Sp4 (Sp4 transcription factor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sp4 (Sp4 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp4
Name: Sp4 transcription factor
RGD ID: 3741
Description: Enables DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of heart contraction. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HF-1b; HF-1b zinc finger protein; Trans-acting transcription factor 4; transcription factor Sp4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86145,330,416 - 145,395,750 (-)NCBIGRCr8
mRatBN7.26139,187,458 - 139,252,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6139,192,147 - 139,252,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6142,629,275 - 142,693,969 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06139,246,735 - 139,311,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,795,393 - 139,860,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06146,135,877 - 146,201,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6146,135,877 - 146,195,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06155,047,728 - 155,113,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46145,553,512 - 145,619,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16145,559,698 - 145,620,144 (-)NCBI
Celera6136,844,006 - 136,908,926 (-)NCBICelera
Cytogenetic Map6q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratcongenital heart disease  ISOSP4 (Homo sapiens)1581309 RGD 
Sp4Ratdilated cardiomyopathy  ISOSP4 (Homo sapiens)1581308 RGD 
Sp4RatSudden Cardiac Death  ISOSp4 (Mus musculus)1580019 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratepilepsy  ISOSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868
Sp4Rathypomyelinating leukodystrophy 5  ISOSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypomyelination and Congenital CataractClinVarPMID:18022865 more ...
Sp4RatMonoclonal B-Cell Lymphocytosis  ISOSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Monoclonal B-Cell LymphocytosisClinVar 
Sp4Ratpleomorphic xanthoastrocytoma  ISOSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Sp4Ratprimary ciliary dyskinesia  ISOSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:18022865 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratbipolar disorder  ISOSP4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19401786
Sp4Ratschizophrenia  ISOSP4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19401786
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratschizophrenia  ISSSp4 (Mus musculus)13592920OMIM:181500MouseDO 

1 to 20 of 93 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Rat1,2-dimethylhydrazine decreases expressionISOSp4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SP4 mRNACTDPMID:22206623
Sp4Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of SP4 mRNACTDPMID:12832660
Sp4Rat17beta-estradiol decreases expressionISOSp4 (Mus musculus)6480464Estradiol results in decreased expression of SP4 mRNACTDPMID:25210133
Sp4Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of SP4 mRNACTDPMID:32145629
Sp4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSp4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of SP4 mRNACTDPMID:21570461 more ...
Sp4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SP4 mRNACTDPMID:33387578
Sp4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOSp4 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SP4 mRNACTDPMID:25975270
Sp4Rat2-butoxyethanol increases expressionISOSp4 (Mus musculus)6480464n-butoxyethanol results in increased expression of SP4 mRNACTDPMID:19812364
Sp4Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of SP4 mRNACTDPMID:28522335
Sp4Rat4,4'-sulfonyldiphenol decreases expressionISOSp4 (Mus musculus)6480464bisphenol S results in decreased expression of SP4 mRNACTDPMID:39298647
Sp4Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of SP4 mRNACTDPMID:30047161
Sp4Ratall-trans-retinoic acid decreases expressionISOSP4 (Homo sapiens)6480464Tretinoin results in decreased expression of SP4 mRNACTDPMID:21934132
Sp4Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of SP4 mRNACTDPMID:30047161
Sp4Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of SP4 mRNACTDPMID:16483693
Sp4Rataristolochic acid A decreases expressionISOSP4 (Homo sapiens)6480464aristolochic acid I results in decreased expression of SP4 mRNACTDPMID:33212167
Sp4Ratarsenite(3-) multiple interactionsISOSP4 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to SP4 mRNA]CTDPMID:32406909
Sp4Ratarsenous acid decreases expressionISOSP4 (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of SP4 mRNA and Arsenic Trioxide results in decreased expression of SP4 proteinCTDPMID:20435036
Sp4Ratbenzo[a]pyrene increases expressionISOSp4 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of SP4 proteinCTDPMID:21987461
Sp4Ratbenzo[a]pyrene multiple interactionsISOSp4 (Mus musculus)6480464POR protein affects the reaction [Benzo(a)pyrene results in increased expression of SP4 protein]CTDPMID:21987461
Sp4Ratbis(2-chloroethyl) sulfide increases expressionISOSp4 (Mus musculus)6480464Mustard Gas results in increased expression of SP4 mRNACTDPMID:15674843

