ADAM17 (ADAM metallopeptidase domain 17) - Rat Genome Database

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Gene: ADAM17 (ADAM metallopeptidase domain 17) Pan paniscus
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Symbol: ADAM17
Name: ADAM metallopeptidase domain 17
RGD ID: 11769981
Description: ENCODES a protein that exhibits metallodipeptidase activity (ortholog); INVOLVED IN B cell differentiation (ortholog); cell motility (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); atopic dermatitis (ortholog); Blister (ortholog); FOUND IN apical part of cell (ortholog); cell surface (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 17
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,969,633 - 117,037,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,974,220 - 117,041,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,641,194 - 9,708,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (IEA)
B cell differentiation  (ISO)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IEA)
cell motility  (ISO)
cellular response to high density lipoprotein particle stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
commissural neuron axon guidance  (IEA)
defense response to Gram-positive bacterium  (IEA)
germinal center formation  (ISO)
membrane protein ectodomain proteolysis  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
Notch receptor processing  (IEA)
Notch signaling pathway  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of epidermal growth factor-activated receptor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
positive regulation of vascular endothelial cell proliferation  (IEA)
production of molecular mediator involved in inflammatory response  (ISO)
protein processing  (IEA)
proteolysis  (IEA)
receptor transactivation  (ISO)
regulation of axon regeneration  (ISO)
regulation of cellular component organization  (IEA)
regulation of mast cell apoptotic process  (ISO)
regulation of neuron migration  (ISO)
response to antineoplastic agent  (ISO)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (IEA)
response to lipopolysaccharide  (IEA)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
signal release  (IEA)
signaling receptor ligand precursor processing  (ISO)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell differentiation in thymus  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
wound healing, spreading of epidermal cells  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,969,633 - 117,037,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,974,220 - 117,041,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,641,194 - 9,708,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensemblpanpan1.1panPan2
ADAM17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3829,488,486 - 9,555,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,488,486 - 9,556,732 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,628,615 - 9,695,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,546,843 - 9,613,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,580,010 - 9,646,496NCBI
Celera29,541,264 - 9,607,791 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,474,897 - 9,541,735 (-)NCBIHuRef
CHM1_129,558,781 - 9,625,197 (-)NCBICHM1_1
T2T-CHM13v2.029,513,510 - 9,580,869 (-)NCBIT2T-CHM13v2.0
Adam17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,373,510 - 21,423,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,373,510 - 21,423,633 (-)EnsemblGRCm39 Ensembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBIMGSCv36mm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
Adam17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,601,583 - 46,663,690 (-)NCBIGRCr8
mRatBN7.2640,872,936 - 40,920,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,872,856 - 40,920,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,195,035 - 41,242,751 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,509,725 - 41,557,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,942,985 - 40,990,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
Adam17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,180,252 - 5,218,216 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,180,241 - 5,218,298 (-)NCBIChiLan1.0ChiLan1.0
ADAM17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,589,874 - 6,638,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,589,878 - 6,638,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,517,667 - 6,566,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,687,702 - 6,737,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,687,697 - 6,737,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,580,977 - 6,629,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,583,178 - 6,631,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,597,002 - 6,645,753 (-)NCBIUU_Cfam_GSD_1.0
Adam17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,109,736 - 51,148,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,864,867 - 5,904,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,864,851 - 5,904,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,795,426 - 126,853,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,795,513 - 126,853,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,176,533 - 135,222,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,092,093 - 98,157,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1498,092,044 - 98,157,217 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,163,022 - 14,230,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624969212,321 - 253,328 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969212,089 - 254,532 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000053290   ⟹   ENSPPAP00000030429
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000053296   ⟹   ENSPPAP00000030435
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A9,674,828 - 9,707,876 (-)Ensembl
RefSeq Acc Id: XM_003826946   ⟹   XP_003826994
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212116,969,633 - 117,037,769 (+)NCBI
NHGRI_mPanPan12A116,974,220 - 117,041,742 (+)NCBI
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBI
PanPan1.12A9,641,194 - 9,708,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008952298   ⟹   XP_008950546
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212116,971,128 - 117,037,769 (+)NCBI
NHGRI_mPanPan12A116,975,127 - 117,041,742 (+)NCBI
Mhudiblu_PPA_v02A9,478,080 - 9,545,358 (-)NCBI
PanPan1.12A9,641,194 - 9,708,054 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055108258   ⟹   XP_054964233
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212116,971,152 - 117,037,769 (+)NCBI
NHGRI_mPanPan12A116,975,125 - 117,041,742 (+)NCBI
RefSeq Acc Id: XM_055108259   ⟹   XP_054964234
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212116,999,065 - 117,037,769 (+)NCBI
NHGRI_mPanPan12A117,003,038 - 117,041,742 (+)NCBI
RefSeq Acc Id: XM_063595055   ⟹   XP_063451125
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212117,003,651 - 117,037,769 (+)NCBI
RefSeq Acc Id: XP_008950546   ⟸   XM_008952298
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003826994   ⟸   XM_003826946
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BL62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000030435   ⟸   ENSPPAT00000053296
Ensembl Acc Id: ENSPPAP00000030429   ⟸   ENSPPAT00000053290
RefSeq Acc Id: XP_054964233   ⟸   XM_055108258
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054964234   ⟸   XM_055108259
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063451125   ⟸   XM_063595055
- Peptide Label: isoform X5
Protein Domains
Disintegrin   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053290.1 UniProtKB/TrEMBL
  ENSPPAT00000053296.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
  4.10.70.30 UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/TrEMBL
  ADAM17_MPD UniProtKB/TrEMBL
  ADAM_Metalloproteinase UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
KEGG Report pps:100988650 UniProtKB/TrEMBL
NCBI Gene ADAM17 ENTREZGENE
PANTHER ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17 UniProtKB/TrEMBL
Pfam ADAM17_MPD UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Reprolysin_5 UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
SMART DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A2R9BL62 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BLB8_PANPA UniProtKB/TrEMBL