Gene: Brd4 (bromodomain containing 4) Rattus norvegicus
Analyze
Symbol:
Brd4
Name:
bromodomain containing 4
RGD ID:
1307282
Description:
Predicted to have several functions, including P-TEFb complex binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin organization; positive regulation of cell cycle; and regulation of transcription, DNA-templated. Predicted to localize to condensed nuclear chromosome; cyclin/CDK positive transcription elongation factor complex; and nuclear chromatin. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
bromodomain-containing protein 4; LOC362844
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
BRD4 (bromodomain containing 4) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Brd4 (bromodomain containing 4) HGNC
Treefam, EggNOG, NCBI, OMA, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Brd4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
BRD4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
BRD4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Brd4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
BRD4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
BRD4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Brd4 (bromodomain containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
BRD4 (bromodomain containing 4)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Brd4 (bromodomain containing 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
brd4 (bromodomain containing 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|PANTHER|PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
BDF1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
bet-1
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|PhylomeDB)
Drosophila melanogaster (fruit fly):
fs(1)h
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 14,222,101 - 14,303,055 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 14,222,101 - 14,303,055 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 14,378,187 - 14,457,537 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 12,772,428 - 12,853,406 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 12,774,215 - 12,853,571 (-) NCBI Celera 7 9,328,703 - 9,362,558 (-) NCBI Celera Cytogenetic Map 7 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Dwarfism ISO RGD:1316385 8554872 ClinVar Annotator: match by term: Short stature ClinVar genetic disease ISO RGD:1316385 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10938129 more ... microcephaly ISO RGD:1316385 8554872 ClinVar Annotator: match by term: Microcephaly ClinVar
Imported Annotations - CTD
alopecia ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25242322 autosomal dominant polycystic kidney disease ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25877301 Chemical and Drug Induced Liver Injury ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25231249 Colonic Neoplasms ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26752646 Cornelia de Lange syndrome ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29379197 glioblastoma ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26455392 , PMID:27388964 Hyperplasia ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25242322 medulloblastoma ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24231268 osteosarcoma ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24646477 Prostatic Neoplasms ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24763052 pulmonary hypertension ISO RGD:1316385 11554173 CTD Direct Evidence: therapeutic CTD PMID:26224795 Thyroid Neoplasms ISO RGD:1316385 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26707881
1,2-dimethylhydrazine increases expression ISO RGD:1316386 6480464 1, 2-Dimethylhydrazine results in increased expression of BRD4 mRNA CTD PMID:22206623 10H-phenothiazine multiple interactions ISO RGD:1316385 6480464 phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein] CTD PMID:26735014 17beta-hydroxy-5alpha-androstan-3-one affects localization ISO RGD:1316385 6480464 Dihydrotestosterone affects the localization of BRD4 protein CTD PMID:24759320 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:1316385 6480464 (+)-JQ1 compound inhibits the reaction [Dihydrotestosterone affects the localization of BRD4 protein] CTD PMID:24759320 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316386 6480464 Tetrachlorodibenzodioxin affects the expression of BRD4 mRNA CTD PMID:21570461 , PMID:24680724 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1316386 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of