Brd4 (bromodomain containing 4) - Rat Genome Database

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Gene: Brd4 (bromodomain containing 4) Rattus norvegicus
Analyze
Symbol: Brd4
Name: bromodomain containing 4
RGD ID: 1307282
Description: Predicted to enable several functions, including P-TEFb complex binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation of T-helper 17 cell lineage commitment; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell proliferation; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in chromatin; condensed nuclear chromosome; and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bromodomain-containing protein 4; LOC362844
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,866,997 - 11,946,575 (-)NCBIGRCr8
mRatBN7.2711,216,446 - 11,296,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,216,446 - 11,295,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,035,041 - 14,114,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,912,454 - 15,992,035 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,783,992 - 13,863,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,222,101 - 14,303,055 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,222,101 - 14,303,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,378,187 - 14,457,537 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,772,428 - 12,853,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,774,215 - 12,853,571 (-)NCBI
Celera79,328,703 - 9,362,558 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
10H-phenothiazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ARV-825  (ISO)
atrazine  (ISO)
bellidifolin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carfilzomib  (ISO)
ceruletide  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
cocaine  (EXP,ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
everolimus  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
immunological adjuvant  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
ochratoxin A  (EXP)
olaparib  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pomalidomide  (ISO)
rucaparib  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer. Gao X, etal., Biochem Biophys Res Commun. 2016 Jan 15;469(3):679-85. doi: 10.1016/j.bbrc.2015.12.008. Epub 2015 Dec 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer. Rodriguez RM, etal., J Mol Med (Berl). 2012 May;90(5):587-95. doi: 10.1007/s00109-011-0837-0. Epub 2011 Nov 27.
6. The bromodomain: From epigenome reader to druggable target. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
7. BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Segura MF, etal., Cancer Res. 2013 Oct 15;73(20):6264-76. doi: 10.1158/0008-5472.CAN-13-0122-T. Epub 2013 Aug 15.
8. BET acetyl-lysine binding proteins control pathological cardiac hypertrophy. Spiltoir JI, etal., J Mol Cell Cardiol. 2013 Oct;63:175-9. doi: 10.1016/j.yjmcc.2013.07.017. Epub 2013 Aug 9.
9. Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis. Tang X, etal., Am J Pathol. 2013 Aug;183(2):470-9. doi: 10.1016/j.ajpath.2013.04.020. Epub 2013 Jun 10.
10. Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder. Yan Y, etal., Int J Clin Exp Pathol. 2014 Jun 15;7(7):4231-8. eCollection 2014.
11. Inhibited HDAC3 or Elevated MicroRNA-494-3p Plays a Protective Role in Myocardial Ischemia-Reperfusion Injury via Suppression of BRD4. Zheng W, etal., Mol Neurobiol. 2021 Sep;58(9):4268-4279. doi: 10.1007/s12035-021-02369-y. Epub 2021 May 12.
12. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Zuber J, etal., Nature. 2011 Aug 3;478(7370):524-8. doi: 10.1038/nature10334.
Additional References at PubMed
PMID:10938129   PMID:11997514   PMID:12477932   PMID:16109376   PMID:16339075   PMID:18039861   PMID:19103749   PMID:20871596   PMID:21555454   PMID:22509028   PMID:23086925   PMID:23154982  
PMID:23317504   PMID:23728299   PMID:23752591   PMID:24360279   PMID:28063381   PMID:29176719   PMID:29352508   PMID:30483785   PMID:30809946   PMID:31075399   PMID:31975410   PMID:32527308  
PMID:32596881   PMID:32812145   PMID:34974082   PMID:37423465   PMID:37485568   PMID:37669164   PMID:38381246   PMID:38432572  


Genomics

Comparative Map Data
Brd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,866,997 - 11,946,575 (-)NCBIGRCr8
mRatBN7.2711,216,446 - 11,296,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,216,446 - 11,295,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,035,041 - 14,114,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,912,454 - 15,992,035 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,783,992 - 13,863,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,222,101 - 14,303,055 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,222,101 - 14,303,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,378,187 - 14,457,537 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,772,428 - 12,853,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,774,215 - 12,853,571 (-)NCBI
Celera79,328,703 - 9,362,558 (-)NCBICelera
Cytogenetic Map7q11NCBI
BRD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,235,519 - 15,332,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,235,519 - 15,332,545 (-)EnsemblGRCh38hg38GRCh38
