(S)-naringenin decreases activity ISO Tpo (Rattus norvegicus) 6480464 naringenin results in decreased activity of TPO protein CTD PMID:26884060 1,3-benzothiazole-2-thiol multiple interactions ISO TPO (Homo sapiens) 6480464 captax binds to and results in decreased activity of TPO protein CTD PMID:26865668 1,3-benzothiazole-2-thiol decreases activity ISO TPO (Homo sapiens) 6480464 captax results in decreased activity of TPO protein CTD PMID:31629072 1,3-benzothiazole-2-thiol decreases activity ISO Tpo (Rattus norvegicus) 6480464 captax results in decreased activity of TPO protein CTD PMID:23959146 more ... 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO TPO (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of TPO mRNA CTD PMID:15953861 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO Tpo (Rattus norvegicus) 6480464 2 more ... CTD PMID:26827900 2,4-Dihydroxybenzophenone decreases activity ISO Tpo (Rattus norvegicus) 6480464 2 and 4-dihydroxybenzophenone results in decreased activity of TPO protein CTD PMID:26884060 4,4'-diaminodiphenylmethane decreases activity ISO Tpo (Rattus norvegicus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased activity of TPO protein CTD PMID:26884060 4-Aminophenyl ether decreases activity ISO Tpo (Rattus norvegicus) 6480464 di-(4-aminophenyl)ether results in decreased activity of TPO protein CTD PMID:26884060 5-azacytidine increases expression ISO TPO (Homo sapiens) 6480464 Azacitidine results in increased expression of TPO mRNA CTD PMID:17679169 6-propyl-2-thiouracil decreases expression ISO TPO (Homo sapiens) 6480464 Propylthiouracil results in decreased expression of TPO mRNA CTD PMID:22342233 6-propyl-2-thiouracil multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 6-propyl-2-thiouracil decreases activity ISO Tpo (Rattus norvegicus) 6480464 Propylthiouracil results in decreased activity of TPO protein CTD PMID:22342233 more ... 6-propyl-2-thiouracil multiple interactions ISO TPO (Homo sapiens) 6480464 Propylthiouracil binds to and results in decreased activity of TPO protein CTD PMID:26865668 6-propyl-2-thiouracil increases expression ISO Tpo (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of TPO mRNA CTD PMID:22342233 6-propyl-2-thiouracil decreases activity ISO TPO (Homo sapiens) 6480464 Propylthiouracil results in decreased activity of TPO protein CTD PMID:22342233 and PMID:31629072 acrylamide increases expression ISO Tpo (Rattus norvegicus) 6480464 Acrylamide results in increased expression of TPO mRNA CTD PMID:28959563 all-trans-retinoic acid increases expression ISO TPO (Homo sapiens) 6480464 Tretinoin results in increased expression of TPO mRNA CTD PMID:17679169 all-trans-retinoic acid affects expression ISO TPO (Homo sapiens) 6480464 Tretinoin affects the expression of TPO mRNA CTD PMID:31600526 amiodarone increases expression ISO Tpo (Rattus norvegicus) 6480464 Amiodarone results in increased expression of TPO mRNA CTD PMID:27197836 amiodarone decreases expression ISO TPO (Homo sapiens) 6480464 Amiodarone results in decreased expression of TPO mRNA CTD PMID:18020914 amitrole decreases activity ISO Tpo (Rattus norvegicus) 6480464 Amitrole results in decreased activity of TPO protein CTD PMID:20937625 amitrole decreases activity ISO TPO (Homo sapiens) 6480464 Amitrole results in decreased activity of TPO protein CTD PMID:31629072 ammonium chloride affects expression ISO Tpo (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of TPO mRNA CTD PMID:16483693 arsane decreases expression ISO TPO (Homo sapiens) 6480464 Arsenic results in decreased expression of TPO mRNA CTD PMID:36861143 arsenic atom decreases expression ISO TPO (Homo sapiens) 6480464 Arsenic results in decreased expression of TPO mRNA CTD PMID:36861143 arsenous acid decreases activity ISO TPO (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of