1 to 20 of 93 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratregulation of heart contraction acts_upstream_of_or_withinISOSp4 (Mus musculus)1624291MGI:2676622 PMID:11007485RGDPMID:11007485
Sp4Ratregulation of transcription by RNA polymerase II acts_upstream_of_or_within_positive_effectISOSP4 (Homo sapiens)1624291 PMID:7559627RGDPMID:7559627
Sp4Ratregulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q02446 and ensembl:ENSP000002225841600115GO_REF:0000107EnsemblGO_REF:0000107
Sp4Ratregulation of transcription by RNA polymerase II involved_inIBACGD:CAL0000177853 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sp4Ratregulation of transcription by RNA polymerase II involved_inISOSP4 (Homo sapiens)1624291 PMID:12560508RGDPMID:12560508

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sp4Ratcytosol located_inIEAUniProtKB:Q02446 and ensembl:ENSP000002225841600115GO_REF:0000107EnsemblGO_REF:0000107
Sp4Ratcytosol located_inISOSP4 (Homo sapiens)1624291 RGDGO_REF:0000052
Sp4Ratnucleoplasm located_inIEAUniProtKB:Q02446 and ensembl:ENSP000002225841600115GO_REF:0000107EnsemblGO_REF:0000107
Sp4Ratnucleoplasm located_inISOSP4 (Homo sapiens)1624291 RGDGO_REF:0000052

Molecular Function
1 to 10 of 10 rows

  
1 to 10 of 10 rows


1 to 14 of 14 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
4. Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation. Hewett KW, etal., Cardiovasc Res. 2005 Aug 15;67(3):548-60.
5. Functional analysis of the rat N-methyl-D-aspartate receptor 2A promoter: multiple transcription starts points, positive regulation by Sp factors, and translational regulation. Liu A, etal., J Biol Chem. 2003 Jul 18;278(29):26423-34. Epub 2003 May 13.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. Mounkes LC, etal., Hum Mol Genet. 2005 Aug 1;14(15):2167-80. Epub 2005 Jun 22.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Nguyen-Tran VT, etal., Cell. 2000 Sep 1;102(5):671-82.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity. Tsika G, etal., Mol Cell Biol. 2004 Dec;24(24):10777-91.
14. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene. Zhu H, etal., Mol Cell Biol 1993 Jul;13(7):4432-44.
1 to 14 of 14 rows
PMID:12560508   PMID:17535924   PMID:19555762   PMID:21645329   PMID:23332764   PMID:24475768   PMID:24894994   PMID:26037489   PMID:26469128  



Sp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86145,330,416 - 145,395,750 (-)NCBIGRCr8
mRatBN7.26139,187,458 - 139,252,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6139,192,147 - 139,252,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6142,629,275 - 142,693,969 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06139,246,735 - 139,311,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,795,393 - 139,860,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06146,135,877 - 146,201,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6146,135,877 - 146,195,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06155,047,728 - 155,113,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46145,553,512 - 145,619,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16145,559,698 - 145,620,144 (-)NCBI
Celera6136,844,006 - 136,908,926 (-)NCBICelera
Cytogenetic Map6q33NCBI
SP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38721,428,083 - 21,514,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl721,428,043 - 21,514,822 (+)EnsemblGRCh38hg38GRCh38
GRCh37721,467,701 - 21,554,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36721,434,214 - 21,520,687 (+)NCBINCBI36Build 36hg18NCBI36
Build 34721,240,928 - 21,324,574NCBI
Celera721,453,188 - 21,539,659 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef721,352,913 - 21,439,390 (+)NCBIHuRef
CHM1_1721,468,431 - 21,554,847 (+)NCBICHM1_1
T2T-CHM13v2.0721,564,221 - 21,650,967 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2721,519,001 - 21,605,471 (+)NCBI
Sp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912118,195,421 - 118,265,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12118,198,668 - 118,265,175 (-)EnsemblGRCm39 Ensembl
GRCm3812118,231,686 - 118,301,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12118,234,933 - 118,301,440 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712119,473,406 - 119,539,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,460,830 - 112,527,871 (-)NCBIMGSCv36mm8
MGSCv3612118,679,035 - 118,745,471 (-)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.48NCBI
Sp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541023,955,408 - 24,015,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541023,955,408 - 24,015,667 (+)NCBIChiLan1.0ChiLan1.0
SP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2626,288,720 - 26,382,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1774,613,443 - 74,707,660 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0722,113,013 - 22,200,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1721,425,584 - 21,512,238 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl721,421,259 - 21,512,238 (+)Ensemblpanpan1.1panPan2
SP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11435,367,764 - 35,444,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1435,367,165 - 35,442,063 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1434,910,211 - 34,987,234 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01435,292,483 - 35,369,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1435,292,533 - 35,369,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11435,411,963 - 35,488,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01435,111,634 - 35,188,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01435,445,222 - 35,521,966 (+)NCBIUU_Cfam_GSD_1.0
Sp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511879,604,405 - 79,667,938 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365467,279,536 - 7,344,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365467,279,531 - 7,342,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl990,337,449 - 90,410,268 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1990,337,355 - 90,410,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2999,754,687 - 99,827,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12136,748,554 - 36,832,879 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2136,747,896 - 36,831,953 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604267,744,520 - 67,830,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247399,170,131 - 9,235,615 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sp4
136 total Variants