BRD4 mRNA CTD PMID:20188158 4,4'-diaminodiphenylmethane increases expression ISO RGD:1316386 6480464 4, 4'-diaminodiphenylmethane results in increased expression of BRD4 mRNA CTD PMID:18648102 4,5,6,7-TETRABROMOBENZOTRIAZOLE multiple interactions ISO RGD:1316386 6480464 4 more ... CTD PMID:26301327 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1316385 6480464 BRD4 mutant form inhibits the reaction [6-chloro-2 more ... CTD PMID:26212199 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of BRD4 mRNA CTD PMID:24780913 acetazolamide increases expression ISO RGD:1316386 6480464 Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 acetylsalicylic acid increases expression ISO RGD:1316385 6480464 Aspirin results in increased expression of BRD4 mRNA CTD PMID:11906190 aflatoxin B1 increases methylation ISO RGD:1316385 6480464 Aflatoxin B1 results in increased methylation of BRD4 intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:1316385 6480464 aflatoxin B2 results in increased methylation of BRD4 intron CTD PMID:30157460 atrazine increases expression ISO RGD:1316385 6480464 Atrazine results in increased expression of BRD4 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression ISO RGD:1316386 6480464 Benzo(a)pyrene results in increased expression of BRD4 mRNA CTD PMID:22228805 benzo[a]pyrene decreases methylation ISO RGD:1316385 6480464 Benzo(a)pyrene results in decreased methylation of BRD4 5' UTR, Benzo(a)pyrene results in decreased methylation of BRD4 exon CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:1316385 6480464 Benzo(a)pyrene affects the methylation of BRD4 promoter CTD PMID:27901495 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of BRD4 mRNA CTD PMID:25181051 buta-1,3-diene decreases expression ISO RGD:1316386 6480464 1, 3-butadiene results in decreased expression of BRD4 mRNA CTD PMID:29038090 carfilzomib multiple interactions ISO RGD:1316385 6480464 carfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 ceruletide multiple interactions ISO RGD:1316386 6480464 (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein], [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein CTD PMID:26390243 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of BRD4 mRNA CTD PMID:23125180 cisplatin decreases expression ISO RGD:1316385 6480464 Cisplatin results in decreased expression of BRD4 mRNA CTD PMID:27392435 , PMID:27594783 cocaine multiple interactions ISO RGD:1316386 6480464 (+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]], Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter] CTD PMID:26558777 cocaine increases expression ISO RGD:1316386 6480464 Cocaine results in increased expression of BRD4 protein CTD PMID:26558777 cocaine increases expression EXP 6480464 Cocaine results in increased expression of BRD4 protein CTD PMID:26558777 cyclosporin A increases expression ISO RGD:1316385 6480464 Cyclosporine results in increased expression of BRD4 mRNA CTD PMID:25562108 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of BRD4 mRNA CTD PMID:23640034 dibenzo[a,l]pyrene increases expression ISO RGD:1316386 6480464 dibenzo(a, l)pyrene results in increased expression of BRD4 mRNA CTD PMID:25908611 dicrotophos increases expression ISO RGD:1316385 6480464 dicrotophos results in increased expression of BRD4 mRNA CTD PMID:28302478 dioxygen increases expression ISO RGD:1316386 6480464 Oxygen deficiency results in increased expression of BRD4 mRNA CTD PMID:24205000 dioxygen increases expression ISO RGD:1316385 6480464 Oxygen deficiency results in increased expression of BRD4 CTD PMID:27292261 dioxygen multiple interactions ISO RGD:1316385 6480464 Oxygen deficiency promotes the reaction [BRD4 protein binds to CA9 promoter], Oxygen deficiency promotes the reaction [BRD4 protein binds to VEGFA promoter] CTD PMID:27292261 diuron decreases expression EXP 6480464 Diuron results in decreased expression of BRD4 mRNA CTD PMID:25152437 dorsomorphin multiple interactions ISO RGD:1316385 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1316385 6480464 Doxorubicin results in decreased expression of BRD4 mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:1316385 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BRD4 protein CTD PMID:23301498 ethanol affects splicing ISO RGD:1316386 6480464 Ethanol affects the splicing of BRD4 mRNA CTD PMID:30319688 everolimus multiple interactions ISO RGD:1316385 6480464 [MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene] CTD PMID:25537515 flutamide increases expression EXP 6480464 Flutamide results in increased expression of BRD4 mRNA CTD PMID:20566332 folic acid decreases expression ISO RGD:1316385 6480464 Folic Acid results in decreased expression of BRD4 mRNA CTD PMID:21867686 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of BRD4 mRNA CTD PMID:22061828 glyphosate increases expression EXP 6480464 glyphosate results in increased expression of BRD4 mRNA CTD PMID:26302742 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of BRD4 gene CTD PMID:31011160 hydrogen peroxide multiple interactions ISO RGD:1316385 6480464 (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]] more ... CTD PMID:24759736 hypochlorous acid decreases expression ISO RGD:1316386 6480464 Hypochlorous Acid results in decreased expression of BRD4 mRNA CTD PMID:19376150 immunological adjuvant increases expression ISO RGD:1316386 6480464 Adjuvants, Immunologic results in increased expression of BRD4 mRNA CTD PMID:25656449 isoprenaline decreases expression ISO RGD:1316386 6480464 Isoproterenol results in decreased expression of BRD4 mRNA CTD PMID:20003209 leflunomide increases expression ISO RGD:1316385 6480464 leflunomide results in increased expression of BRD4 mRNA CTD PMID:28988120 lipopolysaccharide multiple interactions ISO RGD:1316386 6480464 GSK1210151A inhibits the reaction [[Lipopolysaccharides results in increased acetylation of RELA protein] which binds to BRD4 protein] CTD PMID:25778533 methylmercury chloride increases expression ISO RGD:1316385 6480464 methylmercuric chloride results in increased expression of BRD4 mRNA CTD PMID:23179753 , PMID:26272509 methylmercury chloride multiple interactions ISO RGD:1316385 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA CTD PMID:27188386 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1316385 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BRD4 mutant form affects the localization of RELA protein] CTD PMID:23686307 , PMID:26051217 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1316386 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]] CTD PMID:25877301 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of BRD4 mRNA CTD PMID:22124623 paracetamol decreases expression ISO RGD:1316385 6480464 Acetaminophen results in decreased expression of BRD4 mRNA CTD PMID:26690555 pentachlorophenol increases expression ISO RGD:1316386 6480464 Pentachlorophenol results in increased expression of BRD4 mRNA CTD PMID:23892564 perfluorooctanoic acid decreases expression ISO RGD:1316385 6480464 perfluorooctanoic acid results in decreased expression of BRD4 protein CTD PMID:26879310 phenylephrine multiple interactions EXP 6480464 Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter] CTD PMID:23939492 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of BRD4 protein CTD PMID:23939492 pirinixic acid increases expression ISO RGD:1316386 6480464 pirinixic acid results in increased expression of BRD4 mRNA CTD PMID:18445702 pomalidomide multiple interactions ISO RGD:1316385 6480464 pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 SB 431542 multiple interactions ISO RGD:1316385 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA CTD PMID:27188386 Soman increases expression EXP 6480464 Soman results in increased expression of BRD4 mRNA CTD PMID:19281266 sulindac decreases expression ISO RGD:1316385 6480464 Sulindac results in decreased expression of BRD4 mRNA CTD PMID:11906190 sunitinib increases expression ISO RGD:1316385 6480464 Sunitinib results in increased expression of BRD4 mRNA CTD PMID:31533062 troglitazone decreases expression ISO RGD:1316386 6480464 troglitazone results in decreased expression of BRD4 mRNA CTD PMID:28973697 tungsten decreases expression ISO RGD:1316386 6480464 Tungsten results in decreased expression of BRD4 mRNA CTD PMID:30912803 urethane increases expression ISO RGD:1316385 6480464 Urethane results in increased expression of BRD4 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1316386 6480464 Valproic Acid affects the expression of BRD4 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1316385 6480464 Valproic Acid results in increased expression of BRD4 mRNA CTD PMID:23179753 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of BRD4 mRNA CTD PMID:19015723 vorinostat decreases expression ISO RGD:1316385 6480464 vorinostat results in decreased expression of BRD4 mRNA CTD PMID:27188386