TPO protein CTD PMID:25595679 arsenous acid multiple interactions ISO TPO (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPO protein] more ... CTD PMID:25595679 and PMID:26598702 asbestos affects methylation ISO TPO (Homo sapiens) 6480464 Asbestos affects the methylation of TPO gene CTD PMID:28722770 bathocuproine disulfonic acid multiple interactions ISO Tpo (Rattus norvegicus) 6480464 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] CTD PMID:11108245 benzo[a]pyrene increases activity ISO TPO (Homo sapiens) 6480464 Benzo(a)pyrene results in increased activity of TPO protein CTD PMID:21809831 benzo[a]pyrene affects methylation ISO TPO (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of TPO promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO Tpo (Rattus norvegicus) 6480464 Benzo(a)pyrene results in decreased expression of TPO mRNA CTD PMID:21839799 and PMID:30085273 benzo[a]pyrene increases mutagenesis ISO TPO (Homo sapiens) 6480464 Benzo(a)pyrene results in increased mutagenesis of TPO gene CTD PMID:25435355 benzo[e]pyrene increases methylation ISO TPO (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of TPO polyA tail CTD PMID:30157460 benzophenone decreases activity ISO TPO (Homo sapiens) 6480464 benzophenone results in decreased activity of TPO protein CTD PMID:21809831 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of TPO mRNA CTD PMID:15674843 bisphenol A increases expression ISO Tpo (Rattus norvegicus) 6480464 bisphenol A results in increased expression of TPO mRNA CTD PMID:23238275 bisphenol A multiple interactions ISO TPO (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of TPO gene CTD PMID:31601247 bisphenol A decreases methylation ISO TPO (Homo sapiens) 6480464 bisphenol A results in decreased methylation of TPO gene CTD PMID:31601247 bisphenol A decreases activity ISO Tpo (Rattus norvegicus) 6480464 bisphenol A results in decreased activity of TPO protein CTD PMID:30352396 bisphenol A multiple interactions ISO Tpo (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TPO mRNA] CTD PMID:30352396 bisphenol A decreases expression ISO Tpo (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of TPO mRNA CTD PMID:25181051 more ... Butylparaben increases activity ISO Tpo (Rattus norvegicus) 6480464 butylparaben results in increased activity of TPO protein CTD PMID:32798586 Butylparaben increases expression ISO Tpo (Rattus norvegicus) 6480464 butylparaben results in increased expression of TPO mRNA CTD PMID:32798586 C60 fullerene decreases expression ISO Tpo (Rattus norvegicus) 6480464 fullerene C60 results in decreased expression of TPO mRNA CTD PMID:19167457 carbaryl increases activity ISO TPO (Homo sapiens) 6480464 Carbaryl results in increased activity of TPO protein CTD PMID:21809831 CGP 52608 multiple interactions ISO TPO (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to TPO gene] CTD PMID:28238834 copper atom increases expression ISO Tpo (Rattus norvegicus) 6480464 Copper deficiency results in increased expression of TPO mRNA CTD PMID:26033743 copper atom multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of TPO mRNA CTD PMID:26033743 copper(0) increases expression ISO Tpo (Rattus norvegicus) 6480464 Copper deficiency results in increased expression of TPO mRNA CTD PMID:26033743 copper(0) multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of TPO mRNA CTD PMID:26033743 cyclosporin A decreases methylation ISO TPO (Homo sapiens) 6480464 Cyclosporine results in decreased methylation of TPO promoter CTD PMID:27989131 daidzein decreases expression ISO Tpo (Rattus norvegicus) 6480464 daidzein results in decreased expression of TPO mRNA CTD PMID:24793811 daidzein decreases activity ISO TPO (Homo sapiens) 6480464 daidzein results in decreased activity of TPO protein CTD PMID:31629072 decabromodiphenyl ether decreases