Tnfaip6 (TNF alpha induced protein 6) - Rat Genome Database

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Gene: Tnfaip6 (TNF alpha induced protein 6) Rattus norvegicus
Analyze
Symbol: Tnfaip6
Name: TNF alpha induced protein 6
RGD ID: 621359
Description: Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in positive regulation of cell migration. Located in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Tnfip6; tumor necrosis factor alpha induced protein 6; tumor necrosis factor induced protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2336,502,250 - 36,521,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx339,888,035 - 39,907,355 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0348,472,812 - 48,492,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0346,257,353 - 46,276,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
amodiaquine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzyl bromide  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chondroitin sulfate  (ISO)
Chorionic gonadotropin  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cobalt(2+) sulfate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entacapone  (ISO)
epoxiconazole  (ISO)
esmolol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fludrocortisone  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glycitein  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
nebivolol  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
pepstatin A  (ISO)
peptidoglycan  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirprofen  (ISO)
procyclidine  (ISO)
progesterone  (ISO)
propanal  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trazodone  (ISO)
Trihexyphenidyl  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
zafirlukast  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Fulop C, etal., Development 2003 May;130(10):2253-61.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis. Guo P, etal., Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1372-80. doi: 10.1167/iovs.11-8738. Print 2012 Mar.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Oh JY, etal., Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16875-80. doi: 10.1073/pnas.1012451107. Epub 2010 Sep 13.
6. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Park YD, etal., Clin Exp Allergy. 2006 May;36(5):649-57.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6. Roddy GW, etal., Stem Cells. 2011 Oct;29(10):1572-9. doi: 10.1002/stem.708.
11. Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. Wang N, etal., PLoS One. 2012;7(8):e43768. doi: 10.1371/journal.pone.0043768. Epub 2012 Aug 17.
12. Expression of tumor necrosis factor-stimulated gene-6 in the rat ovary in response to an ovulatory dose of gonadotropin. Yoshioka S, etal., Endocrinology. 2000 Nov;141(11):4114-9.
Additional References at PubMed
PMID:12477932   PMID:16873769   PMID:20463016   PMID:21569482   PMID:24488915   PMID:26953231   PMID:27435674   PMID:28975447   PMID:30584538   PMID:30984789   PMID:33670243   PMID:34145502  
PMID:35690131  


Genomics

Comparative Map Data
Tnfaip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2336,502,250 - 36,521,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx339,888,035 - 39,907,355 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0348,472,812 - 48,492,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0346,257,353 - 46,276,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
TNFAIP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382151,357,592 - 151,381,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2151,357,592 - 151,380,046 (+)EnsemblGRCh38hg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
T2T-CHM13v2.02151,809,346 - 151,833,086 (+)NCBIT2T-CHM13v2.0
Tnfaip6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,928,125 - 51,946,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl251,928,021 - 51,946,698 (+)EnsemblGRCm39 Ensembl
GRCm38252,038,113 - 52,056,681 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl252,038,009 - 52,056,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37251,893,633 - 51,912,201 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36251,860,122 - 51,878,690 (+)NCBIMGSCv36mm8
Celera253,762,777 - 53,783,057 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map229.98NCBI
Tnfaip6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544016,916,055 - 16,944,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544016,915,952 - 16,944,375 (+)NCBIChiLan1.0ChiLan1.0
TNFAIP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B54,062,655 - 54,085,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B38,669,652 - 38,692,037 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B155,933,842 - 155,956,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B155,933,842 - 155,956,382 (+)Ensemblpanpan1.1panPan2
TNFAIP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11952,607,598 - 52,623,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1952,607,713 - 52,623,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1952,770,629 - 52,786,812 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01954,118,538 - 54,134,777 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1954,118,552 - 54,135,260 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11952,832,140 - 52,848,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01952,902,916 - 52,919,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01954,369,113 - 54,385,510 (+)NCBIUU_Cfam_GSD_1.0
Tnfaip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303115,472,309 - 115,488,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646926,129,331 - 26,145,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646926,129,339 - 26,145,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15862,015 - 881,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115862,013 - 881,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,132,380 - 157,151,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11036,792,505 - 36,814,271 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1036,792,514 - 36,814,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040162,729,309 - 162,750,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248665,706,850 - 5,728,771 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248665,706,483 - 5,758,666 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnfaip6
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:203
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000070792
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 2 11
Low 3 41 21 6 12 6 8 11 72 35 30 11 8
Below cutoff 2 30 30 6 30

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070792   ⟹   ENSRNOP00000064253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)Ensembl
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)Ensembl
RefSeq Acc Id: NM_053382   ⟹   NP_445834
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2336,502,250 - 36,521,652 (+)NCBI
Rnor_6.0337,545,238 - 37,564,704 (+)NCBI
Rnor_5.0342,649,266 - 42,663,190 (+)NCBI
Celera334,646,103 - 34,665,498 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445834 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD56634 (Get FASTA)   NCBI Sequence Viewer  
  AAI58667 (Get FASTA)   NCBI Sequence Viewer  
  EDM00443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064253
  ENSRNOP00000064253.3
Reference Protein Sequences
RefSeq Acc Id: NP_445834   ⟸   NM_053382
- Peptide Label: precursor
- UniProtKB: B0BN34 (UniProtKB/TrEMBL),   M0R4G8 (UniProtKB/TrEMBL),   A0A9K3Y887 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064253   ⟸   ENSRNOT00000070792
Protein Domains
CUB   Link

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4G8-F1-model_v2 AlphaFold M0R4G8 1-273 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692076
Promoter ID:EPDNEW_R2600
Type:single initiation site
Name:Tnfaip6_1
Description:TNF alpha induced protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0337,545,169 - 37,545,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621359 AgrOrtholog
BioCyc Gene G2FUF-49736 BioCyc
Ensembl Genes ENSRNOG00000050792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070792 ENTREZGENE
  ENSRNOT00000070792.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8370218 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  Link UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
KEGG Report rno:84397 UniProtKB/TrEMBL
MGC_CLONE MGC:187662 IMAGE-MGC_LOAD
NCBI Gene 84397 ENTREZGENE
PANTHER CUBILIN-LIKE PROTEIN UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Xlink UniProtKB/TrEMBL
PhenoGen Tnfaip6 PhenoGen
PRINTS LINKMODULE UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LINK_1 UniProtKB/TrEMBL
  LINK_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050792 RatGTEx
SMART CUB UniProtKB/TrEMBL
  LINK UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
UniProt A0A9K3Y887 ENTREZGENE, UniProtKB/TrEMBL
  B0BN34 ENTREZGENE, UniProtKB/TrEMBL
  M0R4G8 ENTREZGENE
UniProt Secondary M0R4G8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tnfaip6  TNF alpha induced protein 6  Tnfaip6  tumor necrosis factor alpha induced protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tnfaip6  tumor necrosis factor alpha induced protein 6  Tnfip6  tumor necrosis factor induced protein 6  Symbol and Name updated 1299863 APPROVED
2002-08-07 Tnfip6  tumor necrosis factor induced protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL