Gene: Tpo (thyroid peroxidase) Rattus norvegicus
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Symbol: Tpo
Name: thyroid peroxidase
Description: ENCODES a protein that exhibits calcium ion binding (inferred); heme binding (inferred); iodide peroxidase activity (inferred); INVOLVED IN cellular response to nitric oxide; response to lipid; embryonic hemopoiesis (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; cytokine mediated signaling pathway; ASSOCIATED WITH Autoimmune Diseases (ortholog); congenital hypothyroidism (ortholog); Dwarfism (ortholog); FOUND IN cell surface; plasma membrane; INTERACTS WITH (S)-naringenin; 1,3-benzothiazole-2-thiol; 2,2',4,4'-Tetrabromodiphenyl ether
AGR Description: Predicted to have peroxidase activity; involved in cellular response to nitric oxide and response to lipid; localizes to the cell surface and plasma membrane; orthologous to human TPO (thyroid peroxidase).
Merged Description: Predicted to have peroxidase activity; involved in cellular response to nitric oxide and response to lipid; localizes to the cell surface and plasma membrane; orthologous to human TPO (thyroid peroxidase); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; cytokine mediated signaling pathway; INTERACTS WITH (S)-naringenin; 1,3-benzothiazole-2-thiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: truncated thyroid peroxidase
Orthologs:
Homo sapiens (human) : TPO (thyroid peroxidase)  HGNC  Alliance
Mus musculus (house mouse) : Tpo (thyroid peroxidase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpo (thyroid peroxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : TPO (thyroid peroxidase)
Canis lupus familiaris (dog) : TPO (thyroid peroxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpo (thyroid peroxidase)
Sus scrofa (pig) : TPO (thyroid peroxidase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0649,020,918 - 49,089,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0657,702,091 - 57,770,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4647,954,848 - 48,025,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1647,957,973 - 48,028,866 (-)NCBI
Celera645,906,515 - 45,971,940 (-)NCBICelera
Cytogenetic Map6q16NCBI
RH 3.4 Map6299.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tpo
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3900
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.