expression ISO Tpo (Rattus norvegicus) 6480464 decabromobiphenyl ether results in decreased expression of TPO mRNA CTD PMID:23640034 and PMID:30844666 diarsenic trioxide multiple interactions ISO TPO (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPO protein] more ... CTD PMID:25595679 and PMID:26598702 diarsenic trioxide decreases activity ISO TPO (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of TPO protein CTD PMID:25595679 dibenz[a,h]anthracene increases activity ISO TPO (Homo sapiens) 6480464 1 more ... CTD PMID:21809831 dibutyl phthalate increases activity ISO TPO (Homo sapiens) 6480464 Dibutyl Phthalate results in increased activity of TPO protein CTD PMID:21809831 doxorubicin decreases expression ISO TPO (Homo sapiens) 6480464 Doxorubicin results in decreased expression of TPO mRNA CTD PMID:29803840 efavirenz increases expression ISO TPO (Homo sapiens) 6480464 efavirenz results in increased expression of TPO mRNA and efavirenz results in increased expression of TPO protein CTD PMID:16030158 Ethylenethiourea decreases activity ISO TPO (Homo sapiens) 6480464 Ethylenethiourea results in decreased activity of TPO protein CTD PMID:7626075 and PMID:9248629 Ethylenethiourea affects activity ISO TPO (Homo sapiens) 6480464 Ethylenethiourea affects the activity of TPO protein CTD PMID:31629072 fulvestrant increases methylation ISO TPO (Homo sapiens) 6480464 Fulvestrant results in increased methylation of TPO gene CTD PMID:31601247 fulvestrant multiple interactions ISO TPO (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of TPO gene CTD PMID:31601247 genistein decreases activity ISO TPO (Homo sapiens) 6480464 Genistein results in decreased activity of TPO protein CTD PMID:21809831 and PMID:31629072 genistein decreases expression ISO Tpo (Rattus norvegicus) 6480464 Genistein results in decreased expression of TPO mRNA and Genistein results in decreased expression of TPO protein CTD PMID:24793811 glutathione decreases activity ISO TPO (Homo sapiens) 6480464 Glutathione results in decreased activity of TPO protein CTD PMID:25595679 glutathione multiple interactions ISO TPO (Homo sapiens) 6480464 arsenic trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein] and Glutathione promotes the reaction [arsenic trioxide results in decreased activity of TPO protein] CTD PMID:25595679 glyphosate increases expression ISO Tpo (Rattus norvegicus) 6480464 Glyphosate results in increased expression of TPO mRNA CTD PMID:36462676 iodide salt increases oxidation ISO TPO (Homo sapiens) 6480464 TPO protein results in increased oxidation of Iodides CTD PMID:25595679 isoniazide decreases activity ISO Tpo (Rattus norvegicus) 6480464 Isoniazid results in decreased activity of TPO protein CTD PMID:26884060 isoprenaline decreases activity ISO Tpo (Rattus norvegicus) 6480464 Isoproterenol results in decreased activity of TPO protein CTD PMID:26884060 mancozeb decreases activity ISO Tpo (Rattus norvegicus) 6480464 mancozeb results in decreased activity of TPO protein CTD PMID:9418944 methapyrilene increases methylation ISO TPO (Homo sapiens) 6480464 Methapyrilene results in increased methylation of TPO polyA tail CTD PMID:30157460 methimazole multiple interactions ISO TPO (Homo sapiens) 6480464 Methimazole binds to and results in decreased activity of TPO protein and Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:26865668 and PMID:7626075 methimazole decreases activity ISO Tpo (Rattus norvegicus) 6480464 Methimazole results in decreased activity of TPO protein CTD PMID:22342233 more ... methimazole decreases activity ISO TPO (Homo sapiens) 6480464 Methimazole results in decreased activity of TPO protein CTD PMID:21809831 more ... methimazole increases expression ISO Tpo (Rattus norvegicus) 6480464 Methimazole results in increased expression of TPO mRNA CTD PMID:22342233 minocycline decreases activity ISO Tpo (Rattus norvegicus) 6480464 Minocycline results in decreased activity of TPO protein CTD PMID:26884060 mono(2-ethylhexyl) phthalate decreases expression ISO TPO (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of TPO protein CTD PMID:36005737 Muraglitazar decreases expression ISO Tpo (Rattus norvegicus) 6480464 muraglitazar results in decreased expression of TPO mRNA CTD PMID:21515302 N-acetyl-L-cysteine multiple interactions ISO Tpo (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TPO mRNA] CTD PMID:30352396 N-Vinyl-2-pyrrolidone multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TPO mRNA CTD PMID:22037397 nevirapine increases expression ISO TPO (Homo sapiens) 6480464 Nevirapine results in increased expression of TPO mRNA and Nevirapine results in increased expression of TPO protein CTD PMID:16030158 nitrogen dioxide multiple interactions ISO TPO (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene more ... CTD PMID:27448387 o-anisidine decreases activity ISO Tpo (Rattus norvegicus) 6480464 2-anisidine results in decreased activity of TPO protein CTD PMID:26884060 oxymetholone increases expression ISO TPO (Homo sapiens) 6480464 Oxymetholone results in increased expression of TPO mRNA CTD PMID:15953861 ozone decreases expression ISO TPO (Homo sapiens) 6480464 Ozone results in decreased expression of TPO mRNA CTD PMID:27206323 perchlorate increases expression ISO Tpo (Rattus norvegicus) 6480464 perchlorate results in increased expression of TPO mRNA CTD PMID:35385113 perfluorooctane-1-sulfonic acid decreases activity ISO TPO (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in decreased activity of TPO protein CTD PMID:21809831 perfluorooctanoic acid decreases expression ISO Tpo (Rattus norvegicus) 6480464 perfluorooctanoic acid results in decreased expression of TPO mRNA CTD PMID:34246126 phenobarbital increases expression ISO Tpo (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of TPO mRNA CTD PMID:22037397 potassium iodide multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [Potassium Iodide co-treated with TSHB protein co-treated with FOXE1 protein] binds to TPO promoter more ... CTD PMID:27568464 pregnenolone 16alpha-carbonitrile affects expression ISO Tpo (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile affects the expression of TPO mRNA CTD PMID:19162173 propanal decreases expression ISO TPO (Homo sapiens) 6480464 propionaldehyde results in decreased expression of TPO mRNA CTD PMID:26079696 pyridine-2,3-diol decreases activity ISO Tpo (Rattus norvegicus) 6480464 2 and 3-dihydroxypyridine results in decreased activity of TPO protein CTD PMID:26884060 pyrrolidine dithiocarbamate decreases activity ISO Tpo (Rattus norvegicus) 6480464 pyrrolidine dithiocarbamic acid results in decreased activity of TPO promoter CTD PMID:11108245 pyrrolidine dithiocarbamate multiple interactions ISO Tpo (Rattus norvegicus) 6480464 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] and PAX8 protein inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of TPO promoter] CTD PMID:11108245 pyrrolidine dithiocarbamate decreases expression ISO Tpo (Rattus norvegicus) 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA CTD PMID:11108245 quercetin decreases expression ISO Tpo (Rattus norvegicus) 6480464 Quercetin results in decreased expression of TPO mRNA and Quercetin results in decreased expression of TPO protein CTD PMID:24447974 resorcinol multiple interactions ISO TPO (Homo sapiens) 6480464 resorcinol binds to and results in decreased activity of TPO protein CTD PMID:26865668 resorcinol decreases activity ISO Tpo (Rattus norvegicus) 6480464 resorcinol results in decreased activity of TPO protein CTD PMID:31629072 resorcinol decreases activity ISO TPO (Homo sapiens) 6480464 resorcinol results in decreased activity of TPO protein