Tyms (thymidylate synthetase) - Rat Genome Database

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Gene: Tyms (thymidylate synthetase) Chinchilla lanigera
Analyze
Symbol: Tyms
Name: thymidylate synthetase
RGD ID: 8868197
Description: ENCODES a protein that exhibits folic acid binding (ortholog); heterocyclic compound binding (ortholog); mRNA binding (ortholog); INVOLVED IN cartilage development (ortholog); circadian rhythm (ortholog); developmental growth (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thymidylate synthase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,296,321 - 9,306,631 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,295,862 - 9,304,952 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tyms
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,296,321 - 9,306,631 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,295,862 - 9,304,952 (-)NCBIChiLan1.0ChiLan1.0
TYMS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818657,653 - 673,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18657,653 - 673,578 (+)EnsemblGRCh38hg38GRCh38
GRCh3718657,653 - 673,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618647,651 - 663,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 3418647,650 - 663,492NCBI
Celera18532,413 - 547,810 (+)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18617,665 - 633,936 (+)NCBIHuRef
CHM1_118656,968 - 672,692 (+)NCBICHM1_1
T2T-CHM13v2.018811,985 - 827,856 (+)NCBIT2T-CHM13v2.0
Tyms
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,243,544 - 30,279,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,263,200 - 30,278,615 (-)EnsemblGRCm39 Ensembl
GRCm38530,038,546 - 30,073,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,058,202 - 30,073,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,384,740 - 30,400,165 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,389,614 - 30,404,368 (-)NCBIMGSCv36mm8
Celera527,575,630 - 27,591,037 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.81NCBI
Tyms
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,760,057 - 120,776,149 (-)NCBIGRCr8
mRatBN7.29113,313,454 - 113,329,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,313,452 - 113,329,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9121,800,847 - 121,813,531 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,929,987 - 126,942,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,275,890 - 125,288,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,918,875 - 121,931,564 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,918,947 - 121,931,564 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09121,368,418 - 121,381,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49112,604,912 - 112,617,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19112,814,399 - 112,827,186 (-)NCBI
Celera9110,420,900 - 110,433,600 (-)NCBICelera
RH 3.4 Map9866.0RGD
Cytogenetic Map9q38NCBI
TYMS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,829,504 - 37,845,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,522,096 - 23,537,682 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,653,085 - 13,668,478 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,295,182 - 17,310,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,295,182 - 17,310,320 (-)Ensemblpanpan1.1panPan2
TYMS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,487,927 - 67,497,747 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl767,487,927 - 67,497,747 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,941,464 - 66,951,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,553,912 - 67,563,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,553,912 - 67,563,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,230,668 - 67,240,435 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,242,107 - 67,251,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,544,017 - 67,553,794 (+)NCBIUU_Cfam_GSD_1.0
Tyms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494463,774,083 - 63,783,067 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493655034,048 - 41,840 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493655033,797 - 42,233 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYMS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,642,381 - 105,660,578 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16105,642,730 - 105,660,279 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TYMS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,030,640 - 60,043,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1860,030,658 - 60,041,856 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605034,821,625 - 34,834,281 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyms
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,138,652 - 11,149,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477011,138,673 - 11,149,600 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000016793   ⟹   ENSCLAP00000016629
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554029,296,321 - 9,306,631 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016794   ⟹   ENSCLAP00000016630
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554029,296,321 - 9,305,887 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016795   ⟹   ENSCLAP00000016631
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554029,296,321 - 9,305,094 (-)Ensembl
RefSeq Acc Id: XM_013519582   ⟹   XP_013375036
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554029,295,862 - 9,304,952 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013375036 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016629
  ENSCLAP00000016629.1
  ENSCLAP00000016630.1
  ENSCLAP00000016631.1
RefSeq Acc Id: XP_013375036   ⟸   XM_013519582
- UniProtKB: A0A8C2VQ22 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000016630   ⟸   ENSCLAT00000016794
Ensembl Acc Id: ENSCLAP00000016629   ⟸   ENSCLAT00000016793
Ensembl Acc Id: ENSCLAP00000016631   ⟸   ENSCLAT00000016795

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011426 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016793 ENTREZGENE
  ENSCLAT00000016793.1 UniProtKB/TrEMBL
  ENSCLAT00000016794.1 UniProtKB/TrEMBL
  ENSCLAT00000016795.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.572.10 UniProtKB/TrEMBL
InterPro Thymidate_synth/dCMP_Mease UniProtKB/TrEMBL
  Thymidate_synth/dCMP_Mease_dom UniProtKB/TrEMBL
  Thymidate_synth/dCMP_Mease_sf UniProtKB/TrEMBL
  Thymidylate_synthase UniProtKB/TrEMBL
  Thymidylate_synthase_AS UniProtKB/TrEMBL
NCBI Gene Tyms ENTREZGENE
PANTHER PTHR11548 UniProtKB/TrEMBL
  THYMIDYLATE SYNTHASE UniProtKB/TrEMBL
Pfam Thymidylat_synt UniProtKB/TrEMBL
PRINTS THYMDSNTHASE UniProtKB/TrEMBL
PROSITE THYMIDYLATE_SYNTHASE UniProtKB/TrEMBL
Superfamily-SCOP SSF55831 UniProtKB/TrEMBL
UniProt A0A8C2VLX9_CHILA UniProtKB/TrEMBL
  A0A8C2VQ22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VRE3_CHILA UniProtKB/TrEMBL