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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maf1
Name: MAF1 homolog, negative regulator of RNA polymerase III
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maf1multiple interactionsISOMAF1 (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Sirolimus] results in decreased degradation of MAF1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of and results in decreased degradation of MAF1 protein; CUL2 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of MAF1 protein]PMID:31645432
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