Adam17 (ADAM metallopeptidase domain 17) - Rat Genome Database

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Gene: Adam17 (ADAM metallopeptidase domain 17) Rattus norvegicus
Symbol: Adam17
Name: ADAM metallopeptidase domain 17
RGD ID: 620404
Description: Predicted to enable several functions, including PDZ domain binding activity; metallopeptidase activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and response to antineoplastic agent. Located in apical part of cell and cell surface. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM 17; disintegrin and metalloproteinase domain-containing protein 17; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8646,601,583 - 46,663,690 (-)NCBIGRCr8
mRatBN7.2640,872,936 - 40,920,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,872,856 - 40,920,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,195,035 - 41,242,751 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,509,725 - 41,557,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,942,985 - 40,990,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
7alpha-hydroxycholesterol  (EXP)
aceclofenac  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bellidifolin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP)
calcium dichloride  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diosgenin  (EXP)
enzacamene  (EXP)
enzalutamide  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
lipopolysaccharide  (ISO)
melittin  (ISO)
methyl methanesulfonate  (ISO)
Methylthiouracil  (ISO)
N(6),N(6)-dimethyladenosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP)
nicotinic acid  (EXP)
oxycodone  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (IEA,ISO)
B cell differentiation  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IEA,ISO)
cell motility  (ISO)
cellular response to high density lipoprotein particle stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IEP)
commissural neuron axon guidance  (IEA,ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
germinal center formation  (ISO)
membrane protein ectodomain proteolysis  (IBA,IEA,IMP,ISO,ISS,TAS)
negative regulation of apoptotic process  (IDA)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of neuron projection development  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
Notch receptor processing  (IEA,ISO,ISS)
Notch signaling pathway  (IBA,IEA)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of T cell chemotaxis  (IEA,ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
production of molecular mediator involved in inflammatory response  (ISO)
protein processing  (IEA,ISO)
proteolysis  (ISO,ISS,TAS)
receptor transactivation  (IMP)
regulation of axon regeneration  (ISO)
regulation of cellular component organization  (IEA)
regulation of mast cell apoptotic process  (ISO)
regulation of neuron migration  (ISO)
response to antineoplastic agent  (IEP)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (ISO)
signaling receptor ligand precursor processing  (ISO)
spermatogenesis  (IEP)
spleen development  (ISO)
T cell differentiation in thymus  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
wound healing, spreading of epidermal cells  (IEA,ISO)

Cellular Component
actin cytoskeleton  (IEA,ISO)
apical part of cell  (IDA)
apical plasma membrane  (IEA,ISO)
cell surface  (IDA,IEA,ISO)
cell-cell junction  (IEA,ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
focal adhesion  (IEA,ISO)
membrane  (ISO)
membrane raft  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
ruffle membrane  (IEA,ISO)


References - curated
# Reference Title Reference Citation
1. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. Bax DV, etal., J Biol Chem. 2004 May 21;279(21):22377-86. Epub 2004 Feb 16.
2. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
3. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. Cardellini M, etal., Diabetes. 2009 Jul 6.
4. The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8.
5. Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Colon AL, etal., Cytokine 2001 Dec 21;16(6):220-6.
6. ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells. Elliott KJ, etal., J Mol Cell Cardiol. 2013 Sep;62:1-7. doi: 10.1016/j.yjmcc.2013.05.005. Epub 2013 May 17.
7. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats. Ennequin G, etal., J Physiol. 2015 Jun 15;593(12):2665-77. doi: 10.1113/JP270026. Epub 2015 May 14.
8. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Gelling RW, etal., Endocrinology. 2008 Dec;149(12):6053-64. doi: 10.1210/en.2008-0775. Epub 2008 Aug 7.
11. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Hartl D, etal., Mol Psychiatry. 2018 Jul 9. pii: 10.1038/s41380-018-0091-8. doi: 10.1038/s41380-018-0091-8.
14. TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate. Hurtado O, etal., J Cereb Blood Flow Metab 2002 May;22(5):576-85.
15. Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CX3 CL1 in rheumatoid arthritis. Jones BA, etal., Arthritis Rheum. 2013 Nov;65(11):2814-25. doi: 10.1002/art.38095.
16. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Liechti FD, etal., Infect Immun. 2014 Apr;82(4):1710-8. doi: 10.1128/IAI.00073-14. Epub 2014 Feb 3.
17. Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis. Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
20. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Monroy A, etal., Diabetologia. 2009 Jul 25.
21. ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis. Mulder GM, etal., Nephrol Dial Transplant. 2012 May;27(5):2114-22. doi: 10.1093/ndt/gfr583. Epub 2011 Oct 19.
22. Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution. Myhre GM, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1213-9. Epub 2004 Jul 29.
23. Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension. Nadadur RD, etal., J Appl Physiol (1985). 2012 Jul;113(1):149-58. doi: 10.1152/japplphysiol.01349.2011. Epub 2012 May 24.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Okamura Y, etal., Neurosci Res. 2011 Sep;71(1):63-70. doi: 10.1016/j.neures.2011.05.012. Epub 2011 May 27.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. An essential role for ectodomain shedding in mammalian development. Peschon JJ, etal., Science 1998 Nov 13;282(5392):1281-4.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9.
31. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Prakasam HS, etal., Mol Biol Cell. 2014 Nov 15;25(23):3798-812. doi: 10.1091/mbc.E14-03-0818. Epub 2014 Sep 17.
32. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning. Rybnikova E, etal., Neurosci Res. 2012 Apr;72(4):364-73. doi: 10.1016/j.neures.2011.12.010. Epub 2012 Jan 2.
37. Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation. Urriola-Muñoz P, etal., Biol Res. 2014 Jul 4;47:31. doi: 10.1186/0717-6287-47-31.
38. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
39. Effects of aluminium on ß-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. Wang L, etal., Neurochem Res. 2014 Jul;39(7):1338-45. doi: 10.1007/s11064-014-1317-z. Epub 2014 May 3.
40. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. Zeng SY, etal., Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026. Epub 2013 Jul 11.
Additional References at PubMed
PMID:9034190   PMID:9034191   PMID:9574564   PMID:9920899   PMID:12207026   PMID:12535668   PMID:12743035   PMID:12777399   PMID:12849708   PMID:14625290   PMID:14761956   PMID:14960606  
PMID:15337756   PMID:15691827   PMID:15739225   PMID:16034137   PMID:16179345   PMID:16399672   PMID:16737974   PMID:17010968   PMID:17245433   PMID:17371977   PMID:17655843   PMID:17786981  
PMID:17884817   PMID:18276953   PMID:18322947   PMID:18373975   PMID:18383040   PMID:18423996   PMID:18483258   PMID:18625725   PMID:18676862   PMID:18713734   PMID:18772236   PMID:19581512  
PMID:19717015   PMID:19796498   PMID:19946888   PMID:20087163   PMID:20359533   PMID:20501791   PMID:20610799   PMID:21170088   PMID:21357274   PMID:21411748   PMID:22413019   PMID:23389627  
PMID:23834487   PMID:24006456   PMID:24226769   PMID:24227843   PMID:24813629   PMID:24871629   PMID:24990881   PMID:25049354   PMID:25468996   PMID:26175156   PMID:26598506   PMID:26651291  
PMID:26944439   PMID:30046277   PMID:30551445   PMID:30953402   PMID:32170604   PMID:33275250   PMID:33492555   PMID:33660945   PMID:35909160   PMID:36586043  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8646,601,583 - 46,663,690 (-)NCBIGRCr8
mRatBN7.2640,872,936 - 40,920,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,872,856 - 40,920,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,195,035 - 41,242,751 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,509,725 - 41,557,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,942,985 - 40,990,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3829,488,486 - 9,555,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,488,486 - 9,556,732 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,628,615 - 9,695,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,546,843 - 9,613,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,580,010 - 9,646,496NCBI
Celera29,541,264 - 9,607,791 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,474,897 - 9,541,735 (-)NCBIHuRef
CHM1_129,558,781 - 9,625,197 (-)NCBICHM1_1
T2T-CHM13v2.029,513,510 - 9,580,869 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391221,373,510 - 21,423,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,373,510 - 21,423,633 (-)EnsemblGRCm39 Ensembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBIMGSCv36mm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554875,180,252 - 5,218,216 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,180,241 - 5,218,298 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v212116,969,633 - 117,037,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,974,220 - 117,041,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,641,194 - 9,708,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1176,589,874 - 6,638,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,589,878 - 6,638,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,517,667 - 6,566,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,687,702 - 6,737,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,687,697 - 6,737,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,580,977 - 6,629,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,583,178 - 6,631,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,597,002 - 6,645,753 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629251,109,736 - 51,148,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,864,867 - 5,904,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,864,851 - 5,904,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl3126,795,426 - 126,853,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,795,513 - 126,853,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,176,533 - 135,222,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11498,092,093 - 98,157,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1498,092,044 - 98,157,217 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,163,022 - 14,230,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624969212,321 - 253,328 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969212,089 - 254,532 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adam17
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:395
Count of miRNA genes:223
Interacting mature miRNAs:266
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,872,490 - 40,872,671 (+)MAPPERmRatBN7.2
Rnor_6.0643,400,074 - 43,400,254NCBIRnor6.0
Rnor_5.0660,267,783 - 60,267,963UniSTSRnor5.0
RGSC_v3.4641,881,981 - 41,882,161UniSTSRGSC3.4
Celera640,159,553 - 40,159,733UniSTS
RH 3.4 Map6226.2UniSTS
Cytogenetic Map6q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,874,062 - 40,874,213 (+)MAPPERmRatBN7.2
Rnor_6.0643,401,646 - 43,401,796NCBIRnor6.0
Rnor_5.0660,269,355 - 60,269,505UniSTSRnor5.0
RGSC_v3.4641,883,553 - 41,883,703UniSTSRGSC3.4
Celera640,161,125 - 40,161,275UniSTS
Cytogenetic Map6q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,872,997 - 40,873,209 (+)MAPPERmRatBN7.2
Rnor_6.0643,400,581 - 43,400,792NCBIRnor6.0
Rnor_5.0660,268,290 - 60,268,501UniSTSRnor5.0
RGSC_v3.4641,882,488 - 41,882,699UniSTSRGSC3.4
Celera640,160,060 - 40,160,271UniSTS
RH 3.4 Map6227.5UniSTS
Cytogenetic Map6q16UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 48 32 19 32 6 6 74 35 39 11 6
Low 9 9 9 2 5 2 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000081110   ⟹   ENSRNOP00000073012
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,873,110 - 40,901,932 (-)Ensembl
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105140   ⟹   ENSRNOP00000089788
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,872,856 - 40,920,639 (-)Ensembl
RefSeq Acc Id: NM_020306   ⟹   NP_064702
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8646,601,583 - 46,649,344 (-)NCBI
mRatBN7.2640,872,936 - 40,920,700 (-)NCBI
Rnor_6.0643,400,525 - 43,448,280 (-)NCBI
Rnor_5.0660,268,228 - 60,315,989 (-)NCBI
RGSC_v3.4641,882,432 - 41,930,755 (-)RGD
Celera640,160,004 - 40,207,760 (-)RGD
RefSeq Acc Id: XM_039112795   ⟹   XP_038968723
Rat AssemblyChrPosition (strand)Source
GRCr8646,601,583 - 46,621,980 (-)NCBI
mRatBN7.2640,872,936 - 40,893,345 (-)NCBI
RefSeq Acc Id: XM_063262376   ⟹   XP_063118446
Rat AssemblyChrPosition (strand)Source
GRCr8646,601,583 - 46,663,690 (-)NCBI
RefSeq Acc Id: NP_064702   ⟸   NM_020306
- Peptide Label: precursor
- UniProtKB: Q9Z1K9 (UniProtKB/Swiss-Prot),   A6HAW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073012   ⟸   ENSRNOT00000081110
RefSeq Acc Id: XP_038968723   ⟸   XM_039112795
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000089788   ⟸   ENSRNOT00000105140
RefSeq Acc Id: XP_063118446   ⟸   XM_063262376
- Peptide Label: isoform X1
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1K9-F1-model_v2 AlphaFold Q9Z1K9 1-827 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694517
Promoter ID:EPDNEW_R5040
Type:initiation region
Description:ADAM metallopeptidase domain 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,448,175 - 43,448,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620404 AgrOrtholog
BioCyc Gene G2FUF-38036 BioCyc
Ensembl Genes ENSRNOG00000060694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055005728 UniProtKB/Swiss-Prot
  ENSRNOG00060008831 UniProtKB/Swiss-Prot
  ENSRNOG00065010279 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081110 ENTREZGENE
  ENSRNOT00000081110.2 UniProtKB/TrEMBL
  ENSRNOT00000105140.1 UniProtKB/TrEMBL
  ENSRNOT00055009254 UniProtKB/Swiss-Prot
  ENSRNOT00060014809 UniProtKB/Swiss-Prot
  ENSRNOT00065016602 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:57027 UniProtKB/Swiss-Prot
Pfam ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam17 PhenoGen
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060694 RatGTEx
  ENSRNOG00055005728 RatGTEx
  ENSRNOG00060008831 RatGTEx
  ENSRNOG00065010279 RatGTEx
SMART DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A811_RAT UniProtKB/TrEMBL
  ADA17_RAT UniProtKB/Swiss-Prot
  G3V711_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam17  ADAM metallopeptidase domain 17  Adam17  a disintegrin and metallopeptidase domain 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Adam17  a disintegrin and metallopeptidase domain 17  Adam17  a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Adam17  a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)    a disintegrin and metalloproteinase domain 17  Name updated 1299863 APPROVED
2002-08-07 Adam17  a disintegrin and metalloproteinase domain 17      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression increased expression induced by oxygen-glucose deprivation induces release of TNF-alpha, which inhibits apoptosis via activation of NFkappaB 632021
gene_process release of TNF-alpha promotes apoptosis inhibition 632021
gene_regulation upregulated in response to oxygen glucose deprivation 632021