GRCh371915,346,330 - 15,443,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,209,301 - 15,252,262 (-)NCBINCBI36Build 36hg18NCBI36
Build 341915,209,300 - 15,252,262NCBI
Celera1915,243,961 - 15,286,908 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,916,406 - 14,959,159 (-)NCBIHuRef
CHM1_11915,347,786 - 15,390,760 (-)NCBICHM1_1
T2T-CHM13v2.01915,360,431 - 15,457,479 (-)NCBIT2T-CHM13v2.0
Brd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,415,246 - 32,503,717 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,415,248 - 32,503,696 (-)EnsemblGRCm39 Ensembl
GRCm381732,196,272 - 32,284,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,196,274 - 32,284,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv371732,333,219 - 32,421,068 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,924,979 - 32,013,849 (-)NCBIMGSCv36mm8
Celera1733,114,772 - 33,202,572 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.39NCBI
Brd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,957,510 - 7,988,498 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,959,033 - 7,989,216 (+)NCBIChiLan1.0ChiLan1.0
BRD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,150,386 - 20,248,121 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,151,881 - 19,250,932 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,768,239 - 14,805,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,752,096 - 15,789,630 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,754,930 - 15,789,600 (-)Ensemblpanpan1.1panPan2
BRD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,844,795 - 46,927,620 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,891,514 - 46,927,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,692,316 - 46,776,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,331,511 - 47,415,598 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,321,212 - 47,415,118 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,566,265 - 46,650,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,982,908 - 47,066,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,256,472 - 47,340,611 (+)NCBIUU_Cfam_GSD_1.0
Brd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,610,207 - 205,695,648 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,177,147 - 5,246,518 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,176,682 - 5,246,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,250,989 - 62,345,362 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,250,958 - 62,345,851 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,827,913 - 61,923,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,836,332 - 13,883,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,836,324 - 13,873,877 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,569,352 - 5,667,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,346,734 - 2,380,852 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,348,218 - 2,434,429 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brd4
348 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:723
Count of miRNA genes:288
Interacting mature miRNAs:368
Transcripts:ENSRNOT00000008963
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH130228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,294,767 - 11,294,977 (+)MAPPERmRatBN7.2
Rnor_6.0714,301,794 - 14,302,003NCBIRnor6.0
Rnor_5.0714,456,276 - 14,456,485UniSTSRnor5.0
RGSC_v3.4712,852,145 - 12,852,354UniSTSRGSC3.4
Celera79,406,530 - 9,406,739UniSTS
Cytogenetic Map7q11UniSTS
RH129167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,217,696 - 11,217,912 (+)MAPPERmRatBN7.2
Rnor_6.0714,223,352 - 14,223,567NCBIRnor6.0
Rnor_5.0714,379,438 - 14,379,653UniSTSRnor5.0
RGSC_v3.4712,773,679 - 12,773,894UniSTSRGSC3.4
Celera79,329,954 - 9,330,169UniSTS
RH 3.4 Map772.4UniSTS
Cytogenetic Map7q11UniSTS
BE112151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,297,378 - 11,297,536 (+)MAPPERmRatBN7.2
Rnor_6.0714,304,409 - 14,304,566NCBIRnor6.0
Rnor_5.0714,458,788 - 14,458,945UniSTSRnor5.0
RGSC_v3.4712,854,772 - 12,854,929UniSTSRGSC3.4
Celera79,408,790 - 9,408,947UniSTS
RH 3.4 Map768.5UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC091168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008963   ⟹   ENSRNOP00000008963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,216,446 - 11,250,576 (-)Ensembl
Rnor_6.0 Ensembl714,222,101 - 14,303,055 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091368   ⟹   ENSRNOP00000070799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,216,446 - 11,250,576 (-)Ensembl
Rnor_6.0 Ensembl714,222,149 - 14,302,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095545   ⟹   ENSRNOP00000078464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,227,208 - 11,295,539 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102732   ⟹   ENSRNOP00000076893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,216,446 - 11,250,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106678   ⟹   ENSRNOP00000084455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,216,446 - 11,250,576 (-)Ensembl
RefSeq Acc Id: NM_001100903   ⟹   NP_001094373
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,866,997 - 11,946,575 (-)NCBI
mRatBN7.2711,216,446 - 11,296,029 (-)NCBI
Rnor_6.0714,222,101 - 14,303,055 (-)NCBI
Rnor_5.0714,378,187 - 14,457,537 (-)NCBI
RGSC_v3.4712,772,428 - 12,853,406 (-)RGD
Celera79,328,703 - 9,362,558 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241072   ⟹   XP_006241134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,946,151 (-)NCBI
mRatBN7.2711,216,453 - 11,295,596 (-)NCBI
Rnor_6.0714,223,298 - 14,302,565 (-)NCBI
Rnor_5.0714,378,187 - 14,457,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241073   ⟹   XP_006241135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,945,991 (-)NCBI
mRatBN7.2711,216,453 - 11,295,387 (-)NCBI
Rnor_6.0714,222,105 - 14,302,539 (-)NCBI
Rnor_5.0714,378,187 - 14,457,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765171   ⟹   XP_008763393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,946,151 (-)NCBI
mRatBN7.2711,216,453 - 11,295,596 (-)NCBI
Rnor_6.0714,223,298 - 14,302,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594916   ⟹   XP_017450405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,946,151 (-)NCBI
mRatBN7.2711,216,453 - 11,295,596 (-)NCBI
Rnor_6.0714,223,298 - 14,302,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079415   ⟹   XP_038935343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,896,763 (-)NCBI
mRatBN7.2711,216,450 - 11,250,379 (-)NCBI
RefSeq Acc Id: XM_039079416   ⟹   XP_038935344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,877,646 - 11,946,149 (-)NCBI
mRatBN7.2711,227,095 - 11,295,596 (-)NCBI
RefSeq Acc Id: XM_063263751   ⟹   XP_063119821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,946,151 (-)NCBI
RefSeq Acc Id: XM_063263752   ⟹   XP_063119822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,868,196 - 11,937,957 (-)NCBI
RefSeq Acc Id: NP_001094373   ⟸   NM_001100903
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241134   ⟸   XM_006241072
- Peptide Label: isoform X1
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241135   ⟸   XM_006241073
- Peptide Label: isoform X1
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763393   ⟸   XM_008765171
- Peptide Label: isoform X2
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450405   ⟸   XM_017594916
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JYV0 (UniProtKB/TrEMBL),   D3ZGX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008963   ⟸   ENSRNOT00000008963
Ensembl Acc Id: ENSRNOP00000070799   ⟸   ENSRNOT00000091368
RefSeq Acc Id: XP_038935343   ⟸   XM_039079415
- Peptide Label: isoform X5
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935344   ⟸   XM_039079416
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZKZ4 (UniProtKB/TrEMBL),   A6K943 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084455   ⟸   ENSRNOT00000106678
Ensembl Acc Id: ENSRNOP00000076893   ⟸   ENSRNOT00000102732
Ensembl Acc Id: ENSRNOP00000078464   ⟸   ENSRNOT00000095545
RefSeq Acc Id: XP_063119821   ⟸   XM_063263751
- Peptide Label: isoform X4
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119822   ⟸   XM_063263752
- Peptide Label: isoform X1
- UniProtKB: D3ZGX8 (UniProtKB/TrEMBL)
Protein Domains
Bromo   NET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGX8-F1-model_v2 AlphaFold D3ZGX8 1-1403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695068
Promoter ID:EPDNEW_R5591
Type:multiple initiation site
Name:Brd4_1
Description:bromodomain containing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0714,302,565 - 14,302,625EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307282 AgrOrtholog
BioCyc Gene G2FUF-34830 BioCyc
Ensembl Genes ENSRNOG00000006770 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008963.8 UniProtKB/TrEMBL
  ENSRNOT00000091368.2 UniProtKB/TrEMBL
  ENSRNOT00000095545.1 UniProtKB/TrEMBL
  ENSRNOT00000102732.1 UniProtKB/TrEMBL
  ENSRNOT00000106678.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.220 UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930095 IMAGE-MGC_LOAD
InterPro BRD4_CDT UniProtKB/TrEMBL
  Bromo_Brdt_I UniProtKB/TrEMBL
  Bromo_Brdt_II UniProtKB/TrEMBL
  Bromo_chromatin_reader UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  NET_dom UniProtKB/TrEMBL
  NET_sf UniProtKB/TrEMBL
MGC_CLONE MGC:124872 IMAGE-MGC_LOAD
NCBI Gene 362844 ENTREZGENE
PANTHER BROMODOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS UniProtKB/TrEMBL
Pfam BET UniProtKB/TrEMBL
  BRD4_CDT UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
PhenoGen Brd4 PhenoGen
PRINTS BROMODOMAIN UniProtKB/TrEMBL
  PRICHEXTENSN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  NET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006770 RatGTEx
SMART BROMO UniProtKB/TrEMBL
Superfamily-SCOP Bromodomain UniProtKB/TrEMBL
UniProt A0A0G2JYV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y0G8_RAT UniProtKB/TrEMBL
  A0A8I5ZKZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A216_RAT UniProtKB/TrEMBL
  A6K942_RAT UniProtKB/TrEMBL
  A6K943 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGX8 ENTREZGENE, UniProtKB/TrEMBL
  Q497A6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Brd4  bromodomain containing 4  Brd4_predicted  bromodomain containing 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Brd4_predicted  bromodomain containing 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED