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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307568
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rac2
Name: Rac family small GTPase 2
Acc ID: CHEBI:53490
Term: N-formyl-L-methionyl-L-leucyl-L-phenylalanine
Definition: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
Chemical ID: MESH:D009240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rac2increases activityISORac2 (Mus musculus)6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 proteinPMID:16621998 PMID:28779020
Rac2multiple interactionsISORac2 (Mus musculus)6480464CTD6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]PMID:11145705 PMID:16621998 PMID:28779020
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