Gpr183 (G protein-coupled receptor 183)

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Gene: Gpr183 (G protein-coupled receptor 183) Rattus norvegicus

Analyze

Symbol:

Gpr183

Name:

G protein-coupled receptor 183

RGD ID:

1598095

Description:

Predicted to have G protein-coupled receptor activity and oxysterol binding activity. Predicted to be involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Predicted to localize to plasma membrane. Orthologous to human GPR183 (G protein-coupled receptor 183); INTERACTS WITH acetamide; bisphenol A; furan.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Ebi2; EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); epstein-Barr virus-induced G-protein coupled receptor 2; G-protein coupled receptor 183; LOC679975; similar to EBV-induced G-protein coupled receptor 2 (EBI2)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR183 (G protein-coupled receptor 183)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr183 (G protein-coupled receptor 183)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Gpr183 (G protein-coupled receptor 183)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR183 (G protein-coupled receptor 183)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR183 (G protein-coupled receptor 183)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR183 (G protein-coupled receptor 183)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	GPR183 (G protein-coupled receptor 183)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Gpr183 (G protein-coupled receptor 183)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	GPR183 (G protein-coupled receptor 183)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	gpr183a (G protein-coupled receptor 183a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	gpr183b (G protein-coupled receptor 183b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Allele / Splice:

Gpr183^em2Mcwi Gpr183^em1Mcwi Gpr183^em3Mcwi

Genetic Models:

SS-Gpr183^em3Mcwi SS-Gpr183^em1Mcwi SS-Gpr183^em2Mcwi

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	15	108,364,701 - 108,376,221 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	108,364,701 - 108,376,221 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	111,751,148 - 111,763,869 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	107,056,367 - 107,067,887 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	15	97,811,478 - 97,823,000 (-)	NCBI		Celera
Cytogenetic Map	15	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult T-cell leukemia (ISO)

IgA glomerulonephritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

albendazole (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

ferric oxide (ISO)

furan (EXP)

irinotecan (ISO)

ivermectin (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

nickel atom (ISO)

paracetamol (ISO)

pioglitazone (ISO)

rac-lactic acid (ISO)

rosuvastatin calcium (ISO)

sunitinib (ISO)

Tesaglitazar (EXP)

titanium dioxide (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

troglitazone (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (ISO,ISS)

B cell activation involved in immune response (IBA)

biological_process (ND)

cell chemotaxis (ISO)

dendritic cell chemotaxis (ISO,ISS)

dendritic cell homeostasis (ISO,ISS)

G protein-coupled receptor signaling pathway (ISO,ISS)

humoral immune response (ISO)

leukocyte chemotaxis (ISO,ISS)

mature B cell differentiation involved in immune response (ISO)

osteoclast differentiation (ISO,ISS)

positive regulation of B cell proliferation (ISO,ISS)

positive regulation of ERK1 and ERK2 cascade (ISO,ISS)

regulation of astrocyte chemotaxis (ISO,ISS)

T cell chemotaxis (ISO,ISS)

T follicular helper cell differentiation (ISO,ISS)

Cellular Component

cellular_component (ND)

integral component of membrane (IEA)

plasma membrane (ISO,ISS)

Molecular Function

G protein-coupled receptor activity (IBA,ISO,ISS)

molecular_function (ND)

oxysterol binding (ISO,ISS)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for gene-chemical interactions
3.	RGD comprehensive gene curation

Additional References at PubMed

PMID:18628402	PMID:19597478	PMID:21673108	PMID:21796211	PMID:21796212	PMID:22875855	PMID:22930711	PMID:23502855	PMID:23682316	PMID:24678947	PMID:25297897	PMID:25348153
PMID:26438360	PMID:27147029

Genomics

Comparative Map Data

Gpr183
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	15	108,364,701 - 108,376,221 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	108,364,701 - 108,376,221 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	111,751,148 - 111,763,869 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	107,056,367 - 107,067,887 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	15	97,811,478 - 97,823,000 (-)	NCBI		Celera
Cytogenetic Map	15	q25	NCBI

GPR183
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	13	99,294,539 - 99,307,399 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	13	99,294,273 - 99,307,399 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	13	99,946,789 - 99,959,749 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	98,744,790 - 98,757,695 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	13	98,744,790 - 98,757,695	NCBI
Celera	13	80,790,353 - 80,803,314 (-)	NCBI
Cytogenetic Map	13	q32.3	NCBI
HuRef	13	80,541,169 - 80,554,130 (-)	NCBI		HuRef
CHM1_1	13	99,916,965 - 99,929,926 (-)	NCBI		CHM1_1

