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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3921
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tyms
Name: thymidylate synthetase
Acc ID: CHEBI:63616
Term: pemetrexed
Definition: An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Chemical ID: MESH:C085586
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tymsaffects response to substanceISOTYMS (Homo sapiens)6480464CTDTYMS affects the susceptibility to Pemetrexed; TYMS protein affects the susceptibility to PemetrexedPMID:17339891 PMID:21742432
Tymsdecreases activityISOTYMS (Homo sapiens)6480464CTDPemetrexed results in decreased activity of TYMS proteinPMID:17339891
Tymsmultiple interactionsISOTYMS (Homo sapiens)6480464CTDTYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]PMID:15161716
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