CTD PMID:31629072 resveratrol decreases expression ISO Tpo (Rattus norvegicus) 6480464 Resveratrol results in decreased expression of TPO mRNA and Resveratrol results in decreased expression of TPO protein CTD PMID:28668442 salicylhydroxamic acid decreases activity ISO Tpo (Rattus norvegicus) 6480464 salicylhydroxamic acid results in decreased activity of TPO protein CTD PMID:26884060 silver atom increases expression ISO TPO (Homo sapiens) 6480464 Silver analog results in increased expression of TPO mRNA CTD PMID:27180073 silver(0) increases expression ISO TPO (Homo sapiens) 6480464 Silver analog results in increased expression of TPO mRNA CTD PMID:27180073 silver(1+) nitrate increases expression ISO TPO (Homo sapiens) 6480464 Silver Nitrate results in increased expression of TPO mRNA CTD PMID:27180073 sodium azide decreases activity ISO Tpo (Rattus norvegicus) 6480464 Sodium Azide results in decreased activity of TPO protein CTD PMID:26884060 sodium iodide multiple interactions ISO TPO (Homo sapiens) 6480464 Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:7626075 sodium nitrate increases expression ISO Tpo (Rattus norvegicus) 6480464 sodium nitrate results in increased expression of TPO mRNA CTD PMID:34409734 sodium perchlorate decreases activity ISO Tpo (Rattus norvegicus) 6480464 sodium perchlorate results in decreased activity of TPO protein CTD PMID:23959146 sodium perchlorate increases expression ISO Tpo (Rattus norvegicus) 6480464 sodium perchlorate results in increased expression of TPO mRNA and sodium perchlorate results in increased expression of TPO protein CTD PMID:29139221 Tesaglitazar decreases expression ISO Tpo (Rattus norvegicus) 6480464 tesaglitazar results in decreased expression of TPO mRNA CTD PMID:21515302 testosterone increases expression ISO TPO (Homo sapiens) 6480464 Testosterone results in increased expression of TPO mRNA CTD PMID:33359661 thyroxine multiple interactions ISO Tpo (Rattus norvegicus) 6480464 [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 triclocarban decreases activity ISO Tpo (Rattus norvegicus) 6480464 triclocarban results in decreased activity of TPO protein CTD PMID:26827900 triclosan multiple interactions ISO TPO (Homo sapiens) 6480464 Triclosan binds to and results in decreased activity of TPO protein CTD PMID:26865668 triclosan decreases activity ISO Tpo (Rattus norvegicus) 6480464 Triclosan results in decreased activity of TPO protein CTD PMID:26827900 and PMID:31629072 triphenyl phosphate increases expression ISO Tpo (Rattus norvegicus) 6480464 triphenyl phosphate results in increased expression of TPO mRNA CTD PMID:25646720 troglitazone decreases expression ISO Tpo (Rattus norvegicus) 6480464 troglitazone results in decreased expression of TPO mRNA CTD PMID:21515302 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TPO mRNA CTD PMID:17292431 and PMID:17963808 valproic acid increases methylation ISO TPO (Homo sapiens) 6480464 Valproic Acid results in increased methylation of TPO gene CTD PMID:29154799 vemurafenib multiple interactions ISO TPO (Homo sapiens) 6480464 [BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of TPO mRNA more ... CTD PMID:26751190 vinclozolin decreases activity ISO TPO (Homo sapiens) 6480464 vinclozolin results in decreased activity of TPO protein CTD PMID:21809831 vorinostat increases expression ISO TPO (Homo sapiens) 6480464 vorinostat results in increased expression of TPO mRNA CTD PMID:26751190 vorinostat multiple interactions ISO TPO (Homo sapiens) 6480464 BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]] more ... CTD PMID:26751190 zineb decreases activity ISO TPO (Homo sapiens) 6480464 Zineb results in decreased activity of TPO protein CTD PMID:9248629 ziram decreases activity ISO TPO (Homo sapiens) 6480464 Ziram results in decreased activity of TPO protein CTD PMID:9248629