Kif1a (kinesin family member 1A) - Rat Genome Database

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Gene: Kif1a (kinesin family member 1A) Rattus norvegicus
Analyze
Symbol: Kif1a
Name: kinesin family member 1A
RGD ID: 1304996
Description: Enables identical protein binding activity and microtubule binding activity. Involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in several cellular components, including microtubule; neuronal cell body; and secretory vesicle. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A); INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: axonal transport of synaptic vesicles-like; kinesin-like protein KIF1A; LOC363288; neuron-specific kinesin motor KIF1A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,010,447 - 101,094,891 (-)NCBIGRCr8
mRatBN7.2993,563,033 - 93,647,412 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,563,045 - 93,647,480 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.09100,171,851 - 100,253,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,171,772 - 100,253,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,830,158 - 99,911,717 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,296,552 - 92,368,316 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,489,616 - 92,573,089 (-)NCBI
Celera991,101,708 - 91,183,111 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
choline  (ISO)
clofibrate  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glucose  (EXP)
L-methionine  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
p-chloromercuribenzoic acid  (ISO)
parathion  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
2. Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4. Bharat V, etal., Cell Rep. 2017 Nov 21;21(8):2118-2133. doi: 10.1016/j.celrep.2017.10.084.
3. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. Chung CY, etal., J Neurosci. 2009 Mar 18;29(11):3365-73. doi: 10.1523/JNEUROSCI.5427-08.2009.
4. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Erlich Y, etal., Genome Res. 2011 May;21(5):658-64. doi: 10.1101/gr.117143.110. Epub 2011 Apr 12.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
7. Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition. Hammond JW, etal., PLoS Biol. 2009 Mar 31;7(3):e72. doi: 10.1371/journal.pbio.1000072.
8. Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia. Iqbal Z, etal., PLoS One. 2017 Mar 31;12(3):e0174667. doi: 10.1371/journal.pone.0174667. eCollection 2017.
9. KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations. Klebe S, etal., Eur J Hum Genet. 2012 Jun;20(6):645-9. doi: 10.1038/ejhg.2011.261. Epub 2012 Jan 18.
10. Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons. Kramer T, etal., Cell Host Microbe. 2012 Dec 13;12(6):806-14. doi: 10.1016/j.chom.2012.10.013.
11. De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy. Lee JR, etal., Hum Mutat. 2015 Jan;36(1):69-78. doi: 10.1002/humu.22709. Epub 2014 Nov 27.
12. Proteomics of Orbital Tissue in Thyroid-Associated Orbitopathy. Matheis N, etal., J Clin Endocrinol Metab. 2015 Dec;100(12):E1523-30. doi: 10.1210/jc.2015-2976. Epub 2015 Oct 9.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. Rivière JB, etal., Am J Hum Genet. 2011 Aug 12;89(2):219-30. doi: 10.1016/j.ajhg.2011.06.013. Epub 2011 Aug 4.
18. Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha. Shin H, etal., J Biol Chem. 2003 Mar 28;278(13):11393-401. Epub 2003 Jan 8.
19. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, etal., Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.
20. Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Tsai JW, etal., Nat Neurosci. 2010 Dec;13(12):1463-71. doi: 10.1038/nn.2665. Epub 2010 Oct 31.
Additional References at PubMed
PMID:12435738   PMID:15014437   PMID:17360631   PMID:21256924   PMID:22863567   PMID:23527020   PMID:23804637   PMID:26758546   PMID:29698729   PMID:30612907   PMID:33082143   PMID:33496723  
PMID:34287616  


Genomics

Comparative Map Data
Kif1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,010,447 - 101,094,891 (-)NCBIGRCr8
mRatBN7.2993,563,033 - 93,647,412 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,563,045 - 93,647,480 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.09100,171,851 - 100,253,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,171,772 - 100,253,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,830,158 - 99,911,717 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,296,552 - 92,368,316 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,489,616 - 92,573,089 (-)NCBI
Celera991,101,708 - 91,183,111 (-)NCBICelera
Cytogenetic Map9q36NCBI
KIF1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,713,767 - 240,821,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,713,761 - 240,824,293 (-)EnsemblGRCh38hg38GRCh38
GRCh372241,653,184 - 241,760,820 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,301,857 - 241,408,297 (-)NCBINCBI36Build 36hg18NCBI36
Celera2235,326,008 - 235,411,535 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,412,721 - 233,497,777 (-)NCBIHuRef
CHM1_12241,659,240 - 241,765,801 (-)NCBICHM1_1
T2T-CHM13v2.02241,210,501 - 241,320,366 (-)NCBIT2T-CHM13v2.0
Kif1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,943,180 - 93,029,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl192,943,186 - 93,029,673 (-)EnsemblGRCm39 Ensembl
GRCm38193,015,455 - 93,102,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,015,464 - 93,101,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,912,033 - 94,998,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,848,684 - 94,932,228 (-)NCBIMGSCv36mm8
Celera195,964,533 - 96,050,948 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.74NCBI
Kif1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542756,835 - 832,889 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955542756,834 - 832,805 (+)NCBIChiLan1.0ChiLan1.0
KIF1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,398,896 - 143,508,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,413,861 - 143,523,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B127,969,494 - 128,078,282 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,774,669 - 246,883,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,778,679 - 246,860,326 (-)Ensemblpanpan1.1panPan2
KIF1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12550,855,703 - 50,945,014 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2550,858,698 - 50,944,964 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,072,045 - 51,136,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,053,878 - 51,118,327 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,050,905 - 51,139,895 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12550,894,784 - 50,959,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,641,341 - 50,705,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02550,917,144 - 50,981,524 (-)NCBIUU_Cfam_GSD_1.0
Kif1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,242,542 - 192,307,773 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745911,709 - 974,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745911,651 - 976,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,610,627 - 139,694,826 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,610,624 - 139,694,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,512,025 - 157,563,535 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110126,784,843 - 126,890,649 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10126,781,589 - 126,867,219 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604072,498,200 - 72,611,057 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248474,961,552 - 5,035,061 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248474,961,552 - 5,035,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif1a
326 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:70
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000036061, ENSRNOT00000050557, ENSRNOT00000052345, ENSRNOT00000075007
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat

Markers in Region
D9Got244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,638,332 - 93,638,454 (+)MAPPERmRatBN7.2
Rnor_6.09100,244,559 - 100,244,680NCBIRnor6.0
Rnor_5.0999,902,727 - 99,902,848UniSTSRnor5.0
Celera991,174,390 - 91,174,511UniSTS
Cytogenetic Map9q36UniSTS
D29951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,565,826 - 93,565,930 (+)MAPPERmRatBN7.2
Rnor_6.09100,172,039 - 100,172,142NCBIRnor6.0
Rnor_5.0999,830,209 - 99,830,312UniSTSRnor5.0
RGSC_v3.4992,289,079 - 92,289,182UniSTSRGSC3.4
Celera991,101,896 - 91,101,999UniSTS
Cytogenetic Map9q36UniSTS
RH125884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,627,752 - 93,628,063 (+)MAPPERmRatBN7.2
Rnor_6.09100,233,981 - 100,234,291NCBIRnor6.0
Rnor_5.0999,892,149 - 99,892,459UniSTSRnor5.0
RGSC_v3.4992,366,513 - 92,366,823UniSTSRGSC3.4
Celera991,163,814 - 91,164,124UniSTS
Cytogenetic Map9q36UniSTS
RH139334  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q36UniSTS
D29951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,565,839 - 93,565,950 (+)MAPPERmRatBN7.2
Rnor_6.09100,172,052 - 100,172,162NCBIRnor6.0
Rnor_5.0999,830,222 - 99,830,332UniSTSRnor5.0
RGSC_v3.4992,289,092 - 92,289,202UniSTSRGSC3.4
Celera991,101,909 - 91,102,019UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 81 80 49 25 49 6 208 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001070053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AM180765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000036061   ⟹   ENSRNOP00000038927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,563,045 - 93,647,480 (-)Ensembl
