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RGD ID: 621102
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psmc4
Name: proteasome 26S subunit, ATPase 4
Acc ID: CHEBI:42265
Term: epoxomicin
Definition: A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and methyl groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.
Chemical ID: MESH:C078846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7315566480464CTDepoxomicin results in increased expression of PSMC4 mRNA

multiple interactionsISORGD:7315566480464CTDNFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.