Gpr183
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	122,189,743 - 122,202,605 (-)	NCBI	GRCm39		mm39
GRCm38	14	121,952,331 - 121,965,193 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	121,952,551 - 121,965,195 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	122,351,553 - 122,364,415 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	14	121,087,511 - 121,100,373 (-)	NCBI			mm8
Celera	14	120,513,847 - 120,526,678 (-)	NCBI		Celera
Cytogenetic Map	14	E5	NCBI

Gpr183
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	11,264,954 - 11,277,531 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	11,264,954 - 11,277,531 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR183
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	99,600,695 - 99,613,671 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	99,601,220 - 99,602,305 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	80,461,908 - 80,475,046 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GPR183
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	22	49,333,188 - 49,347,593 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	22	49,332,665 - 49,347,721 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

GPR183
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	68,231,851 - 68,245,751 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	68,231,851 - 68,248,627 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	75,527,987 - 75,529,869 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR183
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	77,952,689 - 77,966,317 (-)	NCBI
ChlSab1.1 Ensembl	3	77,953,212 - 77,954,297 (-)	Ensembl

Position Markers

D15Rat27

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	108,368,891 - 108,369,033	NCBI	Rnor6.0
Rnor_5.0	15	111,756,447 - 111,756,589	UniSTS	Rnor5.0
RGSC_v3.4	15	107,060,381 - 107,060,711	RGD	RGSC3.4
RGSC_v3.4	15	107,060,557 - 107,060,699	UniSTS	RGSC3.4
RGSC_v3.1	15	107,076,337 - 107,076,479	RGD
Celera	15	97,815,670 - 97,815,812	UniSTS
Cytogenetic Map	15	q25	UniSTS
RH 3.4 Map	15	706.5	UniSTS
RH 3.4 Map	15	706.5	RGD
RH 2.0 Map	15	609.8	RGD
SHRSP x BN Map	15	66.4899	RGD
FHH x ACI Map	15	74.04	RGD

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	65520564	110520564	Rat
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	75527634	111246239	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	75761024	109400896	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	81255292	109133904	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	83947714	111246239	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	84050550	111246239	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	84050550	111246239	Rat
1358354	Srcrt5	Stress Responsive Cort QTL 5	3.38		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	105348517	108369033	Rat

Genetic Models

This gene Gpr183 is modified in the following models/strains

SS-Gpr183^em3Mcwi

SS-Gpr183^em1Mcwi

SS-Gpr183^em2Mcwi

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	134
Interacting mature miRNAs:	146
Transcripts:	ENSRNOT00000034560
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		8		19					1	5	9
Low	1	33	25	17		17	8	11	60	34	26	2	8
Below cutoff		10	24	24		24			14		9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07072478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01085977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC129791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000034560 ⟹ ENSRNOP00000035137

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	108,364,701 - 108,376,221 (-)	Ensembl

RefSeq Acc Id:

NM_001109386 ⟹ NP_001102856

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	108,364,701 - 108,376,221 (-)	NCBI
Rnor_5.0	15	111,751,148 - 111,763,869 (-)	NCBI
RGSC_v3.4	15	107,056,367 - 107,067,887 (-)	RGD
Celera	15	97,811,478 - 97,823,000 (-)	RGD

Sequence:

show sequence

CAGTCTGGGCAAACACAGACGGCCACCTTGGAGGCTCTAGCCACCCTCTGATACTAACTCTGAC
CACTGCGGATACAGAAATGGCTAACAATTTTACTACACCACTGGCAGCTTCTCACGGCAATAAC
TGTGATCTCTATGCACACCACAGCACGGCCAGGATATTAATGCCTCTGCATTATAGCCTGGTCT
TCATCATTGGTCTGGTGGGAAACTTGTTGGCCTTAGTTGTCATTGTTCAAAATAGAAAAAAAAT
CAACTCAACCACTCTCTATTCAATGAACTTGGTGATTTCCGACATCCTGTTTACCACAGCTTTA
CCTACGCGGATAGTCTACTATGCCCTGGGTTTTGACTGGAGGATTGGTGATGCCCTGTGCCGGA
TAACTGCTCTGTTGTTCTACATCAACACGTATGCAGGTGTGAACTTCATGACTTGTTTGAGCAT
AGACCGATTCTTTGCCGTGGTGCACCCTCTGCGCTACAACAAGATTAAAAGAATTGAATATGCA
AAGGGCATTTGTGTATTTGTCTGGATTTTGGTGTTTGCTCAAACACTGCCACTGCTCCTCAAAC
CCATGTCTAAGCAGGAGGCAGACAAGACTACTTGCATGGAATATCCAAATTTTGAAGGGACAGC
ATCTCTCCCGTGGATTCTGCTCGGAGCCTGCCTGCTAGGCTACGTGCTGCCTCTTGCCATCATT
CTCCTGTGCTACTCTCAGATCTGCTGCAAACTCTTCAGGACTGCCAAGCAGAACCCACTGACCG
AGAAATCTGGTGTGAACAAAAAGGCTCTCAACACGATCATCCTCATCATCGGCGTGTTCGTCTT
GTGCTTCACGCCCTACCACGTGGCCATTATGCAGCACATGGTGAAGACTCTCTACGCCCCCGGA
GCCCTCGGCTGTGGGGTGAGACACTCCTTCCAGATCTCTCTGCACTTCACAGTGTGCCTGATGA
ACTTCAACTGCTGCATGGACCCTTTCATATACTTCTTTGCATGTAAAGGGTACAAGAGAAAGGT
CATGAAGATGCTCAAACGTCAAGTGAGCGTGTCAATCTCCAGTGCAGTGAGGTCAGCCCCTGAG
GAGAACTCACGGGAAATGACGGAGTCACAGATGATGATCCACTCCAAGGCCTCCAATGGGAGGT
AAAGGTGCTTGGGCCCTCACAGCACAGCAAGCTGCAGGGCAGGCGGGCTCTGCCTACCAACTGT
TCTGCTCCCAACCAGGATGCCTTCCAGTTGTCCTCTCTGGGCAGGACTACCCACTGCCACCTCA
CCAGCCAGCGCACTGACATCCAGACCAGACCAAGGAAACAGCAAAAGCAAGTTCTACTTCATAA
ATGAAACAGAATATACAAAGGAAGGCTATCGTAATACGTCTCCATGTAAAAAGAAATGCTGTGT
GAAATTACCATTTCTTGCCAATAGCGTGGCAAAAGAAAGAAGACTGATTGCACTGTATATATTG
CCAGTGTAAAAATGTTAATACTCTAATATATGTAACATATTTCCTAATTTACACCTTTCACTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102856	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4A7K7	(Get FASTA)	NCBI Sequence Viewer
	EDM02572	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102856 ⟸ NM_001109386

- UniProtKB:

D4A7K7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MANNFTTPLAASHGNNCDLYAHHSTARILMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTL
YSMNLVISDILFTTALPTRIVYYALGFDWRIGDALCRITALLFYINTYAGVNFMTCLSIDRFFA
VVHPLRYNKIKRIEYAKGICVFVWILVFAQTLPLLLKPMSKQEADKTTCMEYPNFEGTASLPWI
LLGACLLGYVLPLAIILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIGVFVLCFTPY
HVAIMQHMVKTLYAPGALGCGVRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLK
RQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR

hide sequence

RefSeq Acc Id:

ENSRNOP00000035137 ⟸ ENSRNOT00000034560

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699881

Promoter ID:

EPDNEW_R10405

Type:

multiple initiation site

Name:

Gpr183_1

Description:

G protein-coupled receptor 183

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	108,376,220 - 108,376,280	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1598095	AgrOrtholog
Ensembl Genes	ENSRNOG00000025094	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000035137	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000034560	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	rno:679975	UniProtKB/Swiss-Prot
NCBI Gene	679975	ENTREZGENE
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	Gpr183	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
UniGene	Rn.179130	ENTREZGENE
UniProt	D4A7K7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-08-27	Gpr183	G protein-coupled receptor 183	Ebi2	Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Ebi2	Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)	LOC679975	similar to EBV-induced G-protein coupled receptor 2 (EBI2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC679975	similar to EBV-induced G-protein coupled receptor 2 (EBI2)	LOC686966	similar to EBV-induced G-protein coupled receptor 2 (EBI2)	Data Merged	1643240	APPROVED
2006-11-20	LOC679975	similar to EBV-induced G-protein coupled receptor 2 (EBI2)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC686966	similar to EBV-induced G-protein coupled receptor 2 (EBI2)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD