Mir141 (microRNA 141) - Rat Genome Database

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Gene: Mir141 (microRNA 141) Rattus norvegicus
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Symbol: Mir141
Name: microRNA 141
RGD ID: 2325407
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of Notch signaling pathway; and negative regulation of leukocyte adhesion to vascular endothelial cell. Predicted to act upstream of or within sensory perception of sound. Orthologous to human MIR141 (microRNA 141); INTERACTS WITH 2-methoxyethanol; atrazine; bis(2-ethylhexyl) phthalate.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-141
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,209,525 - 159,209,618 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.24157,523,239 - 157,523,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,523,239 - 157,523,332 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,751,729 - 163,751,822 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,534,634 - 159,534,727 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,176,198 - 158,176,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,236,346 - 157,236,439 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,236,346 - 157,236,439 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,253,942 - 224,254,035 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera4146,261,901 - 146,261,994 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Correlation analysis of miR-200b, miR-200c, and miR-141 with liver metastases in colorectal cancer patients. Zhu SH, etal., Eur Rev Med Pharmacol Sci. 2017 May;21(10):2357-2363.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:22012804   PMID:23646144   PMID:26453334   PMID:28543175   PMID:29264965   PMID:29901110   PMID:31273531   PMID:31532760   PMID:31916393  
PMID:33534373   PMID:33576445   PMID:34897970   PMID:34999183   PMID:35616132   PMID:36328940   PMID:38261732  


Genomics

Comparative Map Data
Mir141
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,209,525 - 159,209,618 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.24157,523,239 - 157,523,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,523,239 - 157,523,332 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,751,729 - 163,751,822 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,534,634 - 159,534,727 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,176,198 - 158,176,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,236,346 - 157,236,439 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,236,346 - 157,236,439 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,253,942 - 224,254,035 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera4146,261,901 - 146,261,994 (-)NCBICelera
Cytogenetic Map4q42NCBI
MIR141
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,964,097 - 6,964,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,964,097 - 6,964,191 (+)Ensemblhg38GRCh38
GRCh37127,073,260 - 7,073,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,943,520 - 6,943,614 (+)NCBIBuild 36Build 36hg18NCBI36
Celera128,694,279 - 8,694,373 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,931,725 - 6,931,819 (+)NCBIHuRef
CHM1_1127,072,213 - 7,072,307 (+)NCBICHM1_1
T2T-CHM13v2.0126,977,572 - 6,977,666 (+)NCBIT2T-CHM13v2.0
Mir141
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,694,877 - 124,694,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,694,877 - 124,694,948 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,717,914 - 124,717,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,717,914 - 124,717,985 (-)Ensemblmm10GRCm38
MGSCv376124,667,932 - 124,668,003 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera6126,399,639 - 126,399,710 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI

Variants

.
Variants in Mir141
1 total Variants
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Elavl4rno-miR-141-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986

Predicted Targets
Summary Value
Count of predictions:8148
Count of gene targets:5034
Count of transcripts:5387
Interacting mature miRNAs:rno-miR-141-3p, rno-miR-141-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 21 24 27 6 10 6 6 45 28 9 2 16 21

Sequence


Ensembl Acc Id: ENSRNOT00000053700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,523,239 - 157,523,332 (-)Ensembl
Rnor_6.0 Ensembl4157,236,346 - 157,236,439 (-)Ensembl
RefSeq Acc Id: NR_031887
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,209,525 - 159,209,618 (-)NCBI
mRatBN7.24157,523,239 - 157,523,332 (-)NCBI
Rnor_6.04157,236,346 - 157,236,439 (-)NCBI
Rnor_5.04224,253,942 - 224,254,035 (-)NCBI
Celera4146,261,901 - 146,261,994 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325407 AgrOrtholog
BioCyc Gene G2FUF-43084 BioCyc
Ensembl Genes ENSRNOG00000035577 Ensembl
miRBase MI0000914 ENTREZGENE
NCBI Gene 100314215 ENTREZGENE
PhenoGen Mir141 PhenoGen
RatGTEx ENSRNOG00000035577 RatGTEx
RNAcentral URS000003E1A9 RNACentral
  URS0000618F93 RNACentral
  URS000075B3F6 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir141  microRNA 141  Mir141  microRNA mir-141  Name updated 61478 APPROVED
2010-06-02 Mir141  microRNA mir-141      Symbol and Name status set to provisional 70820 PROVISIONAL