(S)-naringenin decreases activity EXP 6480464 naringenin results in decreased activity of TPO protein CTD PMID:26884060 1,3-benzothiazole-2-thiol multiple interactions ISO RGD:735786 6480464 captax binds to and results in decreased activity of TPO protein CTD PMID:26865668 1,3-benzothiazole-2-thiol decreases activity ISO RGD:735786 6480464 captax results in decreased activity of TPO protein CTD PMID:31629072 1,3-benzothiazole-2-thiol decreases activity EXP 6480464 captax results in decreased activity of TPO protein CTD PMID:23959146 more ... 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:735786 6480464 Dihydrotestosterone results in increased expression of TPO mRNA CTD PMID:15953861 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:26827900 2,4-Dihydroxybenzophenone decreases activity EXP 6480464 2, 4-dihydroxybenzophenone results in decreased activity of TPO protein CTD PMID:26884060 4,4'-diaminodiphenylmethane decreases activity EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased activity of TPO protein CTD PMID:26884060 4-Aminophenyl ether decreases activity EXP 6480464 di-(4-aminophenyl)ether results in decreased activity of TPO protein CTD PMID:26884060 5-azacytidine increases expression ISO RGD:735786 6480464 Azacitidine results in increased expression of TPO mRNA CTD PMID:17679169 6-propyl-2-thiouracil decreases expression ISO RGD:735786 6480464 Propylthiouracil results in decreased expression of TPO mRNA CTD PMID:22342233 6-propyl-2-thiouracil multiple interactions EXP 6480464 [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 6-propyl-2-thiouracil decreases activity EXP 6480464 Propylthiouracil results in decreased activity of TPO protein CTD PMID:22342233 more ... 6-propyl-2-thiouracil multiple interactions ISO RGD:735786 6480464 Propylthiouracil binds to and results in decreased activity of TPO protein CTD PMID:26865668 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TPO mRNA CTD PMID:22342233 6-propyl-2-thiouracil decreases activity ISO RGD:735786 6480464 Propylthiouracil results in decreased activity of TPO protein CTD PMID:22342233 , PMID:31629072 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of TPO mRNA CTD PMID:28959563 all-trans-retinoic acid increases expression ISO RGD:735786 6480464 Tretinoin results in increased expression of TPO mRNA CTD PMID:17679169 all-trans-retinoic acid affects expression ISO RGD:735786 6480464 Tretinoin affects the expression of TPO mRNA CTD PMID:31600526 amiodarone decreases expression ISO RGD:735786 6480464 Amiodarone results in decreased expression of TPO mRNA CTD PMID:18020914 amitrole decreases activity EXP 6480464 Amitrole results in decreased activity of TPO protein CTD PMID:20937625 amitrole decreases activity ISO RGD:735786 6480464 Amitrole results in decreased activity of TPO protein CTD PMID:31629072 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TPO mRNA CTD PMID:16483693 arsenous acid decreases activity ISO RGD:735786 6480464 Arsenic Trioxide results in decreased activity of TPO protein CTD PMID:25595679 arsenous acid multiple interactions ISO RGD:735786 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPO protein] more ... CTD PMID:25595679 , PMID:26598702 asbestos affects methylation ISO RGD:735786 6480464 Asbestos affects the methylation of TPO gene CTD PMID:28722770 bathocuproine disulfonic acid multiple interactions EXP 6480464 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] CTD PMID:11108245 benzo[a]pyrene increases activity ISO RGD:735786 6480464 Benzo(a)pyrene results in increased activity of TPO protein CTD PMID:21809831 benzo[a]pyrene affects methylation ISO RGD:735786 6480464 Benzo(a)pyrene affects the methylation of TPO promoter CTD PMID:27901495 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of TPO mRNA CTD PMID:21839799 , PMID:30085273 benzo[a]pyrene increases mutagenesis ISO RGD:735786 6480464 Benzo(a)pyrene results in increased mutagenesis of TPO gene CTD PMID:25435355 benzo[e]pyrene increases methylation ISO RGD:735786 6480464 benzo(e)pyrene results in increased methylation of TPO polyA tail CTD PMID:30157460 benzophenone decreases activity ISO RGD:735786 6480464 benzophenone results in decreased activity of TPO protein CTD PMID:21809831 bis(2-chloroethyl) sulfide increases expression ISO RGD:733214 6480464 Mustard Gas results in increased expression of TPO mRNA CTD PMID:15674843 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TPO mRNA CTD PMID:23238275 bisphenol A decreases methylation ISO RGD:735786 6480464 bisphenol A results in decreased methylation of TPO gene CTD PMID:31601247 bisphenol A multiple interactions ISO RGD:735786 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of TPO gene CTD PMID:31601247 bisphenol A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TPO mRNA] CTD PMID:30352396 bisphenol A decreases activity EXP 6480464 bisphenol A results in decreased activity of TPO protein CTD PMID:30352396 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TPO mRNA CTD PMID:25181051 more ... Butylparaben increases activity EXP 6480464 butylparaben results in increased activity of TPO protein CTD PMID:32798586 Butylparaben increases expression EXP 6480464 butylparaben results in increased expression of TPO mRNA CTD PMID:32798586 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of TPO mRNA CTD