Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Adam17 (a disintegrin and metallopeptidase domain 17) Mus musculus
Symbol: Adam17
Name: a disintegrin and metallopeptidase domain 17
Description: Exhibits endopeptidase activity and metallopeptidase activity. Involved in several processes, including PMA-inducible membrane protein ectodomain proteolysis; hematopoietic or lymphoid organ development; and regulation of neurogenesis. Localizes to cytoplasm and membrane. Predicted to colocalize with cell-cell junction; focal adhesion; and ruffle membrane. Is expressed in several structures, including brain; foregut-midgut junction; heart; liver; and lung. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; ADAM 17; CD156b; disintegrin and metalloproteinase domain-containing protein 17; Tace; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Homo sapiens (human) : ADAM17 (ADAM metallopeptidase domain 17)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adam17 (ADAM metallopeptidase domain 17)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam17 (ADAM metallopeptidase domain 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM17 (ADAM metallopeptidase domain 17)
Canis lupus familiaris (dog) : ADAM17 (ADAM metallopeptidase domain 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam17 (ADAM metallopeptidase domain 17)
Sus scrofa (pig) : ADAM17 (ADAM metallopeptidase domain 17)
Chlorocebus sabaeus (African green monkey) : ADAM17 (ADAM metallopeptidase domain 17)
Heterocephalus glaber (naked mole-rat) : Adam17 (ADAM metallopeptidase domain 17)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBImm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Adam17
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731401
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.