Stc1 (stanniocalcin 1) - Rat Genome Database

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Gene: Stc1 (stanniocalcin 1) Rattus norvegicus
Analyze
Symbol: Stc1
Name: stanniocalcin 1
RGD ID: 621776
Description: Predicted to enable identical protein binding activity. Involved in several processes, including cellular response to cAMP; decidualization; and embryo implantation. Located in apical plasma membrane. Orthologous to human STC1 (stanniocalcin 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: stanniocalcin; stanniocalcin-1; STC-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Stc1em2Mcwi  
Genetic Models: SS-Stc1em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81550,709,439 - 50,720,093 (+)NCBIGRCr8
mRatBN7.21544,299,591 - 44,311,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,299,621 - 44,310,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,417,544 - 48,428,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,529,038 - 49,539,692 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,388,378 - 46,399,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01550,891,137 - 50,901,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1550,891,127 - 50,903,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01554,622,230 - 54,632,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,566,885 - 49,577,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11549,582,664 - 49,593,308 (+)NCBI
Celera1543,995,170 - 44,005,824 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fipronil  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (EXP)
glycidol  (EXP)
glycitein  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
hexamethylene diisocyanate  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
pepstatin A  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phosphonoformic acid  (EXP)
pirinixic acid  (EXP)
Platyphylline  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Ito D, etal., Mol Cell Biol. 2004 Nov;24(21):9456-69.
4. Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Johnson KJ, etal., Biol Reprod. 2007 Dec;77(6):978-89. Epub 2007 Sep 19.
5. Effects of dexamethasone and dibutyryl cAMP on stanniocalcin-1 mRNA expression in rat primary Sertoli and Leydig cells. Li L and Wong CK, Mol Cell Endocrinol. 2008 Feb 13;283(1-2):96-103. Epub 2007 Dec 3.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Distribution of stanniocalcin 1 in rat kidney and its regulation by vitamin D3. Ookata K, etal., Exp Nephrol. 2001;9(6):428-35.
9. Ovarian stanniocalcin is structurally unique in mammals and its production and release are regulated through the luteinizing hormone receptor. Paciga M, etal., Endocrinology 2002 Oct;143(10):3925-34.
10. Distribution of stanniocalcin binding sites in the lamina terminalis of the rat. Ratkovic S, etal., Brain Res. 2008 Jul 7;1218:141-50. Epub 2008 May 3.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4
17. Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. Xiao LJ, etal., Reproduction. 2006 Jun;131(6):1137-49.
18. Stanniocalcin 1 stimulates osteoblast differentiation in rat calvaria cell cultures. Yoshiko Y, etal., Endocrinology 2003 Sep;144(9):4134-43.
Additional References at PubMed
PMID:8700837   PMID:11146507   PMID:12663264   PMID:14500721   PMID:14570698   PMID:15489334   PMID:16377640   PMID:17032941   PMID:19732741   PMID:20887770   PMID:21867741   PMID:21975601  
PMID:22343086   PMID:22933020   PMID:23877023   PMID:25251473   PMID:26187698   PMID:31314602   PMID:33025358  


Genomics

Comparative Map Data
Stc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81550,709,439 - 50,720,093 (+)NCBIGRCr8
mRatBN7.21544,299,591 - 44,311,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,299,621 - 44,310,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,417,544 - 48,428,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,529,038 - 49,539,692 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,388,378 - 46,399,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01550,891,137 - 50,901,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1550,891,127 - 50,903,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01554,622,230 - 54,632,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,566,885 - 49,577,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11549,582,664 - 49,593,308 (+)NCBI
Celera1543,995,170 - 44,005,824 (+)NCBICelera
Cytogenetic Map15p11NCBI
STC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,841,929 - 23,854,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,841,929 - 23,854,806 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,699,442 - 23,712,319 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,755,379 - 23,768,265 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,755,378 - 23,768,265NCBI
Celera822,662,875 - 22,675,765 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,244,578 - 22,257,479 (-)NCBIHuRef
CHM1_1823,901,587 - 23,914,473 (-)NCBICHM1_1
T2T-CHM13v2.0824,116,910 - 24,129,801 (-)NCBIT2T-CHM13v2.0
Stc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391469,266,738 - 69,278,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1469,266,687 - 69,279,253 (+)EnsemblGRCm39 Ensembl
GRCm381469,029,289 - 69,041,401 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,029,238 - 69,041,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv371469,647,346 - 69,659,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,982,568 - 67,994,944 (+)NCBIMGSCv36mm8
Celera1466,805,718 - 66,817,778 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1435.98NCBI
Stc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,969,677 - 46,982,191 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,969,837 - 46,982,075 (-)NCBIChiLan1.0ChiLan1.0
STC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,344,546 - 42,357,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,071,706 - 18,084,592 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,089,339 - 23,102,245 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,023,469 - 20,036,321 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,023,469 - 20,036,321 (-)Ensemblpanpan1.1panPan2
STC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12533,615,436 - 33,628,138 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2533,615,451 - 33,625,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2534,203,874 - 34,216,361 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02533,824,454 - 33,836,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,824,446 - 33,834,228 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,768,855 - 33,781,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02533,623,824 - 33,636,315 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,778,666 - 33,791,304 (+)NCBIUU_Cfam_GSD_1.0
Stc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494311,319,017 - 11,331,358 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,239,198 - 7,251,670 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,240,649 - 7,251,668 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl147,950,434 - 7,961,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1147,952,175 - 7,961,365 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,806,997 - 8,816,468 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,975,286 - 21,988,182 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,975,283 - 21,988,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605220,209,581 - 20,222,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,035,338 - 19,047,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475819,035,478 - 19,047,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stc1
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:111
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000020728
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
D15Got53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,299,307 - 44,299,450 (+)MAPPERmRatBN7.2
Rnor_6.01550,890,824 - 50,890,966NCBIRnor6.0
Rnor_5.01554,621,917 - 54,622,059UniSTSRnor5.0
RGSC_v3.41549,566,571 - 49,566,714RGDRGSC3.4
RGSC_v3.41549,566,572 - 49,566,714UniSTSRGSC3.4
RGSC_v3.11549,582,351 - 49,582,494RGD
Celera1543,994,857 - 43,994,999UniSTS
Cytogenetic Map15p11UniSTS
D15Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,299,601 - 44,299,870 (+)MAPPERmRatBN7.2
Rnor_6.01550,891,118 - 50,891,386NCBIRnor6.0
Rnor_5.01554,622,211 - 54,622,479UniSTSRnor5.0
RGSC_v3.41549,566,866 - 49,567,134UniSTSRGSC3.4
Celera1543,995,151 - 43,995,419UniSTS
Cytogenetic Map15p11UniSTS
D19Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,042 - 24,816,202 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,627 - 24,457,786NCBIRnor6.0
Rnor_5.01935,435,631 - 35,435,790UniSTSRnor5.0
RGSC_v3.41926,534,810 - 26,534,971UniSTSRGSC3.4
Celera1924,355,707 - 24,355,866UniSTS
Cytogenetic Map15p11UniSTS
Cytogenetic Map19p11-q11UniSTS


Genetic Models
This gene Stc1 is modified in the following models/strains:
SS-Stc1em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000020728   ⟹   ENSRNOP00000020728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,299,621 - 44,310,264 (+)Ensembl
Rnor_6.0 Ensembl1550,891,127 - 50,903,162 (+)Ensembl
RefSeq Acc Id: NM_031123   ⟹   NP_112385
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81550,709,439 - 50,720,093 (+)NCBI
mRatBN7.21544,299,621 - 44,310,275 (+)NCBI
Rnor_6.01550,891,137 - 50,901,791 (+)NCBI
Rnor_5.01554,622,230 - 54,632,884 (+)NCBI
RGSC_v3.41549,566,885 - 49,577,539 (+)RGD
Celera1543,995,170 - 44,005,824 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112385 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39541 (Get FASTA)   NCBI Sequence Viewer  
  AAC72393 (Get FASTA)   NCBI Sequence Viewer  
  AAH78803 (Get FASTA)   NCBI Sequence Viewer  
  EDM02180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020728.4
  ENSRNOP00055008977
  ENSRNOP00060013817
  ENSRNOP00065025570
GenBank Protein P97574 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112385   ⟸   NM_031123
- Peptide Label: precursor
- UniProtKB: P97574 (UniProtKB/Swiss-Prot),   A6HTG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020728   ⟸   ENSRNOT00000020728

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97574-F1-model_v2 AlphaFold P97574 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699795
Promoter ID:EPDNEW_R10317
Type:single initiation site
Name:Stc1_1
Description:stanniocalcin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01550,891,113 - 50,891,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621776 AgrOrtholog
BioCyc Gene G2FUF-13272 BioCyc
Ensembl Genes ENSRNOG00000015075 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055006923 UniProtKB/Swiss-Prot
  ENSRNOG00060010515 UniProtKB/Swiss-Prot
  ENSRNOG00065019059 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020728.6 UniProtKB/Swiss-Prot
  ENSRNOT00055011409 UniProtKB/Swiss-Prot
  ENSRNOT00060017776 UniProtKB/Swiss-Prot
  ENSRNOT00065032046 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7123665 IMAGE-MGC_LOAD
InterPro Stanniocalcin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93378 IMAGE-MGC_LOAD
NCBI Gene 81801 ENTREZGENE
PANTHER PTHR11245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STANNIOCALCIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Stanniocalcin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stc1 PhenoGen
RatGTEx ENSRNOG00000015075 RatGTEx
  ENSRNOG00055006923 RatGTEx
  ENSRNOG00060010515 RatGTEx
  ENSRNOG00065019059 RatGTEx
UniProt A6HTG7 ENTREZGENE, UniProtKB/TrEMBL
  P97574 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Stc1  stanniocalcin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Stc1  stanniocalcin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs forskolin significantly increased expression levels 628359
gene_expression highly expressed in ovary, in particular in androgen-producing thecal and interstitial cells with a 15-fold increase in expression found during pregnancy 628359
gene_process calcium and phosphate regulating hormone 628359
gene_process increases both sodium-dependent phosphate uptake and Pit1 gene expression in nodule formation stage fetal rat calvaria (RC) cell cultures 737672
gene_protein protein expressed in ovaries is larger than 50-kDa homodimer found in other tissues 628359
gene_regulation human chorioinc gonadotropin, independently and in combination with phosphodiesterase inhibitors enhanced expression levels while protein kinase A inhibitors decreased expression levels 628359