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Gene: Sp4 (trans-acting transcription factor 4) Mus musculus
Symbol: Sp4
Name: trans-acting transcription factor 4
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of heart contraction. Predicted to localize to cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730497N03Rik; HF-1b; HF1-b; transcription factor Sp4
Homo sapiens (human) : SP4 (Sp4 transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sp4 (Sp4 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp4 (Sp4 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SP4 (Sp4 transcription factor)
Canis lupus familiaris (dog) : SP4 (Sp4 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp4 (Sp4 transcription factor)
Sus scrofa (pig) : SP4 (Sp4 transcription factor)
Chlorocebus sabaeus (African green monkey) : SP4 (Sp4 transcription factor)
Heterocephalus glaber (naked mole-rat) : Sp4 (Sp4 transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl12118,234,933 - 118,301,440 (-)EnsemblGRCm38mm10GRCm38
GRCm3812118,231,686 - 118,301,440 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712119,473,406 - 119,539,913 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612118,679,035 - 118,745,471 (-)NCBImm8
MGSCv3612112,460,830 - 112,527,871 (-)NCBImm8
Cytogenetic Map12F2NCBI
cM Map1263.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sp4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11335
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.