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Gene: Sox2 (SRY-box transcription factor 2) Rattus norvegicus
Symbol: Sox2
Name: SRY-box transcription factor 2
RGD ID: 1565646
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including adenohypophysis development; positive regulation of transcription by RNA polymerase II; and tissue regeneration. Localizes to nucleus. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: LOC100912162; LOC499593; RGD1565646; similar to SOX2 protein; SRY (sex determining region Y)-box 2; SRY box 2; SRY-box containing gene 2; transcription factor SOX-2; uncharacterized LOC100912162
Homo sapiens (human) : SOX2 (SRY-box transcription factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Sox2 (SRY (sex determining region Y)-box 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox2 (SRY-box transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX2 (SRY-box transcription factor 2)
Canis lupus familiaris (dog) : SOX2 (SRY-box transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox2 (SRY-box transcription factor 2)
Sus scrofa (pig) : SOX2 (SRY-box transcription factor 2)
Chlorocebus sabaeus (African green monkey) : SOX2 (SRY-box transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Sox2 (SRY-box transcription factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02121,165,137 - 121,167,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2121,165,137 - 121,167,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02140,810,593 - 140,813,001 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42120,969,021 - 120,971,430 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2112,569,723 - 112,572,132 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Sox2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1565646
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.