Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621102
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psmc4
Name: proteasome 26S subunit, ATPase 4
Acc ID: CHEBI:42265
Term: epoxomicin
Definition: A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and methyl groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.
Chemical ID: MESH:C078846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7315566480464CTDepoxomicin results in increased expression of PSMC4 mRNA

PMID:27345029
multiple interactionsISORGD:7315566480464CTDNFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA]

PMID:27345029
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.