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Gene: Tyms (thymidylate synthase) Mus musculus
Symbol: Tyms
Name: thymidylate synthase
Description: Predicted to have several functions, including folic acid binding activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of translation; pyrimidine deoxyribonucleoside monophosphate metabolic process; and tetrahydrofolate interconversion. Predicted to localize to the cytosol; mitochondrion; and nucleolus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TYMS (thymidylate synthetase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TS; Tsase
Homo sapiens (human) : TYMS (thymidylate synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyms (thymidylate synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyms (thymidylate synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMS (thymidylate synthetase)
Canis lupus familiaris (dog) : TYMS (thymidylate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyms (thymidylate synthetase)
Sus scrofa (pig) : TYMS (thymidylate synthetase)
more info ...
Related Pseudogenes: Gm17958   Tyms-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38530,038,546 - 30,073,645 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37530,384,740 - 30,400,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv36530,389,614 - 30,404,368 (-)NCBImm8
Celera527,575,630 - 27,591,037 (-)NCBICelera
Cytogenetic Map5 B1NCBI
cM Map515.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tyms
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736838
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.