PMID:19167457 carbaryl increases activity ISO RGD:735786 6480464 Carbaryl results in increased activity of TPO protein CTD PMID:21809831 CGP 52608 multiple interactions ISO RGD:735786 6480464 CGP 52608 promotes the reaction [RORA protein binds to TPO gene] CTD PMID:28238834 copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of TPO mRNA CTD PMID:26033743 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of TPO mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of TPO mRNA CTD PMID:26033743 copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of TPO mRNA CTD PMID:26033743 cyclosporin A decreases methylation ISO RGD:735786 6480464 Cyclosporine results in decreased methylation of TPO promoter CTD PMID:27989131 daidzein decreases expression EXP 6480464 daidzein results in decreased expression of TPO mRNA CTD PMID:24793811 daidzein decreases activity ISO RGD:735786 6480464 daidzein results in decreased activity of TPO protein CTD PMID:31629072 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of TPO mRNA CTD PMID:23640034 , PMID:30844666 diarsenic trioxide multiple interactions ISO RGD:735786 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPO protein] more ... CTD PMID:25595679 , PMID:26598702 diarsenic trioxide decreases activity ISO RGD:735786 6480464 Arsenic Trioxide results in decreased activity of TPO protein CTD PMID:25595679 dibenz[a,h]anthracene increases activity ISO RGD:735786 6480464 1 more ... CTD PMID:21809831 dibutyl phthalate increases activity ISO RGD:735786 6480464 Dibutyl Phthalate results in increased activity of TPO protein CTD PMID:21809831 doxorubicin decreases expression ISO RGD:735786 6480464 Doxorubicin results in decreased expression of TPO mRNA CTD PMID:29803840 efavirenz increases expression ISO RGD:735786 6480464 efavirenz results in increased expression of TPO mRNA, efavirenz results in increased expression of TPO protein CTD PMID:16030158 Ethylenethiourea decreases activity ISO RGD:735786 6480464 Ethylenethiourea results in decreased activity of TPO protein CTD PMID:7626075 , PMID:9248629 Ethylenethiourea affects activity ISO RGD:735786 6480464 Ethylenethiourea affects the activity of TPO protein CTD PMID:31629072 fulvestrant increases methylation ISO RGD:735786 6480464 Fulvestrant results in increased methylation of TPO gene CTD PMID:31601247 fulvestrant multiple interactions ISO RGD:735786 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of TPO gene CTD PMID:31601247 genistein decreases activity ISO RGD:735786 6480464 Genistein results in decreased activity of TPO protein CTD PMID:21809831 , PMID:31629072 genistein decreases expression EXP 6480464 Genistein results in decreased expression of TPO mRNA, Genistein results in decreased expression of TPO protein CTD PMID:24793811 glutathione decreases activity ISO RGD:735786 6480464 Glutathione results in decreased activity of TPO protein CTD PMID:25595679 glutathione multiple interactions ISO RGD:735786 6480464 arsenic trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein], Glutathione promotes the reaction [arsenic trioxide results in decreased activity of TPO protein] CTD PMID:25595679 iodide salt increases oxidation ISO RGD:735786 6480464 TPO protein results in increased oxidation of Iodides CTD PMID:25595679 isoniazide decreases activity EXP 6480464 Isoniazid results in decreased activity of TPO protein CTD PMID:26884060 isoprenaline decreases activity EXP 6480464 Isoproterenol results in decreased activity of TPO protein CTD PMID:26884060 mancozeb decreases activity EXP 6480464 mancozeb results in decreased activity of TPO protein CTD PMID:9418944 methapyrilene increases methylation ISO RGD:735786 6480464 Methapyrilene results in increased methylation of TPO polyA tail CTD PMID:30157460 methimazole multiple interactions ISO RGD:735786 6480464 Methimazole binds to and results in decreased activity of TPO protein, Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:26865668 , PMID:7626075 methimazole decreases activity EXP 6480464 Methimazole results in decreased activity of TPO protein CTD PMID:22342233 more ... methimazole decreases activity ISO RGD:735786 6480464 Methimazole results in decreased activity of TPO protein CTD PMID:21809831 more ... methimazole increases expression EXP 6480464 Methimazole results in increased expression of TPO mRNA CTD PMID:22342233 minocycline decreases activity EXP 6480464 Minocycline results in decreased activity of TPO protein CTD PMID:26884060 Muraglitazar decreases expression EXP 6480464 muraglitazar results in decreased expression of TPO mRNA CTD PMID:21515302 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TPO mRNA] CTD PMID:30352396 N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TPO mRNA CTD PMID:22037397 nevirapine increases expression ISO RGD:735786 6480464 Nevirapine results in increased expression of TPO mRNA, Nevirapine results in increased expression of TPO protein CTD PMID:16030158 nitrogen dioxide multiple interactions ISO RGD:735786 6480464 [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene more ... CTD PMID:27448387 o-anisidine decreases activity EXP 6480464 2-anisidine results in decreased activity of TPO protein CTD PMID:26884060 oxymetholone increases expression ISO RGD:735786 6480464 Oxymetholone results in increased expression of TPO mRNA CTD PMID:15953861 ozone