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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2072
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr2
Name: angiotensin II receptor, type 2
Acc ID: CHEBI:147302
Term: CGP-42112A
Definition: A hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist.
Chemical ID: MESH:C060894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr2multiple interactionsEXP 6480464CTD[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of and results in increased secretion of Triglycerides [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of Fatty Acids Nonesterified CGP 42112A binds to and results in increased activity of AGTR2 protein

PMID:16003179 PMID:19151255
Agtr2multiple interactionsISORGD:101266480464CTDCGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein] CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]] PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]] PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]

PMID:25446015
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