Gpr183 (G protein-coupled receptor 183) - Rat Genome Database

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Gene: Gpr183 (G protein-coupled receptor 183) Rattus norvegicus
Analyze
Symbol: Gpr183
Name: G protein-coupled receptor 183
RGD ID: 1598095
Description: Predicted to enable G protein-coupled receptor activity and oxysterol binding activity. Predicted to be involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Predicted to be located in plasma membrane. Orthologous to human GPR183 (G protein-coupled receptor 183); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ebi2; EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); epstein-Barr virus-induced G-protein coupled receptor 2; G-protein coupled receptor 183; LOC679975; similar to EBV-induced G-protein coupled receptor 2 (EBI2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Gpr183em2Mcwi   Gpr183em1Mcwi   Gpr183em3Mcwi  
Genetic Models: SS-Gpr183em3Mcwi SS-Gpr183em1Mcwi SS-Gpr183em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21599,037,764 - 99,050,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,036,367 - 99,050,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15102,972,724 - 102,984,243 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015104,064,748 - 104,076,273 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.015100,992,568 - 101,004,093 (-)NCBIRnor_WKY
Rnor_6.015108,364,701 - 108,376,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,364,701 - 108,376,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015111,751,148 - 111,763,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,056,367 - 107,067,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1597,811,478 - 97,823,000 (-)NCBICelera
Cytogenetic Map15q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
albendazole  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
fulvestrant  (ISO)
furan  (EXP)
HC toxin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pioglitazone  (ISO)
rac-lactic acid  (ISO)
rosuvastatin calcium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tacedinaline  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:18628402   PMID:19597478   PMID:21673108   PMID:21796211   PMID:21796212   PMID:22875855   PMID:22930711   PMID:23502855   PMID:23682316   PMID:24678947   PMID:25297897   PMID:25348153  
PMID:26438360   PMID:27147029  


Genomics

Comparative Map Data
Gpr183
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21599,037,764 - 99,050,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,036,367 - 99,050,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15102,972,724 - 102,984,243 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015104,064,748 - 104,076,273 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.015100,992,568 - 101,004,093 (-)NCBIRnor_WKY
Rnor_6.015108,364,701 - 108,376,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,364,701 - 108,376,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015111,751,148 - 111,763,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,056,367 - 107,067,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1597,811,478 - 97,823,000 (-)NCBICelera
Cytogenetic Map15q25NCBI
GPR183
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381399,294,539 - 99,307,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1399,294,539 - 99,307,399 (-)EnsemblGRCh38hg38GRCh38
GRCh371399,946,793 - 99,959,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361398,744,790 - 98,757,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341398,744,790 - 98,757,695NCBI
Celera1380,790,353 - 80,803,314 (-)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1380,541,169 - 80,554,130 (-)NCBIHuRef
CHM1_11399,916,965 - 99,929,926 (-)NCBICHM1_1
T2T-CHM13v2.01398,504,775 - 98,517,640 (-)NCBIT2T-CHM13v2.0
Gpr183
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,189,743 - 122,202,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14122,189,963 - 122,202,607 (-)EnsemblGRCm39 Ensembl
GRCm3814121,952,331 - 121,965,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14121,952,551 - 121,965,195 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714122,351,553 - 122,364,415 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614121,087,511 - 121,100,373 (-)NCBIMGSCv36mm8
Celera14120,513,847 - 120,526,678 (-)NCBICelera
Cytogenetic Map14E5NCBI
Gpr183
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540411,264,954 - 11,277,531 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540411,264,954 - 11,277,531 (+)NCBIChiLan1.0ChiLan1.0
GPR183
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11399,600,695 - 99,613,671 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1399,601,220 - 99,602,305 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01380,461,908 - 80,475,046 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPR183
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,332,665 - 49,347,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2249,333,188 - 49,347,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2249,113,865 - 49,128,934 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02249,773,993 - 49,789,040 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2249,774,006 - 49,789,026 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12249,425,293 - 49,440,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02249,459,634 - 49,474,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02249,495,775 - 49,510,831 (-)NCBIUU_Cfam_GSD_1.0
Gpr183
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945184,753,026 - 184,765,923 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647211,186,267 - 11,198,832 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647211,196,567 - 11,198,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR183
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,231,224 - 68,245,751 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11168,231,851 - 68,248,627 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,527,987 - 75,529,869 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR183
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1377,952,689 - 77,966,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl377,953,212 - 77,954,297 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604634,448,232 - 34,461,198 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gpr183
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:134
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000034560
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)159815000199043291Rat

