Med23 (mediator complex subunit 23) - Rat Genome Database

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Gene: Med23 (mediator complex subunit 23) Rattus norvegicus
Analyze
Symbol: Med23
Name: mediator complex subunit 23
RGD ID: 1307671
Description: Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 17beta-estradiol; allethrin; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3; CRSP complex subunit 3; Crsp3; LOC309565; mediator of RNA polymerase II transcription subunit 23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,309,613 - 22,377,745 (-)NCBIGRCr8
mRatBN7.2120,490,315 - 20,558,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,490,315 - 20,537,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,266,984 - 20,314,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,266,973 - 26,314,118 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,466,878 - 20,514,023 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,539,765 - 21,587,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,539,765 - 21,586,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,019,607 - 23,067,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,013,168 - 21,060,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,013,763 - 21,065,733 (-)NCBI
Celera119,242,971 - 19,290,165 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9989412   PMID:12477932   PMID:15340084   PMID:20508642   PMID:25054639  


Genomics

Comparative Map Data
Med23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,309,613 - 22,377,745 (-)NCBIGRCr8
mRatBN7.2120,490,315 - 20,558,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,490,315 - 20,537,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,266,984 - 20,314,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,266,973 - 26,314,118 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,466,878 - 20,514,023 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,539,765 - 21,587,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,539,765 - 21,586,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,019,607 - 23,067,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,013,168 - 21,060,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,013,763 - 21,065,733 (-)NCBI
Celera119,242,971 - 19,290,165 (-)NCBICelera
Cytogenetic Map1p12NCBI
MED23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,573,966 - 131,628,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,573,966 - 131,628,242 (-)EnsemblGRCh38hg38GRCh38
GRCh376131,895,106 - 131,949,453 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,799 - 131,991,056 (-)NCBINCBI36Build 36hg18NCBI36
Build 346131,936,799 - 131,991,056NCBI
Celera6132,641,744 - 132,696,002 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,476,289 - 129,531,194 (-)NCBIHuRef
CHM1_16132,158,892 - 132,213,170 (-)NCBICHM1_1
T2T-CHM13v2.06132,768,443 - 132,822,783 (-)NCBIT2T-CHM13v2.0
Med23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,745,889 - 24,789,358 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,745,884 - 24,789,579 (+)EnsemblGRCm39 Ensembl
GRCm381024,869,986 - 24,913,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,869,986 - 24,913,681 (+)EnsemblGRCm38mm10GRCm38
MGSCv371024,589,792 - 24,633,335 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,559,463 - 24,602,876 (+)NCBIMGSCv36mm8
Celera1025,800,708 - 25,844,502 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Med23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,249,995 - 12,293,813 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,249,995 - 12,293,812 (-)NCBIChiLan1.0ChiLan1.0
MED23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,592,256 - 151,634,143 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,498,888 - 149,540,825 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,386,301 - 129,428,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,493,587 - 133,535,337 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,481,115 - 133,535,988 (-)Ensemblpanpan1.1panPan2
MED23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112195,638 - 240,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12195,726 - 240,516 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12333,600 - 378,570 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012339,155 - 384,349 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12339,124 - 418,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112195,971 - 241,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012266,817 - 311,872 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012337,561 - 382,633 (+)NCBIUU_Cfam_GSD_1.0
Med23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946119,962,645 - 120,004,052 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937067849 - 41,298 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493706714 - 41,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,959,934 - 32,001,581 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,959,934 - 32,001,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,469,173 - 35,507,325 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,927,266 - 41,969,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,927,308 - 41,969,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604014,088,466 - 14,130,261 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,751,779 - 5,799,413 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,751,782 - 5,799,305 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med23
962 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:183
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000032424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

Markers in Region
BF397912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,511,792 - 20,512,005 (+)MAPPERmRatBN7.2
Rnor_6.0121,561,243 - 21,561,455NCBIRnor6.0
Rnor_5.0123,041,085 - 23,041,297UniSTSRnor5.0
RGSC_v3.4121,034,646 - 21,034,858UniSTSRGSC3.4
Celera119,264,449 - 19,264,661UniSTS
RH 3.4 Map1193.0UniSTS
Cytogenetic Map1p12UniSTS
RH129988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,490,448 - 20,490,642 (+)MAPPERmRatBN7.2
Rnor_6.0121,539,899 - 21,540,092NCBIRnor6.0
Rnor_5.0123,019,741 - 23,019,934UniSTSRnor5.0
RGSC_v3.4121,013,302 - 21,013,495UniSTSRGSC3.4
Celera119,243,105 - 19,243,298UniSTS
RH 3.4 Map1192.1UniSTS
Cytogenetic Map1p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 54 38 19 38 1 1 74 35 40 11 1
Low 16 3 3 3 7 10 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000032424   ⟹   ENSRNOP00000036610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,490,315 - 20,537,463 (-)Ensembl
Rnor_6.0 Ensembl121,539,765 - 21,586,910 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097341   ⟹   ENSRNOP00000090175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,490,315 - 20,537,463 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104432   ⟹   ENSRNOP00000078850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,490,315 - 20,537,374 (-)Ensembl
RefSeq Acc Id: NM_001277054   ⟹   NP_001263983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,613 - 22,356,754 (-)NCBI
mRatBN7.2120,490,315 - 20,537,463 (-)NCBI
Rnor_6.0121,539,765 - 21,586,910 (-)NCBI
Rnor_5.0123,019,607 - 23,067,752 (-)NCBI
Celera119,242,971 - 19,290,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758612   ⟹   XP_008756834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,377,744 (-)NCBI
mRatBN7.2120,490,315 - 20,558,460 (-)NCBI
Rnor_6.0121,539,765 - 21,587,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758613   ⟹   XP_008756835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,377,744 (-)NCBI
mRatBN7.2120,490,315 - 20,558,460 (-)NCBI
Rnor_6.0121,539,765 - 21,587,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080800   ⟹   XP_038936728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,377,745 (-)NCBI
mRatBN7.2120,490,315 - 20,558,461 (-)NCBI
RefSeq Acc Id: XM_039080806   ⟹   XP_038936734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,377,744 (-)NCBI
mRatBN7.2120,490,315 - 20,558,460 (-)NCBI
RefSeq Acc Id: XM_063265558   ⟹   XP_063121628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,357,230 (-)NCBI
RefSeq Acc Id: XM_063265563   ⟹   XP_063121633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,309,616 - 22,377,744 (-)NCBI
RefSeq Acc Id: NP_001263983   ⟸   NM_001277054
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot),   A0A0H2UHV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756834   ⟸   XM_008758612
- Peptide Label: isoform X1
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot),   A0A8I6A9J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756835   ⟸   XM_008758613
- Peptide Label: isoform X5
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036610   ⟸   ENSRNOT00000032424
RefSeq Acc Id: XP_038936728   ⟸   XM_039080800
- Peptide Label: isoform X2
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936734   ⟸   XM_039080806
- Peptide Label: isoform X3
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot),   A0A0H2UHV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078850   ⟸   ENSRNOT00000104432
RefSeq Acc Id: ENSRNOP00000090175   ⟸   ENSRNOT00000097341
RefSeq Acc Id: XP_063121633   ⟸   XM_063265563
- Peptide Label: isoform X4
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121628   ⟸   XM_063265558
- Peptide Label: isoform X1
- UniProtKB: Q5EB59 (UniProtKB/Swiss-Prot),   A0A8I6A9J3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EB59-F1-model_v2 AlphaFold Q5EB59 1-1367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689525
Promoter ID:EPDNEW_R49
Type:initiation region
Name:Med23_1
Description:mediator complex subunit 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,586,892 - 21,586,952EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307671 AgrOrtholog
BioCyc Gene G2FUF-62120 BioCyc
Ensembl Genes ENSRNOG00000013422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032424 ENTREZGENE
  ENSRNOT00000032424.6 UniProtKB/TrEMBL
  ENSRNOT00000097341.1 UniProtKB/TrEMBL
  ENSRNOT00000104432.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325957 IMAGE-MGC_LOAD
InterPro Mediator_Med23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309565 UniProtKB/TrEMBL
MGC_CLONE MGC:109560 IMAGE-MGC_LOAD
NCBI Gene 309565 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12691 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Med23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Med23 PhenoGen
RatGTEx ENSRNOG00000013422 RatGTEx
UniProt A0A0H2UHV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9J3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3Z5_RAT UniProtKB/TrEMBL
  MED23_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Med23  mediator complex subunit 23  Crsp3  cofactor required for Sp1 transcriptional activation, subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Crsp3  cofactor required for Sp1 transcriptional activation, subunit 3  Crsp3_predicted  cofactor required for Sp1 transcriptional activation, subunit 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Crsp3_predicted  cofactor required for Sp1 transcriptional activation, subunit 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED