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Gene: Ucp2 (uncoupling protein 2) Rattus norvegicus
Symbol: Ucp2
Name: uncoupling protein 2
RGD ID: 3932
Description: Predicted to have oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to glucose stimulus; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Localizes to mitochondrion. Used to study hypertension; non-alcoholic fatty liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; fatty liver disease (multiple); hypothyroidism; obstructive jaundice; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitochondrial uncoupling protein 2; solute carrier family 25 member 8; UCP 2; uncoupling protein 2 (mitochondrial, proton carrier); Uncoupling protein 2 mitochondrial; Uncoupling protein 2, mitochondrial
Homo sapiens (human) : UCP2 (uncoupling protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Ucp2 (uncoupling protein 2 (mitochondrial, proton carrier))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp2 (uncoupling protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP2 (uncoupling protein 2)
Canis lupus familiaris (dog) : UCP2 (uncoupling protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp2 (uncoupling protein 2)
Sus scrofa (pig) : UCP2 (uncoupling protein 2)
Chlorocebus sabaeus (African green monkey) : UCP2 (uncoupling protein 2)
Heterocephalus glaber (naked mole-rat) : Ucp2 (uncoupling protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01165,506,375 - 165,512,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,506,361 - 165,512,744 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,707,625 - 171,713,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,925,514 - 157,928,222 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,000,971 - 158,007,311 (+)NCBI
Celera1152,922,529 - 152,928,898 (+)NCBICelera
Cytogenetic Map1q32NCBI
RH 3.4 Map11261.4RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ucp2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3932
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.