Predicted Target Of
Summary Value
Count of predictions:553
Count of miRNA genes:273
Interacting mature miRNAs:339
Transcripts:ENSRNOT00000007625
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000007625   ⟹   ENSRNOP00000007625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6139,192,147 - 139,252,126 (-)Ensembl
Rnor_6.0 Ensembl6146,135,877 - 146,195,819 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106494   ⟹   ENSRNOP00000096725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6139,192,147 - 139,251,668 (-)Ensembl
RefSeq Acc Id: NM_012761   ⟹   NP_036893
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86145,330,416 - 145,395,114 (-)NCBI
mRatBN7.26139,187,458 - 139,252,159 (-)NCBI
Rnor_6.06146,135,877 - 146,201,344 (-)NCBI
Rnor_5.06155,047,728 - 155,113,698 (-)NCBI
RGSC_v3.46145,553,512 - 145,619,389 (-)RGD
Celera6136,844,006 - 136,908,926 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111794   ⟹   XP_038967722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86145,330,416 - 145,395,750 (-)NCBI
mRatBN7.26139,187,458 - 139,252,741 (-)NCBI
RefSeq Acc Id: XM_063261555   ⟹   XP_063117625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86145,330,416 - 145,395,744 (-)NCBI
RefSeq Acc Id: XM_063261556   ⟹   XP_063117626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86145,330,416 - 145,395,744 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_036893 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967722 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117625 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117626 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA17375 (Get FASTA)   NCBI Sequence Viewer  
  EDL89090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007625
  ENSRNOP00000007625.4
  ENSRNOP00000096725.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_036893   ⟸   NM_012761
- UniProtKB: Q63158 (UniProtKB/TrEMBL),   A6KDM5 (UniProtKB/TrEMBL),   A0A8I6B4P2 (UniProtKB/TrEMBL),   F7FMI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007625   ⟸   ENSRNOT00000007625
RefSeq Acc Id: XP_038967722   ⟸   XM_039111794
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B4P2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096725   ⟸   ENSRNOT00000106494
RefSeq Acc Id: XP_063117626   ⟸   XM_063261556
- Peptide Label: isoform X3
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q63158-F1-model_v2 AlphaFold Q63158 1-783 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35472 BioCyc
Ensembl Genes ENSRNOG00000005472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007625 ENTREZGENE
  ENSRNOT00000007625.6 UniProtKB/TrEMBL
  ENSRNOT00000106494.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Sp4-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:25162 UniProtKB/TrEMBL
NCBI Gene 25162 ENTREZGENE
PANTHER SP4 TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Sp4 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005472 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6B4P2 ENTREZGENE, UniProtKB/TrEMBL
  A6KDM5 ENTREZGENE, UniProtKB/TrEMBL
  F7FMI9 ENTREZGENE, UniProtKB/TrEMBL
  Q63158 ENTREZGENE
UniProt Secondary Q63158 UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Sp4  Sp4 transcription factor  Sp4  trans-acting transcription factor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sp4  trans-acting transcription factor 4  Sp4  Sp4 transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Sp4  Sp4 transcription factor    Trans-acting transcription factor 4  Name updated 629478 APPROVED
2002-06-10 Sp4  Trans-acting transcription factor 4      Symbol and Name status set to approved 70586 APPROVED