Biological Process cellular response to DNA damage stimulus ISO RGD:1316385 1624291 (PMID:23728299) RGD PMID:23728299 chromatin remodeling ISO RGD:1316385 1624291 (PMID:23728299) RGD PMID:23728299 chromosome segregation ISO RGD:1316386 1624291 (MGI:3654777, PMID:16339075) RGD MGI:3654777 , PMID:16339075 histone H3-K14 acetylation ISO RGD:1316386 1624291 (MGI:3654777, PMID:16339075) RGD MGI:3654777 , PMID:16339075 histone H4-K12 acetylation ISO RGD:1316386 1624291 (MGI:3654777, PMID:16339075) RGD MGI:3654777 , PMID:16339075 inner cell mass cell proliferation ISO RGD:1316386 1624291 MGI:2674141 (MGI:2179909 , PMID:11997514) RGD MGI:2179909 , PMID:11997514 negative regulation of DNA damage checkpoint ISO RGD:1316385 1624291 (PMID:23728299) RGD PMID:23728299 positive regulation of DNA binding ISO RGD:1316386 1624291 (MGI:3590381, PMID:16109376) RGD MGI:3590381 , PMID:16109376 positive regulation of G2/M transition of mitotic cell cycle ISO RGD:1316385 1624291 (PMID:10938129) RGD PMID:10938129 positive regulation of histone H3-K36 trimethylation ISO RGD:1316385 1624291 (PMID:21555454) RGD PMID:21555454 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1316385 1624291 (PMID:19103749) RGD PMID:19103749 positive regulation of transcription by RNA polymerase II ISO RGD:1316385 1624291 (PMID:23086925), (PMID:23317504), (PMID:24360279) RGD PMID:23086925 more ... positive regulation of transcription elongation from RNA polymerase II promoter ISO RGD:1316385 1624291 (PMID:18039861), (PMID:19103749), (PMID:23086925) RGD PMID:18039861 more ... positive regulation of transcription, DNA-templated ISO RGD:1316385 1624291 (PMID:21555454) RGD PMID:21555454 protein autophosphorylation ISO RGD:1316386 1624291 (MGI:5319557, PMID:22509028) RGD MGI:5319557 , PMID:22509028 protein phosphorylation ISO RGD:1316386 1624291 UniProtKB:O60563 more ... RGD MGI:3590381 , PMID:16109376 regulation of inflammatory response ISO RGD:1316385 1624291 (PMID:19103749) RGD PMID:19103749 regulation of phosphorylation of RNA polymerase II C-terminal domain ISO RGD:1316385 1624291 (PMID:23086925) RGD PMID:23086925 regulation of transcription involved in G1/S transition of mitotic cell cycle ISO RGD:1316385 1624291 (PMID:18039861) RGD PMID:18039861 Cellular Component chromatin ISO RGD:1316386 1624291 (MGI:3654777, PMID:16339075) RGD MGI:3654777 , PMID:16339075 chromosome ISO RGD:1316385 1624291 (PMID:23728299) RGD PMID:23728299 condensed nuclear chromosome ISO RGD:1316385 1624291 (PMID:10938129) RGD PMID:10938129 condensed nuclear chromosome ISO RGD:1316386 1624291 (MGI:1888422 more ... RGD MGI:1888422 more ... cyclin/CDK positive transcription elongation factor complex ISO RGD:1316386 1624291 (MGI:5500979, PMID:23752591) RGD MGI:5500979 , PMID:23752591 nucleolus NOT ISO RGD:1316386 1624291 (MGI:3590381, PMID:16109376) RGD MGI:3590381 , PMID:16109376 nucleoplasm ISO RGD:1316385 1624291 RGD GO_REF:0000052 nucleus ISO RGD:1316385 1624291 (PMID:20871596) RGD PMID:20871596 nucleus ISO RGD:1316386 1624291 (MGI:1888422 more ... RGD MGI:1888422 more ... Molecular Function chromatin binding ISO RGD:1316385 1624291 (PMID:20871596), (PMID:23086925), (PMID:23317504), (PMID:23728299) RGD PMID:20871596 more ... chromatin binding ISO RGD:1316386 1624291 (MGI:5461251 more ... RGD MGI:5461251 more ... DNA binding ISO RGD:1316386 1624291 (MGI:3590381, PMID:16109376) RGD MGI:3590381 , PMID:16109376 enzyme binding ISO RGD:1316385 1624291 UniProtKB:Q6NYC1 , UniProtKB:Q9BZ95 (PMID:21555454) RGD PMID:21555454 GTP-dependent protein kinase activity ISO RGD:1316386 1624291 (MGI:5319557, PMID:22509028) RGD MGI:5319557 , PMID:22509028 lysine-acetylated histone binding ISO RGD:1316385 1624291 (PMID:20871596), (PMID:23086925), (PMID:23317504), (PMID:23728299), (PMID:29176719) RGD PMID:20871596 more ... P-TEFb complex binding ISO RGD:1316385 1624291 (PMID:24360279) RGD PMID:24360279 p53 binding ISO RGD:1316385 1624291 (PMID:23317504) RGD PMID:23317504 protein binding ISO RGD:1316385 1624291 UniProtKB:O60563 more ... RGD PMID:17023018 more ... protein binding ISO RGD:1316386 1624291 PR:P15314 more ... RGD MGI:3590381 more ... RNA polymerase II C-terminal domain binding ISO RGD:1316385 1624291 (PMID:22509028) RGD PMID:22509028 RNA polymerase II C-terminal domain binding ISO RGD:1316386 1624291 PR:P08775 (MGI:5319557, PMID:22509028) RGD MGI:5319557 , PMID:22509028 RNA polymerase II CTD heptapeptide repeat kinase activity ISO RGD:1316385 1624291 (PMID:22509028) RGD PMID:22509028 RNA polymerase II CTD heptapeptide repeat kinase activity ISO RGD:1316386 1624291 (MGI:5319557, PMID:22509028) RGD MGI:5319557 , PMID:22509028 transcription coregulator activity ISO RGD:1316385 1624291 (PMID:24360279) RGD PMID:24360279
Gene-Chemical Interaction Annotations
