Bdkrb1 (bradykinin receptor B1) - Rat Genome Database

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Gene: Bdkrb1 (bradykinin receptor B1) Rattus norvegicus
Analyze
Symbol: Bdkrb1
Name: bradykinin receptor B1
RGD ID: 620401
Description: Enables bradykinin receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Predicted to be active in plasma membrane. Used to study several diseases, including diabetic angiopathy; hypertension; neuropathy (multiple); overactive bladder syndrome; and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B1 bradykinin receptor; b1bkr; B1R; Bdkrb; BK-1 receptor; BKR; bradykinin B1 receptor; bradykinin receptor, beta 1; KB1; kinin B1; kinin B1 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,275,631 - 130,284,968 (+)NCBIGRCr8
mRatBN7.26124,510,827 - 124,514,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,510,870 - 124,513,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,632,115 - 124,634,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,927,381 - 124,929,797 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,288,772 - 124,291,188 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,437,423 - 129,441,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,438,158 - 129,440,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,631,450 - 138,633,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,760,129 - 129,762,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,763,875 - 129,766,292 (+)NCBI
Celera6122,077,962 - 122,080,378 (+)NCBICelera
RH 3.4 Map6821.1RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (ISO)
[des-Arg(9)]-bradykinin  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP)
capsazepine  (EXP)
carbon nanotube  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
D-glucose  (EXP)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP)
goralatide  (ISO)
hydrochlorothiazide  (EXP)
indometacin  (EXP,ISO)
ketamine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
meloxicam  (EXP)
Methanandamide  (ISO)
Mitotane  (EXP)
N-acetyl-L-cysteine  (EXP)
paracetamol  (EXP,ISO)
perindopril  (EXP)
phenobarbital  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercitrin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
streptozocin  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
valsartan  (EXP)
vincristine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
2. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Abe KC, etal., Regul Pept. 2007 Feb 1;138(2-3):56-8. Epub 2006 Dec 20.
3. Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. Bachvarov DR, etal., J Am Soc Nephrol. 1998 Apr;9(4):598-604.
4. Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice. Catanzaro OL, etal., Neuropeptides. 2010 Apr;44(2):187-9. doi: 10.1016/j.npep.2009.12.010. Epub 2010 Jan 21.
5. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. Chopra B, etal., J Physiol. 2005 Feb 1;562(Pt 3):859-71. Epub 2004 Dec 2.
6. Up-regulation of functional kinin B1 receptors in allergic airway inflammation. Christiansen SC, etal., J Immunol. 2002 Aug 15;169(4):2054-60.
7. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. Cui J, etal., J Hypertens. 2005 Jan;23(1):55-62.
8. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
9. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Dias JP, etal., Br J Pharmacol. 2007 Sep;152(2):280-7. Epub 2007 Jul 9.
10. In vivo up-regulation of kinin B1 receptors after treatment with Porphyromonas gingivalis lipopolysaccharide in rat paw. Dornelles FN, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):756-63. Epub 2009 Jun 26.
11. Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. Duka A, etal., Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E268-74. Epub 2006 Feb 28.
12. Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis. Emblom-Callahan MC, etal., Genomics. 2010 Sep;96(3):134-45. Epub 2010 May 6.
13. Regulation and function of spinal and peripheral neuronal B1 bradykinin receptors in inflammatory mechanical hyperalgesia. Fox A, etal., Pain. 2003 Aug;104(3):683-91.
14. Kinin B1 receptor antagonists inhibit diabetes-induced hyperalgesia in mice. Gabra BH and Sirois P, Neuropeptides. 2003 Feb;37(1):36-44.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Renal protective role of bradykinin B1 receptor in stroke-prone spontaneously hypertensive rats. Hagiwara M, etal., Hypertens Res. 2004 Jun;27(6):399-408.
17. The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy. Hayashi I, etal., Life Sci. 2002 Jan 11;70(8):937-49.
18. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
19. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. Jones C, etal., Eur J Pharmacol. 1999 Jun 25;374(3):423-33.
20. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
21. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. Klein J, etal., FASEB J. 2009 Jan;23(1):134-42. doi: 10.1096/fj.08-115600. Epub 2008 Sep 22.
22. Blockade of the kinin B1 receptor ameloriates glomerulonephritis. Klein J, etal., J Am Soc Nephrol. 2010 Jul;21(7):1157-64. doi: 10.1681/ASN.2009090887. Epub 2010 May 6.
23. G(-699)/C polymorphism in the bradykinin-1 receptor gene in patients with renal failure. Knigge H, etal., Nephrol Dial Transplant. 2000 May;15(5):586-8.
24. Kinin-B1 receptors in ischaemia-induced pancreatitis: functional importance and cellular localisation. Kuebler JF, etal., Biol Chem. 2003 Sep;384(9):1311-9.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. Effects of a selective bradykinin B1 receptor antagonist on increased plasma extravasation in streptozotocin-induced diabetic rats: distinct vasculopathic profile of major key organs. Lawson SR, etal., Eur J Pharmacol. 2005 May 2;514(1):69-78. Epub 2005 Apr 21.
27. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
28. Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells. Lu DY, etal., J Cell Biochem. 2010 May;110(1):141-50.
29. Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance. Lungu C, etal., Neuropeptides. 2007 Dec;41(6):375-87. Epub 2007 Nov 7.
30. Induction of B1 receptors in streptozotocin diabetic rats: possible involvement in the control of hyperglycemia-induced glomerular Erk 1 and 2 phosphorylation. Mage M, etal., Can J Physiol Pharmacol 2002 Apr;80(4):328-33.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. The role of bradykinin B1 receptor on cardiac remodeling in stroke-prone spontaneously hypertensive rats (SHR-SP). Moniwa N, etal., Biol Chem. 2006 Feb;387(2):203-9.
33. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
34. Tissue kallikrein and kinins in renal disease. Naicker S, etal., Immunopharmacology. 1999 Oct 15;44(1-2):183-92.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Molecular cloning and expression of rat bradykinin B1 receptor. Ni A, etal., Biochim Biophys Acta 1998 Nov 8;1442(2-3):177-85.
37. Overexpression of Kinin B1 Receptors Induces Hypertensive Response to Des-Arg9-bradykinin and Susceptibility to Inflammation. Ni A, etal., J Biol Chem 2003 Jan 3;278(1):219-25.
38. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
39. Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis. Pereira RL, etal., Kidney Int. 2011 Jun;79(11):1217-27. doi: 10.1038/ki.2011.14. Epub 2011 Mar 16.
40. Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis. Sainz IM, etal., FASEB J. 2004 May;18(7):887-9. Epub 2004 Mar 4.
47. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
48. Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy. Talbot S, etal., J Neuroinflammation. 2010 Jun 29;7(1):36.
49. Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. Vellani V, etal., J Physiol. 2004 Oct 15;560(Pt 2):391-401. Epub 2004 Aug 19.
50. Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence. Vianna RM, etal., Br J Pharmacol 2003 Jan;138(1):13-22.
51. Bradykinin B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury. Wang PH, etal., PLoS One. 2008 Aug 25;3(8):e3050. doi: 10.1371/journal.pone.0003050.
Additional References at PubMed
PMID:8602848   PMID:15087417   PMID:15708952   PMID:16822558   PMID:17570564   PMID:17664391   PMID:18555989   PMID:19276445   PMID:19323833   PMID:19374866   PMID:20637817   PMID:20830306  
PMID:21835216   PMID:22266391   PMID:22862305   PMID:22877648   PMID:23306173   PMID:23417862   PMID:23846981   PMID:24361511   PMID:24724708   PMID:25344431   PMID:25959537   PMID:26565562  
PMID:26669247   PMID:27628189   PMID:27923787   PMID:28726167   PMID:28937259   PMID:29225113   PMID:29285756   PMID:30580020   PMID:31309451   PMID:33687297   PMID:34828323  