Markers in Region
D15Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21599,043,148 - 99,043,291 (+)MAPPERmRatBN7.2
Rnor_6.015108,368,891 - 108,369,033NCBIRnor6.0
Rnor_5.015111,756,447 - 111,756,589UniSTSRnor5.0
RGSC_v3.415107,060,557 - 107,060,699UniSTSRGSC3.4
RGSC_v3.415107,060,381 - 107,060,711RGDRGSC3.4
RGSC_v3.115107,076,337 - 107,076,479RGD
Celera1597,815,670 - 97,815,812UniSTS
RH 3.4 Map15706.5RGD
RH 3.4 Map15706.5UniSTS
RH 2.0 Map15609.8RGD
SHRSP x BN Map1566.4899RGD
FHH x ACI Map1574.04RGD
Cytogenetic Map15q25UniSTS


Genetic Models
This gene Gpr183 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 1 5 9
Low 1 33 25 17 17 8 11 60 34 26 2 8
Below cutoff 10 24 24 24 14 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034560   ⟹   ENSRNOP00000035137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1599,037,613 - 99,050,559 (-)Ensembl
Rnor_6.0 Ensembl15108,364,701 - 108,376,221 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098097   ⟹   ENSRNOP00000097517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1599,036,367 - 99,050,559 (-)Ensembl
RefSeq Acc Id: NM_001109386   ⟹   NP_001102856
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21599,038,959 - 99,050,479 (-)NCBI
Rnor_6.015108,364,701 - 108,376,221 (-)NCBI
Rnor_5.015111,751,148 - 111,763,869 (-)NCBI
RGSC_v3.415107,056,367 - 107,067,887 (-)RGD
Celera1597,811,478 - 97,823,000 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093645   ⟹   XP_038949573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21599,037,764 - 99,050,550 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102856 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A7K7 (Get FASTA)   NCBI Sequence Viewer  
  EDM02572 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102856   ⟸   NM_001109386
- UniProtKB: D4A7K7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035137   ⟸   ENSRNOT00000034560
RefSeq Acc Id: XP_038949573   ⟸   XM_039093645
- Peptide Label: isoform X1
- UniProtKB: D4A7K7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000097517   ⟸   ENSRNOT00000098097

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7K7-F1-model_v2 AlphaFold D4A7K7 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699881
Promoter ID:EPDNEW_R10405
Type:multiple initiation site
Name:Gpr183_1
Description:G protein-coupled receptor 183
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015108,376,220 - 108,376,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598095 AgrOrtholog
BioCyc Gene G2FUF-12364 BioCyc
Ensembl Genes ENSRNOG00000025094 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000035137 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000097517 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034560 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000098097 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:679975 UniProtKB/Swiss-Prot
NCBI Gene 679975 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr183 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt D4A7K7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-27 Gpr183  G protein-coupled receptor 183  Ebi2  Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ebi2  Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)  LOC679975  similar to EBV-induced G-protein coupled receptor 2 (EBI2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679975  similar to EBV-induced G-protein coupled receptor 2 (EBI2)  LOC686966  similar to EBV-induced G-protein coupled receptor 2 (EBI2)  Data Merged 1643240 APPROVED
2006-11-20 LOC679975  similar to EBV-induced G-protein coupled receptor 2 (EBI2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686966  similar to EBV-induced G-protein coupled receptor 2 (EBI2)      Symbol and Name status set to provisional 70820 PROVISIONAL