Rnor_6.0 Ensembl9100,171,772 - 100,253,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106149   ⟹   ENSRNOP00000080676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,563,045 - 93,647,480 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120091   ⟹   ENSRNOP00000087220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,563,045 - 93,647,480 (-)Ensembl
RefSeq Acc Id: NM_001408926   ⟹   NP_001395855
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,447 - 101,094,777 (-)NCBI
mRatBN7.2993,563,033 - 93,647,364 (-)NCBI
RefSeq Acc Id: XM_006245563   ⟹   XP_006245625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Rnor_5.0999,830,158 - 99,911,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596912   ⟹   XP_017452401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596913   ⟹   XP_017452402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596914   ⟹   XP_017452403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596915   ⟹   XP_017452404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596916   ⟹   XP_017452405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,411 (-)NCBI
Rnor_6.09100,171,851 - 100,253,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084750   ⟹   XP_038940678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_039084751   ⟹   XP_038940679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_039084752   ⟹   XP_038940680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_039084754   ⟹   XP_038940682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_039084755   ⟹   XP_038940683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_039084756   ⟹   XP_038940684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,094,891 (-)NCBI
mRatBN7.2993,563,033 - 93,647,412 (-)NCBI
RefSeq Acc Id: XM_063267470   ⟹   XP_063123540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,010,455 - 101,084,741 (-)NCBI
RefSeq Acc Id: XP_006245625   ⟸   XM_006245563
- Peptide Label: isoform X10
- UniProtKB: A0A8L2QJN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452405   ⟸   XM_017596916
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_017452404   ⟸   XM_017596915
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A6V5 (UniProtKB/TrEMBL),   A6JQX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452403   ⟸   XM_017596914
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017452402   ⟸   XM_017596913
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017452401   ⟸   XM_017596912
- Peptide Label: isoform X7
- UniProtKB: F1M4A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038927   ⟸   ENSRNOT00000036061
RefSeq Acc Id: XP_038940683   ⟸   XM_039084755
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038940684   ⟸   XM_039084756
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038940682   ⟸   XM_039084754
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038940680   ⟸   XM_039084752
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940679   ⟸   XM_039084751
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940678   ⟸   XM_039084750
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080676   ⟸   ENSRNOT00000106149
Ensembl Acc Id: ENSRNOP00000087220   ⟸   ENSRNOT00000120091
RefSeq Acc Id: NP_001395855   ⟸   NM_001408926
- UniProtKB: A0A8I5ZRB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123540   ⟸   XM_063267470
- Peptide Label: isoform X1
Protein Domains
FHA   Kinesin motor   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4A4-F1-model_v2 AlphaFold F1M4A4 1-1707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696880
Promoter ID:EPDNEW_R7395
Type:multiple initiation site
Name:Kif1a_1
Description:kinesin family member 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,253,589 - 100,253,649EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304996 AgrOrtholog
BioCyc Gene G2FUF-26658 BioCyc
Ensembl Genes ENSRNOG00000023993 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000036061 ENTREZGENE
  ENSRNOT00000106149 ENTREZGENE
  ENSRNOT00000120091 ENTREZGENE
  ENSRNOT00000138836 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.200.20 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.2520 UniProtKB/Swiss-Prot
InterPro FHA_dom UniProtKB/Swiss-Prot
  FHA_KIF1A UniProtKB/Swiss-Prot
  Kinesin-like UniProtKB/Swiss-Prot
  Kinesin-like_KIF1-typ UniProtKB/Swiss-Prot
  Kinesin_assoc UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_KIFIA_KIFIB UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 363288 ENTREZGENE
PANTHER KINESIN-LIKE PROTEIN KIF1A ISOFORM X1 UniProtKB/Swiss-Prot
  STAR-RELATED LIPID TRANSFER PROTEIN 9 UniProtKB/Swiss-Prot
Pfam DUF3694 UniProtKB/Swiss-Prot
  FHA UniProtKB/Swiss-Prot
  KIF1B UniProtKB/Swiss-Prot
  Kinesin UniProtKB/Swiss-Prot
  Kinesin_assoc UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
PhenoGen Kif1a PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE FHA_DOMAIN UniProtKB/Swiss-Prot
  KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023993 RatGTEx
SMART FHA UniProtKB/Swiss-Prot
  KISc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF49879 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZRB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QJN2 ENTREZGENE, UniProtKB/TrEMBL
  A6JQX4 ENTREZGENE, UniProtKB/TrEMBL
  F1M4A4 ENTREZGENE, UniProtKB/Swiss-Prot
  Q2P9S1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Kif1a  kinesin family member 1A  LOC100362984  axonal transport of synaptic vesicles-like  Data merged from RGD:2323710 1643240 APPROVED
2010-05-06 LOC100362984  axonal transport of synaptic vesicles-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Kif1a  kinesin family member 1A      Symbol and Name updated 1299863 APPROVED
2006-03-07 Kif1a  kinesin family member 1A  Kif1a_predicted  kinesin family member 1A (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Kif1a_predicted  kinesin family member 1A (predicted)      Symbol and Name status set to approved 70820 APPROVED