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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:8927
Term: S-(2,4-dinitrophenyl)glutathione
Definition: A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,4-dinitrophenyl group.
Chemical ID: MESH:C030190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects transportEXP 6480464CTDABCC2 protein affects the transport of S-2 4-dinitrophenylglutathione

PMID:15652244 PMID:15901347 PMID:9430713
Abcc2increases exportEXP 6480464CTDABCC2 protein results in increased export of S-2 4-dinitrophenylglutathione

PMID:19067394
Abcc2increases transportEXP 6480464CTDABCC2 protein results in increased transport of S-2 4-dinitrophenylglutathione

PMID:15276087 PMID:9067317
Abcc2multiple interactionsEXP 6480464CTD[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-2 4-dinitrophenylglutathione] [Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-2 4-dinitrophenylglutathione] [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-2 4-dinitrophenylglutathione [sulfanitran results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-2 4-dinitrophenylglutathione] Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-2 4-dinitrophenylglutathione] S-2 4-dinitrophenylglutathione inhibits the reaction [ABCC2 protein results in increased transport of temocaprilat] temocaprilat inhibits the reaction [ABCC2 protein results in increased transport of S-2 4-dinitrophenylglutathione] Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-2 4-dinitrophenylglutathione]

PMID:15276087 PMID:19067394 PMID:19766108 PMID:19782883 PMID:9067317
Abcc2affects transportISORGD:6195696480464CTDABCC2 protein affects the transport of S-2 4-dinitrophenylglutathione

PMID:15846474 PMID:9525973
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