Genomics

Comparative Map Data
Bdkrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,275,631 - 130,284,968 (+)NCBIGRCr8
mRatBN7.26124,510,827 - 124,514,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,510,870 - 124,513,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,632,115 - 124,634,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,927,381 - 124,929,797 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,288,772 - 124,291,188 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,437,423 - 129,441,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,438,158 - 129,440,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,631,450 - 138,633,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,760,129 - 129,762,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,763,875 - 129,766,292 (+)NCBI
Celera6122,077,962 - 122,080,378 (+)NCBICelera
RH 3.4 Map6821.1RGD
Cytogenetic Map6q32NCBI
BDKRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,256,210 - 96,264,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,722,547 - 96,731,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,792,312 - 95,800,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,792,311 - 95,800,851NCBI
Celera1476,778,278 - 76,786,817 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,907,652 - 76,916,201 (+)NCBIHuRef
CHM1_11496,661,476 - 96,670,026 (+)NCBICHM1_1
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBIT2T-CHM13v2.0
Bdkrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,570,350 - 105,571,770 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,569,344 - 105,571,687 (+)EnsemblGRCm39 Ensembl
GRCm3812105,604,091 - 105,605,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,603,085 - 105,605,428 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,842,301 - 106,843,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612106,005,141 - 106,006,478 (+)NCBIMGSCv36mm8
Celera12106,838,703 - 106,840,040 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.81NCBI
Bdkrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,500,633 - 16,501,691 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,500,219 - 16,505,394 (-)NCBIChiLan1.0ChiLan1.0
BDKRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,412,576 - 97,424,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,629,081 - 96,641,330 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,885,923 - 76,894,456 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,208,312 - 96,221,049 (+)NCBIpanpan1.1PanPan1.1panPan2
BDKRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,017,655 - 65,028,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,541,610 - 64,542,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,289,047 - 65,301,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,297,113 - 65,298,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,970,187 - 64,971,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,031,504 - 65,032,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,355,171 - 65,356,223 (+)NCBIUU_Cfam_GSD_1.0
Bdkrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,515,392 - 9,516,560 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936604551,774 - 567,014 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,491,350 - 117,492,410 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,491,350 - 117,492,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,701,695 - 124,749,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDKRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,136,464 - 74,146,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,145,531 - 74,146,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,287,030 - 61,297,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdkrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,548,356 - 8,549,414 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,545,707 - 8,549,846 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bdkrb1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000005953
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
RH142435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,512,891 - 124,513,107 (+)MAPPERmRatBN7.2
Rnor_6.06129,440,071 - 129,440,286NCBIRnor6.0
Rnor_5.06138,633,363 - 138,633,578UniSTSRnor5.0
RGSC_v3.46129,762,042 - 129,762,257UniSTSRGSC3.4
Celera6122,079,875 - 122,080,090UniSTS
RH 3.4 Map6821.1UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:495960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,513,072 - 124,513,401 (+)MAPPERmRatBN7.2
Rnor_6.06129,440,252 - 129,440,580NCBIRnor6.0
Rnor_5.06138,633,544 - 138,633,872UniSTSRnor5.0
RGSC_v3.46129,762,223 - 129,762,551UniSTSRGSC3.4
Celera6122,080,056 - 122,080,384UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 17 12 12
Below cutoff 74 30 13 5 16 20 78 35 3

Sequence


Ensembl Acc Id: ENSRNOT00000005953   ⟹   ENSRNOP00000005953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,510,870 - 124,513,747 (+)Ensembl
Rnor_6.0 Ensembl6129,438,158 - 129,440,574 (+)Ensembl
RefSeq Acc Id: NM_030851   ⟹   NP_110478
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,275,686 - 130,278,102 (+)NCBI
mRatBN7.26124,510,979 - 124,513,395 (+)NCBI
Rnor_6.06129,438,158 - 129,440,574 (+)NCBI
Rnor_5.06138,631,450 - 138,633,866 (+)NCBI
RGSC_v3.46129,760,129 - 129,762,545 (+)RGD
Celera6122,077,962 - 122,080,378 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764861   ⟹   XP_008763083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,275,631 - 130,284,968 (+)NCBI
mRatBN7.26124,510,827 - 124,514,475 (+)NCBI
Rnor_6.06129,437,423 - 129,441,553 (+)NCBI
Sequence:
RefSeq Acc Id: NP_110478   ⟸   NM_030851
- UniProtKB: O35782 (UniProtKB/Swiss-Prot),   Q9R250 (UniProtKB/Swiss-Prot),   P97583 (UniProtKB/Swiss-Prot),   A6KBC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763083   ⟸   XM_008764861
- Peptide Label: isoform X1
- UniProtKB: O35782 (UniProtKB/Swiss-Prot),   Q9R250 (UniProtKB/Swiss-Prot),   P97583 (UniProtKB/Swiss-Prot),   A6KBC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005953   ⟸   ENSRNOT00000005953
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97583-F1-model_v2 AlphaFold P97583 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694814
Promoter ID:EPDNEW_R5337
Type:single initiation site
Name:Bdkrb1_1
Description:bradykinin receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,438,159 - 129,438,219EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620401 AgrOrtholog
BioCyc Gene G2FUF-36333 BioCyc
Ensembl Genes ENSRNOG00000004488 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028026 UniProtKB/Swiss-Prot
  ENSRNOG00060021683 UniProtKB/Swiss-Prot
  ENSRNOG00065026555 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005953.4 UniProtKB/Swiss-Prot
  ENSRNOT00055048490 UniProtKB/Swiss-Prot
  ENSRNOT00060037544 UniProtKB/Swiss-Prot
  ENSRNOT00065045867 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Brdyknn_1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81509 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81509 ENTREZGENE
PANTHER B2 BRADYKININ RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bdkrb1 PhenoGen
PRINTS BRADYKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRADYKINNB1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004488 RatGTEx
  ENSRNOG00055028026 RatGTEx
  ENSRNOG00060021683 RatGTEx
  ENSRNOG00065026555 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KBC8 ENTREZGENE, UniProtKB/TrEMBL
  BKRB1_RAT UniProtKB/Swiss-Prot
  O35782 ENTREZGENE
  P97583 ENTREZGENE
  Q9R250 ENTREZGENE
UniProt Secondary O35782 UniProtKB/Swiss-Prot
  Q9R250 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Bdkrb1  bradykinin receptor B1  Bdkrb1  bradykinin receptor, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Bdkrb1  bradykinin receptor, beta 1  Bdkrb1  bradykinin receptor B1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Bdkrb1  bradykinin receptor B1    Bradykinin receptor B1  Name updated 1299863 APPROVED
2002-08-07 Bdkrb1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may decrease ERK 1 and 2 phosphorylation and reduce diabetic nephropathy in streptozotocin induced diabetes 727669
gene_expression constitutively expressed 628496
gene_function G-protein coupled receptor for kinin 628496
gene_pathway cellular responses transduced through inositol phosphate or arachidonic acid pathway 628496
gene_process may modulate kinin inflammatory responses 628496
gene_regulation may be induced by tissue inflammation or exposure to noxious stimuli 628496
gene_regulation After exposure of cultured cardiac fibroblasts to IL-1 beta, expression was enhanced in cells from both SHR and WKY strains to equivalent levels. 1358958