Uhrf1 (ubiquitin-like with PHD and ring finger domains 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Uhrf1 (ubiquitin-like with PHD and ring finger domains 1) Rattus norvegicus
Analyze
Symbol: Uhrf1
Name: ubiquitin-like with PHD and ring finger domains 1
RGD ID: 1595855
Description: Predicted to enable several functions, including DNA binding activity; histone H3K9me2/3 reader activity; and histone binding activity. Involved in response to peptide hormone. Predicted to be located in chromosome and nuclear matrix. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-121; E3 ubiquitin-protein ligase UHRF1; liver regeneration-related protein LRRG126; Np95; nuclear protein 95; RING-type E3 ubiquitin transferase UHRF1; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like, containing PHD and RING finger domains, 1 (mapped); ubiquitin-like-containing PHD and RING finger domains protein 1; Uhrf1_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,220,162 - 1,241,792 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,222,063 - 1,241,792 (+)EnsemblGRCr8
mRatBN7.291,133,117 - 1,154,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,580,592 - 1,600,307 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,928,574 - 6,948,303 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,885,636 - 5,905,351 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,738,211 - 10,758,403 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,738,222 - 10,757,954 (-)Ensemblrn6Rnor6.0
Rnor_5.099,729,983 - 9,750,175 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera97,356,596 - 7,375,693 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azoxystrobin  (ISO)
baicalin  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fructose  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hydroquinone  (ISO)
imiquimod  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
MeIQx  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
plumbagin  (ISO)
progesterone  (ISO)
propofol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO,ISS)
euchromatin  (IEA,ISO,ISS)
heterochromatin  (IEA,ISO,ISS)
nuclear matrix  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
replication fork  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal. Lee YJ, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F883-96. doi: 10.1152/ajprenal.00117.2011. Epub 2011 Jul 6.
4. Tudor: a versatile family of histone methylation 'readers'. Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10.
5. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. Walter A, etal., FASEB J. 2010 Sep;24(9):3360-9. doi: 10.1096/fj.09-149419. Epub 2010 May 4.
Additional References at PubMed
PMID:10646863   PMID:12477932   PMID:14993289   PMID:15361834   PMID:17065439   PMID:17673620   PMID:17967883   PMID:17994007   PMID:18692478   PMID:21029866   PMID:21489993   PMID:21745816  
PMID:21777816   PMID:22945642  


Genomics

Comparative Map Data
Uhrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,220,162 - 1,241,792 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,222,063 - 1,241,792 (+)EnsemblGRCr8
mRatBN7.291,133,117 - 1,154,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,580,592 - 1,600,307 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,928,574 - 6,948,303 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,885,636 - 5,905,351 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,738,211 - 10,758,403 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,738,222 - 10,757,954 (-)Ensemblrn6Rnor6.0
Rnor_5.099,729,983 - 9,750,175 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera97,356,596 - 7,375,693 (-)NCBICelera
Cytogenetic Map9q11NCBI
UHRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,903,080 - 4,962,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,903,080 - 4,962,154 (+)Ensemblhg38GRCh38
GRCh37194,903,092 - 4,962,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,860,510 - 4,913,165 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34194,861,813 - 4,913,162NCBI
Celera194,846,530 - 4,899,186 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,671,491 - 4,723,801 (+)NCBIHuRef
CHM1_1194,909,372 - 4,962,038 (+)NCBICHM1_1
T2T-CHM13v2.0194,888,314 - 4,947,375 (+)NCBIT2T-CHM13v2.0
Uhrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,610,405 - 56,630,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,610,321 - 56,630,486 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,303,337 - 56,323,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,303,321 - 56,323,486 (+)Ensemblmm10GRCm38
MGSCv371756,442,760 - 56,462,909 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361755,937,126 - 55,957,195 (+)NCBIMGSCv36mm8
Celera1760,657,174 - 60,672,221 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.26NCBI
Uhrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554954,153,898 - 4,154,611 (-)NCBIChiLan1.0ChiLan1.0
UHRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,302,493 - 9,355,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,531,805 - 8,584,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,926,583 - 3,979,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,872,753 - 4,925,330 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,872,753 - 4,925,330 (+)EnsemblpanPan2panpan1.1
UHRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,858,673 - 54,889,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,859,947 - 54,889,907 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2054,583,125 - 54,615,199 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02055,513,260 - 55,545,335 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,513,262 - 55,545,339 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,574,546 - 54,606,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,055,222 - 55,087,332 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,253,102 - 55,285,205 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Uhrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,944,645 - 214,972,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,862,367 - 2,888,946 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,863,651 - 2,890,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UHRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1273,898,061 - 73,937,727 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,678,503 - 74,712,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UHRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,592,362 - 4,642,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,592,919 - 4,642,445 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660813,489,316 - 3,544,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uhrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,898,677 - 4,929,872 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248284,898,786 - 4,929,136 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Uhrf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1487,693,066 - 87,712,181 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Uhrf1
