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Gene: Tyms (thymidylate synthetase) Rattus norvegicus
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Symbol: Tyms
Name: thymidylate synthetase
Description: Exhibits several functions, including folic acid binding activity; identical protein binding activity; and thymidylate synthase activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; response to steroid hormone; and response to vitamin. Localizes to the mitochondrion and nucleolus. Used to study urinary bladder cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC156654; thymidylate synthase; TS; TSase
Orthologs:
Homo sapiens (human) : TYMS (thymidylate synthetase)  HGNC  Alliance
Mus musculus (house mouse) : Tyms (thymidylate synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyms (thymidylate synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMS (thymidylate synthetase)
Canis lupus familiaris (dog) : TYMS (thymidylate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyms (thymidylate synthetase)
Sus scrofa (pig) : TYMS (thymidylate synthetase)
Chlorocebus sabaeus (African green monkey) : TYMS (thymidylate synthetase)
Heterocephalus glaber (naked mole-rat) : Tyms (thymidylate synthetase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.09121,918,875 - 121,931,564 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,918,947 - 121,931,564 (-)Ensembl
Rnor_5.09121,368,418 - 121,381,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49112,604,912 - 112,617,706 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.19112,814,399 - 112,827,186 (-)NCBI
Celera9110,420,900 - 110,433,600 (-)NCBICelera
Cytogenetic Map9q38NCBI
RH 3.4 Map9866.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 6.0)

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More on Tyms
Alliance Gene
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JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 3921
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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