Mcm5 (minichromosome maintenance complex component 5) - Rat Genome Database

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Gene: Mcm5 (minichromosome maintenance complex component 5) Rattus norvegicus
Analyze
Symbol: Mcm5
Name: minichromosome maintenance complex component 5
RGD ID: 1306616
Description: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA replication initiation; DNA unwinding involved in DNA replication; and double-strand break repair via break-induced replication. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA replication licensing factor MCM5; LOC291885; minichromosome maintenance deficient 5, cell division cycle 46; minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,488,813 - 13,510,131 (+)NCBIGRCr8
mRatBN7.21913,483,030 - 13,504,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,483,066 - 13,504,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,456,666 - 13,477,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,221,931 - 14,243,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,502,926 - 13,524,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,523,482 - 14,561,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,523,554 - 14,561,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,637,492 - 25,681,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,978,940 - 14,000,641 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,983,526 - 14,004,713 (+)NCBI
Celera1913,350,043 - 13,370,664 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (EXP,ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
glycidol  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
CMG complex  (ISO)
MCM complex  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations. Hicks SD, etal., BMC Neurosci. 2012 Oct 25;13:128. doi: 10.1186/1471-2202-13-128.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17296731   PMID:19135898   PMID:19946888   PMID:24625528   PMID:31505169  


Genomics

Comparative Map Data
Mcm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,488,813 - 13,510,131 (+)NCBIGRCr8
mRatBN7.21913,483,030 - 13,504,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,483,066 - 13,504,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,456,666 - 13,477,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,221,931 - 14,243,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,502,926 - 13,524,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,523,482 - 14,561,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,523,554 - 14,561,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,637,492 - 25,681,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,978,940 - 14,000,641 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,983,526 - 14,004,713 (+)NCBI
Celera1913,350,043 - 13,370,664 (+)NCBICelera
Cytogenetic Map19p11NCBI
MCM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,400,140 - 35,455,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,400,134 - 35,425,431 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,796,133 - 35,821,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,126,116 - 34,150,495 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,120,681 - 34,145,048NCBI
Celera2219,598,790 - 19,623,167 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,756,625 - 18,781,112 (+)NCBIHuRef
CHM1_12235,754,846 - 35,779,234 (+)NCBICHM1_1
T2T-CHM13v2.02235,858,159 - 35,913,280 (+)NCBIT2T-CHM13v2.0
Mcm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,836,096 - 75,855,067 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,836,197 - 75,855,067 (+)EnsemblGRCm39 Ensembl
GRCm38875,109,468 - 75,128,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,109,569 - 75,128,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,633,427 - 77,652,338 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36878,005,696 - 78,023,760 (+)NCBIMGSCv36mm8
Celera879,419,119 - 79,438,025 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
Mcm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,132,204 - 43,145,699 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,132,815 - 43,145,699 (+)NCBIChiLan1.0ChiLan1.0
MCM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,340,428 - 45,365,819 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,037,049 - 48,062,429 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,407,145 - 16,431,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,249,831 - 34,274,423 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,249,831 - 34,274,423 (+)Ensemblpanpan1.1panPan2
MCM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,721,421 - 28,738,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,721,660 - 28,738,390 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,660,694 - 28,680,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,507,387 - 29,528,103 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,507,389 - 29,528,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,232,624 - 29,252,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,541,774 - 29,562,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,722,609 - 29,742,263 (-)NCBIUU_Cfam_GSD_1.0
Mcm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,006,530 - 12,028,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,016,323 - 5,038,526 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,016,948 - 5,038,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM5
(Sus scrofa - pig)		 No map positions available.
MCM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,164,743 - 18,189,223 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,164,879 - 18,189,284 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,760,570 - 107,785,009 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750327,304 - 341,325 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750327,444 - 340,790 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcm5
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:121
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000064731
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat

Markers in Region
Mcmd5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,496,258 - 13,496,730 (+)MAPPERmRatBN7.2
Rnor_6.01914,553,151 - 14,553,622NCBIRnor6.0
Rnor_5.01925,674,236 - 25,674,707UniSTSRnor5.0
RGSC_v3.41913,992,585 - 13,993,056UniSTSRGSC3.4
Celera1913,363,065 - 13,363,536UniSTS
Cytogenetic Map19p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064731   ⟹   ENSRNOP00000062524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,483,066 - 13,504,389 (+)Ensembl
Rnor_6.0 Ensembl1914,523,570 - 14,560,830 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084271   ⟹   ENSRNOP00000070472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,483,066 - 13,504,389 (+)Ensembl
Rnor_6.0 Ensembl1914,523,554 - 14,561,278 (+)Ensembl
RefSeq Acc Id: NM_001399204   ⟹   NP_001386133
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,488,813 - 13,510,131 (+)NCBI
mRatBN7.21913,483,068 - 13,504,389 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386133 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66442 (Get FASTA)   NCBI Sequence Viewer  
  EDL87377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062524.3
  ENSRNOP00000070472.2
Ensembl Acc Id: ENSRNOP00000070472   ⟸   ENSRNOT00000084271
Ensembl Acc Id: ENSRNOP00000062524   ⟸   ENSRNOT00000064731
RefSeq Acc Id: NP_001386133   ⟸   NM_001399204
- UniProtKB: A0A0G2JY07 (UniProtKB/TrEMBL),   B2GUX3 (UniProtKB/TrEMBL)
Protein Domains
MCM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JY07-F1-model_v2 AlphaFold A0A0G2JY07 1-734 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700964
Promoter ID:EPDNEW_R11485
Type:initiation region
Name:Mcm5_1
Description:minichromosome maintenance complex component 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01914,523,515 - 14,523,575EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306616 AgrOrtholog
BioCyc Gene G2FUF-6419 BioCyc
Ensembl Genes ENSRNOG00000014336 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064731.3 UniProtKB/TrEMBL
  ENSRNOT00000084271.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  mini-chromosome maintenance (MCM) complex, chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8362933 IMAGE-MGC_LOAD
InterPro MCM UniProtKB/TrEMBL
  MCM5_C UniProtKB/TrEMBL
  MCM_5 UniProtKB/TrEMBL
  MCM_CS UniProtKB/TrEMBL
  MCM_DNA-dep_ATPase UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
MGC_CLONE MGC:187582 IMAGE-MGC_LOAD
NCBI Gene 291885 ENTREZGENE
PANTHER DNA REPLICATION LICENSING FACTOR MCM5 UniProtKB/TrEMBL
  PTHR11630 UniProtKB/TrEMBL
Pfam MCM UniProtKB/TrEMBL
  MCM5_C UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PhenoGen Mcm5 PhenoGen
PRINTS MCMFAMILY UniProtKB/TrEMBL
  MCMPROTEIN5 UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/TrEMBL
  MCM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014336 RatGTEx
SMART MCM UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JY07 ENTREZGENE
  B2GUX3 ENTREZGENE, UniProtKB/TrEMBL
  E9PTS4_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2JY07 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Mcm5  minichromosome maintenance complex component 5  Mcm5  minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mcm5  minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)   Mcm5_predicted  minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mcm5_predicted  minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED