Anxrr23 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Anxrr23 (Anxiety related response QTL 23) Rattus norvegicus

Symbol: Anxrr23
Name: Anxiety related response QTL 23
RGD ID: 2306968
Trait: reflex trait   (VT:0001961)    
Measurement Type: amplitude of the acoustic startle response   (CMO:0001520)    
LOD Score: 4.83
P Value: Not Available
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,631,268 - 46,187,442RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01543,097,470 - 52,831,189RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01548,493,430 - 56,554,042RGDRnor5.0
RGSC_v3.41545,870,097 - 51,526,246RGDRGSC3.4
Cross Type: intercross
Strains Crossed: RLA/Verh RHA/Verh 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait
reflex trait  (IDA)

Rat Strain
RHA/Verh  (IEA)
RLA/Verh  (IEA)

References

References - curated
# Reference Title Reference Citation
1. A quantitative trait locus influencing anxiety in the laboratory rat. Fernandez-Teruel A, etal., Genome Res 2002 Apr;12(4):618-26.
2. Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension. Redina OE, etal., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502.
Related QTLs

Related QTL Description Reference
Srcrt8 maps to same region RGD:10053640


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
61809Gfra2GDNF family receptor alpha 2154594184146033715Rat
2607Fgf17fibroblast growth factor 17154571149845717622Rat
2720Gnrh1gonadotropin releasing hormone 1154197248241976690Rat
2545Egr3early growth response 3154515033545156052Rat
3666Sftpcsurfactant protein C154559656545599615Rat
620739Bmp1bone morphogenetic protein 1154555160345595862Rat
621458Neflneurofilament light chain154230192042305793Rat
621354Bnip3lBCL2 interacting protein 3 like154117459441197730Rat
621616Ppp3ccprotein phosphatase 3 catalytic subunit gamma154528991745362012Rat
620919Ppp2r2aprotein phosphatase 2, regulatory subunit B, alpha154120465941263924Rat
3160Nefmneurofilament medium chain154236044942365753Rat
621776Stc1stanniocalcin 1154429959144311695Rat
727820Adam28ADAM metallopeptidase domain 28154377446343840726Rat
2517Dpysl2dihydropyrimidinase-like 2154100555141111724Rat
620634HrHR, lysine demethylase and nuclear receptor corepressor154562683545646313Rat
2055Adra1aadrenoceptor alpha 1A154083012540935902Rat
62032Adam7ADAM metallopeptidase domain 7154283379642882201Rat
1306561Reep4receptor accessory protein 4154562031745623524Rat
1307026Slc39a14solute carrier family 39 member 14154537680645423549Rat
727816Npm2nucleophosmin/nucleoplasmin 2154572228245729336Rat
1309511Entpd4ectonucleoside triphosphate diphosphohydrolase 4154463087844658654Rat
1305369Nkx3-1NK3 homeobox 1154447385144476443Rat
1308435Loxl2lysyl oxidase-like 2154468344944773067Rat
1311003Cdca2cell division cycle associated 2154189594641942226Rat
1312010Kctd9potassium channel tetramerization domain containing 9154194216541969862Rat
1306872Dock5dedicator of cytokinesis 5154197972842158733Rat
1311079Lgi3leucine-rich repeat LGI family, member 3154560561145612739Rat
1310805Ebf2EBF transcription factor 2154143550941634403Rat
1359203Pdlim2PDZ and LIM domain 2154523542145250187Rat
1310928Xpo7exportin 7154574205345828050Rat
1359361Slc25a37solute carrier family 25 member 37154453428044576697Rat
1310966Dok2docking protein 2154582698445841409Rat
1309922Ccar2cell cycle and apoptosis regulator 2154521279745228001Rat
1309924Rhobtb2Rho-related BTB domain containing 2154486825144888436Rat
1305790Phyhipphytanoyl-CoA 2-hydroxylase interacting protein154553397445545223Rat
1311419Dmtndematin actin binding protein154567797445702261Rat
1308041Tnfrsf10bTNF receptor superfamily member 10b154484038644868318Rat
1306964Piwil2piwi-like RNA-mediated gene silencing 2154543140245498034Rat
1308253Bin3bridging integrator 3154517372545212607Rat
1309861Adamdec1ADAM-like, decysin 1154290062942921684Rat
1308779Chmp7charged multivesicular body protein 7154479098344806216Rat
1308870Fhip2bFHF complex subunit HOOK interacting protein 2B154565664145674603Rat
1307266Pnma2PNMA family member 2154111194241119649Rat
1306149Nkx2-6NK2 homeobox 6154444315144447248Rat
628900Sorbs3sorbin and SH3 domain containing 3154525292145284758Rat
1311816Polr3dRNA polymerase III subunit D154551158745516256Rat
1311790R3hcc1R3H domain and coiled-coil containing 1154477455244781864Rat
1311802Nudt18nudix hydrolase 18154565059745653985Rat
1308117C15h8orf58similar to human chromosome 8 open reading frame 58154522861545235274Rat
1586394Wdr82-ps3WD repeat domain 82, pseudogene 3154341167343412761Rat
1566135Rpl36-ps13ribosomal protein L36, pseudogene154186037541860709Rat
1566115Synbsyncytin b154458081844588417Rat
1590801Set-ps13Set nuclear proto-oncogene, pseudogene 13154457595444604828Rat
1593295Pebp4phosphatidylethanolamine binding protein 4154492094645134188Rat
1593230Rps17-ps4ribosomal protein S17, pseudogene 4154431935144319786Rat
1593231Septin2-ps1septin 2, pseudogene 1154376092743762362Rat
1593232Rrs1-ps13ribosome biogenesis regulator 1 homolog, pseudogene 13154372661343728908Rat
2323508Ube2v1l2ubiquitin conjugating enzyme E2 V1 like 2154313405843134595Rat
2323627Slc25a3-ps1solute carrier family 25 member 3, pseudogene 1154234483742346266Rat
2325539Mir320amicroRNA 320a154551639245516473Rat
2325104Brcc3-ps4BRCA1/BRCA2-containing complex, subunit 3, pseudogene 4154257266442573505Rat
6493460Wdr82-ps4WD repeat domain 82, pseudogene 4154336423643365095Rat
7527777LOC102555410uncharacterized LOC102555410154127338141280579Rat
7630497LOC102550955uncharacterized LOC102550955154490440444907623Rat
7555795Ssxbl1SSX family member B like 1154300099143049036Rat
7707332Rpl7a-ps3ribosomal protein L7a, pseudogene 3154407194944072745Rat
7726377LOC102550654disintegrin and metalloproteinase domain-containing protein 28-like154294109842996816Rat
9098115LOC103693653uncharacterized LOC103693653154197291341976552Rat
9259039LOC103693695uncharacterized LOC103693695154489190444896522Rat
41262530Trnap-agg23transfer RNA proline (anticodon AGG) 23154550234045502412Rat
41365565LOC12009699160S ribosomal protein L31-like154609440746097323Rat
41291261LOC120097030uncharacterized LOC120097030154553294545534370Rat
41400303Rps16-ps5ribosomal protein S16, pseudogene 5154228190142282434Rat
41166600LOC120097025uncharacterized LOC120097025154450623444512838Rat
40973991LOC120097024uncharacterized LOC120097024154266206242704954Rat
40950856LOC120097212small nucleolar RNA SNORA70154549140645491496Rat
41008930LOC120097231small nucleolar RNA SNORA17154178514241785272Rat
41152583LOC120097021uncharacterized LOC120097021154169126041695519Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10672D15Mgh12136154197160441971702Ratregion
11235D15Wox6154603246746032688Ratregion
34619D15Mgh11142154475939144759533Ratregion
36013D15Rat34162154585258545852747Ratregion
36293D15Rat35146154222207442222220Ratregion
37206D15Rat56101154418755044187649Ratregion
36880D15Rat15175154164721641647391Ratregion
37954D15Rat61134154411472844114864Ratregion
34910D15Rat14156154063126840631412Ratregion
35611D15Rat11131154618729146187442Ratregion
35661D15Rat33125154579421645794341Ratregion
39490D15Rat112143154461786244618004Ratregion
42012D15Arb6234154197156041971801Ratregion
42405D15Rat164202154240210642402305Ratregion
45267D15Got46266154128623041286492Ratregion
45268D15Got51225154063348740633712Ratregion
45270D15Got50252154088782040888072Ratregion
45271D15Got49159154108101141081170Ratregion
60101D15Got53148154429930744299450Ratregion
60102D15Got54281154417997244180253Ratregion
60103D15Got55208154445381444454022Ratregion
60104D15Got56254154479651144796765Ratregion
66640D15Mco5223154437024644370459Ratregion
67268D15Arb7219154475931244759531Ratregion
1631609D15Uwm1156154101087941011035Ratregion
1631895D15Got229141154533378745333928Ratregion
1640756D15Wox4202154475932944759531Ratregion
1635969D15Got109167154561881145618979Ratregion
1636394D15Wox14269154429960144299870Ratregion
7206382fj36f03.x10154514402945145335Ratregion
5036428Nfm221154236080742361028Ratregion
5031282PMC125376P1222154236045742360679Ratregion
5028627RH124140158154476667344767926Ratregion
5028709RH18022211154431133244311543Ratregion
5034331AI548197192154092297740923169Ratregion
5029327RH144377278154129981341300091Ratregion
5032231U58889111154525337745253488Ratregion
5029831BI278614169154555181745551986Ratregion
5032545WI-18898142154120478741204929Ratregion
5027477AW04987096154554489945544995Ratregion
5027641AU016692145154522895545229100Ratregion
5028165D14Mit157108154183391441834022Ratregion
5051949RH94752169154559795545598125Ratregion
5055155RH143637145154567612345676268Ratregion
5056663RH144508201154237062742370828Ratregion
5051947RH94751120154559678045596906Ratregion
5051951RH94753190154559863245598824Ratregion
5054515RH143269209154196843141968640Ratregion
5055559RH143871159154555613245556291Ratregion
5055585RH143886127154522887645229003Ratregion
5055059RH143582119154526435145264470Ratregion
5058682BI284489177154100639541006572Ratregion
505220328.MMHAP16FRB10.seq169154505471645054885Ratregion
5055689RH143945104154092692340927027Ratregion
5050862RH134301190154564601845646208Ratregion
5041896RH129121178154567797645678154Ratregion
5044420RH130592203154230681042307013Ratregion
5045150RH131013213154236726842367481Ratregion
5041822RH129078184154562329445623478Ratregion
5046276RH131659180154479107044791250Ratregion
5046408RH131735215154120323641203451Ratregion
5049272RH1333850154093563540935832Ratregion
5046658RH131880150154525292245253072Ratregion
5049174RH133328187154117665641176843Ratregion
5046804RH131964194154229628942296483Ratregion
5039682RH127846209154551167945511888Ratregion
5039942RH127996220154453434644534566Ratregion
5039956RH128005198154198001541980213Ratregion
5042266RH129335220154574211945742339Ratregion
5042380RH129401197154554501245545209Ratregion
5042662RH129569175154477464644774821Ratregion
5041282RH128767181154477280744772988Ratregion
5073994RH137758127154242137842421505Ratregion
5072380RH136815135154573933045739465Ratregion
5072450RH136856191154559668245596873Ratregion
5075908RH138866130154528409345284223Ratregion
5079414RH140982194154117467441174868Ratregion
5076896RH139441141154447558944475730Ratregion
5077844RH139992202154525125845251460Ratregion
5076454RH139185154154100591041006064Ratregion
5077606RH139853185154537699645377181Ratregion
5079016RH140685195154117648441176677Ratregion
5072956RH137151219154196943641969655Ratregion
5079356RH140947180154486801444868194Ratregion
5072058RH135440183154125114341251326Ratregion
5073498RH137471216154518451245184728Ratregion
5071564RH135155215154487037944870594Ratregion
5066710AU048196162154584509745845261Ratregion
5066880AU048096175154267167042671841Ratregion
5067000AU048025259154096399340964247Ratregion
5067144AU047935221154570251645702737Ratregion
5070023RH94423192154197379241973984Ratregion
5069258AU04661593154172195341722042Ratregion
5061100AW532315179154118357441183753Ratregion
5063090BF398353127154189540641895533Ratregion
5087444PMC179881P1499154431085244311351Ratregion
5088265AU048465101154145045041450551Ratregion
5088833AU048797243154233238742332630Ratregion
5081310RH142086196154486827744868473Ratregion
5085724BQ203388217154163263941632856Ratregion
5081130RH141982198154565270245652900Ratregion
5503216UniSTS:237223210154522869045228901Ratregion
5503400D17S1860655154513385945134514Ratregion
5503656Nefl440154230468642305660Ratregion
5503662UniSTS:465485335154236080442361139Ratregion
5504284D20S527E163154574212945742292Ratregion
5505083Sftpc113154559786645598233Ratregion
5505056Fgf17200154571207145712271Ratregion
5505302Ppp2r2a153154121088441211037Ratregion
5504879ha29890154482489344825977Ratregion
5506045UniSTS:498231402154163211341632515Ratregion
5501151PMC15073P3300154230464142305475Ratregion
5501025PMC123165P1506154083216240832668Ratregion
5501097PMC134715P392154163168541631777Ratregion
5501157PMC150908P476154083287840832954Ratregion
5501914MARC_17376-17377:1021902296:2116154574481745746323Ratregion
Position Markers

Flank 1: (D15Rat14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,631,268 - 40,631,412 (+)MAPPER
Rnor_6.01543,097,470 - 43,097,613NCBI
Rnor_5.01548,493,430 - 48,493,573UniSTS
RGSC_v3.41545,870,098 - 45,870,241UniSTS
RGSC_v3.41545,870,097 - 45,870,241RGD
RGSC_v3.11545,885,878 - 45,886,021RGD
Celera1540,303,246 - 40,303,389UniSTS
RH 3.4 Map15310.4RGD
RH 3.4 Map15310.4UniSTS
RH 2.0 Map15290.6RGD
SHRSP x BN Map1533.4699RGD
Peak: (D15Wox3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,353,977 - 40,354,096 (+)MAPPER
Rnor_6.01542,820,558 - 42,820,674NCBI
Rnor_5.01548,773,415 - 48,773,531UniSTS
RGSC_v3.41545,582,469 - 45,582,586RGD
RGSC_v3.41545,582,470 - 45,582,586UniSTS
RGSC_v3.11545,598,249 - 45,598,366RGD
Celera1540,027,310 - 40,027,432UniSTS
RH 2.0 Map15296.8RGD
Cytogenetic Map15p12UniSTS
Flank 2: (D15Rat11)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21546,187,291 - 46,187,442 (+)MAPPER
Rnor_6.01552,831,039 - 52,831,189NCBI
Rnor_5.01556,553,892 - 56,554,042UniSTS
RGSC_v3.41551,526,095 - 51,526,246RGD
RGSC_v3.41551,526,096 - 51,526,246UniSTS
RGSC_v3.11551,541,875 - 51,542,026RGD
Celera1545,863,184 - 45,863,334UniSTS
SHRSP x BN Map1533.4699UniSTS
SHRSP x BN Map1533.4699RGD
FHH x ACI Map1546.36RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general allele:RHA allele increases acoustic startle response and entries in the closed arm of the elevated plus maze 625384
qtl_general measurement method: rats were kept ina plexiglas sound-attenuated chamber lit by a bulb; after 5-min acclimatization, an acoustic stimuli of 110dB was given for 50 msec followed by startle-stimulus onset, mean startle response amplitude was calculated 625384
qtl_general software used:MAPMAKER-QTL 625384