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:125
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000075265
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
RH138759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,136,126 - 1,136,356 (-)MAPPERmRatBN7.2
Rnor_6.0910,756,493 - 10,756,722NCBIRnor6.0
Rnor_5.099,748,265 - 9,748,494UniSTSRnor5.0
Celera97,373,783 - 7,374,012UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 355 192 11 140 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075265   ⟹   ENSRNOP00000066794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,222,063 - 1,241,792 (+)Ensembl
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)Ensembl
Rnor_6.0 Ensembl910,739,309 - 10,757,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083848   ⟹   ENSRNOP00000070294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,222,307 - 1,241,790 (+)Ensembl
mRatBN7.2 Ensembl91,135,146 - 1,154,631 (+)Ensembl
Rnor_6.0 Ensembl910,738,222 - 10,757,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170673   ⟹   ENSRNOP00000109975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,223,368 - 1,241,783 (+)Ensembl
RefSeq Acc Id: NM_001393844   ⟹   NP_001380773
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,300 - 1,241,792 (+)NCBI
mRatBN7.291,135,146 - 1,154,639 (+)NCBI
RefSeq Acc Id: NM_001393845   ⟹   NP_001380774
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,223,186 - 1,241,792 (+)NCBI
mRatBN7.291,136,032 - 1,154,639 (+)NCBI
RefSeq Acc Id: NM_001393846   ⟹   NP_001380775
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,063 - 1,241,792 (+)NCBI
mRatBN7.291,134,909 - 1,154,639 (+)NCBI
RefSeq Acc Id: XM_039083462   ⟹   XP_038939390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,220,162 - 1,241,792 (+)NCBI
mRatBN7.291,133,117 - 1,154,639 (+)NCBI
RefSeq Acc Id: XM_063267061   ⟹   XP_063123131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,289 - 1,241,792 (+)NCBI
RefSeq Acc Id: XM_063267062   ⟹   XP_063123132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,223,195 - 1,241,792 (+)NCBI
Ensembl Acc Id: ENSRNOP00000066794   ⟸   ENSRNOT00000075265
Ensembl Acc Id: ENSRNOP00000070294   ⟸   ENSRNOT00000083848
RefSeq Acc Id: XP_038939390   ⟸   XM_039083462
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380775   ⟸   NM_001393846
- Peptide Label: isoform 2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380773   ⟸   NM_001393844
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380774   ⟸   NM_001393845
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123131   ⟸   XM_063267061
- Peptide Label: isoform X2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123132   ⟸   XM_063267062
- Peptide Label: isoform X2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot),   A0A0G2JT07 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109975   ⟸   ENSRNOT00000170673
Protein Domains
PHD-type   RING-type   Ubiquitin-like   YDG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPK1-F1-model_v2 AlphaFold Q7TPK1 1-774 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696466
Promoter ID:EPDNEW_R6986
Type:initiation region
Name:Uhrf1_1
Description:ubiquitin-like with PHD and ring finger domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,757,671 - 10,757,731EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595855 AgrOrtholog
BioCyc Gene G2FUF-28535 BioCyc
Ensembl Genes ENSRNOG00000048411 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000075265 ENTREZGENE
  ENSRNOT00000083848 ENTREZGENE
  ENSRNOT00000170673 ENTREZGENE
Gene3D-CATH 2.30.280.10 UniProtKB/Swiss-Prot
  2.30.30.1150 UniProtKB/Swiss-Prot
  2.30.30.140 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7388089 IMAGE-MGC_LOAD
InterPro PUA-like_sf UniProtKB/Swiss-Prot
  SRA-YDG_sf UniProtKB/Swiss-Prot
  SRA_YDG UniProtKB/Swiss-Prot
  TTD_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/Swiss-Prot
  Ubl_UHRF1 UniProtKB/Swiss-Prot
  UHRF1/2-like UniProtKB/Swiss-Prot
  Znf_FYVE_PHD UniProtKB/Swiss-Prot
  Znf_PHD UniProtKB/Swiss-Prot
  Znf_PHD-finger UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:116402 IMAGE-MGC_LOAD
NCBI Gene 316129 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UHRF1 UniProtKB/Swiss-Prot
  PTHR14140 UniProtKB/Swiss-Prot
Pfam PHD UniProtKB/Swiss-Prot
  SAD_SRA UniProtKB/Swiss-Prot
  TTD UniProtKB/Swiss-Prot
  ubiquitin UniProtKB/Swiss-Prot
PhenoGen Uhrf1 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/Swiss-Prot
  YDG UniProtKB/Swiss-Prot
  ZF_PHD_1 UniProtKB/Swiss-Prot
  ZF_PHD_2 UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000048411 RatGTEx
SMART PHD UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
  SRA UniProtKB/Swiss-Prot
  UBQ UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF57903 UniProtKB/Swiss-Prot
  SSF88697 UniProtKB/Swiss-Prot
UniProt A0A0G2JT07 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JXJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KQY6_RAT UniProtKB/TrEMBL
  A6KQY7_RAT UniProtKB/TrEMBL
  Q4FZR4 ENTREZGENE
  Q7TPK1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4FZR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Uhrf1  ubiquitin-like with PHD and ring finger domains 1  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   ubiquitin-like, containing PHD and RING finger domains, 1  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Name updated 737654 APPROVED
2007-04-11 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Uhrf1_mapped  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Data merged from RGD:3190 737654 APPROVED
2006-11-20 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Uhrf1_mapped  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Symbol and Name updated 1556543 APPROVED
2004-09-10 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Np95  nuclear protein 95  Symbol and Name updated 1299863 APPROVED
2002-06-10 Np95  Nuclear protein 95      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains RING finger associated domain 634611
gene_domains contains zinc finger domain 634611
gene_function possesses zinc chelating function 634611
gene_function involved in cell cycle progression and/or DNA replication 1302256