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Gene: Bdkrb1 (bradykinin receptor B1) Rattus norvegicus
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Symbol: Bdkrb1
Name: bradykinin receptor B1
Description: Exhibits bradykinin receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Localizes to the neuron projection and plasma membrane. Used to study several diseases, including diabetic angiopathy; diabetic retinopathy; hypertension; neuropathy (multiple); and pleurisy. Biomarker of hypertension and myocardial infarction. Human ortholog(s) of this gene implicated in diabetic retinopathy; end stage renal failure; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: B1 bradykinin receptor; b1bkr; B1R; Bdkrb; BK-1 receptor; BKR; bradykinin B1 receptor; bradykinin receptor, beta 1; KB1; kinin B1; kinin B1 receptor
Orthologs:
Homo sapiens (human) : BDKRB1 (bradykinin receptor B1)  HGNC  Alliance
Mus musculus (house mouse) : Bdkrb1 (bradykinin receptor, beta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bdkrb1 (bradykinin receptor B1)
Pan paniscus (bonobo/pygmy chimpanzee) : BDKRB1 (bradykinin receptor B1)
Canis lupus familiaris (dog) : BDKRB1 (bradykinin receptor B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bdkrb1 (bradykinin receptor B1)
Sus scrofa (pig) : BDKRB1 (bradykinin receptor B1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06129,437,423 - 129,441,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06138,631,450 - 138,633,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,760,129 - 129,762,545 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16129,763,875 - 129,766,292 (+)NCBI
Celera6122,077,962 - 122,080,378 (+)NCBICelera
Cytogenetic Map6q32NCBI
RH 3.4 Map6821.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Bdkrb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620401
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.