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Gene: Tyms (thymidylate synthase) Mus musculus
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Symbol: Tyms
Name: thymidylate synthase
Description: Predicted to have several functions, including folic acid binding activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of translation; pyrimidine deoxyribonucleoside monophosphate metabolic process; and tetrahydrofolate interconversion. Predicted to localize to the cytosol; mitochondrion; and nucleolus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TYMS (thymidylate synthetase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TS; Tsase
Orthologs:
Homo sapiens (human) : TYMS (thymidylate synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyms (thymidylate synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyms (thymidylate synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMS (thymidylate synthetase)
Canis lupus familiaris (dog) : TYMS (thymidylate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyms (thymidylate synthetase)
Sus scrofa (pig) : TYMS (thymidylate synthetase)
more info ...
Related Pseudogenes: Gm17958   Tyms-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38530,038,546 - 30,073,645 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37530,384,740 - 30,400,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv36530,389,614 - 30,404,368 (-)NCBImm8
Celera527,575,630 - 27,591,037 (-)NCBICelera
Cytogenetic Map5 B1NCBI
cM Map515.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tyms
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736838
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.