) : Adam17 (a disintegrin and metallopeptidase domain 17)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam17 (ADAM metallopeptidase domain 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM17 (ADAM metallopeptidase domain 17)
Canis lupus familiaris (dog) : ADAM17 (ADAM metallopeptidase domain 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam17 (ADAM metallopeptidase domain 17)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adam17
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620404
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2018-07-10
Status: ACTIVE