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Gene: Ptbp1 (polypyrimidine tract binding protein 1) Rattus norvegicus
Symbol: Ptbp1
Name: polypyrimidine tract binding protein 1
RGD ID: 62047
Description: Exhibits nucleic acid binding activity and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including mRNA metabolic process; positive regulation of cellular component organization; and posttranscriptional regulation of gene expression. Localizes to cytoplasm; neuron projection terminus; and nucleus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: heterogeneous nuclear ribonucleoprotein I; hnRNP I; polypyrimidine tract binding protein ; polypyrimidine tract-binding protein 1; Ptb; PTB1; Pybp; Pybp1; Pybp2; pyrimidine binding protein 1; pyrimidine binding protein 2; pyrimidine-binding protein
Homo sapiens (human) : PTBP1 (polypyrimidine tract binding protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Ptbp1 (polypyrimidine tract binding protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptbp1 (polypyrimidine tract binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTBP1 (polypyrimidine tract binding protein 1)
Canis lupus familiaris (dog) : PTBP1 (polypyrimidine tract binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptbp1 (polypyrimidine tract binding protein 1)
Sus scrofa (pig) : PTBP1 (polypyrimidine tract binding protein 1)
Chlorocebus sabaeus (African green monkey) : PTBP1 (polypyrimidine tract binding protein 1)
Heterocephalus glaber (naked mole-rat) : Ptbp1 (polypyrimidine tract binding protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0712,663,965 - 12,673,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,663,965 - 12,673,718 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,833,687 - 12,843,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,355,538 - 11,365,188 (-)NCBIRGSC3.4rn4RGSC3.4
Celera78,017,276 - 8,027,027 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptbp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62047
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.