decreases expression ISO RGD:735786 6480464 Ozone results in decreased expression of TPO mRNA CTD PMID:27206323 perchlorate increases expression EXP 6480464 perchlorate results in increased expression of TPO mRNA CTD PMID:35385113 perfluorooctane-1-sulfonic acid decreases activity ISO RGD:735786 6480464 perfluorooctane sulfonic acid results in decreased activity of TPO protein CTD PMID:21809831 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of TPO mRNA CTD PMID:34246126 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of TPO mRNA CTD PMID:22037397 pregnenolone 16alpha-carbonitrile affects expression EXP 6480464 Pregnenolone Carbonitrile affects the expression of TPO mRNA CTD PMID:19162173 propanal decreases expression ISO RGD:735786 6480464 propionaldehyde results in decreased expression of TPO mRNA CTD PMID:26079696 pyridine-2,3-diol decreases activity EXP 6480464 2, 3-dihydroxypyridine results in decreased activity of TPO protein CTD PMID:26884060 pyrrolidine dithiocarbamate decreases activity EXP 6480464 pyrrolidine dithiocarbamic acid results in decreased activity of TPO promoter CTD PMID:11108245 pyrrolidine dithiocarbamate multiple interactions EXP 6480464 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA], PAX8 protein inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of TPO promoter] CTD PMID:11108245 pyrrolidine dithiocarbamate decreases expression EXP 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA CTD PMID:11108245 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of TPO mRNA, Quercetin results in decreased expression of TPO protein CTD PMID:24447974 resorcinol multiple interactions ISO RGD:735786 6480464 resorcinol binds to and results in decreased activity of TPO protein CTD PMID:26865668 resorcinol decreases activity ISO RGD:735786 6480464 resorcinol results in decreased activity of TPO protein CTD PMID:31629072 resorcinol decreases activity EXP 6480464 resorcinol results in decreased activity of TPO protein CTD PMID:31629072 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of TPO mRNA, resveratrol results in decreased expression of TPO protein CTD PMID:28668442 salicylhydroxamic acid decreases activity EXP 6480464 salicylhydroxamic acid results in decreased activity of TPO protein CTD PMID:26884060 silver atom increases expression ISO RGD:735786 6480464 Silver analog results in increased expression of TPO mRNA CTD PMID:27180073 silver(0) increases expression ISO RGD:735786 6480464 Silver analog results in increased expression of TPO mRNA CTD PMID:27180073 silver(1+) nitrate increases expression ISO RGD:735786 6480464 Silver Nitrate results in increased expression of TPO mRNA CTD PMID:27180073 sodium azide decreases activity EXP 6480464 Sodium Azide results in decreased activity of TPO protein CTD PMID:26884060 sodium iodide multiple interactions ISO RGD:735786 6480464 Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:7626075 sodium nitrate increases expression EXP 6480464 sodium nitrate results in increased expression of TPO mRNA CTD PMID:34409734 sodium perchlorate decreases activity EXP 6480464 sodium perchlorate results in decreased activity of TPO protein CTD PMID:23959146 sodium perchlorate increases expression EXP 6480464 sodium perchlorate results in increased expression of TPO mRNA, sodium perchlorate results in increased expression of TPO protein CTD PMID:29139221 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of TPO mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:735786 6480464 Testosterone results in increased expression of TPO mRNA CTD PMID:33359661 thyroxine multiple interactions EXP 6480464 [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 triclocarban decreases activity EXP 6480464 triclocarban results in decreased activity of TPO protein CTD PMID:26827900 triclosan decreases activity EXP 6480464 Triclosan results in decreased activity of TPO protein CTD PMID:26827900 , PMID:31629072 triclosan multiple interactions ISO RGD:735786 6480464 Triclosan binds to and results in decreased activity of TPO protein CTD PMID:26865668 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of TPO mRNA CTD PMID:25646720 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of TPO mRNA CTD PMID:21515302 valproic acid affects expression ISO RGD:733214 6480464 Valproic Acid affects the expression of TPO mRNA CTD PMID:17292431 , PMID:17963808 valproic acid increases methylation ISO RGD:735786 6480464 Valproic Acid results in increased methylation of TPO gene CTD PMID:29154799 vemurafenib multiple interactions ISO RGD:735786 6480464 [BRAF protein mutant form affects the susceptibility to Vemurafenib] which affects the expression of TPO mRNA more ... CTD PMID:26751190 vinclozolin decreases activity ISO RGD:735786 6480464 vinclozolin results in decreased activity of TPO protein CTD PMID:21809831 vorinostat increases expression ISO RGD:735786 6480464 vorinostat results in increased expression of TPO mRNA CTD PMID:26751190 vorinostat multiple interactions ISO RGD:735786 6480464 BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]] more ... CTD PMID:26751190 zineb decreases activity ISO RGD:735786 6480464 Zineb results in decreased activity of TPO protein CTD PMID:9248629 ziram decreases activity ISO RGD:735786 6480464 Ziram results in decreased activity of TPO protein CTD PMID:9248629
